phenobarbital has been researched along with Drug-Induced Stevens Johnson Syndrome in 44 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have demonstrated a strong association between carbamazepine (CBZ)-induced Stevens-Johnson syndrome (SJS) and HLA-B*1502 in Han Chinese." | 3.80 | Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China. ( He, XL; Hu, JS; Liu, ZS; Mao, B; Sun, D; Wu, GF; Wu, SH; Xiang, HH; Yu, CH, 2014) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| " Phenytoin, on the other hand, causes gingival hyperplasia in many patients, irreversible hypertrichosis in some patients and lethal reactions, such as Stevens-Johnson syndrome, in a few patients." | 3.66 | Phenobarbital vs. phenytoin for grand mal epilepsy. ( Kramer, II; Livingston, S; Pauli, LL; Pruce, I, 1980) |
| "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications." | 1.35 | Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. ( Banelli, E; Bulzonetti, N; Caiazzo, R; Dionisi, F; Lichtner, M; Musio, D; Parisi, E; Parisi, G; Raffetto, N; Vullo, V, 2009) |
| "Several bullae and erosions were noted on grafted areas 3 weeks later." | 1.28 | Transient intraepidermal bullous reaction after skin graft for toxic epidermal necrolysis. Ultrastructural and immunohistochemical features similar to those of inherited epidermolysis bullosa simplex. ( André, C; Bourgault, I; Chosidow, O; Prost, C; Revuz, J; Villada, G; Wechsler, J, 1991) |
| "The authors report 18 children with toxic epidermal necrolysis (T." | 1.27 | [Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases]. ( Cloup, M; De Frost, Y; Hubert, P; Marsol, P; Richard, P; Roujeau, JC; Teillac, D, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (45.45) | 18.7374 |
| 1990's | 9 (20.45) | 18.2507 |
| 2000's | 10 (22.73) | 29.6817 |
| 2010's | 5 (11.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hosohata, K | 1 |
| Inada, A | 1 |
| Oyama, S | 1 |
| Niinomi, I | 1 |
| Wakabayashi, T | 1 |
| Iwanaga, K | 1 |
| Sun, D | 1 |
| Yu, CH | 1 |
| Liu, ZS | 1 |
| He, XL | 1 |
| Hu, JS | 1 |
| Wu, GF | 1 |
| Mao, B | 1 |
| Wu, SH | 1 |
| Xiang, HH | 1 |
| Kaputu-Kalala-Malu, C | 1 |
| Ntumba-Tshitenge, O | 1 |
| Misson, JP | 1 |
| Ordoñez, L | 1 |
| Salgueiro, E | 1 |
| Jimeno, FJ | 1 |
| Manso, G | 1 |
| Cornelis, I | 1 |
| Vandenabeele, S | 1 |
| Dunon, D | 1 |
| Van Ham, L | 1 |
| Soto, I | 1 |
| Núñez Calvo, ML | 1 |
| Pintos, A | 1 |
| Gómez, R | 1 |
| Alvarez, J | 1 |
| Riu, M | 1 |
| Musio, D | 1 |
| Parisi, E | 1 |
| Dionisi, F | 1 |
| Parisi, G | 1 |
| Caiazzo, R | 1 |
| Bulzonetti, N | 1 |
| Lichtner, M | 1 |
| Raffetto, N | 1 |
| Vullo, V | 1 |
| Banelli, E | 1 |
| Mamishi, S | 1 |
| Fattahi, F | 1 |
| Pourpak, Z | 1 |
| Aghaee, FM | 1 |
| Moinfar, Z | 1 |
| Mohammadi, M | 1 |
| Ashrafi, M | 1 |
| Moin, M | 1 |
| Uzüm, K | 1 |
| Caksen, H | 1 |
| Gündüz, Z | 1 |
| Ustünbaş, HB | 1 |
| Kandemir, O | 1 |
| Vincenzi, B | 1 |
| Santini, D | 1 |
| Grilli, C | 1 |
| La Cesa, A | 1 |
| Dianzani, C | 1 |
| Tonini, G | 1 |
| Mockenhaupt, M | 1 |
| Messenheimer, J | 1 |
| Tennis, P | 1 |
| Schlingmann, J | 1 |
| Kobayashi, A | 1 |
| Yoshita, T | 1 |
| Sugiyama, K | 1 |
| Miyashita, K | 1 |
| Niida, Y | 1 |
| Koizumi, S | 1 |
| Tseng, SC | 1 |
| Ruggiero, A | 1 |
| Buonuomo, PS | 1 |
| Maurizi, P | 1 |
| Cefalo, MG | 1 |
| Cefalo, MP | 1 |
| Corsello, M | 1 |
| Riccardi, R | 1 |
| Iijima, M | 1 |
| Vandvik, IH | 1 |
| Brahams, D | 1 |
| Livingston, S | 1 |
| Pauli, LL | 1 |
| Pruce, I | 1 |
| Kramer, II | 1 |
| Koukoulis, A | 1 |
| Sopeña, B | 1 |
| Muñoz, D | 1 |
| de la Fuente, J | 1 |
| Errani, A | 1 |
| Reggiani, M | 1 |
| Schianchi, S | 1 |
| Staffa, M | 1 |
| Stewart, MG | 1 |
| Duncan, NO | 1 |
| Franklin, DJ | 1 |
| Friedman, EM | 1 |
| Sulek, M | 1 |
| Weltman, E | 1 |
| Salvajoli, JV | 1 |
| Labandeira García, J | 1 |
| Duncan, KO | 1 |
| Tigelaar, RE | 1 |
| Bolognia, JL | 1 |
| Stutts, JT | 1 |
| Washington, K | 1 |
| Barnard, JA | 1 |
| Z'Graggen, WJ | 1 |
| Itin, PH | 1 |
| Conen, D | 1 |
| Taaffe, A | 1 |
| O'Brien, C | 1 |
| Adams, N | 1 |
| Addison, CM | 1 |
| Pollack, MA | 1 |
| Burk, PG | 1 |
| Nathanson, G | 1 |
| Kirby, JD | 1 |
| Darley, CR | 1 |
| Nozicková, M | 1 |
| Danda, J | 1 |
| Hamáková, K | 1 |
| Kraus, Z | 1 |
| Giallorenzi, AF | 1 |
| Goldstein, BH | 1 |
| Deviller, G | 1 |
| Langevin, P | 1 |
| Drouin, M | 1 |
| Lleonart, R | 1 |
| Nomdedeu, J | 1 |
| Sambeat, MA | 1 |
| Bourgault, I | 1 |
| Prost, C | 1 |
| André, C | 1 |
| Villada, G | 1 |
| Wechsler, J | 1 |
| Chosidow, O | 1 |
| Revuz, J | 1 |
| Teillac, D | 1 |
| Marsol, P | 1 |
| Richard, P | 1 |
| Hubert, P | 1 |
| Roujeau, JC | 1 |
| Cloup, M | 1 |
| De Frost, Y | 1 |
| de Rego, JA | 1 |
| Goldstein, DM | 1 |
| Avery, JK | 1 |
| Messaritakis, J | 1 |
| Adams, RM | 1 |
| Farber, EM | 1 |
| Stüttgen, G | 1 |
| Monnat, A | 1 |
| Bell, DR | 1 |
| Adeloye, A | 1 |
| Familusi, JB | 1 |
| Alabi, GO | 1 |
| Latunde Odeku, E | 1 |
| Haraszti, A | 1 |
| Urbán, G | 1 |
1 review available for phenobarbital and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
[Judicial judgment for severe adverse drug reaction (ADR)].
Topics: Clinical Competence; Humans; Indomethacin; Liability, Legal; Malpractice; Phenobarbital; Referral an | 2007 |
43 other studies available for phenobarbital and Drug-Induced Stevens Johnson Syndrome
| Article | Year |
|---|---|
Adverse Cutaneous Drug Reactions Associated with Old- and New- Generation Antiepileptic Drugs Using the Japanese Pharmacovigilance Database.
Topics: Anticonvulsants; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Exanthema; Fem | 2019 |
Association of HLA-B*1502 and *1511 allele with antiepileptic drug-induced Stevens-Johnson syndrome in central China.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; China; F | 2014 |
[Toxic epidermal necrolysis induced by phenobarbital in a Rwandan child: report of a case].
Topics: Anticonvulsants; Child, Preschool; Humans; Male; Phenobarbital; Rwanda; Stevens-Johnson Syndrome | 2014 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Pr | 2015 |
Presumed phenobarbital-induced Stevens-Johnson syndrome in a 4-year-old female Great Dane.
Topics: Animals; Anticonvulsants; Bromides; Dog Diseases; Dogs; Female; Phenobarbital; Potassium Compounds; | 2016 |
[Fever and skin lesions in patients treated with phenobarbital].
Topics: Aged; Anticonvulsants; Female; Fever; Humans; Phenobarbital; Skin Diseases; Stevens-Johnson Syndrome | 2008 |
Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases.
Topics: Anticonvulsants; Bone Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Mid | 2009 |
Severe cutaneous reactions caused by barbiturates in seven Iranian children.
Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Epilepsy; Female; Humans; Infant; | 2009 |
A fatal case of toxic epidermal necrolysis associated with liver cirrhosis.
Topics: Child; Disease Progression; Dose-Response Relationship, Drug; Emergency Service, Hospital; Fatal Out | 2003 |
Complications of therapy in cancer patients: Case 3. Toxic epidermal necrolysis induced by oral phenobarbital and whole-brain radiotherapy in a breast cancer patient.
Topics: Administration, Oral; Anticonvulsants; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Femal | 2004 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Amniotic membrane transplantation in acute phase of toxic epidermal necrolysis with severe corneal involvement.
Topics: Acute Disease; Amnion; Cell Count; Child; Conjunctival Diseases; Corneal Diseases; Cryopreservation; | 2006 |
Stevens-Johnson syndrome in children receiving phenobarbital therapy and cranial radiotherapy.
Topics: Anticonvulsants; Brain Neoplasms; Child; Combined Modality Therapy; Cranial Irradiation; Female; Hum | 2007 |
[Toxic epidermal necrolysis. Epidermolysis necroticans combustiforme].
Topics: Child, Preschool; Exanthema; Humans; Male; Phenobarbital; Phenytoin; Stevens-Johnson Syndrome | 1967 |
Medicine and the law. Risk of Stevens-Johnson syndrome due to phenobarbitone too remote to be foreseeable.
Topics: Adult; Humans; Male; Malpractice; Phenobarbital; Stevens-Johnson Syndrome; United Kingdom | 1982 |
Phenobarbital vs. phenytoin for grand mal epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epi | 1980 |
[The Stevens-Johnson syndrome induced by phenobarbital in a patient with Becker's disease].
Topics: Adolescent; Genetic Linkage; Humans; Male; Muscular Dystrophies; Phenobarbital; Psoriasis; Seizures; | 1994 |
Toxic epidermal necrolysis induced by barbiturates and radiotherapy.
Topics: Aged; Humans; Male; Phenobarbital; Radiotherapy; Stevens-Johnson Syndrome | 1994 |
Head and neck manifestations of erythema multiforme in children.
Topics: Adolescent; Anti-Bacterial Agents; Anticonvulsants; Child; Child, Preschool; Conjunctival Diseases; | 1994 |
Stevens-Johnson syndrome resulting from whole-brain irradiation and phenytoin.
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Brain Neoplasms; Combined Modality Therapy; Dexame | 1996 |
[Stevens-Johnson syndrome and fixed drug eruption].
Topics: Diagnosis, Differential; Drug Eruptions; Humans; Hypnotics and Sedatives; Phenobarbital; Stevens-Joh | 1995 |
Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital.
Topics: Biopsy; Combined Modality Therapy; Humans; Male; Middle Aged; Phenobarbital; Radiotherapy; Stevens-J | 1999 |
Cholestatic jaundice with skin desquamation in a 12-year-old girl.
Topics: Atropine; Child; Cholestasis; Cryptogenic Organizing Pneumonia; Drug Combinations; Fatal Outcome; Fe | 1999 |
[Progressive, small spotted, confluent erythema with bullae formation and general symptoms. Acute Lyell syndrome].
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; S | 2000 |
A case of Stevens-Johnson syndrome associated with the anti-convulsants sulthiame and ethosuximide.
Topics: Adolescent; Epilepsy, Absence; Ethosuximide; Humans; Male; Phenobarbital; Prednisolone; Stevens-John | 1975 |
How to learn from a case where nearly everything went right: making your best better.
Topics: Child, Preschool; Humans; Male; Patient Care Planning; Patient Isolation; Pediatric Nursing; Phenoba | 1978 |
Mucocutaneous eruptions due to antiepileptic drug therapy in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Erythema Multiforme; Female; Humans; Male; | 1979 |
Eruptive melanocytic naevi following severe bullous disease.
Topics: Child; Female; Humans; Male; Nevus, Pigmented; Phenobarbital; Phenytoin; Skin Neoplasms; Stevens-Joh | 1978 |
[Toxic epidermal necrolosys -- Lyell's syndrome in a patient protractedly treated by anti-epileptic agents].
Topics: Adult; Anticonvulsants; Barbiturates; Epilepsy; Humans; Male; Mephenytoin; Phenobarbital; Phenytoin; | 1976 |
Acute (toxic) epidermal necrolysis. Report of a case.
Topics: Child, Preschool; Dextroamphetamine; Humans; Male; Mouth Diseases; Mouth Mucosa; Phenobarbital; Phen | 1975 |
[Toxic epidermic necrolysis].
Topics: Child; Female; Humans; Phenobarbital; Seizures; Stevens-Johnson Syndrome | 1975 |
[Stevens-Johnson syndrome induced by tetrabamate in a patient with HIV infection].
Topics: Adult; Barbiturates; Drug Combinations; Female; HIV Seropositivity; Humans; Phenobarbital; Psychotro | 1992 |
Transient intraepidermal bullous reaction after skin graft for toxic epidermal necrolysis. Ultrastructural and immunohistochemical features similar to those of inherited epidermolysis bullosa simplex.
Topics: Blister; Collagen; Epidermis; Epidermolysis Bullosa Acquisita; Epidermolysis Bullosa Simplex; Female | 1991 |
[Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases].
Topics: Child; Child, Preschool; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Male; Oxy | 1987 |
Case report: psychosis with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Topics: Adult; Basal Ganglia; Female; Humans; Phenobarbital; Phenytoin; Psychotic Disorders; Stevens-Johnson | 1985 |
Without a quarterback--you lose!
Topics: Child; Communication; Humans; Male; Phenobarbital; Stevens-Johnson Syndrome | 1985 |
Toxic epidermal necrolysis in children. (Description of 4 cases).
Topics: Child, Preschool; Dermatitis, Exfoliative; Diagnosis, Differential; Epidermolysis Bullosa; Female; H | 1966 |
Treatment dermatitis. 2. Dermatitis medicamentosa.
Topics: Chlortetracycline; Drug Eruptions; Gold; Heparin; Humans; Lichen Planus; Lupus Vulgaris; Phenobarbit | 1969 |
Toxic epidermal necrolysis provoked by barbiturates.
Topics: Adrenal Cortex Hormones; Aged; Endocarditis; Female; Gastrointestinal Hemorrhage; Humans; Phenobarbi | 1973 |
[Comparative study of Lyell's and Stevens-Johnson syndromes: etiologic role of drugs].
Topics: Adolescent; Adult; Aged; Aspirin; Caffeine; Child; Child, Preschool; Codeine; Female; Humans; Hydant | 1972 |
Drugs for convulsions.
Topics: Adult; Child; Child, Preschool; Diazepam; Humans; Phenobarbital; Phenytoin; Seizures; Stevens-Johnso | 1973 |
Stevens-Johnson syndrome following anticonvulsant therapy in penetrating head injury.
Topics: Adult; Anticonvulsants; Child; Craniocerebral Trauma; Female; Humans; Male; Phenobarbital; Stevens-J | 1971 |
[Fatal Lyell syndrome caused by Meristin].
Topics: Adolescent; Aminopyrine; Female; Humans; Phenobarbital; Stevens-Johnson Syndrome | 1966 |