phenobarbital has been researched along with Dementia Praecox in 39 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The steady state plasma concentrations of clozapine and its two major metabolites, norclozapine and clozapine N-oxide, were compared in patients with schizophrenia treated with clozapine in combination with phenobarbital (n=7), and in control patients treated with clozapine alone (n=15)." | 7.70 | Inducing effect of phenobarbital on clozapine metabolism in patients with chronic schizophrenia. ( Avenoso, A; Facciolà, G; Perucca, E; Spina, E, 1998) |
| "The steady state plasma concentrations of clozapine and its two major metabolites, norclozapine and clozapine N-oxide, were compared in patients with schizophrenia treated with clozapine in combination with phenobarbital (n=7), and in control patients treated with clozapine alone (n=15)." | 3.70 | Inducing effect of phenobarbital on clozapine metabolism in patients with chronic schizophrenia. ( Avenoso, A; Facciolà, G; Perucca, E; Spina, E, 1998) |
| " In this case, it seems necessary to diminish the interval between injections than to give higher dosage in order to maintain plasma concentrations." | 1.29 | Do enzyme inducers modify haloperidol decanoate rate of release? ( Agenet, C; Barges-Bertocchio, MH; Levron, JC; Pupeschi, G, 1994) |
| "Homovanillic acid accumulation was decreased in this group." | 1.26 | Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology. ( Peters, JG, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (84.62) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 1 (2.56) | 29.6817 |
| 2010's | 1 (2.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhardwaj, SK | 1 |
| Forcelli, PA | 1 |
| Palchik, G | 1 |
| Gale, K | 1 |
| Srivastava, LK | 1 |
| Kondratyev, A | 1 |
| BRUCK, MA | 1 |
| TURNER, WJ | 1 |
| CARL, A | 1 |
| MERLIS, S | 1 |
| WILCOXON, F | 1 |
| LEVIN, ML | 1 |
| CASEY, JF | 2 |
| BENNETT, IF | 1 |
| LINDLEY, CJ | 1 |
| HOLLISTER, LE | 2 |
| GORDON, MH | 1 |
| SPRINGER, NN | 1 |
| LASKY, JJ | 1 |
| KLETT, CJ | 2 |
| MARKS, J | 1 |
| BLACHLY, PH | 1 |
| RAY, TS | 1 |
| RAGLAND, RE | 1 |
| CLARK, ML | 1 |
| BRILL, NQ | 1 |
| KOEGLER, RR | 1 |
| EPSTEIN, LJ | 1 |
| FORGY, EW | 1 |
| GALLANT, DM | 3 |
| EDWARDS, CG | 1 |
| BISHOP, MP | 3 |
| GALBRAITH, GC | 1 |
| ULETT, GA | 1 |
| BOWERS, CA | 1 |
| HEUSLER, AF | 1 |
| QUICK, R | 1 |
| WORD, T | 1 |
| WORD, V | 1 |
| GRINSPOON, L | 2 |
| SHADER, RI | 1 |
| CHATTERJEE, S | 2 |
| COHLER, J | 1 |
| PFEIFFER, CC | 1 |
| GOLDSTEIN, L | 1 |
| MURPHREE, HB | 1 |
| SUGERMAN, AA | 1 |
| BAN, TA | 2 |
| LEHMANN, HE | 1 |
| Helland, A | 1 |
| Spigset, O | 1 |
| Burstein, S | 1 |
| Kimball, HL | 1 |
| Klaiber, EL | 1 |
| Gut, M | 1 |
| Prakash, R | 1 |
| Reed, RM | 1 |
| Bass, AD | 1 |
| Solomon, PR | 1 |
| Crider, A | 1 |
| Winkelman, JW | 1 |
| Turi, A | 1 |
| Kamer, RM | 1 |
| Kaplan, LJ | 1 |
| Campbell, M | 1 |
| Cueva, JE | 1 |
| Pupeschi, G | 1 |
| Agenet, C | 1 |
| Levron, JC | 1 |
| Barges-Bertocchio, MH | 1 |
| Facciolà, G | 1 |
| Avenoso, A | 1 |
| Spina, E | 1 |
| Perucca, E | 1 |
| Prein, RF | 1 |
| Caffey, EM | 1 |
| Tinklenberg, JR | 1 |
| Gillin, JC | 1 |
| Murphy, GM | 1 |
| Staub, R | 1 |
| Wyatt, RJ | 1 |
| Peters, JG | 1 |
| Trimble, MR | 1 |
| Reynolds, EH | 1 |
| Rodin, EA | 1 |
| Suzuki, T | 1 |
| Koizumi, J | 1 |
| Moroji, T | 1 |
| Shiraishi, H | 1 |
| Hori, T | 1 |
| Baba, A | 1 |
| Kawai, N | 1 |
| Tada, K | 1 |
| Yamamoto, K | 1 |
| Yamamoto, Y | 1 |
| Hattori, H | 1 |
| Ueda, M | 1 |
| Watanabe, A | 1 |
| Neĭkoya, M | 1 |
| Feinberg, I | 1 |
| Wender, PH | 1 |
| Koresko, RL | 1 |
| Gottlieb, F | 1 |
| Piehuta, JA | 1 |
| St Jean, A | 1 |
| Sterlin, C | 1 |
| Noe, W | 1 |
| Altman, H | 1 |
| Evenson, RC | 1 |
| Sletten, IW | 1 |
| Cho, DW | 1 |
| Nesselhof, WM | 1 |
| Sprehe, DJ | 1 |
| Ohler, J | 1 |
| Shader, R | 1 |
| Zlotlow, M | 1 |
| Yvonneau, M | 1 |
| Kinsala, S | 1 |
| Lafforgue, J | 1 |
1 review available for phenobarbital and Dementia Praecox
| Article | Year |
|---|---|
Psychopharmacology in child and adolescent psychiatry: a review of the past seven years. Part II.
Topics: Adolescent; Alprazolam; Anticonvulsants; Antipsychotic Agents; Anxiety, Separation; Bipolar Disorder | 1995 |
4 trials available for phenobarbital and Dementia Praecox
| Article | Year |
|---|---|
Clinical studies with propericiazine (R.P. 8909).
Topics: Acute Disease; Adolescent; Adult; Aged; Association; Behavior; Chlorpromazine; Chronic Disease; Clin | 1967 |
Further observations on trifluperidol: a butyrophenone derivative.
Topics: Butyrophenones; Clinical Trials as Topic; Humans; Hypnotics and Sedatives; Phenobarbital; Psychologi | 1965 |
Observations of placebo response in chronic schizophrenic patients.
Topics: Adult; Chlorpromazine; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Phenobarbital; P | 1966 |
Behavioral correlates of the guessing game. Side effects and double-blind studies.
Topics: Atropine; Clinical Trials as Topic; Humans; Lactose; Male; Phenobarbital; Schizophrenia; Thioridazin | 1966 |
34 other studies available for phenobarbital and Dementia Praecox
| Article | Year |
|---|---|
Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat.
Topics: Age Factors; Animals; Animals, Newborn; Female; Phenobarbital; Pregnancy; Rats; Rats, Sprague-Dawley | 2012 |
Electroencephalographic changes in chronic schizophrenics under chemotherapy.
Topics: Chlorpromazine; Electroencephalography; Humans; Phenobarbital; Phenothiazines; Schizophrenia | 1958 |
Chemotherapeutic trials in psychosis. II. Design and conduct of a trial of raunormine versus reserpine and phenobarbital in chronic schizophrenia.
Topics: Antihypertensive Agents; Phenobarbital; Psychotic Disorders; Reserpine; Schizophrenia; Secologanin T | 1958 |
A comparison of the effects of phenobarbital, promethazine, chlorpromazine, and placebo upon mental hospital patients.
Topics: Chlorpromazine; Hospitals; Hospitals, Psychiatric; Humans; Inpatients; Mentally Ill Persons; Phenoba | 1959 |
Drug therapy in schizophrenia. A controlled study of the relative effectiveness of chlorpromazine, promazine, phenobarbital, and placebo.
Topics: Chlorpromazine; Phenobarbital; Promazine; Research Design; Schizophrenia; Tranquilizing Agents | 1960 |
Treatment of schizophrenic reactions with phenothiazine derivatives. A comparative study of chlorpromazine, triflupromazine, mepazine, prochlorperazine, perphenazine, and phenobarbital.
Topics: Antipsychotic Agents; Chlorpromazine; Perphenazine; Phenobarbital; Phenothiazines; Prochlorperazine; | 1960 |
PREDRUG BEHAVIOR AS A PREDICTOR OF RESPONSE TO PHENOTHIAZINES AMONG SCHIZOPHRENICS.
Topics: Antipsychotic Agents; Chlorpromazine; Humans; Perphenazine; Phenobarbital; Phenothiazines; Prochlorp | 1963 |
PROCEDURE FOR WITHDRAWAL OF BARBITURATES.
Topics: Aged; Barbiturates; Depression; Electroconvulsive Therapy; Humans; Phenobarbital; Phenothiazines; Sc | 1964 |
CHLORPROMAZINE IN CHRONIC SCHIZOPHRENIC WOMEN: COMPARISON OF DIFFERENTIAL EFFECTS ON VARIOUS PSYCHOLOGICAL MODALITES DURING AND AFTER TREATMENT.
Topics: Behavior; Biomedical Research; Chlorpromazine; Female; Humans; Mental Disorders; Phenobarbital; Plac | 1964 |
CONTROLLED STUDY OF PSYCHIATRIC OUTPATIENT TREATMENT.
Topics: Ambulatory Care; Biomedical Research; Hospitals, Psychiatric; Humans; Meprobamate; MMPI; Neurotic Di | 1964 |
WITHDRAWAL SYMPTOMS AFTER ABRUPT CESSATION OF ANTIPSYCHOTIC COMPOUNDS: CLINICAL CONFIRMATION IN CHRONIC SCHIZOPHRENICS.
Topics: Antipsychotic Agents; Biomedical Research; Phenobarbital; Phenothiazines; Placebos; Schizophrenia; S | 1964 |
A STUDY OF THE BEHAVIOR AND EEG PATTERNS OF PATIENTS RECEIVING TRANQUILIZERS WITH AND WITHOUT THE ADDITION OF CHLORDIAZEPOXIDE.
Topics: Bipolar Disorder; Chlordiazepoxide; Drug Synergism; Drug Therapy; Electroencephalography; Fluphenazi | 1964 |
SIDE EFFECTS AND DOUBLE-BLIND STUDIES. I. A CLINICAL COMPARISON BETWEEN THIORIDAZINE HYDROCHLORIDE AND A COMBINATION OF PHENOBARBITAL AND ATROPINE SULFATE.
Topics: Atropine; Biomedical Research; Double-Blind Method; Drug Therapy; Phenobarbital; Placebos; Schizophr | 1964 |
TIME-SERIES, FREQUENCY ANALYSIS, AND ELECTROGENESIS OF THE EEGS OF NORMALS AND PSYCHOTICS BEFORE AND AFTER DRUGS.
Topics: Amphetamine; Antidepressive Agents; Barbiturates; Biomedical Research; Caffeine; Central Nervous Sys | 1965 |
SKIN PIGMENTATION, A RARE SIDE EFFECT OF CHLORPROMAZINE.
Topics: Chemical Phenomena; Chemistry; Chlorpromazine; Diagnosis, Differential; Drug Therapy; Epilepsy; Eye | 1965 |
Low serum concentrations of reboxetine in 2 patients treated with CYP3A4 inducers.
Topics: Adrenergic Uptake Inhibitors; Adult; Anticonvulsants; Bulimia Nervosa; Carbamazepine; Cytochrome P-4 | 2007 |
Metabolism of 2-alpha- and 6-beta-hydroxycortisol in man: determination of production rates of 6-beta-hydroxycortisol with and without phenobarbital administration.
Topics: Adrenal Glands; Adult; Carbon Isotopes; Chromatography, Paper; Chromatography, Thin Layer; Humans; H | 1967 |
Combination of phenobarbital and haloperidol in resistant schizophrenia.
Topics: Adult; Drug Resistance; Drug Therapy, Combination; Haloperidol; Humans; Male; Phenobarbital; Prolact | 1984 |
Disrupted latent inhibition in the rat with chronic amphetamine or haloperidol-induced supersensitivity: relationship to schizophrenic attention disorder.
Topics: Animals; Attention; Avoidance Learning; Chlorpromazine; Dextroamphetamine; Dopamine; Dose-Response R | 1981 |
Do enzyme inducers modify haloperidol decanoate rate of release?
Topics: Antipsychotic Agents; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Haloperido | 1994 |
Inducing effect of phenobarbital on clozapine metabolism in patients with chronic schizophrenia.
Topics: Adult; Clozapine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Female; Human | 1998 |
Polypharmacy in the psychiatric treatment of elderly hospitalized patients: a survey of 12 Veterans Administration Hospitals.
Topics: Age Factors; Aged; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; | 1976 |
Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para-tyrosine and l-dopa.
Topics: Animals; Behavior, Animal; Dopamine; Drug Antagonism; Eye Movements; Haplorhini; Humans; Levodopa; M | 1979 |
Dopamine, noradrenaline and serotonin spinal fluid metabolites in temporal lobe epileptic patients with schizophrenic symptomatology.
Topics: Adolescent; Adult; Child; Dopamine; Epilepsy, Temporal Lobe; Homovanillic Acid; Humans; Hydroxyindol | 1979 |
Anticonvulsant drugs and mental symptoms: a review.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Folic Acid | 1976 |
Psychosocial management of patients with complex partial seizures.
Topics: Adult; Alcoholism; Carbamazepine; Delivery of Health Care; Drug Administration Schedule; Epilepsy; E | 1975 |
Effects of long-term anticonvulsant therapy on copper, zinc, and magnesium in hair and serum of epileptics.
Topics: Adult; Anticonvulsants; Carbamazepine; Copper; Drug Therapy, Combination; Epilepsy, Generalized; Fem | 1992 |
An unusual case of fatal poisoning by phenobarbital overdosage.
Topics: Adult; Female; Humans; Iatrogenic Disease; Malpractice; Phenobarbital; Pulmonary Edema; Schizophreni | 1985 |
Effect of chronic administration of centrally acting compounds on chloramphenicol metabolism in schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Chloramphenicol; Chronic Disease; Female; Glucuronates; Half-Life; Huma | 1974 |
[Treatment of acute schizophrenia with antibiotics, gamma-globulin and vitamins].
Topics: Acute Disease; Adolescent; Adult; Amobarbital; Anti-Bacterial Agents; Antimalarials; Ascorbic Acid; | 1966 |
Differential effects of chlorpromazine and phenobarbital on EEG sleep patterns.
Topics: Adult; Antisocial Personality Disorder; Chlorpromazine; Electroencephalography; Eye Movements; Human | 1969 |
Patterns of psychotropic drug prescription in four midwestern state hospitals.
Topics: Alcoholism; Antidepressive Agents; Antipsychotic Agents; Chlorpromazine; Computers; Drug Utilization | 1972 |
Temporal lobe "spike focus" associated with confusion, complete amnesia and fugues in a paranoid schizophrenic.
Topics: Adult; Amnesia; Chlorpromazine; Cognition Disorders; Dissociative Disorders; Electroencephalography; | 1968 |
[Toxic thrombopenic purpura perhaps due to gardenal (phenobarbital). Post-traumatic catatonia].
Topics: Accidents; Adult; Catatonia; Female; Femoral Neck Fractures; Humans; Middle Aged; Phenobarbital; Pur | 1968 |