phenobarbital has been researched along with Disease Models, Animal in 274 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 53 (19.34) | 18.7374 |
| 1990's | 38 (13.87) | 18.2507 |
| 2000's | 67 (24.45) | 29.6817 |
| 2010's | 95 (34.67) | 24.3611 |
| 2020's | 21 (7.66) | 2.80 |
| Authors | Studies |
|---|---|
| Biziere, K; Brochard, J; Brodin, R; Chambon, JP; Hallot, A; Merlier, J | 1 |
| Chai, KY; Kwak, KC; Piao, HR; Quan, ZS; Xie, ZF | 1 |
| Al-Eryani, YA; Amin, KM; Rahman, DE | 1 |
| DeMarco, E; Kohn, H; Morieux, P; Park, KD; Salomé, C; Salomé-Grosjean, E; Stables, JP; Swendiman, R | 1 |
| Deng, XQ; Guan, LP; Quan, YC; Quan, ZS; Sui, X | 1 |
| Baruah, PK; De Ryck, M; Dinsmore, J; Kaminski, R; King, AM; Kohn, H; Provins, L; Salomé, C | 1 |
| Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR | 1 |
| Chońska, J; Dawidowski, M; Mika, W; Turło, J | 1 |
| Edayadulla, N; Ramesh, P | 1 |
| Andres-Mach, M; Lemieszek, MK; Raszewski, G; Szala-Rycaj, J; Szewczyk, A; Zagaja, A; Zagaja, M | 1 |
| Allison, BJ; Bennet, L; Boyd, BJ; Castillo-Melendez, M; Fahey, MC; Hirst, JJ; Hunt, RW; Jenkin, G; Malhotra, A; McDonald, C; Mihelakis, J; Miller, SL; Nitsos, I; Pham, Y; Sutherland, AE; Walker, DW; Wong, F; Yawno, T | 1 |
| Banach, M; Borowicz-Reutt, K | 2 |
| Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ | 1 |
| Bernat, P; Kołodziejczyk, P; Tutka, P; Zagaja, M; Łuszczki, JJ | 1 |
| Bojar, H; Chmielewski, J; Florek-Łuszczki, M; Jankiewicz, K; Skalicka-Woźniak, K; Łuszczki, JJ | 1 |
| Auer, T; Erker, T; Schreppel, P; Schwarzer, C | 1 |
| Bosch, J; Boyer-Diaz, Z; Gracia-Sancho, J; Lozano, JJ; Maeso-Díaz, R; Ortega-Ribera, M; Peralta, C | 1 |
| Guofeng, W; Kang, Y; Shi, H; Wang, L | 1 |
| Furukawa, S; Nishitani, Y; Ohtsu, Y; Sasao, A; Tsutsumi, H; Yonemitsu, K | 1 |
| Adler, DA; Ammanuel, S; Kadam, SD; Kang, SK | 1 |
| Banach, M; Borowicz-Reutt, KK; Rudkowska, M | 1 |
| Ardinger, CE; Beske, PH; Bodner, PM; Dubée, PB; Dunn, EN; Eisen, MR; Haines, KM; Honnold, CL; McCarren, HS; McDonough, JH; McNutt, PM; Nguyen, DL; Ondeck, CA; Santoro, AN | 1 |
| Ma, WW; Peng, IF; Wang, YY | 1 |
| Barker-Haliski, M; Knox, KM; Koneval, Z; Memon, A; White, HS; Zierath, DK | 1 |
| Czuczwar, SJ; Raszewski, G; Łukawski, K | 1 |
| Bealer, SL; Dudek, FE; Smolik, M; Spampanato, J | 1 |
| Ala-Kurikka, T; Gailus, B; Hampel, P; Johne, M; Kaila, K; Löscher, W; Römermann, K; Theilmann, W | 1 |
| Banach, M; Borowicz-Reutt, KK | 1 |
| Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D | 1 |
| Bertram, EH; Edelbroek, P | 1 |
| Hassan, ME; Mahmoud, AM; Mostafa-Hedeab, G; Zaki, AR | 1 |
| Berardis, S; El Taghdouini, A; El-Kehdy, H; Evraerts, J; Henriet, P; Lombard, C; Najimi, M; Rosseels, V; Sokal, EM; van Grunsven, L | 1 |
| Raol, YH; Sampath, D; Valdez, R; White, AM | 1 |
| Brown, FC; Conway, AJ; Curtis, DJ; Fullinfaw, RO; Jane, SM; Kile, BT | 1 |
| Andres-Mach, M; Chmielewski, J; Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Patrzylas, P; Szpringer, M; Zagaja, M; Zaluska, K | 1 |
| Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ | 1 |
| Dunn, R; Forcelli, PA; Pak, DTS; Queenan, BN | 1 |
| Germanova, EL; Kirova, YI; Lukyanova, LD | 1 |
| Kondrat-Wróbel, MW; Łuszczki, JJ | 1 |
| Florek-Luszczki, M; Luszczki, JJ; Mazurkiewicz, LP; Ossowska, G; Szpringer, M; Wlaz, A; Wroblewska-Luczka, P; Zolkowska, D | 1 |
| Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S | 1 |
| Boylan, GB; Henshall, DC; Jimenez-Mateos, EM; Madden, SF; Molloy, EJ; Quinlan, SMM; Rodriguez-Alvarez, N | 1 |
| Berraondo, P; Corrales, F; de Salamanca, RE; Fontanellas, A; Millet, O; Sampedro, A; Sanz-Parra, A; Serna, N; Serrano-Mendioroz, I | 1 |
| Carter, BM; Kadam, SD; Landers, JR; Sullivan, BJ | 1 |
| Carter, BM; Kadam, SD; Kharod, SC | 1 |
| Anderson, A; Bray, C; Calderon, R; Corr, SJ; Curley, S; Ho, J; Jain, S; Law, J; Nagaraj, A; Rios, J; Toombs, B; Ware, M | 1 |
| Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF | 1 |
| Aebisher, D; Bartusik-Aebisher, D; Buszewicz, G; Kołodziejczyk, P; Mróz, K; Mróz, T; Tutka, P; Łuszczki, JJ | 1 |
| Chmielewski, J; Daniluk, J; Florek-Łuszczki, M; Karwan, S; Sawicka, KM; Wawryniuk, A; Łuszczki, JJ | 1 |
| Fontanellas, A; Jericó, D; Parra-Guillén, ZP; Sampedro, A; Serrano-Mendioroz, I; Trocóniz, IF; Vera-Yunca, D | 1 |
| Bonkovsky, HL; Desnick, RJ; Gan, L; Pulgar, VM; Yasuda, M | 1 |
| Desnick, RJ; Yasuda, M | 1 |
| Chen, B; Desnick, RJ; Gan, L; Wang, M; Yasuda, M; Zhang, B | 1 |
| Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ | 1 |
| Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA | 1 |
| de Lange, EC; Eriksson, J; Koepp, M; Labots, M; Lammertsma, AA; Potschka, H; Rongen, M; Russmann, V; Schuit, R; Seeger, N; Syvänen, S; van Kooij, R; Verbeek, J; Voskuyl, RA; Windhorst, AD; Zellinger, C | 1 |
| Barrera-Bailón, B; Garcia-Cairasco, N; López, DE; Muñoz, LJ; Oliveira, JA; Sancho, C | 1 |
| Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A | 1 |
| Bellance, N; Bing, H; Damm, A; Fox, IJ; Handa, K; Moss, TJ; Nagrath, D; Nishikawa, T; Oertel, M; Pipinos, II; Ram, PT; Sehgal, V; Soto-Gutierrez, A; Yovchev, MI; Zhu, Z | 1 |
| Asgari, A; Atapour, N; Mirnajafi-Zadeh, J; Moradi, H; Semnanian, S; Shojaei, A | 1 |
| Brandt, C; Brunhofer, G; Erker, T; Feit, PW; Gabriel, M; Kaila, K; Lindfors, J; Löscher, W; Töllner, K; Töpfer, M | 1 |
| Aronica, E; Gorter, J; Potschka, H; Salvamoser, JD; Soerensen, J; van Vliet, EA; Zellinger, C | 1 |
| Bogdanović, RM; de Lange, EC; Eriksson, J; Lammertsma, AA; Michler, C; Potschka, H; Russmann, V; Syvänen, S; Voskuyl, RA; Windhorst, AD | 1 |
| Borowicz, KK; Borowicz, KM; Latalski, M; Zarczuk, R | 1 |
| Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A | 1 |
| Hayashi, H; Kanki, M; Minami, K; Mitsumori, K; Morikawa, Y; Omura, K; Ono, A; Uehara, T; Urushidani, T; Yamada, H | 2 |
| Boussadia, B; de Bock, F; Ghosh, C; Janigro, D; Marchi, N; Pascussi, JM; Plaud, C; Rousset, MC | 1 |
| Akman, O; Galanopoulou, AS; Moshé, SL | 1 |
| Fu, P; Han, B; Wang, G; Ye, Y; Zhang, H | 1 |
| Brandt, C; Erker, T; Löscher, W; Töllner, K | 1 |
| Bankstahl, M; Klein, S; Löscher, W | 1 |
| Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K | 1 |
| Cao, F; Chen, X; Kim, TH; Ma, N; Niu, G; Sun, Z; Tong, G | 1 |
| Carvalho, AL; da Rocha Tomé, A; da Silva, JA; de Freitas, RM; Figueiredo, KA; Medeiros, SC; Neves, JK | 1 |
| Löscher, W | 1 |
| Desquiret-Dumas, V; Deybach, JC; Gouya, L; Gueguen, N; Homedan, C; Karim, Z; Laafi, J; Lenglet, H; Malthièry, Y; Puy, H; Reynier, P; Schmitt, C; Simard, G | 1 |
| Cohen, SM; Lake, BG; Yamada, T | 1 |
| Johnston, MV; Kadam, SD; Kang, SK | 1 |
| Abadi, AH; Abdelfattah, MA; Habib, MM | 1 |
| Borowicz, KK; Popławska, M; Wróblewska, D | 1 |
| Shi, J; Wang, LK; Wu, GF; Zhou, F | 1 |
| Khazipov, R | 1 |
| Banach, M; Borowicz-Reutt, KK; Piskorska, B | 1 |
| Luszczki, JJ | 1 |
| Brandt, C; Erker, T; Löscher, W; Schidlitzki, A; Schreppel, P; Töllner, K; Twele, F | 1 |
| Löscher, W; Töllner, K; Twele, F | 1 |
| Asgari, A; Atapour, N; Ghafouri, S; Mirnajafi-Zadeh, J; Moradi-Chameh, H; Semnanian, S; Sheibani, V; Shojaei, A | 1 |
| Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM | 1 |
| Bruckmueller, H; Cascorbi, I; Haenisch, S; Michler, C; Potschka, H; Rettenbeck, ML; Russmann, V; von Rüden, EL; Waetzig, V; Wahmkow, H | 1 |
| Bruno Blanch, L; Castaño, R; Enrique, A; Girardi, E; Goicoechea, S; Orozco, S; Rocha, L; Taborda, F | 1 |
| Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G | 1 |
| Bethmann, K; Brandt, C; Fritschy, JM; Löscher, W | 1 |
| Bankstahl, JP; Löscher, W | 1 |
| Ampasala, DR; Raveendra, A; Sandhya, D; Thyagaraju, K | 1 |
| Ali, MS; Bepary, S; Chowdhury, AA; Das, BK; Datta, BK; Rouf, AS | 1 |
| Bishayee, A; Dhir, N | 1 |
| Deguchi, Y; Hirose, Y; Kawamura, S; Kushida, M; Nagahori, H; Nishioka, K; Okuno, Y; Sukata, T; Sumida, K; Tomigahara, Y; Uwagawa, S; Yamada, T | 1 |
| Cohen, SM; Kaneko, H; Okuno, Y; Uwagawa, S; Yamada, T | 1 |
| Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH | 1 |
| Good, LB; Marsh, ST; Treiman, DM; Wang, NC | 1 |
| Girardi, E; Gonzalez, NN; Höcht, C; Lazarowski, A; Mayer, MA; Opezzo, JA; Taira, CA | 1 |
| Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER | 1 |
| Brandt, C; Löscher, W | 1 |
| Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E | 1 |
| Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Hill, AJ; Jones, NA; Stephens, GJ; Whalley, BJ; Williams, CM | 1 |
| Barks, JD; Liu, YQ; Shangguan, Y; Silverstein, FS | 1 |
| Mehvar, R; Shaik, IH | 1 |
| Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G | 1 |
| Brandt, C; Heuchert, N; Löscher, W; Nozadze, M; Rattka, M | 1 |
| Bartmann, H; Fuest, C; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Winter, P | 1 |
| Bartenstein, P; Bartmann, H; Böning, G; Cumming, P; Fuest, C; Just, T; la Fougere, C; Pekcec, A; Potschka, H; Schlichtiger, J; Soerensen, J; Wängler, B; Winter, P; Xiong, G | 1 |
| Andres-Mach, M; Cioczek, JD; Kocharov, SL; Kominek, M; Luszczki, JJ; Zolkowska, D | 1 |
| Braeuning, A; Buchmann, A; Drasdo, D; Godoy, P; Hammad, S; Hengstler, JG; Hoehme, S; Othman, A; Rignall, B; Schwarz, M; Singh, Y; von Recklinghausen, I | 1 |
| Kakizaki, S; Kamino, H; Moore, R; Negishi, M; Saito, K; Takizawa, D; Yamazaki, Y | 1 |
| Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR | 1 |
| Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH | 1 |
| Andres-Mach, M; Barcicka-Klosowska, B; Czuczwar, SJ; Florek-Luszczki, M; Haratym-Maj, A; Luszczki, JJ | 1 |
| Cha, DS; Jeon, H; Park, HJ | 1 |
| He, X; Liu, W; Liu, Y; Peng, B; Wang, H; Wang, Y; Yin, J; Yu, F | 1 |
| Arai, Y; Higuchi, H; Maeda, S; Miyawaki, T; Shimada, M; Tomoyasu, Y | 1 |
| Adio, O; Fageyinbo, S; Sowemimo, AA | 1 |
| Degawa, M; Gamou, T; Habano, W; Hikida, T; Ikeda, A; Inoue, K; Ito, S; Mizukami, M; Nemoto, K; Nishikawa, A; Ozawa, S; Tanaka, T; Yoshida, M | 1 |
| Bankstahl, JP; Bankstahl, M; Löscher, W | 1 |
| Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W | 1 |
| Barks, JD; Liu, Y; Shangguan, Y; Silverstein, FS | 1 |
| Becker, K; Boger, RJ; Ehrenberg, KR; Hahn, M; Hövelmeyer, N; Jäger, D; Longerich, T; Schuchmann, M; Schulze-Bergkamen, H; Urbanik, T; Waisman, A; Wörns, MA | 1 |
| Banerjee, A; Gartel, AL; Halasi, M; Kabirov, K; Landolfi, J; Lyubimov, AV; Wang, M | 1 |
| Gupta, YK; Kleekal, T; Pahuja, M; Reeta, KH; Tripathi, M | 1 |
| Brandt, C; Löscher, W; Rattka, M | 1 |
| Bílková, E; Haugvicová, R; Kubová, H; Mares, P | 1 |
| Hodgson, HJ; Rahman, TM; Selden, AC | 1 |
| Baraban, SC; Barbaro, NM; Smyth, MD | 1 |
| Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S | 1 |
| Corley, SM; Gilbert, TH; Teskey, GC | 1 |
| Bittigau, P; Dikranian, K; Dzietko, M; Genz, K; Govindarajalu, S; Ikonomidou, C; Mai, I; Olney, JW; Pesditschek, S; Pospischil, D; Reith, E; Sifringer, M | 1 |
| Hammer, J; Kondziella, D; Sletvold, O; Sonnewald, U | 1 |
| Aoki, H; Doi, Y; Hagiwara, A; Hirota, T; Imai, N; Kawabe, M; Koda, T; Nabae, K; Nakamura, M; Shirai, T; Tsushima, Y; Yasuhara, K; Yoshino, H | 1 |
| Chiba, K; Hosokawa, M; Kobayashi, K; Mimura, N; Nakamura, Y; Shimada, N | 1 |
| Stanojlovic, O; Stojanovic, J; Susic, V; Zivanovic, D | 1 |
| de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S | 1 |
| Blomberg, P; Harper, P; Johansson, A; Möller, C; Nowak, G | 1 |
| De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ | 1 |
| Löscher, W; Potschka, H; Rieck, S; Rundfeldt, C; Tipold, A | 1 |
| Borowicz, KK; Czuczwar, SJ | 1 |
| Borowicz, KK; Czuczwar, SJ; Drelewska, E; Rwiader, M | 1 |
| Brandt, C; Löscher, W; Volk, HA | 1 |
| Pasha, MK; Rajput, AH; Sharma, RK | 1 |
| Asimiadou, S; Bittigau, P; Dzietko, M; Felderhoff-Mueser, U; Ikonomidou, C; Kaindl, AM; Manthey, D; Mozrzymas, JW; Pesditschek, S; Pytel, M; Sifringer, M; Studniarczyk, D | 1 |
| Adler, R; Amacher, DE; Herath, A; Townsend, RR | 1 |
| Shahjahan, M; Shyamaladevi, CS; Vani, G | 1 |
| Arabadzisz, D; Bethmann, K; Brandt, C; Fritschy, JM; Löscher, W; Volk, HA | 1 |
| Conney, AH; Kauffman, FC; Mesia-Vela, S; Reuhl, KR; Sanchez, RI | 1 |
| Butler, WH; Capen, CC; Finch, JM; Gabriel, KL; Henderson, WJ; Lake, BG; Martin, T; Osimitz, TG | 1 |
| Chakraborty, T; Chatterjee, A; Chatterjee, M; Saralaya, MG | 1 |
| Barotto, NN; Bongiovanni, GA; Díaz, MP; Eynard, AR; Valentich, MA | 1 |
| Ben-Shaanan, TL; Haimovitch, H; Katz, S; Kazma, M; Yanai, J | 1 |
| Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N | 1 |
| Gilbert, TH; Teskey, GC | 1 |
| Bethmann, K; Brandt, C; Löscher, W | 1 |
| Levene, M | 1 |
| Erbayat-Altay, E; Gutmann, DH; Wong, M; Xu, L; Zeng, LH | 1 |
| Ago, Y; Baba, A; Hashimoto, H; Matsuda, T; Nakamura, S; Takahashi, K | 1 |
| Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N | 1 |
| Borowicz, KK; Czuczwar, SJ; Furmanek-Karwowska, K; Luszczki, JJ; Morawska, M | 1 |
| Banach, M; Borowicz, KK; Czuczwar, SJ; Lukasik, D; Luszczki, JJ; Zarczuk, R | 1 |
| Iwaki, H; Iwakiri, K; Kaneshiro, Y; Masada, T; Oda, Y; Ohashi, H; Takaoka, K | 1 |
| Abdul-Karim, B; Barnhart, SD; Burnett, TJ; Engleking, DR; Freise, KJ; Newhall, K; Peters, SC; Shannon, HE; Territo, PR | 1 |
| Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL | 1 |
| Chang, LH; Chuu, JJ; Huang, ZN; Lin-Shiau, SY; Yu, HH | 1 |
| Cappelari, SE; da Silva Brum, LF; de Oliveira, PA; Lino, FL; Pereira, P; Picada, JN | 1 |
| Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH | 1 |
| Bankstahl, JP; Brandt, C; Gastens, AM; Löscher, W | 1 |
| Mowat, AP; Trivedi, P | 1 |
| Crawford, KD; Crawford, RD; Johnson, DD | 1 |
| Bruinvels, J; Pepplinkhuizen, L; Schouten, MJ; Wilson, JH | 1 |
| Holtzman, D; Olson, JE; Scher, MS | 1 |
| Lajtha, A; Toth, E | 1 |
| Duffy, SW; Monk, SJ; Ross, JA | 1 |
| Carnel, SB; Lathers, CM; Schraeder, PL | 1 |
| Kupferberg, HJ | 1 |
| Congdon, WC; DuCharme, LL; Levy, RH; Lockard, JS | 1 |
| Reichen, J | 1 |
| Cavalheiro, EA; de Campos, CJ; Izquierdo, I | 1 |
| Blum, K; Briggs, AH; Cull, DL | 1 |
| Halperin, JM; Iorio, LC; Miller, D | 1 |
| Alberton, TE; Bowyer, JF | 1 |
| Adams, JF; Cousins, MJ; Gourlay, GK; Sharp, JH | 1 |
| Bastidas Ramírez, BE; García Estrada, J; García López, P; Garzón, P; Navarro Ruíz, A | 1 |
| García-Teno, M; González-Darder, JM | 1 |
| Patil, PA; Wali, RS | 1 |
| Handforth, A; Treiman, DM | 1 |
| Balansky, RM; Blagoeva, PM; De Flora, S; Mircheva, ZI | 1 |
| Laviola, G | 1 |
| Bandyopadhyay, AM; Blouin, RA; Robertson, LW; Zannikos, PN | 1 |
| Asano, Y; Serikawa, T; Yamada, J | 1 |
| Devor, DE; Henneman, JR; Ward, JM; Weghorst, CM | 1 |
| Hönack, D; Löscher, W; Rundfeldt, C | 1 |
| Dragan, YP; Drinkwater, N; Koleske, AJ; Laufer, C; Pitot, HC | 1 |
| McClain, RM | 1 |
| Aguzzi, A; Brandner, S; Bürki, K; Grandchamp, B; Ledermann, B; Lindberg, RL; Meyer, UA; Porcher, C | 1 |
| Godlevsky, LS; Mazarati, AM; Shandra, AA; Vastyanov, RS | 1 |
| Gervais-Fagnou, DD; Tuchek, JM | 1 |
| Kubova, H; Lanstiakova, M; Mares, P; Mockova, M; Vorlicek, J | 1 |
| Burgos, AA; Jaffe, BM; Martinez-Noack, M | 1 |
| Hirohashi, M; Kitano, Y; Nomura, M; Takasuna, K; Usui, C | 1 |
| Burnstock, G; Mathie, RT; Moore, KP; Ralevic, V | 1 |
| Santoni-Rugiu, E; Thorgeirsson, SS | 1 |
| Satishchandra, P; Shankar, SK; Ullal, GR | 1 |
| Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z | 1 |
| Krupp, E; Löscher, W | 1 |
| Bolanos, AR; Helmers, SL; Holmes, GL; Hori, A; Mikati, M; Sarkisian, M; Stafstrom, CE; Tandon, P; Yang, Y | 1 |
| Fujiwara, K; Ogata, I; Tomiya, T | 1 |
| George, B; Kulkarni, SK; Mathur, R | 1 |
| Brain, EG; Drewes, P; Gustafsson, K; Hecht, JE; Waxman, DJ; Yu, LJ | 1 |
| D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR | 1 |
| Brum, LF; Elisabetsky, E; Souza, DO | 1 |
| Czuczwar, SJ; Haberek, G; Kleinrok, Z; Matyska, J; Pilip, S; Tomczyk, T; Turski, WA; Urbanska, EM | 1 |
| Goto, K; Kobayashi, K; Mutai, M; Sakairi, T; Sugimoto, J; Tsuchiya, T | 1 |
| Fiedler, M; Löscher, W | 1 |
| Löscher, W; Richter, A | 1 |
| Fukushima, S; Otani, S; Takada, N; Vijayaraghavan, M; Wanibuchi, H; Yamamoto, S; Yano, Y | 1 |
| Brandão, CG; de Nucci, G; Ferraz, JG; Ferreira, HH; Pedrazzoli, J; Piovesana, H; Polimeno, NC | 1 |
| Reddy, DS; Rogawski, MA | 1 |
| Akasaki, Y; Hashiguchi, W; Nagatomo, I; Takigawa, M; Tominaga, M; Uchida, M | 1 |
| Johnson, DR; Klaassen, CD | 1 |
| Snead, OC | 1 |
| Green, JR; Sato, M; Troupin, AS; Wada, JA; Wake, A | 1 |
| Horton, RW; Meldrum, BS; Toseland, PA | 1 |
| Stiehl, A | 1 |
| Crawford, RD; Davis, HL; Johnson, DD | 1 |
| Wada, JA | 1 |
| Killam, EK; Weinberger, SB | 1 |
| Brown, BR; McLain, GE; Sipes, IG | 1 |
| Hoffer, BJ; Oliver, AP; Wyatt, RJ | 1 |
| Buck, DR; Hendricks, DG; Mahoney, AW | 1 |
| Congdon, WC; DuCharme, LL; Huntsman, BJ; Lockard, JS | 1 |
| Congdon, WC; DuCharme, LL; Franklin, SC; Lockard, JS | 1 |
| Corcoran, ME; Osawa, T; Sato, M; Troupin, AS; Wada, JA; Wake, A | 1 |
| Sato, PH; Zannoni, VG | 1 |
| Hill, JB; Maret, SM; McAdams, JL; Palaia, FL; Palmer, PJ; Skinner, JT | 1 |
| Anlezark, G; Balzamo, E; Horton, RW; Meldrum, BS; Trimble, M | 1 |
| DuCharme, LL; Farquhar, JA; Huntsman, BJ; Lockard, JS; Uhlir, V | 1 |
| Hill, JB; Maret, SM; McAdams, JL; Palaia, FL; Palmer, PJ | 1 |
| Fratter, R; Hickman, R; Miller, DJ; Saunders, SJ; Terblanche, J | 1 |
| Mares, P; Stanková, L | 1 |
| Inoue, K; Ishizu, H; Kawai, K; Morimoto, K; Otsuki, S; Sato, K; Yamada, N | 1 |
| Dragan, YP; Pitot, HC; Xu, YD | 1 |
| Serikawa, T | 1 |
| Gil-Salú, JL; Gómez-Cárdenas, E; Gonzàlez-Darder, JM; Guerrero, M; Segura-Pastor, D | 1 |
| Fredow, G; Löscher, W | 1 |
| Nadkarni, GD; Noronha, OP; Shimpi, HH | 1 |
| Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM | 1 |
| Chauvelot-Moachon, L; Fournier, C; Giroud, JP; Levy, F; Poüs, C | 1 |
| Kilfoil, T; Michel, A; Montgomery, D; Whiting, RL | 1 |
| Herren-Freund, SL; Pereira, MA | 1 |
| Samanin, R; Tullii, M; Vezzani, A; Wu, HQ | 1 |
| Ehret, CF; Groh, KR; Meinert, JC; Peraino, C; Readey, MA | 1 |
| Alp, MH; Hickman, R | 1 |
| Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Dailey, JW; Jobe, PC | 1 |
| Lennox-Buchthal, MA | 1 |
| Beard, ME; Burns, RP; Squires, EL; Weimar, VL | 1 |
| Edmonds, HL; Hollinger, MA; Stark, LG | 1 |
| Petri, G; Pórszász, J; Pórszász-Gibiszer, K | 1 |
| Freund, G | 1 |
| Selye, H; Szabo, S | 1 |
| Fish, CA; Haddow, JE; Lester, R; Marshall, PC | 1 |
| Racusen, LC; Smith, DB | 1 |
| Goldberg, AM; Silbergeld, EK | 1 |
| Killam, EK; Killam, KF; Stark, LG | 1 |
12 review(s) available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Murine models of the human porphyrias: Contributions toward understanding disease pathogenesis and the development of new therapies.
Topics: Anemia; Animals; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Genetic Therapy; Humans; Liver; Mice; Phenobarbital; Porphobilinogen Synthase; Porphyrias; Porphyrias, Hepatic; Protoporphyria, Erythropoietic | 2019 |
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Ketamine; Lithium; Phenobarbital; Pilocarpine; Rats; Seizures; Status Epilepticus | 2015 |
GABAergic Synchronization in Epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Cortical Synchronization; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Humans; Nerve Net; Phenobarbital; Rats; Receptors, GABA; Synaptic Transmission | 2016 |
Minimising neonatal brain injury: how research in the past five years has changed my clinical practice.
Topics: Animals; Birth Injuries; Brain Diseases; Dexamethasone; Disease Models, Animal; Ethamsylate; Humans; Hypocapnia; Indomethacin; Infant, Newborn; Infant, Premature, Diseases; Lung Diseases; Phenobarbital | 2007 |
Sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kinetics; Phenobarbital; Seizures; Structure-Activity Relationship; Valproic Acid | 1980 |
Mouse models of emotional postpartum disorders.
Topics: Animals; Benzodiazepines; Disease Models, Animal; Emotions; Female; Hormones; Humans; Male; Maternal Behavior; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mood Disorders; Neurotransmitter Agents; Phenobarbital; Pregnancy; Pregnancy, Animal; Psychotropic Drugs; Puerperal Disorders; Rats | 1993 |
Phenobarbital mouse liver tumors: implications of hepatic tumor promotion for cancer risk assessment.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Disease Models, Animal; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Mice; Phenobarbital; Risk Assessment | 1995 |
Disturbances of bile acid metabolism in cholestasis.
Topics: Bile Acids and Salts; Bile Ducts; Cholestasis; Cholestyramine Resin; Deoxycholic Acid; Disease Models, Animal; Female; Glucuronates; Hepatitis; Humans; Ligation; Lithocholic Acid; Liver; Liver Cirrhosis; Male; Phenobarbital; Pregnancy; Pregnancy Complications; Sterols; Sulfates | 1977 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; Female; Humans; Male; Mutation; Phenobarbital; Phenytoin; Photic Stimulation; Primidone; Seizures; Valproic Acid | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carbamazepine; Catecholamines; Cats; Cerebral Cortex; Chlorpromazine; Clorazepate Dipotassium; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Epilepsy; Haplorhini; Hydroxydopamines; Phenobarbital; Phenytoin; Rats; Reserpine; Seizures; Valproic Acid | 1977 |
[Review: development of the spontaneously epileptic rat].
Topics: Animals; Crosses, Genetic; Disease Models, Animal; Epilepsy; Female; Male; Phenobarbital; Rats; Rats, Inbred WKY; Rats, Mutant Strains | 1992 |
Febrile convulsions. A reappraisal.
Topics: Age Factors; Animals; Animals, Newborn; Body Temperature; Brain; Brain Damage, Chronic; Child, Preschool; Disease Models, Animal; Diseases in Twins; Dysentery; Electroencephalography; Epilepsy; Female; Fever; Genes, Dominant; Humans; Hypoglycemia; Infant; Infant, Newborn; Infant, Newborn, Diseases; Infections; Intellectual Disability; Male; Muscle Spasticity; Phenobarbital; Phenytoin; Prognosis; Seizures; Sex Factors; Sound | 1973 |
1 trial(s) available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromatography, High Pressure Liquid; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Fruit; Glutathione; Lipid Peroxidation; Male; Maze Learning; Phenobarbital; Phenytoin; Phytotherapy; Rats; Rats, Wistar; Seizures; Ziziphus | 2012 |
261 other study(ies) available for phenobarbital and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and activity of 6-aryl-3-(hydroxypolymethyleneamino)pyridazines in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Female; Hypnotics and Sedatives; Kindling, Neurologic; Male; Mice; Motor Skills; Papio; Pentylenetetrazole; Photic Stimulation; Pyridazines; Rats; Rats, Inbred Strains; Seizures; Structure-Activity Relationship | 1986 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizures; Structure-Activity Relationship | 2005 |
Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Molecular Structure; Pentylenetetrazole; Seizures; Stereoisomerism; Structure-Activity Relationship; Strychnine | 2008 |
Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides.
Topics: Acetamides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Hippocampus; Kindling, Neurologic; Male; Mice; Molecular Structure; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Serine; Structure-Activity Relationship | 2010 |
Synthesis and anticonvulsant activity of a new 6-alkoxy-[1,2,4]triazolo[4,3-b]pyridazine.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Mice; Molecular Structure; Motor Activity; Pyridazines; Rotarod Performance Test; Seizures; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2010 |
Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred Strains; Molecular Structure; Neuralgia; Seizures; Structure-Activity Relationship | 2012 |
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain | 2014 |
Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: synthesis and anticonvulsant evaluation in animal models of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Halogenation; Hydrocarbons, Fluorinated; Male; Mice; Molecular Structure; Pentylenetetrazole; Pilocarpine; Pyrazines; Pyrroles; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2014 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Mice; Models, Molecular; Molecular Structure; Pentylenetetrazole; Seizures; Structure-Activity Relationship; Thiazines | 2015 |
Influence of Umbelliferone on the Anticonvulsant and Neuroprotective Activity of Selected Antiepileptic Drugs: An In Vivo and In Vitro Study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Lacosamide; Mice; Phenobarbital; Seizures; Umbelliferones | 2022 |
Ganaxolone versus Phenobarbital for Neonatal Seizure Management.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Disease Models, Animal; Epilepsy; Humans; Infant, Newborn; Phenobarbital; Pregnanolone; Seizures; Sheep | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Mice; Phenobarbital; Phenytoin; Trimetazidine; Valproic Acid | 2022 |
Ranolazine Interacts Antagonistically with Some Classical Antiepileptic Drugs-An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Epilepsy; Mice; Phenobarbital; Phenytoin; Ranolazine; Seizures | 2022 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Mice; Phenobarbital; Seizures; Valproic Acid | 2023 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Humans; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Varenicline | 2023 |
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Electroshock; Humans; Mice; Phenobarbital; Phenytoin; Seizures | 2023 |
Functional characterization of novel bumetanide derivatives for epilepsy treatment.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Kainic Acid; Mice; Pentylenetetrazole; Phenobarbital; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Solute Carrier Family 12, Member 2 | 2020 |
New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease.
Topics: Animals; Carbon Tetrachloride; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fatty Liver; Inflammation; Liver; Liver Cirrhosis; Male; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Phenobarbital; Rats; Rats, Wistar; Transcriptome | 2019 |
Hippocampal low-frequency stimulation improves cognitive function in pharmacoresistant epileptic rats.
Topics: Animals; Anticonvulsants; Cognition; Disease Models, Animal; Electric Stimulation; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Memory; Phenobarbital; Phenytoin; Rats, Sprague-Dawley; Seizures | 2020 |
Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model.
Topics: Administration, Oral; Animals; Biomarkers; Carboxymethylcellulose Sodium; Chromatography, Liquid; Diazepam; Disease Models, Animal; Drug Overdose; GABA Modulators; Male; Neurotransmitter Agents; Phenobarbital; Rats, Wistar; Tandem Mass Spectrometry | 2020 |
Rescue of PB-resistant neonatal seizures with single-dose of small-molecule TrkB antagonist show long-term benefits.
Topics: Animals; Anticonvulsants; Azepines; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Mice; Phenobarbital; Receptor, trkB; Seizures; Spatial Memory | 2020 |
Nebivolol attenuates the anticonvulsant action of carbamazepine and phenobarbital against the maximal electroshock-induced seizures in mice.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Female; Memory, Long-Term; Mice; Nebivolol; Phenobarbital; Seizures; Tissue Distribution | 2020 |
Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Levetiracetam; Mice; Nerve Agents; Phenobarbital; Soman; Status Epilepticus; Valproic Acid | 2020 |
Screening of sleep assisting drug candidates with a Drosophila model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Circadian Rhythm; Disease Models, Animal; Drosophila melanogaster; Gene Expression Regulation; Humans; Melatonin; Mutation; Panax notoginseng; Phenobarbital; Plant Extracts; Sleep; Sleep Deprivation; Sleep Wake Disorders; Withania | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Drug Resistant Epilepsy; Electroshock; Kindling, Neurologic; Lamotrigine; Levetiracetam; Locomotion; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Open Field Test; Phenobarbital; Seizures; Treatment Outcome; Valproic Acid | 2020 |
Effect of aliskiren on the anticonvulsant activity of antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Amides; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Epilepsy, Temporal Lobe; Fumarates; Mice; Pentylenetetrazole; Phenobarbital; Seizures | 2020 |
Delayed Adjunctive Treatment of Organophosphate-Induced Status Epilepticus in Rats with Phenobarbital, Memantine, or Dexmedetomidine.
Topics: Animals; Anticonvulsants; Brain; Cell Death; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroencephalography; Isoflurophate; Male; Memantine; Neurons; Phenobarbital; Prohibitins; Rats; Rats, Sprague-Dawley; Status Epilepticus; Time-to-Treatment; Treatment Outcome | 2020 |
Phenobarbital and midazolam suppress neonatal seizures in a noninvasive rat model of birth asphyxia, whereas bumetanide is ineffective.
Topics: Animals; Animals, Newborn; Anticonvulsants; Asphyxia Neonatorum; Bumetanide; Disease Models, Animal; Female; Hypnotics and Sedatives; Male; Midazolam; Phenobarbital; Rats; Rats, Wistar; Seizures; Sodium Potassium Chloride Symporter Inhibitors; Treatment Outcome | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy; Female; Male; Memory, Long-Term; Mice; Moclobemide; Monoamine Oxidase Inhibitors; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2021 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Compounding; Drug Discovery; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Temporal Lobe; Everolimus; High-Throughput Screening Assays; Kainic Acid; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Seizures; Translational Research, Biomedical | 2021 |
Chronic limbic epilepsy models for therapy discovery: Protocols to improve efficiency.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Epilepsy; Levetiracetam; Pharmaceutical Preparations; Phenobarbital; Phenytoin; Rats; Seizures | 2021 |
Commiphora molmol resin attenuates diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis by modulating oxidative stress, inflammation, angiogenesis and Nrf2/ARE/HO-1 signaling.
Topics: Animals; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Heme Oxygenase-1; Inflammation; Liver; Liver Neoplasms, Experimental; Male; Neovascularization, Pathologic; NF-E2-Related Factor 2; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Signal Transduction; Terpenes; Vesicular Transport Proteins | 2017 |
Human liver mesenchymal stem/progenitor cells inhibit hepatic stellate cell activation: in vitro and in vivo evaluation.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Coculture Techniques; Culture Media, Conditioned; Disease Models, Animal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Liver Regeneration; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Phenobarbital; Rats; Rats, Wistar; Time Factors | 2017 |
Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Disease Progression; Electrocorticography; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Phenobarbital; Random Allocation; Rats, Sprague-Dawley; Seizures; Time Factors | 2017 |
A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen.
Topics: Anemia, Hypochromic; Animals; Base Sequence; Biosynthetic Pathways; Coproporphyria, Hereditary; Coproporphyrinogen Oxidase; Disease Models, Animal; Ethylnitrosourea; Fasting; Feces; Female; Heme; Male; Mice, Mutant Strains; Mutagenesis; Mutation; Phenobarbital; Phenotype; Pregnancy | 2017 |
Effects of arachidonyl-2'-chloroethylamide (ACEA) on the protective action of various antiepileptic drugs in the 6-Hz corneal stimulation model in mice.
Topics: Acetamides; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Benzodiazepines; Clobazam; Cornea; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy, Complex Partial; Lacosamide; Levetiracetam; Male; Mice; Muscle Strength; Nipecotic Acids; Phenobarbital; Phenylmethylsulfonyl Fluoride; Piracetam; Psychomotor Performance; Receptor, Cannabinoid, CB1; Tiagabine; Valproic Acid | 2017 |
The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain Injuries; Disease Models, Animal; Female; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Magnetic Resonance Imaging; Male; Motor Skills; Neuroprotection; Phenobarbital; Rats; Rats, Wistar; Seizures; Temperature; Time Factors | 2018 |
Divergent effects of levetiracetam and tiagabine against spontaneous seizures in adult rats following neonatal hypoxia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Hypoxia; Levetiracetam; Male; Phenobarbital; Prohibitins; Rats, Long-Evans; Seizures; Tiagabine | 2018 |
The Role of Succinate in Regulation of Immediate HIF-1α Expression in Hypoxia.
Topics: Adaptation, Physiological; Altitude Sickness; Animals; Cerebral Cortex; Citric Acid Cycle; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex II; gamma-Aminobutyric Acid; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Phenobarbital; Picolines; Rats; Rats, Inbred Strains; Semicarbazides; Signal Transduction; Succinate Dehydrogenase; Succinic Acid | 2018 |
Isobolographic additivity among lacosamide, lamotrigine and phenobarbital in a mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epilepsy; Lacosamide; Lamotrigine; Male; Mice; Phenobarbital; Seizures | 2018 |
Combination of phenobarbital with phenytoin and pregabalin produces synergy in the mouse tonic-clonic seizure model: An isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electric Stimulation; Male; Mice; Muscle Strength; Phenobarbital; Phenytoin; Pregabalin; Seizures | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbamazepine; Diazepam; Disease Models, Animal; Essential Tremor; Ethosuximide; Male; Mice, Inbred Strains; Nicotine; Phenobarbital; Propranolol; Pyridines; Valproic Acid | 2018 |
Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Hippocampus; Hypoxia; Hypoxia-Ischemia, Brain; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Seizures | 2018 |
Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria.
Topics: Animals; Computer Simulation; Disease Models, Animal; Genetic Therapy; Hydroxymethylbilane Synthase; Kinetics; Male; Mammals; Mice; Phenobarbital; Porphyria, Acute Intermittent; Protein Conformation; Sequence Analysis, Protein; Therapeutic Index | 2018 |
Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Female; Gene Expression Regulation; Humans; Infant, Newborn; K Cl- Cotransporters; Male; Membrane Glycoproteins; Phenobarbital; Protein-Tyrosine Kinases; Seizures; Symporters | 2018 |
Pharmaco-resistant Neonatal Seizures: Critical Mechanistic Insights from a Chemoconvulsant Model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; K Cl- Cotransporters; Male; Mice; Phenobarbital; Seizures; Symporters | 2018 |
Improved, Shorter-Latency Carcinogen-Induced Hepatocellular Carcinoma Model in Pigs.
Topics: Animals; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Synergism; Female; Injections, Intraperitoneal; Liver Neoplasms, Experimental; Phenobarbital; Swine; Swine, Miniature | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pentylenetetrazole; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2018 |
Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Androgens; Androsterone; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy; Gabapentin; Male; Mice; Phenobarbital; Psychomotor Performance; Seizures | 2019 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Dronedarone; Drug Interactions; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2019 |
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Topics: Aminolevulinic Acid; Animals; Computer Simulation; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Phenobarbital; Porphobilinogen; Porphyria, Acute Intermittent; Porphyrins | 2019 |
Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria.
Topics: Acetylcholine; Animals; Disease Models, Animal; Female; Heme; Hydroxymethylbilane Synthase; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Phenobarbital; Phenylephrine; Porphyria, Acute Intermittent; Sex Factors; Vasodilation | 2019 |
Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electron Transport; Gene Expression Profiling; Liver; Male; Mice; Mice, Inbred C57BL; Mitochondria; Mutation; Phenobarbital; Porphyria, Acute Intermittent; Transcriptome | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Male; Mice; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2019 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Humans; Hydroxides; Hydroxybenzoates; Liver Neoplasms, Experimental; Mice; Nanoparticles; Phenobarbital | 2019 |
[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzazepines; Carbon Radioisotopes; Chronic Disease; Disease Models, Animal; Epilepsy; Female; Gene Expression Regulation; Kinetics; Male; Phenobarbital; Positron-Emission Tomography; Quinidine; Quinolines; Radiochemistry; Rats; Rats, Sprague-Dawley; Recurrence; Treatment Outcome | 2013 |
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal).
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Homeodomain Proteins; Levetiracetam; Locomotion; Male; Mass Spectrometry; Phenobarbital; Piracetam; Time Factors; Transcription Factors; Valproic Acid | 2013 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemical; Diethylnitrosamine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Induction; Glutathione S-Transferase pi; Hepatocytes; Liver Neoplasms; Male; Microsomes, Liver; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Reactive Oxygen Species | 2013 |
A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Anticonvulsants; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Glucose; Glycolysis; Hepatocytes; Humans; Liver Cirrhosis, Experimental; Membrane Proteins; Mitochondria; Oxygen Consumption; Phenobarbital; Rats, Inbred Lew; Severity of Illness Index | 2014 |
Combined sub-threshold dosages of phenobarbital and low-frequency stimulation effectively reduce seizures in amygdala-kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Combined Modality Therapy; Deep Brain Stimulation; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Kindling, Neurologic; Male; Phenobarbital; Rats; Rats, Wistar; Seizures | 2014 |
A novel prodrug-based strategy to increase effects of bumetanide in epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Brain; Bumetanide; Convulsants; Disease Models, Animal; Diuretics; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Epilepsy; Humans; In Vitro Techniques; Mice; Neurons; Pentylenetetrazole; Phenobarbital; Rats; Rats, Sprague-Dawley; Rats, Wistar; Serum; Sodium Potassium Chloride Symporter Inhibitors; Species Specificity; Time Factors | 2014 |
Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Kindling, Neurologic; Male; Mice; Phenobarbital; Quinolones; Seizures | 2014 |
(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.
Topics: Animals; Anticonvulsants; Brain; Carbon Radioisotopes; Carrier Proteins; Chronic Disease; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Epilepsy, Temporal Lobe; Female; Isoquinolines; Microglia; Neuroimmunomodulation; Phenobarbital; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Epilepsy; Male; Memory, Long-Term; Mice; Morpholines; Motor Activity; Phenobarbital; Phenytoin; Reboxetine; Valproic Acid | 2014 |
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Environment; Epilepsy; Male; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors; Valproic Acid | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Glutathione Transferase; Liver Neoplasms; Male; Methapyrilene; Mutagenicity Tests; Oxidative Stress; Phenobarbital; Rats, Sprague-Dawley; Thioacetamide | 2014 |
Effect of status epilepticus and antiepileptic drugs on CYP2E1 brain expression.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Brain; Carbamazepine; Cells, Cultured; Central Nervous System Depressants; Child, Preschool; Cytochrome P-450 CYP2E1; Disease Models, Animal; Endothelial Cells; Ethanol; Female; Humans; Infant; Male; Mice; Mice, Inbred C57BL; Middle Aged; Neurons; Phenobarbital; Phenytoin; Status Epilepticus | 2014 |
Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Convulsants; Disease Models, Animal; Female; Fluoresceins; Learning Disabilities; Male; Maternal Deprivation; Maze Learning; Phenobarbital; Pregnancy; Rats; Sex Characteristics; Status Epilepticus; Stress, Psychological | 2015 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Gene Expression; Glutathione Transferase; Liver; Liver Neoplasms; Male; Phenobarbital; Rats, Sprague-Dawley | 2014 |
Protective effects of tetrandrine on brain cells in phenobarbital-dependent and -withdrawn rats.
Topics: Animals; bcl-2-Associated X Protein; Benzylisoquinolines; Brain; Disease Models, Animal; Drugs, Chinese Herbal; Female; Immunohistochemistry; Male; Neuroprotective Agents; Phenobarbital; Proto-Oncogene Proteins c-bcl-2; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 2015 |
Bumetanide is not capable of terminating status epilepticus but enhances phenobarbital efficacy in different rat models.
Topics: Animals; Anticonvulsants; Basolateral Nuclear Complex; Bumetanide; Disease Models, Animal; Drug Synergism; Electric Stimulation; Kainic Acid; Lithium; Male; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2015 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Hippocampus; Kainic Acid; Levetiracetam; Mice; Phenobarbital; Phenytoin; Piracetam; Seizures; Valproic Acid | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Hippocampus; Lithium Chloride; Neurons; Phenobarbital; Pilocarpine; Polypharmacy; Rats, Sprague-Dawley; Scopolamine; Seizures; Status Epilepticus; Time Factors; Treatment Outcome | 2015 |
PEGylated exendin-4, a modified GLP-1 analog exhibits more potent cardioprotection than its unmodified parent molecule on a dose to dose basis in a murine model of myocardial infarction.
Topics: Aminophylline; Animals; Atropine; Blotting, Western; Cardiovascular Agents; Disease Models, Animal; Drug Combinations; Exenatide; Glucagon-Like Peptide 1; Heart; Heart Function Tests; Histocytochemistry; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Nitroglycerin; Papaverine; Peptides; Phenobarbital; Survival Analysis; Treatment Outcome; Venoms | 2015 |
In vivo evaluation of anticonvulsant and antioxidant effects of phenobarbital microemulsion for transdermal administration in pilocarpine seizure rat model.
Topics: Administration, Cutaneous; Animals; Anticonvulsants; Antioxidants; Disease Models, Animal; Emulsions; Female; Hippocampus; Lipid Peroxidation; Oxidative Stress; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Seizures | 2015 |
Mitochondrial energetic defects in muscle and brain of a Hmbs-/- mouse model of acute intermittent porphyria.
Topics: Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex II; Enzyme Activation; Humans; Hydroxymethylbilane Synthase; Mice; Mice, Knockout; Mitochondria; Models, Biological; Muscles; Phenobarbital; Porphyria, Acute Intermittent | 2015 |
The Mode of Action for Phenobarbital-Induced Rodent Liver Tumor Formation Is not Relevant for Humans: Recent Studies With Humanized Mice.
Topics: Animals; Chimera; Constitutive Androstane Receptor; Disease Models, Animal; Humans; Liver; Liver Neoplasms, Experimental; Mice; Phenobarbital; Receptors, Cytoplasmic and Nuclear | 2015 |
Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Azepines; Benzamides; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Electroencephalography; Female; K Cl- Cotransporters; Male; Mice; Phenobarbital; Receptor, trkB; Seizures; Solute Carrier Family 12, Member 2; Symporters | 2015 |
Design and Synthesis of Novel Phenylpiperazine Derivatives as Potential Anticonvulsant Agents.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Design; Male; Mice; Molecular Structure; Pentylenetetrazole; Phenobarbital; Piperazines; Seizures; Structure-Activity Relationship; Strychnine | 2015 |
Interactions between an antidepressant reboxetine and four classic antiepileptic drugs in the mouse model of myoclonic seizures.
Topics: Animals; Anticonvulsants; Antidepressive Agents; Avoidance Learning; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Male; Mice; Morpholines; Motor Skills; Pentylenetetrazole; Phenobarbital; Reboxetine; Valproic Acid | 2015 |
Synaptic vesicle protein2A decreases in amygdaloid-kindling pharmcoresistant epileptic rats.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Drug Resistance; Electric Stimulation; Epilepsy; Gene Expression Regulation; Hippocampus; Kindling, Neurologic; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptic Transmission; Synaptic Vesicles | 2015 |
Propafenone enhances the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Male; Mice; Phenobarbital; Phenytoin; Propafenone; Valproic Acid | 2016 |
Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Electroshock; Fructose; Male; Mice; Phenobarbital; Seizures; Topiramate | 2016 |
The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice.
Topics: Animals; Anticonvulsants; Bumetanide; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroencephalography; Electroshock; Epilepsy, Temporal Lobe; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Prodrugs | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagonists; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Pilocarpine; Piracetam; Rats; Seizures; Status Epilepticus; Valproic Acid | 2016 |
Low-frequency electrical stimulation enhances the effectiveness of phenobarbital on GABAergic currents in hippocampal slices of kindled rats.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Combined Modality Therapy; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Kindling, Neurologic; Male; Miniature Postsynaptic Potentials; Phenobarbital; Pyramidal Cells; Rats, Wistar; Receptors, GABA-A; Seizures; Tissue Culture Techniques | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; Electrocorticography; Epilepsy; Female; Immunohistochemistry; Male; Neuropeptide Y; Pentylenetetrazole; Phenobarbital; Pilocarpine; Proto-Oncogene Proteins c-fos; Seizures; Valproic Acid | 2016 |
miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Resistant Epilepsy; Dyrk Kinases; Electric Stimulation; Epilepsy, Temporal Lobe; Female; Gene Expression; Hep G2 Cells; Hippocampus; Humans; Implantable Neurostimulators; MicroRNAs; Mutation; Phenobarbital; Potassium Channels, Tandem Pore Domain; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats, Sprague-Dawley; Status Epilepticus | 2016 |
New model of pharmacoresistant seizures induced by 3-mercaptopropionic acid in mice.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Drug Resistant Epilepsy; Hippocampus; Immunohistochemistry; Male; Mice; Phenobarbital; Phenytoin; Random Allocation; Seizures | 2017 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; Female; Levetiracetam; Lithium Compounds; Male; Phenobarbital; Pilocarpine; Piracetam; Random Allocation; Rats, Wistar; Reperfusion Injury; Stroke | 2017 |
Antiepileptic drug resistant rats differ from drug responsive rats in GABA A receptor subunit expression in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Resistance; Electric Stimulation; Epilepsy, Temporal Lobe; Female; GABA Modulators; gamma-Aminobutyric Acid; Hippocampus; Kindling, Neurologic; Nerve Degeneration; Neural Inhibition; Neurons; Phenobarbital; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Species Specificity | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease Models, Animal; Drug Resistance; Electric Stimulation; Endothelium, Vascular; Female; Gene Expression Regulation; Genes, MDR; Hippocampus; Phenobarbital; Phenytoin; Pilocarpine; Quinolines; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2008 |
Oral administration of Azadirachta indica (L.) seed kernel active principle protects rat liver hepatocytes and testis seminiferous tubules from phenobarbitol-induced damage.
Topics: Administration, Oral; Animals; Azadirachta; Disease Models, Animal; Dose-Response Relationship, Drug; Hepatocytes; Lipid Peroxidation; Male; Phenobarbital; Phytotherapy; Plant Extracts; Protective Agents; Rats; Rats, Wistar; Seminiferous Tubules; Testis | 2007 |
Hepatoprotective activity of Phyllanthus reticulatus.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Euphorbiaceae; Hypnotics and Sedatives; Liver; Liver Diseases; Male; Necrosis; Phenobarbital; Plant Components, Aerial; Protective Agents; Rats; Rats, Long-Evans; Sleep | 2008 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Screening Assays, Antitumor; Eating; Female; Immunohistochemistry; Liver Neoplasms, Experimental; Organ Size; Phenobarbital; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes | 2009 |
Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation.
Topics: Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Cell Proliferation; Constitutive Androstane Receptor; Cyclopropanes; Cytochrome P-450 CYP2B1; Disease Models, Animal; Female; Fluorobenzenes; Gene Expression Regulation, Neoplastic; Liver; Liver Neoplasms, Experimental; Male; Microsomes, Liver; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA Interference; Statistics, Nonparametric | 2009 |
Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action.
Topics: Animals; Cell Proliferation; Constitutive Androstane Receptor; Cyclopropanes; Cytochrome P-450 Enzyme System; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fluorobenzenes; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Phenobarbital; Pyrethrins; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Risk Assessment; Species Specificity; Time Factors | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Female; Flurothyl; Kainic Acid; KCNQ Potassium Channels; Male; Phenobarbital; Pregnancy; Rats; Seizures; Spectrum Analysis; Status Epilepticus; Time Factors | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progression; Electroencephalography; Lithium Chloride; Male; Phenobarbital; Pilocarpine; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Reaction Time; Status Epilepticus; Time Factors | 2009 |
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid.
Topics: 3-Mercaptopropionic Acid; Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Disease Models, Animal; Epilepsy; Hippocampus; Male; Microdialysis; Nimodipine; Phenobarbital; Rats; Rats, Wistar; Seizures; Time | 2009 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Phenobarbital; Probability; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus; Videotape Recording | 2010 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Electroshock; Epilepsy; Levetiracetam; Male; Mice; Phenobarbital; Piracetam; Psychomotor Performance; Valproic Acid | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Levetiracetam; Male; Mice; Pentylenetetrazole; Phenobarbital; Piracetam; Seizures; Valproic Acid | 2009 |
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electrodes; Electrophysiology; Epilepsy; Felbamate; Female; Hippocampus; In Vitro Techniques; Magnesium Deficiency; Membrane Potentials; Phenobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Time Factors | 2010 |
Phenobarbital augments hypothermic neuroprotection.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain; Disease Models, Animal; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley; Sensory Gating; Time Factors | 2010 |
Cytochrome P450 induction by phenobarbital exacerbates warm hepatic ischemia-reperfusion injury in rat livers.
Topics: Alanine Transaminase; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Catalase; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP3A; Disease Models, Animal; Enzyme Induction; Glutathione; Heme; Lipid Peroxidation; Liver; Liver Diseases; Male; Membrane Proteins; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxidative Stress; Phenobarbital; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Warm Ischemia | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; GABA Modulators; gamma-Aminobutyric Acid; Organoselenium Compounds; Phenobarbital; Picrotoxin; Rats; Seizures | 2010 |
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Bumetanide; Cell Count; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy, Temporal Lobe; Female; Hippocampus; Immunohistochemistry; Motor Activity; Neurons; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Status Epilepticus | 2010 |
Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Administration Schedule; Drug Resistance; Epilepsy, Temporal Lobe; Female; Phenobarbital; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides | 2010 |
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Disease Models, Animal; Drug Resistance, Multiple; Epilepsy, Temporal Lobe; Hippocampus; Humans; Phenobarbital; Positron-Emission Tomography; Quinolines; Rats; Rats, Sprague-Dawley; Seizures | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Male; Memory; Mice; Motor Activity; Muscle Strength; Muscle, Skeletal; Phenobarbital; Phenytoin; Seizures; Succinimides; Valproic Acid | 2010 |
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.
Topics: Animals; beta Catenin; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cell Separation; Cell Size; Connexins; Cytochrome P-450 CYP2E1; Disease Models, Animal; DNA Mutational Analysis; Female; Gene Expression; Glutamate-Ammonia Ligase; Hepatocytes; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Knockout; Phenobarbital; Phenotype; RNA, Messenger | 2010 |
Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors.
Topics: Animals; Cell Line, Tumor; Cell Movement; Constitutive Androstane Receptor; Disease Models, Animal; Female; GABA Modulators; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Neoplasm Proteins; Neoplasm Staging; Phenobarbital; Promoter Regions, Genetic; Protein Transport; Receptors, Cytoplasmic and Nuclear; Sex Factors | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Functional Laterality; Male; Mental Disorders; Mice; Neurogenesis; Phenobarbital; Recovery of Function; Seizures; Stroke | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Epilepsy; Male; Maze Learning; Phenobarbital; Phenytoin; Random Allocation; Rats; Rats, Wistar; Valproic Acid | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Clonazepam; Disease Models, Animal; Drug Synergism; Ethosuximide; Hand Strength; Male; Mice; Morpholines; Naphthalenes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Hypnotics and Sedatives; Indomethacin; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Phenobarbital; Plant Extracts; Plants, Medicinal; Reaction Time; Sleep; Time Factors; Tramadol | 2011 |
Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures.
Topics: Aminopyridines; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Female; Fever; KCNQ Potassium Channels; Male; Maze Learning; Memory; Nerve Degeneration; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley; Risk Factors; Secondary Prevention; Seizures, Febrile | 2011 |
Effects of midazolam and phenobarbital on brain oxidative reactions induced by pentylenetetrazole in a convulsion model.
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Gene Expression; Heme Oxygenase-1; Hippocampus; Hypothalamus; Male; Malondialdehyde; Mice; Midazolam; Oxidation-Reduction; Pentylenetetrazole; Phenobarbital; Seizures; Treatment Outcome | 2012 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; Medicine, African Traditional; Methanol; Mice; Nigeria; Phenobarbital; Phytotherapy; Picrotoxin; Plant Extracts; Plant Leaves; Seizures; Solvents; Strychnine | 2011 |
Super-induced gene expression of the N-methyl-D-aspartate receptor 2C subunit in chemical-induced hypertrophic liver in rats.
Topics: Animals; Clofibrate; Disease Models, Animal; Gene Expression; Hepatomegaly; Liver; Male; Oligonucleotide Array Sequence Analysis; Organ Size; Phenobarbital; Piperonyl Butoxide; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Inter-individual variation in the anticonvulsant effect of phenobarbital in the pilocarpine rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Exploratory Behavior; Female; Hippocampus; Hyperkinesis; Maze Learning; Muscarinic Agonists; Nerve Degeneration; Phenobarbital; Pilocarpine; Rats; Rats, Sprague-Dawley; Time Factors; Touch; Video Recording | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol | 2012 |
Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.
Topics: Animals; Animals, Newborn; Bumetanide; Disease Models, Animal; Drug Synergism; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Phenobarbital; Rats; Rats, Sprague-Dawley | 2012 |
Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice.
Topics: Animals; Biliary Tract Diseases; Cysteine Endopeptidases; Deubiquitinating Enzyme CYLD; Dimethylnitrosamine; Disease Models, Animal; Exons; Fibrosis; Gene Deletion; Genetic Predisposition to Disease; Homeostasis; In Vitro Techniques; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Phenobarbital; Phenotype; Risk Factors | 2012 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Models, Animal; Liver; Liver Neoplasms; Mice; Phenobarbital; Pyrazines; Thiostrepton | 2012 |
The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Hyperkinesis; Kainic Acid; Phenobarbital; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2013 |
Effects of classical antiepileptics on thresholds for phenomena induced by cortical stimulation in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electric Stimulation; Electroencephalography; Electrophysiology; Epilepsies, Myoclonic; Ethosuximide; Humans; Male; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 2002 |
A novel model of acetaminophen-induced acute hepatic failure in rabbits.
Topics: Acetaminophen; Acute Disease; Animals; Antimetabolites; Buthionine Sulfoximine; Disease Models, Animal; Drug Synergism; Glutathione; Hepatic Encephalopathy; Injections, Intravenous; Injections, Subcutaneous; Liver; Liver Failure; Male; Methylcholanthrene; Phenobarbital; Rabbits | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Hippocampus; In Vitro Techniques; Lamotrigine; Methylazoxymethanol Acetate; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Triazines; Valproic Acid | 2002 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electroencephalography; Lithium Chloride; Male; Muscarinic Agonists; Phenobarbital; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Status Epilepticus; Time Factors | 2002 |
Conventional anticonvulsant drugs in the guinea pig kindling model of partial seizures: effects of acute phenobarbital, valproate, and ethosuximide.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Partial; Ethosuximide; Female; Forecasting; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Valproic Acid | 2002 |
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Models, Animal; DNA Primers; Humans; Nerve Degeneration; Nerve Tissue Proteins; Phenobarbital; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
The pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions.
Topics: Acetic Acid; Age Factors; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Epilepsy; Glucose; Kindling, Neurologic; Magnetic Resonance Spectroscopy; Mice; Neuroglia; Neurons; Pentylenetetrazole; Phenobarbital | 2003 |
Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carotenoids; Disease Models, Animal; Food Coloring Agents; Liver; Liver Neoplasms; Male; Organ Size; Phenobarbital; Rats; Rats, Inbred F344 | 2003 |
Metabolism of medroxyprogesterone acetate (MPA) via CYP enzymes in vitro and effect of MPA on bleeding time in female rats in dependence on CYP activity in vivo.
Topics: Animals; Bleeding Time; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Male; Medroxyprogesterone Acetate; Microsomes, Liver; Phenobarbital; Proadifen; Rats; Rats, Wistar; Recombinant Proteins; Thrombophilia | 2003 |
The effects of phenytoin and phenobarbital on seizures induced by imipenem/cilastatin in rats.
Topics: Animals; Anticonvulsants; Cilastatin; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Imipenem; Injections, Intraventricular; Male; Phenobarbital; Phenytoin; Prohibitins; Rats; Rats, Wistar; Seizures | 2004 |
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraventricular; Male; Neurons; Phenobarbital; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar | 2004 |
Adenoviral-mediated expression of porphobilinogen deaminase in liver restores the metabolic defect in a mouse model of acute intermittent porphyria.
Topics: Adenoviridae; Aminolevulinic Acid; Animals; Disease Models, Animal; Gene Expression; Genetic Therapy; Hydroxymethylbilane Synthase; Liver; Luciferases; Mice; Mice, Mutant Strains; Phenobarbital; Porphyria, Acute Intermittent; Tissue Distribution | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combinations; Drug Synergism; Electroshock; Epilepsy; Epilepsy, Absence; Hippocampus; Male; Mice; Mice, Inbred DBA; Neuroprotective Agents; Phenobarbital; Phenytoin; Piracetam; Valproic Acid | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Ethosuximide; Felbamate; Female; Humans; Lethal Dose 50; Mice; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Phenylcarbamates; Propylene Glycols; Seizures; Valproic Acid | 2004 |
Anticonvulsant efficacy of the low-affinity partial benzodiazepine receptor agonist ELB 138 in a dog seizure model and in epileptic dogs with spontaneously recurrent seizures.
Topics: Animals; Anticonvulsants; Bromides; Chronic Disease; Disease Models, Animal; Dog Diseases; Dogs; Drug Therapy, Combination; Epilepsy; Flumazenil; GABA Agonists; GABA-A Receptor Agonists; Imidazoles; Pentylenetetrazole; Phenobarbital; Potassium Compounds; Primidone; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome; Treatment Outcome | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsy; Female; Kindling, Neurologic; Male; Mineralocorticoid Receptor Antagonists; Phenobarbital; Rats; Rats, Wistar; Seizures; Spironolactone; Valproic Acid | 2005 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Male; Memory; Mice; Motor Activity; Phenobarbital; Phenytoin; Riluzole; Seizures; Valproic Acid | 2004 |
Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Kindling, Neurologic; Monitoring, Physiologic; Phenobarbital; Rats; Rats, Sprague-Dawley; Status Epilepticus; Videotape Recording | 2004 |
Increased myocardial N-myristoyltransferase activity in rotenone model of Parkinsonism.
Topics: Acyl Coenzyme A; Aminophylline; Animals; Atropine; Disease Models, Animal; Drug Combinations; Humans; Male; Nitroglycerin; Papaverine; Parkinson Disease; Phenobarbital; Rats; Rats, Inbred Lew; Rotenone | 2005 |
Protection with estradiol in developmental models of apoptotic neurodegeneration.
Topics: Animals; Animals, Newborn; Apoptosis; Bicuculline; Blotting, Western; Brain; Caenorhabditis elegans Proteins; Cell Count; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Estrogen Antagonists; Extracellular Signal-Regulated MAP Kinases; GABA Antagonists; Hypoxia; Immunohistochemistry; In Situ Nick-End Labeling; Membrane Potentials; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Phenobarbital; Phenytoin; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, GABA-A; Silver Staining; Tamoxifen | 2005 |
Use of proteomic methods to identify serum biomarkers associated with rat liver toxicity or hypertrophy.
Topics: 1-Naphthylisothiocyanate; Acetaminophen; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertrophy; Liver Diseases; Male; Methylcellulose; Organ Size; Phenobarbital; Proteomics; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity | 2005 |
Effect of Solanum trilobatum on the antioxidant status during diethyl nitrosamine induced and phenobarbital promoted hepatocarcinogenesis in rat.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Carcinogens; Chemoprevention; Diethylnitrosamine; Disease Models, Animal; Enzymes; Lipid Peroxidation; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Plant Extracts; Precancerous Conditions; Rats; Solanum; Thiobarbituric Acid Reactive Substances | 2005 |
Antiepileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABA(A) receptor ligand binding in a model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Autoradiography; Disease Models, Animal; Drug Resistance; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Ligands; Nerve Degeneration; Phenobarbital; Rats; Receptors, GABA-A | 2006 |
Phenobarbital treatment inhibits the formation of estradiol-dependent mammary tumors in the August-Copenhagen Irish rat.
Topics: Animals; Antioxidants; Disease Models, Animal; Estradiol; Female; Liver; Mammary Glands, Animal; Mammary Neoplasms, Animal; Metabolic Clearance Rate; Organ Size; Oxidation-Reduction; Phenobarbital; Rats; Rats, Inbred ACI | 2006 |
A mode of action for induction of thyroid gland tumors by Pyrethrins in the rat.
Topics: Administration, Oral; Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glucuronosyltransferase; Insecticides; Male; Microsomes, Liver; Organ Size; Phenobarbital; Pyrethrins; Rats; Rats, Sprague-Dawley; Sex Factors; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosine; Diethylnitrosamine; Disease Models, Animal; DNA Damage; Elements; Liver; Liver Neoplasms, Experimental; Male; Metallothionein; Phenobarbital; Rats; Rats, Sprague-Dawley; Spectrometry, X-Ray Emission; Vanadium | 2006 |
Effect of the co-administration of phenobarbital, quercetin and mancozeb on nitrosomethylurea-induced pancreatic tumors in rats.
Topics: Alkylating Agents; Animals; Animals, Newborn; Carcinogens; Carcinoma in Situ; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Female; Fungicides, Industrial; Hyperplasia; Maneb; Maternal Exposure; Maternal-Fetal Exchange; Methylnitrosourea; Pancreatic Neoplasms; Phenobarbital; Pregnancy; Quercetin; Rats; Rats, Wistar; Zineb | 2006 |
Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity.
Topics: Animals; Behavior, Animal; Chickens; Disease Models, Animal; Female; Heroin; Hippocampus; Mice; Phenobarbital; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Teratogens | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Ethosuximide; Male; Mice; Neurotoxicity Syndromes; Pentylenetetrazole; Phenobarbital; Seizures; Valproic Acid | 2006 |
Conventional anticonvulsant drugs in the guinea-pig kindling model of partial seizures: effects of repeated administration.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Electric Stimulation; Epilepsies, Partial; Ethosuximide; Female; Guinea Pigs; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Predictive Value of Tests; Reproducibility of Results; Species Specificity; Treatment Outcome; Valproic Acid | 2007 |
Resistance to phenobarbital extends to phenytoin in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Epilepsy, Temporal Lobe; Female; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus; Videotape Recording | 2007 |
The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy; Gene Silencing; Mice; Mice, Knockout; Mice, Neurologic Mutants; Monitoring, Physiologic; Neuroglia; Phenobarbital; Phenytoin; Tuberous Sclerosis; Tumor Suppressor Proteins; Videotape Recording | 2007 |
Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Central Nervous System Stimulants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; GABA Antagonists; GABA Modulators; Male; Methamphetamine; Mice; Motor Activity; Phenobarbital; Social Isolation | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Epilepsy; Epilepsy, Tonic-Clonic; Male; Memory; Mice; Motor Skills; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Injections, Intraperitoneal; Male; Mental Recall; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Vitamins | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Electroshock; Fluorescent Antibody Technique; Male; Memory; Mianserin; Mice; Motor Activity; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 2007 |
Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model.
Topics: Anesthetics, Intravenous; Animals; Antifungal Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Enzyme Induction; Excitatory Amino Acid Antagonists; Female; Femur Head Necrosis; Glucocorticoids; Incidence; Itraconazole; Liver; Methylprednisolone; Midazolam; Phenobarbital; Prevalence; Rabbits; Risk Factors | 2008 |
Development and validation of the maximal electro-shock seizure model in dogs.
Topics: Animals; Anticonvulsants; Area Under Curve; Disease Models, Animal; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Tonic-Clonic; Male; Phenobarbital; Reproducibility of Results | 2007 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation | 2008 |
Attenuation by methyl mercury and mercuric sulfide of pentobarbital induced hypnotic tolerance in mice through inhibition of ATPase activities and nitric oxide production in cerebral cortex.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Calcium-Transporting ATPases; Cerebral Cortex; Cytochrome P-450 Enzyme System; Disease Models, Animal; Drug Synergism; Drug Tolerance; Hypnotics and Sedatives; Liver; Male; Mercury Compounds; Methylmercury Compounds; Mice; Nitric Oxide; Phenobarbital; Sleep; Sodium-Potassium-Exchanging ATPase | 2008 |
Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice.
Topics: Animals; Anticonvulsants; Brain; Comet Assay; Convulsants; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Drug Administration Schedule; Epilepsy; Kindling, Neurologic; Lactones; Male; Mice; Nerve Degeneration; Pentylenetetrazole; Phenobarbital; Treatment Outcome | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cognition Disorders; Disease Models, Animal; Drug Resistance; Electric Stimulation; Electroencephalography; Epilepsy; Exploratory Behavior; Female; Hippocampus; Maze Learning; Phenobarbital; Predictive Value of Tests; Rats; Rats, Sprague-Dawley; Secondary Prevention; Statistics, Nonparametric; Swimming; Time Factors | 2008 |
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Collagen; Disease Models, Animal; Hydroxyproline; Liver; Liver Cirrhosis, Experimental; Male; Phenobarbital; Procollagen-Proline Dioxygenase; Rats; Rats, Inbred Strains; Time Factors | 1983 |
Febrile seizures in epileptic chicks: the effects of phenobarbital, phenytoin and valproate.
Topics: Animals; Chickens; Disease Models, Animal; Phenobarbital; Phenytoin; Reaction Time; Seizures, Febrile; Valproic Acid | 1983 |
Serine and glycine-induced catalepsy in porphyric rats: an animal model for psychosis?
Topics: Allylisopropylacetamide; Aminolevulinic Acid; Animals; Catalepsy; Disease Models, Animal; Glycine; Humans; Male; Phenobarbital; Porphobilinogen; Porphyrias; Psychotic Disorders; Rats; Rats, Inbred Strains; Serine | 1983 |
Effects of anticonvulsants on hyperthermia-induced seizures in the rat pup.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Differential Threshold; Disease Models, Animal; Electroencephalography; Phenobarbital; Phenytoin; Rats; Seizures, Febrile; Valproic Acid | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Drug Synergism; Glycine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentylenetetrazole; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1984 |
Effect of nitrous oxide on halothane-induced hepatotoxicity in hypoxic, enzyme-induced rats.
Topics: Animals; Disease Models, Animal; Drug Synergism; Halothane; Liver; Male; Nitrous Oxide; Oxygen; Phenobarbital; Rats; Rats, Inbred Strains | 1984 |
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Animal; Electrocardiography; Electroencephalography; Epilepsy; Heart; Heart Rate; Lung; Pentylenetetrazole; Phenobarbital | 1984 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalography; Kinetics; Macaca mulatta; Male; Phenobarbital; Phenytoin; Primidone; Seizures; Valproic Acid | 1982 |
Familial unconjugated hyperbilirubinemia syndromes.
Topics: Animals; Bile Acids and Salts; Bilirubin; Crigler-Najjar Syndrome; Diagnosis, Differential; Disease Models, Animal; Female; Gilbert Disease; Glucuronosyltransferase; Hexosyltransferases; Humans; Hyperbilirubinemia, Hereditary; Liver; Male; Phenobarbital; Phototherapy; Prospective Studies; Rats; Rats, Gunn; Rats, Inbred Strains; Sulfobromophthalein | 1983 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epilepsy; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains | 1980 |
An improved technique for the induction of barbiturate dependence in mice.
Topics: Animals; Barbiturates; Disease Models, Animal; Feeding Behavior; Humans; Mice; Mice, Inbred Strains; Phenobarbital; Species Specificity; Substance Withdrawal Syndrome; Substance-Related Disorders | 1980 |
Sleep-inducing effects of three hypnotics in a new model of insomnia in rats.
Topics: Animals; Disease Models, Animal; Electroencephalography; Electromyography; Flurazepam; Humans; Hypnotics and Sedatives; Light; Male; Phenobarbital; Rats; Sleep; Sleep Initiation and Maintenance Disorders; Sleep, REM | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Male; Pentylenetetrazole; Phenobarbital; Rats; Rats, Inbred Strains | 1981 |
Time-course of formation of volatile reductive metabolites of halothane in humans and an animal model.
Topics: Adult; Animals; Chemical and Drug Induced Liver Injury; Chlorofluorocarbons; Disease Models, Animal; Enzyme Induction; Ethylenes; Female; Halothane; Humans; Hydrocarbons, Halogenated; Kinetics; Male; Middle Aged; Phenobarbital; Rats; Rats, Inbred F344 | 1980 |
Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Injections, Subcutaneous; Male; Mexico; Pentylenetetrazole; Phenobarbital; Phenytoin; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Seizures | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricular; Male; Midazolam; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid | 1995 |
Aspirin and anticonvulsant interaction.
Topics: Animals; Aspirin; Carbamazepine; Disease Models, Animal; Drug Synergism; Electroshock; Female; Male; Phenobarbital; Phenytoin; Rats; Seizures | 1995 |
A new, non-pharmacologic model of convulsive status epilepticus induced by electrical stimulation: behavioral/electroencephalographic observations and response to phenytoin and phenobarbital.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Tonic-Clonic; Infusions, Intravenous; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1994 |
Modulation of diethylnitrosamine carcinogenesis in rat liver and oesophagus.
Topics: Animals; Antineoplastic Agents; Antioxidants; Ascorbic Acid; Caffeine; Diethylnitrosamine; Disease Models, Animal; Esophageal Neoplasms; Female; Liver Neoplasms, Experimental; Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred Strains; Survival; Theophylline; Tretinoin | 1994 |
Expression of the CYP3A and CYP2C11 enzymes in a nutritionally obese rodent model: response to phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diet; Disease Models, Animal; Hydroxylation; Male; Obesity; Phenobarbital; Rats; Rats, Sprague-Dawley; RNA, Messenger; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Testosterone | 1994 |
Improvement of poor operant performance by continual intake of phenobarbital in spontaneously epileptic rats.
Topics: Administration, Oral; Animals; Conditioning, Operant; Disease Models, Animal; Epilepsy; Male; Phenobarbital; Rats; Rats, Wistar | 1994 |
Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age.
Topics: Adenoma, Liver Cell; Animals; Diethylhexyl Phthalate; Diethylnitrosamine; Disease Models, Animal; Female; Incidence; Liver Neoplasms; Male; Mice; Mice, Inbred C3H; Phenobarbital | 1994 |
Pharmacological characterization of phenytoin-resistant amygdala-kindled rats, a new model of drug-resistant partial epilepsy.
Topics: Amino Acids; Aminocaproates; Amygdala; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Resistance; Electric Stimulation; Electrodes, Implanted; Epilepsies, Partial; Female; Kindling, Neurologic; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Valproic Acid; Vigabatrin | 1993 |
Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.
Topics: Albumins; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Female; Glutathione Transferase; Liver; Liver Neoplasms; Male; Mutation; Phenobarbital; Phenotype; Rats; Serum Albumin | 1993 |
Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria.
Topics: Aminolevulinic Acid; Animals; Atrophy; Axons; Base Sequence; Chimera; Disease Models, Animal; Female; Gene Targeting; Humans; Hydroxymethylbilane Synthase; Kidney; Liver; Male; Mice; Molecular Sequence Data; Motor Activity; Muscle, Skeletal; Nervous System Diseases; Phenobarbital; Porphyria, Acute Intermittent; RNA, Messenger | 1996 |
Chemical kindling: implications for antiepileptic drugs - sensitive and resistant epilepsy models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Kindling, Neurologic; Male; Phenobarbital; Phenytoin; Picrotoxin; Rats; Rats, Wistar; Seizures | 1996 |
Learning impairment in 1-2-day-old epileptic chicks.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chickens; Discrimination Learning; Disease Models, Animal; Epilepsy; Female; Learning Disabilities; Male; Memory; Phenobarbital | 1996 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Male; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Severity of Illness Index; Valproic Acid | 1996 |
The use of jejunal transplants to treat a genetic enzyme deficiency.
Topics: Animals; Bilirubin; Crigler-Najjar Syndrome; Disease Models, Animal; Jejunum; Phenobarbital; Rats; Rats, Gunn; Rats, Wistar | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Interactions; Ear; Electrodes; Electroshock; Ethosuximide; Injections, Intravenous; Male; Mice; Morphine; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1996 |
Vasoconstrictor responsiveness of the rat mesenteric arterial bed in cirrhosis.
Topics: Adenosine Triphosphate; Animals; Arginine; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Liver Cirrhosis, Experimental; Male; Mesenteric Arteries; Methoxamine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Phenobarbital; Rats; Rats, Wistar; Vasopressins | 1996 |
Transgenic mouse models in carcinogenesis: interaction of c-myc with transforming growth factor alpha and hepatocyte growth factor in hepatocarcinogenesis.
Topics: Albumins; Animals; Disease Models, Animal; Female; Genes, myc; Hepatocyte Growth Factor; Liver Neoplasms, Experimental; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Phenobarbital; Transforming Growth Factor alpha | 1996 |
Effect of antiepileptic drugs and calcium channel blocker on hyperthermic seizures in rats: animal model for hot water epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Disease Models, Animal; Electroencephalography; Epilepsy; Hippocampus; Hyperthermia, Induced; Injections, Intraperitoneal; Male; Nifedipine; Phenobarbital; Phenytoin; Rats; Rats, Wistar; Seizures | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Calcium Channel Agonists; Calcium Channel Blockers; Carbamazepine; Dantrolene; Dihydropyridines; Disease Models, Animal; Drug Interactions; Electroshock; Epilepsy; Female; Isradipine; Lethal Dose 50; Mice; Motor Activity; Phenobarbital; Phenytoin; Random Allocation; Seizures; Valproic Acid | 1997 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Female; Phenobarbital; Rats; Rats, Wistar; Seizures; Time Factors; Valproic Acid | 1998 |
Comparison of valproate and phenobarbital treatment after status epilepticus in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Maze Learning; Phenobarbital; Rats; Rats, Sprague-Dawley; Status Epilepticus; Stress, Physiological; Valproic Acid | 1998 |
Transforming growth factor alpha levels in liver and blood correlate better than hepatocyte growth factor with hepatocyte proliferation during liver regeneration.
Topics: Animals; Apoptosis; Carbon Tetrachloride; Cell Division; Dimethylnitrosamine; Disease Models, Animal; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Mitotic Index; Necrosis; Phenobarbital; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha | 1998 |
Development of self-sustaining limbic status epilepticus by continuous ventral hippocampal stimulation followed by low dose pilocarpine in rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dizocilpine Maleate; Electroencephalography; Hippocampus; Limbic System; Lithium; Male; Neuroprotective Agents; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus; Stereotyped Behavior | 1998 |
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Brain Neoplasms; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Disease Models, Animal; Enzyme Induction; Female; Gliosarcoma; Half-Life; Hydroxylation; Ifosfamide; Liver; Male; Microsomes, Liver; Phenobarbital; Rats; Rats, Inbred F344; Troleandomycin | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy; Ethosuximide; Female; Male; Models, Genetic; Mutation; Phenobarbital; Rats; Rats, Mutant Strains; Rats, Wistar; Seizures; Valproic Acid | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Glutamic Acid; Kindling, Neurologic; Male; Monoterpenes; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Seizures; Terpenes | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Epilepsy, Tonic-Clonic; Kainic Acid; Male; Mice; N-Methylaspartate; Phenobarbital; Phenytoin; Receptors, N-Methyl-D-Aspartate; Valproic Acid | 1999 |
Establishment and characterization of a cell line from a chemically-induced mouse hepatoblastoma.
Topics: Animals; Carcinogens; Cell Line; Diethylnitrosamine; Disease Models, Animal; Hepatoblastoma; Liver Neoplasms; Male; Mice; Microscopy, Electron; Phenobarbital; Polymerase Chain Reaction | 2000 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; Drug Synergism; Electric Stimulation; Epilepsy; Female; Kindling, Neurologic; Periodicity; Phenobarbital; Rats; Rats, Wistar; Seasons; Valproic Acid | 2000 |
Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model.
Topics: Aging; Animals; Area Under Curve; Behavior, Animal; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Excitatory Amino Acid Antagonists; Female; Male; Mutation; Phenobarbital; Severity of Illness Index; Time Factors | 2000 |
Inhibitory effects of S-methylcysteine and cysteine on the promoting potential of sodium phenobarbital on rat liver carcinogenesis.
Topics: Animals; Carcinogens; Cysteine; Disease Models, Animal; Glutathione Transferase; Immunohistochemistry; Liver Neoplasms; Male; Ornithine Decarboxylase; Phenobarbital; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred F344 | 2000 |
Development of an experimental model of liver cirrhosis in rabbits.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver Cirrhosis, Experimental; Male; Phenobarbital; Rabbits | 2000 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Menstrual Cycle; Pentylenetetrazole; Phenobarbital; Pregnanolone; Pseudopregnancy; Rats; Rats, Sprague-Dawley; Receptors, GABA; Steroids; Substance Withdrawal Syndrome; Valproic Acid | 2001 |
Alterations of nitric oxide and monoamines in the brain of the EL mouse treated with phenobarbital and zonisamide.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Isoxazoles; Mice; Mice, Neurologic Mutants; Nitric Oxide; Phenobarbital; Receptors, N-Methyl-D-Aspartate; Zonisamide | 2001 |
Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction.
Topics: Animals; Bile; Disease Models, Animal; Drug Resistance, Multiple; Enzyme Induction; Hyperbilirubinemia; Male; Membrane Transport Proteins; Microsomes, Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Phenobarbital; Pregnenolone Carbonitrile; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Sulfobromophthalein | 2002 |
Gamma hydroxybutyrate in the monkey. II. Effect of chronic oral anticonvulsant drugs.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Ethosuximide; Haplorhini; Hydroxybutyrates; Levodopa; Macaca mulatta; Phenobarbital; Phenytoin | 1978 |
Prophylactic effects of phenytoin, phenobarbital, and carbamazepine examined in kindling cat preparations.
Topics: Animals; Carbamazepine; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimulation; Epilepsy; Male; Phenobarbital; Phenytoin; Seizures; Synaptic Transmission | 1976 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Electroencephalography; Ethosuximide; Female; Glycine; Male; Myoclonus; Papio; Phenobarbital; Phenytoin; Photic Stimulation; Primidone; Seizures; Thiazines | 1975 |
A comparison of the effects of chronically administered diazepam and phenobarbital and learning in the Papio papio model of epilepsy.
Topics: Animals; Diazepam; Disease Models, Animal; Haplorhini; Learning; Papio; Phenobarbital; Seizures; Stimulation, Chemical; Time Factors | 1977 |
An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia.
Topics: Alanine Transaminase; Anesthesia, Inhalation; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Fluorides; Glutathione; Halothane; Hypoxia; Injections, Intraperitoneal; Lipid Metabolism; Liver; Liver Circulation; Male; Microsomes, Liver; Necrosis; Phenobarbital; Rats | 1979 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Penicillin G; Pentobarbital; Phenobarbital; Phenytoin; Seizures; Succinimides | 1977 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobarbital; Phenytoin; Rats; Rodent Diseases; Sex Factors | 1978 |
Prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. I. Twelve months of treatment: seizure, EEG, blood, and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Follow-Up Studies; Haplorhini; Macaca mulatta; Male; Phenobarbital; Phenytoin; Reaction Time; Seizures | 1976 |
Prophylaxis with diphenylhydantoin and phenobarbital in alumina-gel monkey model. II. Fourth-month follow-up period: seizure, EEG, blood and behavioral data.
Topics: Aluminum Hydroxide; Animals; Behavior, Animal; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Follow-Up Studies; Haplorhini; Humans; Macaca mulatta; Male; Phenobarbital; Phenytoin; Seizures; Substance Withdrawal Syndrome; Time Factors | 1976 |
Acute anticonvulsant effects of diphenylhydantoin, phenobarbital, and carbamazepine: a combined electroclinical and serum level study in amygdaloid kindled cats and baboons.
Topics: Amygdala; Animals; Carbamazepine; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Electric Stimulation; Haplorhini; Light; Male; Papio; Phenobarbital; Phenytoin; Seizures; Time Factors | 1976 |
The effect of certain vitamin deficiencies on hepatic drug metabolism.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Disease Models, Animal; Enzyme Induction; Guinea Pigs; Kinetics; Liver; Microsomes, Liver; Mixed Function Oxygenases; Oxidoreductases; Oxidoreductases, N-Demethylating; Phenobarbital; Riboflavin Deficiency; Vitamin E Deficiency | 1976 |
The rationale for fixed-bed charcoal in hemoperfusion.
Topics: Adsorption; Animals; Blood Platelets; Charcoal; Disease Models, Animal; Dogs; Filtration; Kidneys, Artificial; Male; Particle Size; Phenobarbital; Poisoning; Renal Dialysis; Salicylates | 1976 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Glycine; Humans; Norepinephrine; Papio; Phenobarbital; Phenytoin; Photic Stimulation; Serotonin; Spasms, Infantile | 1975 |
Efficacy of standard anticonvulsants in monkey model with spontaneous motor seizures.
Topics: Aluminum; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Feeding Behavior; Humans; Macaca; Male; Motor Cortex; Phenobarbital; Phenytoin; Primidone; Reaction Time; Seizures; Substance Withdrawal Syndrome | 1975 |
Efficacy of activated charcoal hemoperfusion in removing lethal doses of barbiturates and salicylate from the blood of rats and dogs.
Topics: Animals; Barbiturates; Charcoal; Disease Models, Animal; Dogs; Pentobarbital; Perfusion; Phenobarbital; Poisoning; Rats; Salicylates | 1976 |
An animal model of fulminant hepatic failure: a feasibility study.
Topics: Acetaminophen; Animals; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Induction; Hepatic Encephalopathy; Liver; Male; Phenobarbital; Swine | 1976 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electrodes; Electroencephalography; Epilepsy; Ethosuximide; Injections, Intraperitoneal; Male; Pentylenetetrazole; Phenobarbital; Prohibitins; Rats; Rats, Wistar; Valproic Acid | 1992 |
A model of status epilepticus induced by intermittent electrical stimulation of the deep prepyriform cortex in rats.
Topics: Animals; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Electric Stimulation; Electroencephalography; Hippocampus; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Status Epilepticus | 1992 |
Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis.
Topics: Adenosine Triphosphatases; Administration, Oral; Animals; Biomarkers, Tumor; Carcinogens; Diethylnitrosamine; Disease Models, Animal; Drug Evaluation, Preclinical; Female; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Glutathione Transferase; Liver Neoplasms, Experimental; Phenobarbital; Rats; Rats, Inbred F344; Tamoxifen | 1991 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsy; Hemodynamics; Infusions, Parenteral; Male; Midazolam; Phenobarbital; Rats; Rats, Inbred Strains; Valproic Acid | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Aminobutyric Acid; Mesocricetus; Mutation; Pentylenetetrazole; Phenobarbital; Phenytoin; Synaptic Transmission; Valproic Acid | 1991 |
Biokinetics of 99mTc-labelled liver-imaging agents in an animal model of liver cirrhosis.
Topics: Animals; Carbon Tetrachloride; Disease Models, Animal; Liver; Liver Cirrhosis, Experimental; Male; Organotechnetium Compounds; Phenobarbital; Phytic Acid; Radionuclide Imaging; Rats; Rats, Inbred Strains; Technetium Tc 99m Sulfur Colloid | 1991 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Disease Models, Animal; DNA, Neoplasm; Female; Liver Neoplasms; Male; Phenobarbital; Ploidies; Prohibitins; Rats | 1990 |
Enzyme-inducing drugs and rat alpha 1-acid glycoprotein--2--Phenobarbital effects on acute inflammation in DA rats.
Topics: Acute-Phase Reaction; Animals; Arthritis; Carrageenan; Collagen; Cytochrome P-450 Enzyme System; Disease Models, Animal; Edema; Enzyme Induction; Inflammation; Macrophages; Orosomucoid; Phenobarbital; Rats; Rats, Inbred Strains | 1989 |
Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Chlordiazepoxide; Disease Models, Animal; Exploratory Behavior; Indoles; Male; Mice; Mice, Inbred C57BL; Motor Activity; Phenobarbital; Receptors, Serotonin; Serotonin Antagonists; Tropisetron | 1989 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; gamma-Glutamyltransferase; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; Male; Phenobarbital; Precancerous Conditions; Rats; Rats, Inbred Strains | 1985 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Male; Phenobarbital; Phenytoin; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1986 |
Circadian manifestations of barbiturate habituation, addiction and withdrawal in the rat.
Topics: Animals; Body Temperature; Circadian Rhythm; Disease Models, Animal; Habituation, Psychophysiologic; Male; Models, Biological; Phenobarbital; Rats; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
A predictable pathophysiological model of porcine hepatic failure.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Disease Models, Animal; Hepatic Artery; Hepatic Encephalopathy; Ligation; Necrosis; Phenobarbital; Swine | 1986 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroencephalography; Epilepsy, Absence; Ethosuximide; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Trimethadione; Valproic Acid | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease Models, Animal; Epilepsy; Ethosuximide; Imipramine; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Seizures; Valproic Acid | 1985 |
Modification of 1-tyrosine-induced keratopathy by adrenal corticosteroids.
Topics: Animals; Betamethasone; Corneal Opacity; Dexamethasone; Dietary Proteins; Disease Models, Animal; Female; Glucocorticoids; Injections, Intramuscular; Keratitis; Liver; Ophthalmic Solutions; Phenobarbital; Prednisone; Rats; Tyrosine; Tyrosine Transaminase | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsies, Partial; Male; Penicillin G; Phenobarbital; Phenytoin; Rats; Rats, Inbred Strains; Scintillation Counting; Seizures | 1974 |
The action of sympatholytic drugs in experimental intestinal paralysis.
Topics: Anesthesia; Animals; Cats; Chlorpromazine; Disease Models, Animal; Ganglionic Blockers; Gastrointestinal Motility; Hexobarbital; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Parasympathomimetics; Phenobarbital; Postoperative Complications; Sympathetic Nervous System; Sympatholytics; Tranquilizing Agents; Trifluperidol | 1971 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, Animal; Ethanol; Humans; Mice; Paralysis; Phenobarbital; Posture; Potassium; Seizures; Substance Withdrawal Syndrome; Substance-Related Disorders | 1973 |
Effect of phenobarbital and steroids on the adrenal apoplexy produced by acrylonitrile in rats.
Topics: Acrylates; Adrenal Cortex Hormones; Adrenal Gland Diseases; Animals; Biotransformation; Disease Models, Animal; Female; Hemorrhage; Nitriles; Phenobarbital; Rats | 1972 |
Biliary excretion of mercury enhanced by spironolactone.
Topics: Animals; Bile; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Kidney; Liver; Male; Mercury; Mercury Isotopes; Mercury Poisoning; Phenobarbital; Rats; Spironolactone | 1972 |
Folate metabolism and the anticonvulsant efficacy of phenobarbital.
Topics: Animals; Disease Models, Animal; Flurothyl; Folic Acid; Folic Acid Deficiency; Male; Phenobarbital; Rats; Seizures; Vitamin B 12 | 1973 |
Lead-induced behavioral dysfunction: an animal model of hyperactivity.
Topics: Amphetamine; Animals; Chloral Hydrate; Dextroamphetamine; Disease Models, Animal; Female; Humans; Hyperkinesis; Lead Poisoning; Methylphenidate; Mice; Phenobarbital; Pregnancy; Time Factors | 1974 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencephalography; Female; Haplorhini; Light; Male; Motor Activity; Phenobarbital; Phenytoin; Seizures | 1970 |