phenobarbital has been researched along with Developmental Disabilities in 18 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Developmental Disabilities: Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 9.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 5.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 5.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "Odds for epilepsy were higher among people who had positive family history (O." | 2.69 | A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country. ( Chopra, JS; Kaur, P; Sawhney, IM; Singh, A; Suri, G, 1999) |
| "Survivors of neonatal seizures are at risk for developmental delay, epilepsy, and further neurological comorbidities." | 1.51 | Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury. ( Brady, J; Cabassa Miskimen, AC; Ghosh, S; Kang, PB; Robinson, MA; Weiss, M; Zou, B, 2019) |
| "There were 73 children with seizures, 80% of whom had a greater than 50% reduction in seizure frequency following the start of simple anticonvulsant medication." | 1.32 | A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children. ( Allen, S; Burton, KJ, 2003) |
| "Seizures were categorised as EEG seizure discharges only (electrographic), or as EEG seizure discharges with accompanying clinical manifestations (electroclinical)." | 1.31 | Phenobarbitone, neonatal seizures, and video-EEG. ( Binnie, CD; Boylan, GB; Morton, M; Pressler, RM; Rennie, JM; Wilson, G, 2002) |
| "With the diagnosis of neonatal Graves' disease established, both twins were treated with propranolol (2 mg/kg." | 1.30 | [Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism]. ( Grüters, A; Hüfner, M; Lakomek, M; Roth, C; Siggelkow, H, 1997) |
| " In the first experiment, the lower end of the malformation dose-response curves for diphenylhydantoin (DPH), trimethadione (TMD) and phenobarbital (PB) were established." | 1.27 | Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring. ( Vorhees, CV, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (33.33) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 4 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ghosh, S | 1 |
| Cabassa Miskimen, AC | 1 |
| Brady, J | 1 |
| Robinson, MA | 1 |
| Zou, B | 1 |
| Weiss, M | 1 |
| Kang, PB | 1 |
| Imataka, G | 1 |
| Noguchi, M | 1 |
| Tsukada, K | 1 |
| Takahashi, T | 1 |
| Yamanouchi, H | 1 |
| Arisaka, O | 1 |
| Cherian, A | 1 |
| Jabeen, SA | 1 |
| Kandadai, RM | 1 |
| Iype, T | 1 |
| Moturi, P | 1 |
| Reddy, M | 1 |
| Kanikannan, MA | 1 |
| Borgohain, R | 1 |
| Padmanabhan, S | 1 |
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 1 |
| Ramsey, PS | 1 |
| Rouse, DJ | 1 |
| Burton, KJ | 1 |
| Allen, S | 1 |
| Guillet, R | 2 |
| Kwon, J | 1 |
| Vorhees, CV | 1 |
| Barnhill, J | 1 |
| Carlos, A | 1 |
| Roth, C | 1 |
| Siggelkow, H | 1 |
| Grüters, A | 1 |
| Hüfner, M | 1 |
| Lakomek, M | 1 |
| Sawhney, IM | 1 |
| Singh, A | 1 |
| Kaur, P | 1 |
| Suri, G | 1 |
| Chopra, JS | 1 |
| McBride, MC | 1 |
| Laroia, N | 1 |
| Boylan, GB | 1 |
| Rennie, JM | 1 |
| Pressler, RM | 1 |
| Wilson, G | 1 |
| Morton, M | 1 |
| Binnie, CD | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 2 |
| Smith, DW | 1 |
| Plöchl, E | 1 |
| Hohenwallner, W | 1 |
| Ruth, V | 1 |
| Virkola, K | 1 |
| Paetau, R | 1 |
| Raivio, KO | 1 |
| Fowler, GW | 1 |
| Dumars, KW | 1 |
2 reviews available for phenobarbital and Developmental Disabilities
| Article | Year |
|---|---|
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Therapies administered to mothers at risk for preterm birth and neurodevelopmental outcome in their infants.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Developmental Disabilities; Excitatory Amino Acid A | 2002 |
4 trials available for phenobarbital and Developmental Disabilities
| Article | Year |
|---|---|
Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis.
Topics: Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Epilepsy, Benign Neonatal; Fem | 2007 |
A case control study and one year follow-up of registered epilepsy cases in a resettlement colony of North India, a developing tropical country.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Craniocerebral Trauma; Developmenta | 1999 |
Electrographic seizures in neonates correlate with poor neurodevelopmental outcome.
Topics: Anticonvulsants; Asphyxia Neonatorum; Demography; Developmental Disabilities; Electroencephalography | 2000 |
Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants.
Topics: Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Developmental Disabilities; Drug Adminis | 1988 |
12 other studies available for phenobarbital and Developmental Disabilities
| Article | Year |
|---|---|
Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury.
Topics: Anticonvulsants; Brain Injuries; Case-Control Studies; Developmental Disabilities; Female; Gestation | 2019 |
Partial epilepsy and developmental delay in infant with ring chromosome 14.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Chromosome Disorders; Chromosomes, Human, Pair 1 | 2013 |
Epilepsy with myoclonic absences in siblings.
Topics: Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Electroencephalography; Epilepsie | 2014 |
A review of neurological disorders presenting at a paediatric neurology clinic and response to anticonvulsant therapy in Gambian children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Developmental Disabilities; Fem | 2003 |
Fetal anticonvulsant syndrome in rats: dose- and period-response relationships of prenatal diphenylhydantoin, trimethadione and phenobarbital exposure on the structural and functional development of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Developmental Disabilities; Dose-Response Re | 1983 |
Phenobarbital-induced disinhibition in the developmentally disabled: case report.
Topics: Adult; Anticonvulsants; Child; Developmental Disabilities; Humans; Male; Personality Disorders; Phen | 1997 |
[Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism].
Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Autoantibodies; Developmental Disabilities; | 1997 |
Phenobarbitone, neonatal seizures, and video-EEG.
Topics: Anticonvulsants; Developmental Disabilities; Electroencephalography; Follow-Up Studies; Humans; Infa | 2002 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
[Treatment of Crigler-Najjar's congenital familial non-hemolytic jaundice with kernicterus].
Topics: Crigler-Najjar Syndrome; Developmental Disabilities; Epilepsy; Female; Humans; Hyperbilirubinemia; H | 1978 |
Cutis aplasia and cerebral malformation.
Topics: Cephalometry; Cerebrospinal Fluid Proteins; Developmental Disabilities; Female; Humans; Hydranenceph | 1973 |