phenobarbital has been researched along with Drug Hypersensitivity in 77 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Drug Hypersensitivity: Immunologically mediated adverse reactions to medicinal substances used legally or illegally.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 8.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| " A 3-year-old boy developed alopecia areata (AA) universalis in the convalescent status of phenobarbital-induced AHS, compatible to the evidences of increased lymphocyte proliferation and increased dead cells percentages while his peripheral blood mononuclear cells were incubated with phenobarbital." | 7.75 | Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome. ( Chen, ST; Hsiao, PF; Hsieh, MY; Huang, JL; Huang, YL; Kuo, HC; Lee, WI; Sheen, JM; Yang, KD; Yu, HR, 2009) |
| "To report a case of type 1 diabetes mellitus (T1DM) in a child with phenobarbital hypersensitivity syndrome with an emphasis on the clinical presentation, diagnostic modalities and treatment options." | 7.74 | Type 1 diabetes mellitus in a child with phenobarbital hypersensitivity syndrome. ( Fu, JF; Liang, L; Zou, CC, 2008) |
| "A 68-year-old man was diagnosed as drug-induced hypersensitivity syndrome (DIHS) with erythema and liver dysfunction three weeks after an administration of phenobarbital." | 7.73 | [Limbic encephalitis associated with drug-induced hypersensitivity syndrome due to phenobarbital--a case report]. ( Chiba, A; Ito, T; Ooishi, C; Sakuma, K; Sakuta, M; Shiohara, T, 2005) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 7.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| "The antiepileptic drug hypersensitivity syndrome (AHS) is an adverse drug reaction associated with the aromatic antiepileptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), and primidone." | 4.80 | Antiepileptic drug hypersensitivity syndrome. ( Schlienger, RG; Shear, NH, 1998) |
| "Anticonvulsant hypersensitivity syndrome (AHS) is an uncommon but potentially fatal adverse effect that can occur from exposure to phenytoin, carbamazepine, or phenobarbital." | 4.79 | Anticonvulsant hypersensitivity syndrome. ( Miller, MB; Morkunas, AR, 1997) |
| "A 2-yr-old child developed massive hepatic necrosis caused by an unusual hypersensitivity response to phenobarbital that was prescribed for presumed febrile seizures." | 4.77 | Massive hepatic necrosis in a child after administration of phenobarbital. ( Crowley, M; Mockli, G; Stern, R; Warnock, ML, 1989) |
| "Phenobarbital hypersensitivity is one of the common drug hypersensitivity syndromes in children." | 3.83 | Association of HLA genotypes with phenobarbital hypersensitivity in children. ( Benjaponpitak, S; Inunchot, W; Kamchaisatian, W; Likkasittipan, P; Mahasirimongkol, S; Manuyakorn, W; Visudtibhan, A; Wattanapokayakit, S; Wichukchinda, N, 2016) |
| " A 3-year-old boy developed alopecia areata (AA) universalis in the convalescent status of phenobarbital-induced AHS, compatible to the evidences of increased lymphocyte proliferation and increased dead cells percentages while his peripheral blood mononuclear cells were incubated with phenobarbital." | 3.75 | Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome. ( Chen, ST; Hsiao, PF; Hsieh, MY; Huang, JL; Huang, YL; Kuo, HC; Lee, WI; Sheen, JM; Yang, KD; Yu, HR, 2009) |
| " We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease." | 3.74 | Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome. ( Fukuhara, M; Kano, Y; Sakuma, K; Shiohara, T, 2008) |
| "To report a case of type 1 diabetes mellitus (T1DM) in a child with phenobarbital hypersensitivity syndrome with an emphasis on the clinical presentation, diagnostic modalities and treatment options." | 3.74 | Type 1 diabetes mellitus in a child with phenobarbital hypersensitivity syndrome. ( Fu, JF; Liang, L; Zou, CC, 2008) |
| "A 68-year-old man was diagnosed as drug-induced hypersensitivity syndrome (DIHS) with erythema and liver dysfunction three weeks after an administration of phenobarbital." | 3.73 | [Limbic encephalitis associated with drug-induced hypersensitivity syndrome due to phenobarbital--a case report]. ( Chiba, A; Ito, T; Ooishi, C; Sakuma, K; Sakuta, M; Shiohara, T, 2005) |
| "We describe the case of a patient in whom anticonvulsant hypersensitivity syndrome developed during treatment with phenytoin and progressed when therapy was changed to phenobarbital." | 3.72 | Anticonvulsant hypersensitivity syndrome: treatment with corticosteroids and intravenous immunoglobulin. ( Finch, CK; Jones, R; Mostella, J; Pieroni, R, 2004) |
| " the LTA by using trypan blue exclusion and to determine the utility of the assay to confirm drug hypersensitivity syndrome (DHS) to sulphonamides (SMX) and aromatic anticonvulsants." | 3.70 | A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. ( Malkiewicz, IM; Neuman, MG; Shear, NH, 2000) |
| "Anticonvulsant hypersensitivity syndrome is a potentially fatal drug reaction with cutaneous and systemic reactions (incidence, one in 1000 to one in 10,000 exposures) to the arene oxide-producing anticonvulsants--phenytoin, carbamazepine, and phenobarbital sodium." | 3.69 | Anticonvulsant hypersensitivity syndrome. ( Muglia, JJ; Vittorio, CC, 1995) |
| " We report a patient with severe phenobarbital-induced anticonvulsant hypersensitivity syndrome in whom a fulminant haemophagocytic syndrome was associated with HHV6 infection." | 3.69 | Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome. ( Aslangul, E; Belaich, S; Bouscarat, F; Crickx, B; Descamps, D; Descamps, V; Grange, MJ; Grossin, M; Laglenne, S; Navratil, E; Saraux, JL; Veber, B, 1997) |
| "Four-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam." | 3.68 | Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome. ( Bertz, RJ; Howrie, DL, 1993) |
| " Investigations ruled out an infectious etiology; an adverse event following phenobarbital administration was considered." | 1.32 | Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment. ( Bavdekar, SB; Gogtay, NJ; Kantharia, V; Kshirsagar, NA; Muranjan, MN, 2004) |
| "This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs." | 1.32 | [Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004) |
| " In addition, there was a significant dose-response association between the development of procarbazine hypersensitivity and the presence of therapeutic anticonvulsant serum levels (p = 0." | 1.30 | Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors. ( Coyle, TE; Hurteau, TE; Lehmann, DF; Newman, N, 1997) |
| "The laboratory findings revealed leukocytosis with atypical lymphocytes, eosinophilia and altered liver function." | 1.27 | [Hypersensitivity syndrome caused by phenytoins and phenobarbital]. ( Azulay, DR; Azulay, RD; Fonseca, JC; Rozembau, I, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (49.35) | 18.7374 |
| 1990's | 12 (15.58) | 18.2507 |
| 2000's | 19 (24.68) | 29.6817 |
| 2010's | 8 (10.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sohn, SJ | 1 |
| Jeung, SY | 1 |
| Chae, HK | 1 |
| Cho, HS | 1 |
| An, JH | 1 |
| Li, Q | 1 |
| Song, WJ | 1 |
| Youn, HY | 1 |
| Witcher, RH | 1 |
| Ramirez, MM | 1 |
| Manuyakorn, W | 2 |
| Siripool, K | 1 |
| Kamchaisatian, W | 2 |
| Pakakasama, S | 1 |
| Visudtibhan, A | 2 |
| Vilaiyuk, S | 1 |
| Rujirawat, T | 1 |
| Benjaponpitak, S | 2 |
| Mahasirimongkol, S | 1 |
| Likkasittipan, P | 1 |
| Wattanapokayakit, S | 1 |
| Inunchot, W | 1 |
| Wichukchinda, N | 1 |
| Bosseler, L | 1 |
| Cornelis, I | 1 |
| Defauw, P | 1 |
| Daminet, S | 1 |
| Ducatelle, R | 1 |
| Taillia, H | 1 |
| Alla, P | 1 |
| Fournier, B | 1 |
| Bounolleau, P | 1 |
| Ouologem, M | 1 |
| Ricard, D | 1 |
| Sallansonnet-Froment, M | 1 |
| de Greslan, T | 1 |
| Renard, JL | 1 |
| Voltolini, S | 1 |
| Bignardi, D | 1 |
| Minale, P | 1 |
| Pellegrini, S | 1 |
| Troise, C | 1 |
| Huang, YL | 1 |
| Hsieh, MY | 1 |
| Hsiao, PF | 1 |
| Sheen, JM | 1 |
| Yu, HR | 1 |
| Kuo, HC | 1 |
| Chen, ST | 1 |
| Huang, JL | 1 |
| Yang, KD | 1 |
| Lee, WI | 1 |
| Saida, S | 1 |
| Yoshida, A | 1 |
| Tanaka, R | 1 |
| Abe, J | 1 |
| Hamahata, K | 1 |
| Okumura, M | 1 |
| Momoi, T | 1 |
| LEVY, AJ | 1 |
| Dredge, DC | 1 |
| Parsons, EC | 1 |
| Carter, LP | 1 |
| Staley, KJ | 1 |
| Zeng, Q | 1 |
| Wu, Y | 1 |
| Zhan, Y | 1 |
| Tang, L | 1 |
| Zhou, Y | 1 |
| Yin, J | 1 |
| Fan, F | 1 |
| Zhang, G | 1 |
| Lu, Q | 1 |
| Xiao, R | 1 |
| Fujino, Y | 1 |
| Nakajima, M | 1 |
| Inoue, H | 1 |
| Kusuhara, T | 1 |
| Yamada, T | 1 |
| PAUN, R | 1 |
| POPESCU, IG | 1 |
| MARCUS, N | 1 |
| GOCIU, M | 1 |
| GEORGESCU, C | 1 |
| BRANCO, F | 1 |
| GANDER, G | 1 |
| Chen, CJ | 1 |
| Huang, YC | 1 |
| Wang, CY | 1 |
| Lin, TY | 1 |
| Mostella, J | 1 |
| Pieroni, R | 1 |
| Jones, R | 1 |
| Finch, CK | 1 |
| Turner, RB | 1 |
| Kim, CC | 1 |
| Streams, BN | 1 |
| Culpepper, K | 1 |
| Haynes, HA | 1 |
| Bavdekar, SB | 1 |
| Muranjan, MN | 1 |
| Gogtay, NJ | 1 |
| Kantharia, V | 1 |
| Kshirsagar, NA | 1 |
| Papp, Z | 1 |
| Török, L | 1 |
| Li, AM | 1 |
| Nelson, EA | 1 |
| Hon, EK | 1 |
| Cheng, FW | 1 |
| Chan, DF | 1 |
| Sin, NC | 1 |
| Ma, KC | 1 |
| Cheung, KL | 1 |
| Fok, TF | 1 |
| Kano, Y | 2 |
| Shiohara, T | 3 |
| Ito, T | 1 |
| Ooishi, C | 1 |
| Chiba, A | 1 |
| Sakuta, M | 1 |
| Sakuma, K | 2 |
| Okumura, A | 1 |
| Tsuge, I | 1 |
| Kamachi, Y | 1 |
| Negoro, T | 1 |
| Watanabe, K | 1 |
| Fukuhara, M | 1 |
| Zou, CC | 1 |
| Liang, L | 1 |
| Fu, JF | 1 |
| Fonseca, JC | 1 |
| Azulay, DR | 1 |
| Rozembau, I | 1 |
| Azulay, RD | 1 |
| Knutsen, AP | 2 |
| Anderson, J | 1 |
| Satayaviboon, S | 1 |
| Slavin, RG | 1 |
| Gleichmann, H | 1 |
| Kahn, HD | 1 |
| Faguet, GB | 1 |
| Agee, JF | 1 |
| Middleton, HM | 1 |
| Skach, M | 1 |
| Liska, K | 1 |
| Lane, T | 1 |
| Peterson, EA | 1 |
| Vittorio, CC | 1 |
| Muglia, JJ | 1 |
| Riley, RJ | 1 |
| Smith, G | 1 |
| Wolf, CR | 1 |
| Cook, VA | 1 |
| Leeder, JS | 1 |
| Bertz, RJ | 1 |
| Howrie, DL | 1 |
| Gorraiz, A | 1 |
| Sanchez, J | 1 |
| Lozano, A | 1 |
| Vives, R | 1 |
| Tiberio, G | 1 |
| Lehmann, DF | 1 |
| Hurteau, TE | 1 |
| Newman, N | 1 |
| Coyle, TE | 1 |
| Morkunas, AR | 1 |
| Miller, MB | 1 |
| Descamps, V | 1 |
| Bouscarat, F | 1 |
| Laglenne, S | 1 |
| Aslangul, E | 1 |
| Veber, B | 1 |
| Descamps, D | 1 |
| Saraux, JL | 1 |
| Grange, MJ | 1 |
| Grossin, M | 1 |
| Navratil, E | 1 |
| Crickx, B | 1 |
| Belaich, S | 1 |
| Canaday, BR | 1 |
| Schlienger, RG | 1 |
| Shear, NH | 3 |
| Chinen, J | 1 |
| Piecuch, S | 1 |
| Neuman, MG | 1 |
| Malkiewicz, IM | 1 |
| Bessmertny, O | 1 |
| Hatton, RC | 1 |
| Gonzalez-Peralta, RP | 1 |
| Yamada, N | 1 |
| Kaneko, K | 1 |
| Saito, Y | 1 |
| Tatsuno, I | 1 |
| Caers, G | 1 |
| Montowska, L | 1 |
| Romański, B | 1 |
| Wilewska-Kłubo, T | 1 |
| Wilensky, AJ | 1 |
| Menghini, G | 1 |
| Pallotta, B | 1 |
| Maxwell, JD | 1 |
| Meyer, UA | 1 |
| Sawaishi, Y | 1 |
| Komatsu, K | 1 |
| Takeda, O | 1 |
| Tazawa, Y | 1 |
| Takahashi, I | 1 |
| Hayasaka, K | 1 |
| Takada, G | 1 |
| Pirmohamed, M | 1 |
| Kitteringham, NR | 1 |
| Breckenridge, AM | 1 |
| Park, BK | 1 |
| Gennis, MA | 1 |
| Vemuri, R | 1 |
| Burns, EA | 1 |
| Hill, JV | 1 |
| Miller, MA | 1 |
| Spielberg, SP | 2 |
| Mockli, G | 1 |
| Crowley, M | 1 |
| Stern, R | 1 |
| Warnock, ML | 1 |
| Frank, DM | 1 |
| Blumer, JL | 1 |
| Savich, RD | 1 |
| Traisman, HS | 1 |
| Higashi, A | 1 |
| Chen, C | 1 |
| Matsuda, I | 1 |
| Palomeque, A | 1 |
| Doménech, P | 1 |
| Martínez-Gutiérrez, A | 1 |
| Lequerica, P | 1 |
| Shah, M | 1 |
| Schwarz, KB | 1 |
| Tsai, CC | 1 |
| Parsonage, M | 1 |
| Dhar, GJ | 1 |
| Pierach, CA | 1 |
| Ahamed, PN | 1 |
| Howard, RB | 1 |
| Kleine-Natrop, HE | 1 |
| Bakshi, S | 1 |
| Bhakoo, ON | 1 |
| Brassai, Z | 1 |
| Hadnagy, C | 1 |
| Horváth, E | 1 |
| Nagy, L | 1 |
| Gassel, WD | 1 |
| Schneider, D | 1 |
| Sheffer, AL | 1 |
| Jacobs, HD | 1 |
| Singh, R | 2 |
| Kaur, D | 2 |
| Pandhi, RK | 1 |
| Skrotskiĭ, IuA | 1 |
| Saha, K | 1 |
| Harms, D | 1 |
| Moskalewska, K | 1 |
| Maciejowska, E | 1 |
| Cygler, J | 1 |
| Plonka, T | 1 |
| Schulz, KH | 1 |
| Schmidt, P | 1 |
| Abdalla, RE | 1 |
| Iskander, S | 1 |
| Haseeb, MA | 1 |
| Schreiber, MM | 1 |
| McGregor, JG | 1 |
3 reviews available for phenobarbital and Drug Hypersensitivity
| Article | Year |
|---|---|
Anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Drug Interactions; Felbamate; Humans; Phenoba | 1997 |
Antiepileptic drug hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Diagnosis, Differential; D | 1998 |
Massive hepatic necrosis in a child after administration of phenobarbital.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Humans; Liver Disea | 1989 |
1 trial available for phenobarbital and Drug Hypersensitivity
| Article | Year |
|---|---|
Clinical evaluation of side-effects of drugs.
Topics: Accident Prevention; Aged; Anti-Bacterial Agents; Anticoagulants; Carbamazepine; Dibenzazepines; Dru | 1973 |
73 other studies available for phenobarbital and Drug Hypersensitivity
| Article | Year |
|---|---|
Phenobarbital-induced anticonvulsant hypersensitivity syndrome in a cat.
Topics: Animals; Anticonvulsants; Cat Diseases; Cats; Drug Hypersensitivity; Epilepsy; Fever; Lymphadenopath | 2019 |
Successful Phenobarbital Desensitization After DRESS Reaction in the Management of Refractory Status Epilepticus.
Topics: Anticonvulsants; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Drug-Related | 2019 |
Phenobarbital-induced severe cutaneous adverse drug reactions are associated with CYP2C19*2 in Thai children.
Topics: Adolescent; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Child; Child, Preschool; | 2013 |
Association of HLA genotypes with phenobarbital hypersensitivity in children.
Topics: Adolescent; Alleles; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Hypersensitivity; | 2016 |
Suspected phenobarbitone hypersensitivity with acute liver failure in a dog.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Drug Hypersens | 2017 |
[Anticonvulsant hypersensitivity syndrome and lamotrigine-associated anticonvulsant hypersensitivity syndrome].
Topics: Adult; Aged; Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 2009 |
Phenobarbital-induced DiHS and ceftriaxone hypersensitivity reaction: a case of multiple drug allergy.
Topics: Adult; Cefotaxime; Ceftriaxone; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Phenob | 2009 |
Alopecia areata universalis after phenobarbital-induced anti-convulsant hypersensitivity syndrome.
Topics: Alopecia Areata; Anticonvulsants; Child, Preschool; Drug Hypersensitivity; Humans; Male; Phenobarbit | 2009 |
A case of drug-induced hypersensitivity syndrome-like symptoms following HHV-6 encephalopathy.
Topics: Anticonvulsants; Brain Diseases, Metabolic; Diagnosis, Differential; Drug Hypersensitivity; Eosinoph | 2010 |
Skin eruption due to phenobarbital among mentally defective epileptic patients.
Topics: Drug Hypersensitivity; Epilepsy; Exanthema; Humans; Hypersensitivity; Phenobarbital | 1946 |
Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin.
Topics: Child, Preschool; Drug Hypersensitivity; Humans; Immunoglobulins, Intravenous; Male; Phenobarbital; | 2010 |
Leukemoid reaction secondary to hypersensitivity syndrome to phenobarbital: a case report.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Epilepsy; Female; Humans; Leukemoid Reaction; Phenoba | 2013 |
Human herpesvirus 6 encephalitis associated with hypersensitivity syndrome.
Topics: Anticonvulsants; Antiporters; DNA, Viral; Drug Hypersensitivity; Encephalitis, Viral; Exanthema Subi | 2002 |
[CONTRIBUTION TO THE CLINICAL MANIFESTATIONS OF DRUG ALLERGY].
Topics: Aminopyrine; Aspirin; Atropa belladonna; Drug Hypersensitivity; Liver Extracts; Parasympatholytics; | 1963 |
[LYMPHADENOPATHIES AND BLOOD PROTEIN DISORDERS OR MEDICINAL ORIGIN, SIMULATING A MALIGNANT DISEASE].
Topics: Blood Protein Disorders; Blood Protein Electrophoresis; Diagnosis, Differential; Drug Hypersensitivi | 1964 |
Fatal anticonvulsant hypersensitivity syndrome in an infant.
Topics: Anticonvulsants; Drug Hypersensitivity; Fatal Outcome; Female; Humans; Infant; Multiple Organ Failur | 2003 |
Anticonvulsant hypersensitivity syndrome: treatment with corticosteroids and intravenous immunoglobulin.
Topics: Adult; Anticonvulsants; Cross Reactions; Drug Hypersensitivity; Female; Glucocorticoids; Humans; Imm | 2004 |
Anticonvulsant hypersensitivity syndrome associated with Bellamine S, a therapy for menopausal symptoms.
Topics: Anticonvulsants; Belladonna Alkaloids; Drug Combinations; Drug Hypersensitivity; Ergotamines; Female | 2004 |
Anticonvulsant hypersensitivity syndrome: lymphocyte toxicity assay for the confirmation of diagnosis and risk assessment.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Female; Humans; Lymphocyte Count; Lymphocytes; Phenob | 2004 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug | 2004 |
Hepatic failure in a child with anti-epileptic hypersensitivity syndrome.
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Humans; Immunoglobulins, Intravenous; Liver Failure, | 2005 |
Sequential reactivation of herpesvirus in drug-induced hypersensitivity syndrome.
Topics: Adult; Antibodies, Viral; Anticonvulsants; Cytomegalovirus; Drug Hypersensitivity; Humans; Immunoglo | 2004 |
[Limbic encephalitis associated with drug-induced hypersensitivity syndrome due to phenobarbital--a case report].
Topics: Aged; Drug Hypersensitivity; Herpesvirus 6, Human; Humans; Limbic Encephalitis; Male; Phenobarbital; | 2005 |
Transient hypogammaglobulinemia after antiepileptic drug hypersensitivity.
Topics: Agammaglobulinemia; Anticonvulsants; Child, Preschool; Drug Hypersensitivity; Humans; Male; Phenobar | 2007 |
Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome.
Topics: Acyclovir; Aged; Anticonvulsants; Antiviral Agents; Coma; Drug Hypersensitivity; Encephalitis; Epile | 2008 |
Type 1 diabetes mellitus in a child with phenobarbital hypersensitivity syndrome.
Topics: Adrenal Cortex Hormones; Child, Preschool; Diabetes Mellitus, Type 1; Drug Hypersensitivity; Female; | 2008 |
[Hypersensitivity syndrome caused by phenytoins and phenobarbital].
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Eruptions; Drug Hypersensitivity; Eosinophilia; | 1984 |
Immunologic aspects of phenobarbital hypersensitivity.
Topics: Adolescent; Child; Child, Preschool; Drug Hypersensitivity; Humans; Infant; Lymphocyte Activation; P | 1984 |
Studies on the mechanism of drug sensitization: T-cell-dependent popliteal lymph node reaction to diphenylhydantoin.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Hypersensitivity; Lymph Nodes; Lympho | 1981 |
Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital.
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Cross Reactions; Drug Hypersensitivity; Female; | 1984 |
[Toxic-allergic reactions to hydantoinate and its transformation into carcinoma after 30 years].
Topics: Anticonvulsants; Carcinoma, Squamous Cell; Drug Hypersensitivity; Humans; Hydantoins; Leukoplakia, O | 1983 |
Hepatitis as a manifestation of phenobarbital hypersensitivity.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Drug Hypersensitivity; Erythema Multiforme | 1984 |
Anticonvulsant hypersensitivity syndrome.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Female; Fever; Humans; Lymphatic Disea | 1995 |
Human anti-endoplasmic reticulum autoantibodies produced in aromatic anticonvulsant hypersensitivity reactions recognise rodent CYP3A proteins and a similarly regulated human P450 enzyme(s)
Topics: Adult; Animals; Anticonvulsants; Autoantibodies; Autoantigens; Carbamazepine; Cell Line; Cross React | 1993 |
Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Hypersensitivity; Female; Hospitals, Pediatric; Ho | 1993 |
[The anticonvulsant hypersensitivity syndrome caused by phenobarbital].
Topics: Aged; Anticonvulsants; Drug Hypersensitivity; Female; Humans; Phenobarbital | 1995 |
Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain | 1997 |
Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Female; Herpesviridae Infections; Herpesvirus 6, Huma | 1997 |
Anticonvulsant cross-sensitivity.
Topics: Anticonvulsants; Carbamazepine; Cross Reactions; Drug Hypersensitivity; Humans; Phenobarbital; Pheny | 1997 |
Anticonvulsant hypersensitivity syndrome vs Kawasaki disease: a challenging clinical diagnosis with therapeutic implications.
Topics: Anticonvulsants; Diagnosis, Differential; Drug Hypersensitivity; Humans; Infant; Lymphocyte Activati | 2000 |
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Carbamazepine; Case-Control Studies; Cell Surviva | 2000 |
Antiepileptic hypersensitivity syndrome in children.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anticonvulsants; Child; Diethylcarbamazi | 2001 |
Anticonvulsant hypersensitivity syndrome with marked eosinophilia in treatment of diabetic neuropathy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Drug Hypers | 2002 |
[The otorhinolaryngologist facing the toxic effects of drugs and drug interactions].
Topics: Analgesics; Antihypertensive Agents; Contraceptives, Oral; Drug Hypersensitivity; Drug Interactions; | 1977 |
[Case of severe allergic skin changes caused by phenobarbital administered for diagnostic purposes].
Topics: Dermatitis, Atopic; Drug Hypersensitivity; Erythema; Female; Humans; Middle Aged; Phenobarbital | 1979 |
Phenytoin hypersensitivity.
Topics: Drug Hypersensitivity; Humans; Phenobarbital; Phenytoin; Skin Diseases | 1977 |
Marked increase in serum levels of liver enzymes in patients receiving chenic acid and phenobarbital for gallstone dissolution.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chenodeoxycholic Acid; Chol | 1976 |
Effect of lead on hepatic delta-aminolaevulinic acid synthetase activity in the rat: a model for drug sensitivity in intermittent acute porphyria.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Cytochrome P-450 Enzyme System; Drug Hyp | 1976 |
A case of tubulo-interstitial nephritis with exfoliative dermatitis and hepatitis due to phenobarbital hypersensitivity.
Topics: Chemical and Drug Induced Liver Injury; Child, Preschool; Dermatitis, Exfoliative; Drug Eruptions; D | 1992 |
Detection of an autoantibody directed against human liver microsomal protein in a patient with carbamazepine hypersensitivity.
Topics: Adolescent; Animals; Autoantibodies; Carbamazepine; Cell Death; Chemical and Drug Induced Liver Inju | 1992 |
Familial occurrence of hypersensitivity to phenytoin.
Topics: Adult; Animals; Carbamazepine; Drug Hypersensitivity; Female; Humans; In Vitro Techniques; Mice; Phe | 1991 |
Alteration of methylcholanthrene-mediated suppression of cutaneous delayed hypersensitivity by benzoflavone treatment of C57BL/6J mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme | 1988 |
Phenobarbital hypersensitivity reaction.
Topics: Child; Drug Eruptions; Drug Hypersensitivity; Female; Fever; Humans; Liver Function Tests; Phenobarb | 1986 |
Zinc status and delayed cutaneous hypersensitivity in handicapped children treated with anticonvulsants.
Topics: Adolescent; Child; Child, Preschool; Dinitrochlorobenzene; Disabled Persons; Drug Hypersensitivity; | 1987 |
Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; D | 1988 |
[Severe hypersensitivity to phenobarbital with erythema multiforme, cholestatic hepatitis and aplastic anemia].
Topics: Anemia, Aplastic; Chemical and Drug Induced Liver Injury; Child; Cholestasis; Drug Hypersensitivity; | 1986 |
Graft versus host-like illness in a child with phenobarbital hypersensitivity.
Topics: Antigen-Antibody Complex; Autoimmune Diseases; Biopsy; Child; Drug Hypersensitivity; Female; Graft v | 1986 |
Epilepsy.
Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec | 1974 |
Diphenylhydantoin--induced hepatic necrosis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epilepsy, Tonic-Clonic; Female | 1974 |
[Pathomechanic variants of allergic drug induced skin injuries].
Topics: Allergens; Aminopyrine; Dermatitis, Contact; Drug Eruptions; Drug Hypersensitivity; Exanthema; Femal | 1969 |
Unusual phenobarbitone sensitivity.
Topics: Child; Drug Eruptions; Drug Hypersensitivity; Female; Hepatomegaly; Humans; Phenobarbital | 1971 |
Data regarding the problem of physical allergies.
Topics: Acetylcholine; Acetylcholinesterase; Adolescent; Adult; Antibodies; Atropine; Chlorpromazine; Cold T | 1970 |
[Acute drug allergic thrombocytopenia caused by antazoline].
Topics: Aged; Ajmaline; Aniline Compounds; Arrhythmias, Cardiac; Benzyl Compounds; Bone Marrow Examination; | 1974 |
Biochemical effects of halothane.
Topics: Adult; Animals; Autoantibodies; Biotransformation; Chemical and Drug Induced Liver Injury; Child; Dr | 1972 |
Treatment of anaphylaxis.
Topics: Anaphylaxis; Desensitization, Immunologic; Diphenhydramine; Drug Hypersensitivity; Ephedrine; Epinep | 1973 |
Diagnosis of drug allergy.
Topics: Drug Hypersensitivity; Humans; Lymphocyte Activation; Oxytetracycline; Penicillins; Phenobarbital; S | 1973 |
[Complications of medical therapy for epilepsy in children and adolescents].
Topics: Anticonvulsants; Child; Diplopia; Drug Hypersensitivity; Drug Therapy, Combination; Epilepsy; Headac | 1973 |
'Lymphocyte transformation in drug hypersensitivity'.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Drug Hypersensitivity; Female; Humans; Lymphocyte Activati | 1973 |
[Speech disorders in children with cerebral convulsions].
Topics: Adolescent; Barbiturates; Carbamazepine; Drug Hypersensitivity; Electroencephalography; Epilepsy; Et | 1972 |
Investigations on modern methods of detection of drug allergy.
Topics: Aminopyrine; Basophils; Drug Hypersensitivity; Humans; In Vitro Techniques; Lymphocyte Activation; L | 1971 |
[Fixed exanthema due to 3 different drugs with separate localization. Contribution to the problem of barbiturate allergy].
Topics: Antipyrine; Barbiturates; Drug Hypersensitivity; Exanthema; Female; Humans; Middle Aged; Phenobarbit | 1967 |
Further observations on the use of ambilhar in the treatment of schistosomiasis mansoni in the Sudan.
Topics: Adolescent; Adult; Anthelmintics; Central Nervous System Diseases; Child; Drug Hypersensitivity; Fec | 1968 |
Pseudolymphoma syndrome. A sensitivity to anticonvulsant drugs.
Topics: Biopsy; Blood Cell Count; Blood Chemical Analysis; Chlordiazepoxide; Drug Hypersensitivity; Female; | 1968 |