phenobarbital has been researched along with Developmental Psychomotor Disorders in 15 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gravid Sprague-Dawley-derived rats were injected SC twice daily with either 20 or 40 mg/kg pentobarbital sodium (PT), sodium phenobarbital (PH), or the same volume of the saline vehicle on days 9-21 of pregnancy." | 3.67 | Maternal barbiturate administration and offspring response to shock. ( Chao, S; Grace, R; Mackler, B; Martin, DC; Martin, JC; Shores, P, 1985) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| "Hypertonia and hyperreflexia/ankle clonus were most common." | 1.28 | Periventricular-intraventricular hemorrhage, sonographic localization, phenobarbital, and motor abnormalities in low birth weight infants. ( Allred, EN; Brown, ER; Krishnamoorthy, KS; Kuban, KC; Leviton, A; Sullivan, KF, 1990) |
| "Eleven preschool children with febrile convulsions or epilepsy were started on phenobarbital." | 1.26 | Influence of phenobarbital on the psychomotor development and behaviour in preschool children with convulsions. ( Barlach-Christoffersen, M; Hellström, B, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yasuda, M | 1 |
| Gan, L | 1 |
| Chen, B | 1 |
| Yu, C | 1 |
| Zhang, J | 1 |
| Gama-Sosa, MA | 1 |
| Pollak, DD | 1 |
| Berger, S | 1 |
| Phillips, JD | 1 |
| Edelmann, W | 1 |
| Desnick, RJ | 1 |
| Fujikawa, Y | 1 |
| Sugai, K | 1 |
| Hanaoka, S | 1 |
| Fukumizu, M | 1 |
| Sasaki, M | 1 |
| Kaga, M | 1 |
| Burton, KJ | 1 |
| Allen, S | 1 |
| Boylan, GB | 1 |
| Rennie, JM | 1 |
| Chorley, G | 1 |
| Pressler, RM | 1 |
| Fox, GF | 1 |
| Farrer, K | 1 |
| Morton, M | 1 |
| Binnie, CD | 1 |
| Hellström, B | 1 |
| Barlach-Christoffersen, M | 1 |
| Gaetti, MT | 1 |
| Carotti, G | 1 |
| Vianelli, P | 1 |
| Pellegrini, L | 1 |
| Bini, PL | 1 |
| Scalseggi, V | 1 |
| Karbowski, K | 1 |
| Meienberg, O | 1 |
| Krishnamoorthy, KS | 1 |
| Kuban, KC | 1 |
| Leviton, A | 1 |
| Brown, ER | 1 |
| Sullivan, KF | 1 |
| Allred, EN | 1 |
| Karler, R | 1 |
| Calder, LD | 1 |
| Turkanis, SA | 1 |
| Gallassi, R | 1 |
| Lorusso, S | 1 |
| Stracciari, A | 1 |
| Morreale, A | 1 |
| Procaccianti, G | 1 |
| Baruzzi, A | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Mackler, B | 1 |
| Grace, R | 1 |
| Shores, P | 1 |
| Chao, S | 1 |
| Borbély, F | 1 |
| Pasi, A | 1 |
| Velvart, J | 1 |
| Flügel, KA | 1 |
| Reynolds, EH | 1 |
| Travers, RD | 1 |
| Wiszczor-Adamczyk, B | 1 |
| Koślacz-Folga, A | 1 |
1 review available for phenobarbital and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
[Dysmorphisms and psychomotor retardation in infants of mothers treated with anticonvulsants in pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Fetus; Humans; | 1979 |
1 trial available for phenobarbital and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
Second-line anticonvulsant treatment of neonatal seizures: a video-EEG monitoring study.
Topics: Anticonvulsants; Clonazepam; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Infa | 2004 |
13 other studies available for phenobarbital and Developmental Psychomotor Disorders
| Article | Year |
|---|---|
Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria.
Topics: Aminolevulinic Acid; Animals; Central Nervous System; Gene Knock-In Techniques; Genes, Dominant; Hom | 2019 |
[Three cases with severe motor and intellectual disabilities presenting the severest condition caused by prolonged non-convulsive status epilepticus].
Topics: Child, Preschool; Disabled Children; Disease Progression; Electroencephalography; Female; Humans; In | 2003 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
Influence of phenobarbital on the psychomotor development and behaviour in preschool children with convulsions.
Topics: Child; Child Behavior; Child Development; Child, Preschool; Female; Humans; Male; Motor Activity; Ph | 1980 |
[Epileptic seizures with psychomotor symptoms and generalized spike-wave-pattern].
Topics: Adolescent; Adult; Carbamazepine; Child; Diagnosis, Differential; Drug Therapy, Combination; Electro | 1976 |
Periventricular-intraventricular hemorrhage, sonographic localization, phenobarbital, and motor abnormalities in low birth weight infants.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Follow-Up Studies; Humans; Infant; Infant, Low Birth Weigh | 1990 |
Prolonged CNS hyperexcitability in mice after a single exposure to delta-9-tetrahydrocannabinol.
Topics: Animals; Central Nervous System; Dronabinol; Drug Tolerance; Electroshock; Male; Mice; Phenobarbital | 1986 |
Withdrawal of phenobarbital and carbamazepine in epileptic patients: a preliminary neuropsychological report.
Topics: Adolescent; Adult; Carbamazepine; Cognition Disorders; Dose-Response Relationship, Drug; Female; Hum | 1986 |
Maternal barbiturate administration and offspring response to shock.
Topics: Animals; Avoidance Learning; Body Weight; Brain; Conditioning, Operant; Electroshock; Female; Humans | 1985 |
[Acute peroral intoxication with 2-amino-5-phenyl-oxazoline fumarate in humans, based upon 30 observed cases].
Topics: Appetite Depressants; Blood Pressure; Central Nervous System; Chlorpromazine; Diazepam; Erythema; Fu | 1970 |
[Treatment of acute emotional disturbances].
Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char | 1974 |
Serum anticonvulsant concentrations in epileptic patients with mental symptoms. A preliminary report.
Topics: Adolescent; Adult; Aged; Epilepsy; Female; Humans; Intelligence; Male; Mental Disorders; Middle Aged | 1974 |
[Observations on the effects of Tegretol in salaam seizures in children].
Topics: Central Nervous System; Cerebral Palsy; Child; Child, Preschool; Drug Synergism; Electroencephalogra | 1971 |