phenobarbital and Delayed Hypersensitivity studies

phenobarbital and Delayed Hypersensitivity

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

Excerpt	Relevance	Reference
"Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make antibody to Salmonella typhi and tetanus toxoid."	1.25	Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro. ( Forbes, IJ; Sorrell, TC, 1975)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (75.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

3 (75.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

1 (25.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Lachgar, T	1
Touil, Y	1
Sorrell, TC	1
Forbes, IJ	1
Frank, DM	1
Blumer, JL	1
Higashi, A	1
Chen, C	1
Matsuda, I	1

Studies

Lachgar, T

Touil, Y

Sorrell, TC

Forbes, IJ

Frank, DM

Blumer, JL

Higashi, A

Chen, C

Matsuda, I

Other Studies

4 other studies available for phenobarbital and Delayed Hypersensitivity

Article	Year
[The drug hypersensitivity syndrome or DRESS syndrome to phenobarbital]. Allergie et immunologie, 2001, Volume: 33, Issue:4 Topics: Aged; Anticonvulsants; Cholestasis, Intrahepatic; Drug Eruptions; Edema; Eosinophilia; Epilepsy; Fem	2001
Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro. Clinical and experimental immunology, 1975, Volume: 20, Issue:2 Topics: Adolescent; Adult; Aged; Antibodies, Bacterial; Antibody Formation; Carbamazepine; Depression, Chemi	1975
Alteration of methylcholanthrene-mediated suppression of cutaneous delayed hypersensitivity by benzoflavone treatment of C57BL/6J mice. Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme	1988
Zinc status and delayed cutaneous hypersensitivity in handicapped children treated with anticonvulsants. Developmental pharmacology and therapeutics, 1987, Volume: 10, Issue:1 Topics: Adolescent; Child; Child, Preschool; Dinitrochlorobenzene; Disabled Persons; Drug Hypersensitivity;	1987

Article

Year

[The drug hypersensitivity syndrome or DRESS syndrome to phenobarbital].

Allergie et immunologie, 2001, Volume: 33, Issue:4

Topics: Aged; Anticonvulsants; Cholestasis, Intrahepatic; Drug Eruptions; Edema; Eosinophilia; Epilepsy; Fem

2001

Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro.

Clinical and experimental immunology, 1975, Volume: 20, Issue:2

Topics: Adolescent; Adult; Aged; Antibodies, Bacterial; Antibody Formation; Carbamazepine; Depression, Chemi

1975

Alteration of methylcholanthrene-mediated suppression of cutaneous delayed hypersensitivity by benzoflavone treatment of C57BL/6J mice.

Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 Enzyme

1988

Zinc status and delayed cutaneous hypersensitivity in handicapped children treated with anticonvulsants.

Developmental pharmacology and therapeutics, 1987, Volume: 10, Issue:1

Topics: Adolescent; Child; Child, Preschool; Dinitrochlorobenzene; Disabled Persons; Drug Hypersensitivity;

1987