phenobarbital has been researched along with Disease Models, Animal in 274 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 7.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 7.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 7.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| "To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar." | 7.79 | [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness. ( de Lange, EC; Eriksson, J; Koepp, M; Labots, M; Lammertsma, AA; Potschka, H; Rongen, M; Russmann, V; Schuit, R; Seeger, N; Syvänen, S; van Kooij, R; Verbeek, J; Voskuyl, RA; Windhorst, AD; Zellinger, C, 2013) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 7.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 7.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In the present study, we used a post-status epilepticus model of TLE to examine whether rats with spontaneous recurrent seizures (SRSs) differ in their individual responses to phenobarbital (PB)." | 7.72 | Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. ( Brandt, C; Löscher, W; Volk, HA, 2004) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 7.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 7.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 7.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 5.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 5.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 5.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "Neonatal seizures have an incidence of 3." | 5.48 | Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12. ( Carter, BM; Kadam, SD; Landers, JR; Sullivan, BJ, 2018) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Neonatal seizures are commonly associated with hypoxic-ischemic encephalopathy." | 5.42 | Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. ( Johnston, MV; Kadam, SD; Kang, SK, 2015) |
| "All the seizure parameters were significantly reduced when phenobarbital (3 mg/kg) was administered prior to the application of the non-effective pattern of LFS." | 5.40 | Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats. ( Asgari, A; Atapour, N; Mirnajafi-Zadeh, J; Moradi, H; Semnanian, S; Shojaei, A, 2014) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 5.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " The aim of this study was to determine the anticonvulsant profiles of scoparone (a simple coumarin) and borneol (a bicyclic monoterpenoid) when administered separately and in combination, as well as their impact on the antiseizure effects of four classic ASMs (carbamazepine, phenytoin, phenobarbital and valproate) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation. ( Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| " This study was aimed at determining the influence of isopimpinellin (ISOP-a coumarin) when administered either separately or in combination with borneol (BOR-a monoterpenoid), on the antiseizure potencies of four classic ASMs (carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and valproate (VPA)) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation. ( Bojar, H; Chmielewski, J; Florek-Łuszczki, M; Jankiewicz, K; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| ", lacosamide (LCM), levetiracetam (LEV), phenobarbital (PB) and valproate (VPA)) to prevent seizures evoked by the 6-Hz corneal-stimulation-induced seizure model." | 4.12 | Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study. ( Andres-Mach, M; Lemieszek, MK; Raszewski, G; Szala-Rycaj, J; Szewczyk, A; Zagaja, A; Zagaja, M, 2022) |
| "Ganaxolone provided better seizure control than phenobarbital in this perinatal asphyxia model and was neuroprotective for the newborn brain, affording a new therapeutic opportunity for treatment of neonatal seizures." | 4.12 | Ganaxolone versus Phenobarbital for Neonatal Seizure Management. ( Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T, 2022) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| " In pentylenetetrazole-induced acute seizures only BUM532 combined with a sub-effective dose of PB increased the seizure threshold." | 3.96 | Functional characterization of novel bumetanide derivatives for epilepsy treatment. ( Auer, T; Erker, T; Schreppel, P; Schwarzer, C, 2020) |
| "A recently characterized CD-1 mouse model of phenobarbital (PB)-resistant neonatal ischemic-seizures (i." | 3.96 | Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits. ( Adler, DA; Ammanuel, S; Kadam, SD; Kang, SK, 2020) |
| "This study evaluated the effect of androsterone (AND), a metabolite of testosterone, on the ability of selected classical and novel antiepileptic drugs to prevent seizures caused by maximal electroshock (MES), which may serve as an experimental model of human generalized tonic-clonic seizures in mice." | 3.91 | Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ, 2019) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| ", phenobarbital [PB], phenytoin [PHT] and pregabalin [PGB]) at the fixed-ratio of 1:1:1, we used a model of tonic-clonic seizures in male albino Swiss mice." | 3.88 | Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis. ( Florek-Luszczki, M; Luszczki, JJ; Mazurkiewicz, LP; Ossowska, G; Szpringer, M; Wlaz, A; Wroblewska-Luczka, P; Zolkowska, D, 2018) |
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| " This model consists in inducing daily generalized seizures for 23 consecutive days by administration of 3-mercaptopropionic acid (MP)." | 3.85 | New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice. ( Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F, 2017) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular chloride homeostasis." | 3.80 | A novel prodrug-based strategy to increase effects of bumetanide in epilepsy. ( Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M, 2014) |
| " We tested the hypothesis that status epilepticus (SE) or exposure to phenytoin or phenobarbital affects brain expression of the metabolic enzyme CYP2E1." | 3.80 | Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression. ( Boussadia, B; de Bock, F; Ghosh, C; Janigro, D; Marchi, N; Pascussi, JM; Plaud, C; Rousset, MC, 2014) |
| "To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [(11)C]quinidine and [(11)C]laniquidar." | 3.79 | [11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness. ( de Lange, EC; Eriksson, J; Koepp, M; Labots, M; Lammertsma, AA; Potschka, H; Rongen, M; Russmann, V; Schuit, R; Seeger, N; Syvänen, S; van Kooij, R; Verbeek, J; Voskuyl, RA; Windhorst, AD; Zellinger, C, 2013) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "05) the onset and reduced the duration of the seizures induced by picrotoxin (5 mg/kg, i." | 3.77 | Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders. ( Adio, O; Fageyinbo, S; Sowemimo, AA, 2011) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "We made a microPET evaluation of the effects of tariquidar on the brain kinetics of the P-glycoprotein substrate [(18) F]MPPF in a rat model with spontaneous recurrent seizures, in which it has previously been demonstrated that phenobarbital nonresponders exhibit higher P-glycoprotein expression than do phenobarbital responders." | 3.76 | Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy. ( Bartenstein, P; Bartmann, H; Böning, G; Cumming, P; Fuest, C; Just, T; la Fougere, C; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Wängler, B; Winter, P; Xiong, G, 2010) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| " The aim of the present work was to assess the involvement of P-glycoprotein in carbamazepine and phenobarbital hippocampal pharmacokinetics in an experimental model of epilepsy, induced by repetitive MP administration." | 3.75 | Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. ( Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA, 2009) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| " Some selected compounds were assayed against seizures induced by pentylenetetrazole (PTZ) and strychnine in mice." | 3.74 | Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents. ( Al-Eryani, YA; Amin, KM; Rahman, DE, 2008) |
| "In the present study we examined if rats with PB-resistant seizures are also resistant to phenytoin (PHT), using continuous EEG/video recording of spontaneous seizures." | 3.74 | Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy. ( Bethmann, K; Brandt, C; Löscher, W, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45." | 3.74 | The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. ( Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| " injection of nitrosomethylurea (NMU) in 3-day-old rats orally treated with the pesticide mancozeb (MZ), the flavonoid quercetin (Q) or in combination (MZ-Q) induces hyperplasia, atypical acinar cell proliferation and carcinoma in situ (CIS) in the pancreas." | 3.73 | Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats. ( Barotto, NN; Bongiovanni, GA; Díaz, MP; Eynard, AR; Valentich, MA, 2006) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| "The effects of phenytoin (PHT) and phenobarbital (PHB) on EEG activity and behavior was studied in the model of epilepsy induced by intracerebroventricular (i." | 3.72 | The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats. ( Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D, 2004) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " In a prospective trial in dogs with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than the standard drugs." | 3.72 | Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures. ( Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A, 2004) |
| " In the present study, we used a post-status epilepticus model of TLE to examine whether rats with spontaneous recurrent seizures (SRSs) differ in their individual responses to phenobarbital (PB)." | 3.72 | Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. ( Brandt, C; Löscher, W; Volk, HA, 2004) |
| "The induction with 20-methylcholanthrene, glutathione depletion with buthionine sulfoxime, and subcutaneous administration of acetaminophen have led to the development of an animal model that parallels clinical, biochemical, and histological features of human hepatic failure." | 3.71 | A novel model of acetaminophen-induced acute hepatic failure in rabbits. ( Hodgson, HJ; Rahman, TM; Selden, AC, 2002) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| " However, hepatic HGF levels were decreased despite an increased number of mitotic hepatocytes and increased or unchanged plasma HGF levels in rats given phenobarbital and in rats after dimethylnitrosamine intoxication, which can induce hepatic necrosis after apoptosis of hepatic stellate cells." | 3.70 | Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration. ( Fujiwara, K; Ogata, I; Tomiya, T, 1998) |
| "Sequential treatment of rats with low doses of lithium and pilocarpine, a high dose of pilocarpine, or continuous hippocampal stimulation [CHS] (9 epochs, 10 min each) is reported to result in status epilepticus (SE)." | 3.70 | Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats. ( George, B; Kulkarni, SK; Mathur, R, 1998) |
| "We established a cell line (MHB-2) from a hepatoblastoma (HB) induced by diethylnitrosamine (DEN) and sodium phenobarbital (PB) in male B6C3F1 mice and examined the biological characteristics of MHB-2." | 3.70 | Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma. ( Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T, 2000) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| " The compounds were screened in mice for their ability to antagonize maximal electroshock- and bicuculline-induced seizures; neurotoxicity was evaluated in the rotorod test." | 3.67 | Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy. ( Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J, 1986) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "It was investigated whether an increased demand for glycine, as postulated to occur in patients who have suffered from episodic psychoses accompanied by multiple perceptual distortions, could evoke psychotic reactions." | 3.66 | Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis? ( Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH, 1983) |
| "Exposure of phenobarbital-pretreated male Sprague-Dawley rats to halothane, 1 per cent, for two hours under conditions of hypoxia (FIO2 0." | 3.66 | An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. ( Brown, BR; McLain, GE; Sipes, IG, 1979) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| " To test the validity of this primate model, the effects of diphenylhydantoin (DPH), phenobarbital, and primidone on spontaneous seizures evaluated for 8 months with a Latin-Squar experimental design." | 3.65 | Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures. ( DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V, 1975) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| "Since arrhythmia often accompanies seizures, patients suffering from epilepsy are frequently co-treated with antiepileptic and antiarrhythmic drugs." | 1.72 | Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, K, 2022) |
| "Neonatal seizures are the most frequent type of neurological emergency in newborn infants, often being a consequence of prolonged perinatal asphyxia." | 1.62 | Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective. ( Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W, 2021) |
| "Spontaneous recurrent seizures (SRS) in TLE can present after a latent period following a neurological insult (traumatic brain injury, SE event, viral infection, etc." | 1.62 | Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital. ( Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D, 2021) |
| " Similar dose-related responses were seen following the week-long dosing protocol for carbamazepine, phenobarbital, and phenytoin, and these responses were associated with drug levels that were in the human therapeutic range." | 1.62 | Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency. ( Bertram, EH; Edelbroek, P, 2021) |
| "In this study, we tested several sleep deprivation protocols (mechanical shakes and light interruptions) on Drosophila and delineated their influences on Drosophila sleep." | 1.56 | Screening of sleep assisting drug candidates with a Drosophila model. ( Ma, WW; Peng, IF; Wang, YY, 2020) |
| "Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease." | 1.51 | New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease. ( Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C, 2019) |
| " Finally, a theoretical hemin effect was implemented to illustrate the applicability of the model to dosage optimization in drug therapies." | 1.51 | Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model. ( Fontanellas, A; Jericó, D; Parra-Guillén, ZP; Sampedro, A; Serrano-Mendioroz, I; Trocóniz, IF; Vera-Yunca, D, 2019) |
| "Electrically-induced tonic-clonic seizures were experimentally evoked in adult male albino Swiss mice." | 1.51 | New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. ( Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ, 2019) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 1.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "Hypoxia-induced seizures (HS) during the neonatal period can also lead to spontaneous seizures in adulthood." | 1.48 | Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia. ( Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN, 2018) |
| "Epilepsy is a serious neurological disease affecting about 1% of people worldwide (65 million)." | 1.48 | Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model. ( Kondrat-Wróbel, MW; Łuszczki, JJ, 2018) |
| "Neonatal seizures have an incidence of 3." | 1.48 | Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12. ( Carter, BM; Kadam, SD; Landers, JR; Sullivan, BJ, 2018) |
| "Neonatal seizures are harmful to the developing brain and are associated with mortality and long-term neurological comorbidities." | 1.48 | Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model. ( Carter, BM; Kadam, SD; Kharod, SC, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| "Progressive liver fibrosis leads to cirrhosis and end-stage liver disease." | 1.46 | Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation. ( Berardis, S; El Taghdouini, A; El-Kehdy, H; Evraerts, J; Henriet, P; Lombard, C; Najimi, M; Rosseels, V; Sokal, EM; van Grunsven, L, 2017) |
| "Flupirtine is a KCNQ potassium channel opener." | 1.46 | Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy. ( Raol, YH; Sampath, D; Valdez, R; White, AM, 2017) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| " Type I isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to analyze the 3-drug combination." | 1.43 | Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model. ( Luszczki, JJ, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Tet alleviates the phenobarbital withdrawal symptoms and protects the brain cells against apoptosis, which may be a result of the regulation of the mRNA and protein expression levels of Bcl‑2 and Bax." | 1.42 | Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats. ( Fu, P; Han, B; Wang, G; Ye, Y; Zhang, H, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "Neonatal seizures are commonly associated with hypoxic-ischemic encephalopathy." | 1.42 | Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. ( Johnston, MV; Kadam, SD; Kang, SK, 2015) |
| " Pharmacokinetic parameters of nicorandil and its isomers, as well as the plasma concentrations of the corresponding denitrated metabolites and also nicotinamide and nitrite were determined." | 1.40 | Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers. ( Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR, 2014) |
| "All the seizure parameters were significantly reduced when phenobarbital (3 mg/kg) was administered prior to the application of the non-effective pattern of LFS." | 1.40 | Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats. ( Asgari, A; Atapour, N; Mirnajafi-Zadeh, J; Moradi, H; Semnanian, S; Shojaei, A, 2014) |
| " A low dosage of phenobarbital caused a significant increase of the generalized seizure threshold in the L-701,324 pre-treated group, whereas it did not exert a comparable effect in animals that received vehicle during the massive kindling phase." | 1.40 | Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model. ( Aronica, E; Gorter, J; Potschka, H; Salvamoser, JD; Soerensen, J; van Vliet, EA; Zellinger, C, 2014) |
| " This type of protocol can be used to further evaluate AEDs and test effects of chronic administration of AEDs." | 1.40 | Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats. ( Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A, 2014) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| "In animal convulsion models, some anticonvulsants have been found to suppress oxidative reactions associated with convulsions." | 1.38 | Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model. ( Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y, 2012) |
| "During drug development, seizure threshold tests are widely used to identify potential proconvulsant activity of investigational drugs." | 1.38 | Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models. ( Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W, 2012) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "The flupirtine-treated group showed less impairment in learning and memory and less obvious pathological changes in the brain following RFS compared with the phenobarbital-treated group." | 1.37 | Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. ( He, X; Liu, W; Liu, Y; Peng, B; Wang, H; Wang, Y; Yin, J; Yu, F, 2011) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| " Based on pharmacokinetic studies with bumetanide, which showed extremely rapid elimination and low brain penetration of this drug in rats, bumetanide was administered systemically with different dosing protocols, including continuous intravenous infusion." | 1.36 | Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy. ( Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M, 2010) |
| "Metofluthrin did not cause cytotoxicity or peroxisome proliferation." | 1.35 | Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. ( Deguchi, Y; Hirose, Y; Kawamura, S; Kushida, M; Nagahori, H; Nishioka, K; Okuno, Y; Sukata, T; Sumida, K; Tomigahara, Y; Uwagawa, S; Yamada, T, 2009) |
| " Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose-response effects was used to characterize the consequent anticonvulsant interactions between the various drug combinations." | 1.35 | Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. ( Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E, 2009) |
| "Midazolam clearance was significantly increased and decreased, compared with baseline in groups P and I respectively (p < 0." | 1.35 | Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model. ( Iwaki, H; Iwakiri, K; Kaneshiro, Y; Masada, T; Oda, Y; Ohashi, H; Takaoka, K, 2008) |
| "Lithocholic acid (LCA) was used to induce intrahepatic cholestasis." | 1.35 | Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. ( Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL, 2008) |
| " The nontoxic HgS dosing (0." | 1.35 | Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex. ( Chang, LH; Chuu, JJ; Huang, ZN; Lin-Shiau, SY; Yu, HH, 2008) |
| "Treatment with phenobarbital or phenytoin caused a reduction in seizure frequency, but did not improve EEG background or prevent death." | 1.34 | The natural history and treatment of epilepsy in a murine model of tuberous sclerosis. ( Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH, 2007) |
| "Rotenone is a mitochondrial toxin which can produce Parkinson syndrome (PS) in rats." | 1.33 | Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism. ( Pasha, MK; Rajput, AH; Sharma, RK, 2005) |
| "Treatment with Pyrethrins and NaPB increased hepatic microsomal thyroxine UDPglucuronosyltransferase activity and serum thyroid stimulating hormone levels (TSH), but reduced serum levels of either thyroxine (T4) and/or triiodothyronine (T3)." | 1.33 | A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat. ( Butler, WH; Capen, CC; Finch, JM; Gabriel, KL; Henderson, WJ; Lake, BG; Martin, T; Osimitz, TG, 2006) |
| "Medroxyprogesterone acetate (MPA) is a drug commonly used in endocrine therapy for advanced breast cancer, although it is known to cause thrombosis as a serious side effect." | 1.32 | Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo. ( Chiba, K; Hosokawa, M; Kobayashi, K; Mimura, N; Nakamura, Y; Shimada, N, 2003) |
| "Quinolinic acid (QA) has been used as a model for experimental overstimulation of the glutamatergic system." | 1.32 | Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine. ( de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S, 2004) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| "When phenobarbital was readministered 1 week later, the hamsters again exhibited severe dystonia." | 1.31 | Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model. ( Löscher, W; Richter, A, 2000) |
| " For comparison of drug potencies, doses increasing seizure thresholds by 20 or 50% were calculated from dose-response curves." | 1.30 | Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models. ( Krupp, E; Löscher, W, 1998) |
| " The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model." | 1.30 | In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. ( Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ, 1999) |
| "This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat." | 1.30 | Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999) |
| "Phenobarbital treatment increased the concentrations of total cytochrome P450 in both lean and obese rats to the same extent." | 1.29 | Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment. ( Bandyopadhyay, AM; Blouin, RA; Robertson, LW; Zannikos, PN, 1994) |
| "Treatment of phenytoin responders and nonresponders with other primary antiepileptic drugs showed that valproate and phenobarbital induced much smaller increases in focal seizure threshold in phenytoin nonresponders than in responders, whereas carbamazepine induced about the same threshold increase in both groups." | 1.29 | Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy. ( Hönack, D; Löscher, W; Rundfeldt, C, 1993) |
| "Two protocols were used: assessment of seizures immediately after the completion of the kindling procedure and after the 2-week postkindling PTX-free period, as compared with acute PTX seizures." | 1.29 | Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models. ( Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS, 1996) |
| "Phenobarbital treatment of Gunn recipients of jejunal transplants from Wistar rats normalizes serum bilirubin levels." | 1.29 | The use of jejunal transplants to treat a genetic enzyme deficiency. ( Burgos, AA; Jaffe, BM; Martinez-Noack, M, 1996) |
| "The seizures were predominantly clonic jerks accompanied by large spikes and slow waves lasting for 30-60s." | 1.29 | Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy. ( Satishchandra, P; Shankar, SK; Ullal, GR, 1996) |
| "Tamoxifen is a well-tolerated palliative and adjuvant treatment for human breast cancer and requires continuous, long-term administration for optimal therapeutic effectiveness." | 1.28 | Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis. ( Dragan, YP; Pitot, HC; Xu, YD, 1991) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| "Nitrous oxide was found to produce no effect in the absence of halothane, but to potentiate the hepatotoxicity of 0." | 1.27 | Effect of nitrous oxide on halothane-induced hepatotoxicity in hypoxic, enzyme-induced rats. ( Duffy, SW; Monk, SJ; Ross, JA, 1984) |
| "The recognition that Gilbert's syndrome is a quite heterogeneous entity will allow a better understanding of the mode of inheritance of this disorder; its relationship to Crigler-Najjar type II disease also awaits further definition." | 1.27 | Familial unconjugated hyperbilirubinemia syndromes. ( Reichen, J, 1983) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "This results in deep hepatic coma over a narrowly predictable time span and death within 12-52 h." | 1.27 | A predictable pathophysiological model of porcine hepatic failure. ( Alp, MH; Hickman, R, 1986) |
| "Carbamazepine and phenytoin were ineffective or aggravated the seizures." | 1.27 | Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. ( Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Gamma hydroxybutyrate (GHB) was administered intravenously to monkeys that had been pretreated orally for 2 weeks with various anticonvulsant drugs or with L-DOPA at different dosage levels." | 1.26 | Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs. ( Snead, OC, 1978) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| "The effects of riboflavin deficiency on electron transport components and drug metabolism activities have been noted only in adult animals after prolonged periods of deficiency." | 1.26 | The effect of certain vitamin deficiencies on hepatic drug metabolism. ( Sato, PH; Zannoni, VG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (19.34) | 18.7374 |
| 1990's | 38 (13.87) | 18.2507 |
| 2000's | 67 (24.45) | 29.6817 |
| 2010's | 95 (34.67) | 24.3611 |
| 2020's | 21 (7.66) | 2.80 |
| Authors | Studies |
|---|---|
| Hallot, A | 1 |
| Brodin, R | 1 |
| Merlier, J | 1 |
| Brochard, J | 1 |
| Chambon, JP | 1 |
| Biziere, K | 1 |
| Xie, ZF | 1 |
| Chai, KY | 1 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 2 |
| Amin, KM | 1 |
| Rahman, DE | 1 |
| Al-Eryani, YA | 1 |
| Salomé, C | 2 |
| Salomé-Grosjean, E | 1 |
| Park, KD | 1 |
| Morieux, P | 1 |
| Swendiman, R | 1 |
| DeMarco, E | 1 |
| Stables, JP | 2 |
| Kohn, H | 2 |
| Guan, LP | 1 |
| Sui, X | 1 |
| Deng, XQ | 1 |
| Quan, YC | 1 |
| Baruah, PK | 1 |
| Dinsmore, J | 1 |
| King, AM | 1 |
| De Ryck, M | 1 |
| Kaminski, R | 1 |
| Provins, L | 1 |
| César, IC | 1 |
| Godin, AM | 1 |
| Araujo, DP | 1 |
| Oliveira, FC | 1 |
| Menezes, RR | 1 |
| Santos, JR | 1 |
| Almeida, MO | 1 |
| Dutra, MM | 1 |
| Santos, DA | 1 |
| Machado, RR | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
12 reviews available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Murine models of the human porphyrias: Contributions toward understanding disease pathogenesis and the development of new therapies.
Topics: Anemia; Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Gen | 2019 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
GABAergic Synchronization in Epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Cortical Synchronization; Disease Models, Animal; Epile | 2016 |
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; | 2007 |
Sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kinetics; Phenobarbital; Seizures; Structu | 1980 |
Mouse models of emotional postpartum disorders.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Emotions; Female; Hormones; Humans; Male; Maternal | 1993 |
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Humans; Liver Neoplasms; Liver | 1995 |
Disturbances of bile acid metabolism in cholestasis.
Topics: Bile Acids and Salts; Bile Ducts; Cholestasis; Cholestyramine Resin; Deoxycholic Acid; Disease Model | 1977 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
[Review: development of the spontaneously epileptic rat].
Topics: Animals; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; Male; Phenobarbital; Rats; Rats | 1992 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Presc | 1973 |
1 trial available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
261 other studies available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 1986 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; | 2008 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus | 2010 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, | 2010 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclini | 2012 |
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Ep | 2014 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interaction | 2022 |
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; H | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug | 2023 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2023 |
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2023 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Anima | 2020 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Li | 2019 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippoca | 2020 |
Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model.
Topics: Administration, Oral; Animals; Biomarkers; Carboxymethylcellulose Sodium; Chromatography, Liquid; Di | 2020 |
Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits.
Topics: Animals; Anticonvulsants; Azepines; Benzamides; Disease Models, Animal; Dose-Response Relationship, | 2020 |
Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal | 2020 |
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Mice; Nerve Agents; Phenobarbital; | 2020 |
Screening of sleep assisting drug candidates with a Drosophila model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Disease Models, Animal; Drosoph | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; | 2020 |
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Dexmedetomidine; Disease Models, Animal; Dose-Response | 2020 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Co | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceut | 2021 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammat | 2017 |
Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Culture Media, | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease P | 2017 |
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Topics: Anemia, Hypochromic; Animals; Base Sequence; Biosynthetic Pathways; Coproporphyria, Hereditary; Copr | 2017 |
Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Benzodiazepines; Clobaz | 2017 |
The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain Injuries; Disease Models, Animal | 2018 |
Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Hypoxia; Levetiracetam; M | 2018 |
The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia.
Topics: Adaptation, Physiological; Altitude Sickness; Animals; Cerebral Cortex; Citric Acid Cycle; Disease M | 2018 |
Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epileps | 2018 |
Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; Drug Synergism; Drug Th | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; E | 2018 |
Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria.
Topics: Animals; Computer Simulation; Disease Models, Animal; Genetic Therapy; Hydroxymethylbilane Synthase; | 2018 |
Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalo | 2018 |
Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; K Cl- Cotransporters; Mal | 2018 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2019 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Mo | 2019 |
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Topics: Aminolevulinic Acid; Animals; Computer Simulation; Disease Models, Animal; Male; Mice; Mice, Inbred | 2019 |
Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria.
Topics: Acetylcholine; Animals; Disease Models, Animal; Female; Heme; Hydroxymethylbilane Synthase; Male; Me | 2019 |
Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electron Transport; Gene Expression Profiling; Li | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Carbon Radioisotopes | 2013 |
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal).
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liqu | 2013 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Dr | 2014 |
Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Combined Modality Therapy; Deep Brain Stimulation; Disease Model | 2014 |
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Bumetanide; Convulsants; Disease Models, Animal | 2014 |
Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Behavior, Animal; | 2014 |
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbon Radioisotopes; Carrier Proteins; Chronic Disease; Disease Mo | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Central Nervous | 2014 |
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Disease | 2015 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats.
Topics: Animals; bcl-2-Associated X Protein; Benzylisoquinolines; Brain; Disease Models, Animal; Drugs, Chin | 2015 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Syne | 2015 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction.
Topics: Aminophylline; Animals; Atropine; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; | 2015 |
In vivo evaluation of anticonvulsant and antioxidant effects of phenobarbital microemulsion for transdermal administration in pilocarpine seizure rat model.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Emulsions | 2015 |
Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.
Topics: Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Electron Transport Complex I; Electr | 2015 |
The Mode of Action for Phenobarbital-Induced Rodent Liver Tumor Formation Is not Relevant for Humans: Recent Studies With Humanized Mice.
Topics: Animals; Chimera; Constitutive Androstane Receptor; Disease Models, Animal; Humans; Liver; Liver Neo | 2015 |
Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Azepines; Benzamides; Brain; Brain Ischemia; Brain-Deriv | 2015 |
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Design; Male; Mice; Molecular Structur | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Ani | 2015 |
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; E | 2015 |
Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2016 |
Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Co | 2016 |
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationshi | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistant Epilepsy; Dyrk Kinases; Electric St | 2016 |
New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, M | 2017 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulati | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Oral administration of Azadirachta indica (L.) seed kernel active principle protects rat liver hepatocytes and testis seminiferous tubules from phenobarbitol-induced damage.
Topics: Administration, Oral; Animals; Azadirachta; Disease Models, Animal; Dose-Response Relationship, Drug | 2007 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, A | 2008 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Constitutive Androstane Recep | 2009 |
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Cyclopropanes; Cytochrome P-450 Enzym | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Trans | 2009 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Rec | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation | 2010 |
Phenobarbital augments hypothermic neuroprotection.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Hypothe | 2010 |
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Catalase; Cytochrome P-450 | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; | 2010 |
Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Celecoxib; | 2010 |
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2010 |
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.
Topics: Animals; beta Catenin; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cell Separation; | 2010 |
Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
Topics: Animals; Cell Line, Tumor; Cell Movement; Constitutive Androstane Receptor; Disease Models, Animal; | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocam | 2012 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; | 2011 |
Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.
Topics: Animals; Clofibrate; Disease Models, Animal; Gene Expression; Hepatomegaly; Liver; Male; Oligonucleo | 2011 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; E | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; | 2012 |
Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.
Topics: Animals; Animals, Newborn; Bumetanide; Disease Models, Animal; Drug Synergism; Hypothermia, Induced; | 2012 |
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.
Topics: Animals; Biliary Tract Diseases; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Dimethylnitr | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal Lobe; Fema | 2013 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Elec | 2002 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Anim | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Part | 2002 |
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Mod | 2002 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions.
Topics: Acetic Acid; Age Factors; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; G | 2003 |
Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carotenoids; Disease Models, Animal; Food | 2003 |
Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.
Topics: Animals; Bleeding Time; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Anim | 2003 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2004 |
Adenoviral-mediated expression of porphobilinogen deaminase in liver restores the metabolic defect in a mouse model of acute intermittent porphyria.
Topics: Adenoviridae; Aminolevulinic Acid; Animals; Disease Models, Animal; Gene Expression; Genetic Therapy | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Dru | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2004 |
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans | 2005 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Di | 2005 |
Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Autoradiography; Disease Models, Animal; Drug Resistance; Electroencephalo | 2006 |
Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish rat.
Topics: Animals; Antioxidants; Disease Models, Animal; Estradiol; Female; Liver; Mammary Glands, Animal; Mam | 2006 |
A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat.
Topics: Administration, Oral; Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationshi | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosi | 2006 |
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Topics: Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Carcinoma in Situ; Disease Models, Animal | 2006 |
Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity.
Topics: Animals; Behavior, Animal; Chickens; Disease Models, Animal; Female; Heroin; Hippocampus; Mice; Phen | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; | 2007 |
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug R | 2007 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalograp | 2007 |
Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Central N | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model.
Topics: Anesthetics, Intravenous; Animals; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A | 2008 |
Development and validation of the maximal electro-shock seizure model in dogs.
Topics: Animals; Anticonvulsants; Area Under Curve; Disease Models, Animal; Dog Diseases; Dogs; Dose-Respons | 2007 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytopro | 2008 |
Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Calcium-Transporting ATPases; Cerebral Cor | 2008 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose- | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; | 2008 |
Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cognition Disorders; Dis | 2008 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1983 |
Febrile seizures in epileptic chicks: the effects of phenobarbital, phenytoin and valproate.
Topics: Animals; Chickens; Disease Models, Animal; Phenobarbital; Phenytoin; Reaction Time; Seizures, Febril | 1983 |
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; H | 1983 |
Effects of anticonvulsants on hyperthermia-induced seizures in the rat pup.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Differential Threshold; Disease Model | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
Effect of nitrous oxide on halothane-induced hepatotoxicity in hypoxic, enzyme-induced rats.
Topics: Animals; Disease Models, Animal; Drug Synergism; Halothane; Liver; Male; Nitrous Oxide; Oxygen; Phen | 1984 |
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima | 1984 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
Familial unconjugated hyperbilirubinemia syndromes.
Topics: Animals; Bile Acids and Salts; Bilirubin; Crigler-Najjar Syndrome; Diagnosis, Differential; Disease | 1983 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
An improved technique for the induction of barbiturate dependence in mice.
Topics: Animals; Barbiturates; Disease Models, Animal; Feeding Behavior; Humans; Mice; Mice, Inbred Strains; | 1980 |
Sleep-inducing effects of three hypnotics in a new model of insomnia in rats.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electromyography; Flurazepam; Humans; Hypno | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
Time-course of formation of volatile reductive metabolites of halothane in humans and an animal model.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Disease Models, Animal; | 1980 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Su | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; | 1995 |
A new, non-pharmacologic model of convulsive status epilepticus induced by electrical stimulation: behavioral/electroencephalographic observations and response to phenytoin and phenobarbital.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epi | 1994 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease M | 1994 |
Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Di | 1994 |
Improvement of poor operant performance by continual intake of phenobarbital in spontaneously epileptic rats.
Topics: Administration, Oral; Animals; Conditioning, Operant; Disease Models, Animal; Epilepsy; Male; Phenob | 1994 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Fe | 1994 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Anim | 1993 |
Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.
Topics: Albumins; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Female; Glutathione Tra | 1993 |
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Atrophy; Axons; Base Sequence; Chimera; Disease Models, Animal; Female | 1996 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbita | 1996 |
Learning impairment in 1-2-day-old epileptic chicks.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chickens; Discrimination Learning; | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
The use of jejunal transplants to treat a genetic enzyme deficiency.
Topics: Animals; Bilirubin; Crigler-Najjar Syndrome; Disease Models, Animal; Jejunum; Phenobarbital; Rats; R | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Vasoconstrictor responsiveness of the rat mesenteric arterial bed in cirrhosis.
Topics: Adenosine Triphosphate; Animals; Arginine; Disease Models, Animal; Electric Stimulation; Enzyme Inhi | 1996 |
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Topics: Albumins; Animals; Disease Models, Animal; Female; Genes, myc; Hepatocyte Growth Factor; Liver Neopl | 1996 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electr | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1998 |
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; | 1998 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippo | 1998 |
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-45 | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver N | 2000 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.
Topics: Aging; Animals; Area Under Curve; Behavior, Animal; Cricetinae; Disease Models, Animal; Dose-Respons | 2000 |
Inhibitory effects of S-methylcysteine and cysteine on the promoting potential of sodium phenobarbital on rat liver carcinogenesis.
Topics: Animals; Carcinogens; Cysteine; Disease Models, Animal; Glutathione Transferase; Immunohistochemistr | 2000 |
Development of an experimental model of liver cirrhosis in rabbits.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combinat | 2001 |
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Topics: Animals; Bile; Disease Models, Animal; Drug Resistance, Multiple; Enzyme Induction; Hyperbilirubinem | 2002 |
Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epil | 1978 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimula | 1976 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
A comparison of the effects of chronically administered diazepam and phenobarbital and learning in the Papio papio model of epilepsy.
Topics: Animals; Diazepam; Disease Models, Animal; Haplorhini; Learning; Papio; Phenobarbital; Seizures; Sti | 1977 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytoc | 1979 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
Prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. I. Twelve months of treatment: seizure, EEG, blood, and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; | 1976 |
Acute anticonvulsant effects of diphenylhydantoin, phenobarbital, and carbamazepine: a combined electroclinical and serum level study in amygdaloid kindled cats and baboons.
Topics: Amygdala; Animals; Carbamazepine; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Dr | 1976 |
The effect of certain vitamin deficiencies on hepatic drug metabolism.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Cytochrome P-450 Enzyme System; Cyto | 1976 |
The rationale for fixed-bed charcoal in hemoperfusion.
Topics: Adsorption; Animals; Blood Platelets; Charcoal; Disease Models, Animal; Dogs; Filtration; Kidneys, A | 1976 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior | 1975 |
Efficacy of activated charcoal hemoperfusion in removing lethal doses of barbiturates and salicylate from the blood of rats and dogs.
Topics: Animals; Barbiturates; Charcoal; Disease Models, Animal; Dogs; Pentobarbital; Perfusion; Phenobarbit | 1976 |
An animal model of fulminant hepatic failure: a feasibility study.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; He | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
A model of status epilepticus induced by intermittent electrical stimulation of the deep prepyriform cortex in rats.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electro | 1992 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnit | 1991 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; O | 1991 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
Enzyme-inducing drugs and rat alpha 1-acid glycoprotein--2--Phenobarbital effects on acute inflammation in DA rats.
Topics: Acute-Phase Reaction; Animals; Arthritis; Carrageenan; Collagen; Cytochrome P-450 Enzyme System; Dis | 1989 |
Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Chlordiazepoxide; Disease Models, Animal; Explorat | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
Circadian manifestations of barbiturate habituation, addiction and withdrawal in the rat.
Topics: Animals; Body Temperature; Circadian Rhythm; Disease Models, Animal; Habituation, Psychophysiologic; | 1988 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hep | 1986 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Modification of 1-tyrosine-induced keratopathy by adrenal corticosteroids.
Topics: Animals; Betamethasone; Corneal Opacity; Dexamethasone; Dietary Proteins; Disease Models, Animal; Fe | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
The action of sympatholytic drugs in experimental intestinal paralysis.
Topics: Anesthesia; Animals; Cats; Chlorpromazine; Disease Models, Animal; Ganglionic Blockers; Gastrointest | 1971 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, An | 1973 |
Effect of phenobarbital and steroids on the adrenal apoplexy produced by acrylonitrile in rats.
Topics: Acrylates; Adrenal Cortex Hormones; Adrenal Gland Diseases; Animals; Biotransformation; Disease Mode | 1972 |
Biliary excretion of mercury enhanced by spironolactone.
Topics: Animals; Bile; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Kidney; Liver | 1972 |
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; | 1973 |
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Topics: Amphetamine; Animals; Chloral Hydrate; Dextroamphetamine; Disease Models, Animal; Female; Humans; Hy | 1974 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencepha | 1970 |