Page last updated: 2024-11-02

phenobarbital and Direct Hyperbilirubinemia, Neonatal

phenobarbital has been researched along with Direct Hyperbilirubinemia, Neonatal in 6 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

ExcerptRelevanceReference
"Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia."8.12Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022)
"Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia."4.12Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022)
" The adverse events were assessed as well."2.76[A multicenter randomized controlled study on the efficacy and safety of Yinzhihuang oral solution for the treatment of neonatal indirect hyperbilirubinemia in term newborn infants]. ( , 2011)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Cozzi, L1
Nuti, F1
Degrassi, I1
Civeriati, D1
Paolella, G1
Nebbia, G1
Osuorah, CDI1
Ekwochi, U1
Asinobi, IN1
Chawla, D1
Parmar, V1
Arya, VB1
Agarwal, R1
Paul, VK1
Deorari, AK1
Smits-Wintjens, VE1
Walther, FJ1
Lopriore, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency[NCT02594904]Phase 4300 participants (Anticipated)Interventional2015-07-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for phenobarbital and Direct Hyperbilirubinemia, Neonatal

ArticleYear
Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: a systematic review and meta-analysis.
    Indian pediatrics, 2010, Volume: 47, Issue:5

    Topics: Bilirubin; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn;

2010
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
    Seminars in fetal & neonatal medicine, 2008, Volume: 13, Issue:4

    Topics: Albumins; Anemia, Neonatal; Cholestasis; Fluid Therapy; Humans; Hydrops Fetalis; Hyperbilirubinemia,

2008

Trials

2 trials available for phenobarbital and Direct Hyperbilirubinemia, Neonatal

ArticleYear
[A multicenter randomized controlled study on the efficacy and safety of Yinzhihuang oral solution for the treatment of neonatal indirect hyperbilirubinemia in term newborn infants].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2011, Volume: 49, Issue:9

    Topics: Drugs, Chinese Herbal; Female; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Male; Phenobar

2011
Efficacy of oral phenobarbitone in term "at risk" neonates in decreasing neonatal hyperbilirubinemia: a randomized double-blinded, placebo controlled trial.
    Indian pediatrics, 2004, Volume: 41, Issue:4

    Topics: Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperbilirubinemia, Neonatal; Infant

2004

Other Studies

2 other studies available for phenobarbital and Direct Hyperbilirubinemia, Neonatal

ArticleYear
Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity.
    Italian journal of pediatrics, 2022, Apr-18, Volume: 48, Issue:1

    Topics: Bilirubin; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyperb

2022
Clinical evaluation of severe neonatal Hyperbilirubinaemia in a resource-limited setting: a 4-year longitudinal study in south-East Nigeria.
    BMC pediatrics, 2018, 06-23, Volume: 18, Issue:1

    Topics: Age of Onset; Early Diagnosis; Exchange Transfusion, Whole Blood; Family; Female; Health Education;

2018