phenobarbital has been researched along with Direct Hyperbilirubinemia, Neonatal in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 8.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 4.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| " The adverse events were assessed as well." | 2.76 | [A multicenter randomized controlled study on the efficacy and safety of Yinzhihuang oral solution for the treatment of neonatal indirect hyperbilirubinemia in term newborn infants]. ( , 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Cozzi, L | 1 |
| Nuti, F | 1 |
| Degrassi, I | 1 |
| Civeriati, D | 1 |
| Paolella, G | 1 |
| Nebbia, G | 1 |
| Osuorah, CDI | 1 |
| Ekwochi, U | 1 |
| Asinobi, IN | 1 |
| Chawla, D | 1 |
| Parmar, V | 1 |
| Arya, VB | 1 |
| Agarwal, R | 1 |
| Paul, VK | 1 |
| Deorari, AK | 1 |
| Smits-Wintjens, VE | 1 |
| Walther, FJ | 1 |
| Lopriore, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter Study to Evaluate the Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency[NCT02594904] | Phase 4 | 300 participants (Anticipated) | Interventional | 2015-07-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenobarbital and Direct Hyperbilirubinemia, Neonatal
| Article | Year |
|---|---|
Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: a systematic review and meta-analysis.
Topics: Bilirubin; Exchange Transfusion, Whole Blood; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; | 2010 |
Rhesus haemolytic disease of the newborn: Postnatal management, associated morbidity and long-term outcome.
Topics: Albumins; Anemia, Neonatal; Cholestasis; Fluid Therapy; Humans; Hydrops Fetalis; Hyperbilirubinemia, | 2008 |
2 trials available for phenobarbital and Direct Hyperbilirubinemia, Neonatal
| Article | Year |
|---|---|
[A multicenter randomized controlled study on the efficacy and safety of Yinzhihuang oral solution for the treatment of neonatal indirect hyperbilirubinemia in term newborn infants].
Topics: Drugs, Chinese Herbal; Female; Humans; Hyperbilirubinemia, Neonatal; Infant, Newborn; Male; Phenobar | 2011 |
Efficacy of oral phenobarbitone in term "at risk" neonates in decreasing neonatal hyperbilirubinemia: a randomized double-blinded, placebo controlled trial.
Topics: Double-Blind Method; Excitatory Amino Acid Antagonists; Humans; Hyperbilirubinemia, Neonatal; Infant | 2004 |
2 other studies available for phenobarbital and Direct Hyperbilirubinemia, Neonatal
| Article | Year |
|---|---|
Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity.
Topics: Bilirubin; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyperb | 2022 |
Clinical evaluation of severe neonatal Hyperbilirubinaemia in a resource-limited setting: a 4-year longitudinal study in south-East Nigeria.
Topics: Age of Onset; Early Diagnosis; Exchange Transfusion, Whole Blood; Family; Female; Health Education; | 2018 |