phenobarbital has been researched along with Delayed Effects, Prenatal Exposure in 97 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure." | 7.85 | Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017) |
| "Phenobarbital appears to produce similar behavioral effects on mice and humans with excitation at low and sedation or depression at higher doses." | 5.27 | Phenobarbital during pregnancy in mouse and man. ( Middaugh, LD, 1986) |
| "The objective of this paper is to determine if phenobarbital exposure during pregnancy affects developmental outcome at age 2 years." | 5.09 | Does perinatal phenobarbital exposure affect developmental outcome at age 2? ( Belden, B; Hoffman, EL; Jones, AM; O'Connor, M; Thorp, JA, 1999) |
| "Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure." | 3.85 | Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017) |
| " Exposure to phenobarbital during this period has been associated with deficits in learning and memory, anxiety-like behavior, and social behavior, among other domains." | 3.83 | Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats. ( Forcelli, PA; Frankel, S; Gutherz, S; Kondratyev, A; Kulick, C; Medvedeva, N, 2016) |
| "To study the effect of large doses of phenobarbital used for a suicide attempt during pregnancy for fetuses to estimate the teratogenic potential of phenobarbital." | 3.75 | Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnany: the use of a disaster epidemiological model for the evaluation of drug teratogenicity. ( Acs, N; Bánhidy, F; Czeizel, AE; Timmermann, G, 2009) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| "we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy." | 3.71 | [Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report]. ( Abraham, R; Assencio-Ferreira, VJ; Santos, KC; Veiga, JC, 2001) |
| "A full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy." | 3.70 | [A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord]. ( Adachi, M; Ai, Y; Maeda, E, 1999) |
| "Exposed subjects were adult men born at the largest hospital in Copenhagen between 1959 and 1961 who were exposed to phenobarbital during gestation via maternal medical treatment and whose mothers had no history of a central nervous system disorder and no treatment during pregnancy with any other psychopharmacological drug." | 3.69 | In utero exposure to phenobarbital and intelligence deficits in adult men. ( Mortensen, EL; Reinisch, JM; Rubin, DB; Sanders, SA, 1995) |
| "While cocaine is now used much more frequently than heroin by women of childbearing age, we have found that a significant number of mothers have abused both drugs during their pregnancy." | 3.67 | Perinatal outcome of infants exposed to cocaine and/or heroin in utero. ( Durand, DJ; Fulroth, R; Phillips, B, 1989) |
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "Barbiturates, such as phenobarbital (PHB), are often used during pregnancy and early neonatal life to prevent epileptic seizures, hyperbilirubinemia and the stressful effects of labor." | 3.67 | The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus. ( Antolick, LL; Jacobson, CD; Scholey, R; Uemura, E, 1988) |
| "Gravid Sprague-Dawley-derived rats were injected SC twice daily with either 20 or 40 mg/kg pentobarbital sodium (PT), sodium phenobarbital (PH), or the same volume of the saline vehicle on days 9-21 of pregnancy." | 3.67 | Maternal barbiturate administration and offspring response to shock. ( Chao, S; Grace, R; Mackler, B; Martin, DC; Martin, JC; Shores, P, 1985) |
| "Offspring of C57BL/6J mice injected daily with phenobarbital (20 or 40 mg/kg) for the last 6 or 7 days of pregnancy were compared with offspring of saline control mice on behavioral and neurochemical measures of brain function at 21 days of age." | 3.66 | Effects of prenatal maternal injections of phenobarbital on brain neurotransmitters and behavior of young C57 mice. ( Middaugh, LD; Simpson, LW; Thomas, TN; Zemp, JW, 1981) |
| "Adult female offspring of C57BL/6J mice injected daily with phenobarbital for the last third of pregnancy were more active than control offspring during a 3-min test period in an open field arena, thus confirming previous reports of lasting effects of prenatal exposure to phenobarbital." | 3.66 | Prenatal maternal phenobarbital increases reactivity and retards habituation of mature offspring to environmental stimuli. ( Middaugh, LD; Simpson, LW; Thomas, TN; Zemp, JW, 1981) |
| "Pregnant mice were fed a phenobarbital-containing diet on days nine through 18 of pregnancy." | 3.66 | Prenatal phenobarbital treatment and temperature-controlling dopamine receptors. ( Kuprys, R; Tabakoff, B, 1983) |
| "The effect of prenatal exposure to phenobarbital (40mg/Kg/day from day 12 to day 19 of pregnancy) on sexual development of male offspring was investigated." | 3.66 | Reproductive dysfunction in male rats following prenatal exposure to phenobarbital. ( Gupta, C; Shapiro, BH; Yaffe, SJ, 1980) |
| "Infants with intracranial hemorrhage (23%) had significantly lower mental developmental index and psychomotor developmental index scores than infants with no intracranial hemorrhage, independent of antenatal phenobarbital exposure." | 2.70 | Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure. ( Donovan, EF; Ehrenkranz, RA; Fanaroff, AA; Korones, SB; Lemons, JA; Mele, L; Oh, W; Papile, LA; Shankaran, S; Stevenson, DK; Stoll, BJ; Verter, J; Wright, LL, 2002) |
| "Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0." | 1.72 | Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022) |
| " Carbamazepine (CBZ) and phenobarbital (PHB) during pregnancy should be used at the lowest dosage compatible with maternal disease." | 1.34 | Unilateral multicystic dysplastic kidney in infants exposed to antiepileptic drugs during pregnancy. ( Carta, M; Cimador, M; Corsello, G; De Grazia, E; Di Pace, MR; Giuffrè, M; Sergio, M, 2007) |
| "Heroin exposure was accomplished by injecting dams during the same gestational period." | 1.29 | Neural grafting as a tool for the study and reversal of neurobehavioral birth defects. ( Abu-Roumi, M; Silverman, WF; Steingart, RA; Yanai, J, 1996) |
| "Phenobarbital (PhB) was administered to pregnant mice during days 9-18 of gestation." | 1.28 | Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors. ( Fares, F; Gavish, M; Pick, CG; Weizman, A; Yanai, J, 1990) |
| "Phenobarbital (PB) was administered to pregnant mice during days 9-21 of gestation." | 1.27 | Effects of prenatal phenobarbital on benzodiazepine receptor development. ( Garrett, KM; Tabakoff, B, 1986) |
| "Phenobarbital appears to produce similar behavioral effects on mice and humans with excitation at low and sedation or depression at higher doses." | 1.27 | Phenobarbital during pregnancy in mouse and man. ( Middaugh, LD, 1986) |
| "Phenobarbital pretreatment appears to be effective as an inducing agent for all the enzymes studied, but only after birth." | 1.26 | Perinatal development of cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethylase in rat liver nuclear membranes. ( Assael, BM; Clos, V; Romano, M; Salmona, M, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (41.24) | 18.7374 |
| 1990's | 31 (31.96) | 18.2507 |
| 2000's | 17 (17.53) | 29.6817 |
| 2010's | 7 (7.22) | 24.3611 |
| 2020's | 2 (2.06) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, SV | 1 |
| Jeemon, P | 1 |
| Jose, M | 1 |
| Amrithum, LM | 1 |
| Bhaskar, D | 1 |
| Nair, MKC | 1 |
| George, B | 1 |
| Shi, X | 1 |
| Wang, Y | 1 |
| Zhang, Y | 1 |
| Song, C | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Xia, L | 1 |
| Ma, L | 1 |
| Jiang, W | 1 |
| MacMillan, KDL | 1 |
| Erol, S | 1 |
| Ozcan, B | 1 |
| Celik, IH | 1 |
| Bas, AY | 1 |
| Demirel, N | 1 |
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 1 |
| Frankel, S | 1 |
| Medvedeva, N | 1 |
| Gutherz, S | 1 |
| Kulick, C | 1 |
| Kondratyev, A | 1 |
| Forcelli, PA | 2 |
| Timmermann, G | 1 |
| Acs, N | 1 |
| Bánhidy, F | 1 |
| Czeizel, AE | 1 |
| Janssen, MJ | 1 |
| Stamps, LA | 1 |
| Sweeney, C | 1 |
| Vicini, S | 1 |
| Gale, K | 1 |
| Tomson, T | 1 |
| Battino, D | 1 |
| Bonizzoni, E | 1 |
| Craig, J | 1 |
| Lindhout, D | 1 |
| Sabers, A | 1 |
| Perucca, E | 1 |
| Vajda, F | 1 |
| Kieviet, N | 1 |
| Dolman, K | 1 |
| Wennink, H | 1 |
| Heres, M | 1 |
| Honig, A | 1 |
| Shankaran, S | 2 |
| Papile, LA | 1 |
| Wright, LL | 1 |
| Ehrenkranz, RA | 1 |
| Mele, L | 1 |
| Lemons, JA | 1 |
| Korones, SB | 1 |
| Stevenson, DK | 1 |
| Donovan, EF | 1 |
| Stoll, BJ | 1 |
| Fanaroff, AA | 1 |
| Oh, W | 1 |
| Verter, J | 1 |
| Bokhari, A | 1 |
| Coull, BA | 2 |
| Holmes, LB | 2 |
| Smyth, MD | 1 |
| Barbaro, NM | 1 |
| Baraban, SC | 1 |
| Thorp, JA | 2 |
| O'Connor, M | 2 |
| Belden, B | 2 |
| Etzenhouser, J | 1 |
| Hoffman, EL | 2 |
| Jones, PG | 1 |
| Gupta, C | 3 |
| Yaffe, SJ | 5 |
| Christensen, HD | 1 |
| Gonzalez, CL | 1 |
| Rayburn, WF | 2 |
| Beer, A | 1 |
| Slotkin, TA | 3 |
| Seidler, FJ | 1 |
| Aldridge, JE | 1 |
| Yanai, J | 23 |
| Dorfman, J | 1 |
| Rosenberger, PB | 1 |
| Ben-Shaanan, TL | 1 |
| Haimovitch, H | 1 |
| Katz, S | 1 |
| Kazma, M | 1 |
| Carta, M | 1 |
| Cimador, M | 1 |
| Giuffrè, M | 1 |
| Sergio, M | 1 |
| Di Pace, MR | 1 |
| De Grazia, E | 1 |
| Corsello, G | 1 |
| Kwon, P | 1 |
| Lefkowitz, W | 1 |
| Johri, A | 1 |
| Yadav, S | 1 |
| Dhawan, A | 1 |
| Parmar, D | 1 |
| Middaugh, LD | 3 |
| Thomas, TN | 2 |
| Simpson, LW | 2 |
| Zemp, JW | 2 |
| Fishman, RH | 1 |
| Vinarchuk, MP | 2 |
| Kononenko, LI | 2 |
| Bykorez, AI | 2 |
| Sonawane, BR | 1 |
| Chapman, JB | 1 |
| Cutler, MG | 1 |
| McBride, MC | 1 |
| Rosman, NP | 1 |
| Tsuchiya, E | 1 |
| Concetti, HF | 1 |
| Sugano, H | 1 |
| Kitagawa, T | 1 |
| Patsalos, PN | 1 |
| Wiggins, RC | 1 |
| Romano, M | 1 |
| Clos, V | 1 |
| Assael, BM | 1 |
| Salmona, M | 1 |
| Kuprys, R | 1 |
| Tabakoff, B | 2 |
| Lenn, NJ | 1 |
| Hamill, JS | 1 |
| Soliman, KF | 1 |
| Richardson, SD | 1 |
| Woolf, M | 1 |
| Feigenbaum, JJ | 1 |
| Shapiro, BH | 1 |
| Reinisch, JM | 2 |
| Sanders, SA | 2 |
| Mortensen, EL | 2 |
| Rubin, DB | 2 |
| Zamir, I | 1 |
| Lam, SK | 1 |
| To, WK | 1 |
| Laviola, G | 1 |
| Terranova, ML | 1 |
| Sedowofia, K | 1 |
| Clayton, R | 1 |
| Manning, A | 2 |
| Bonner, MJ | 1 |
| Katz, Y | 1 |
| Amiri, Z | 1 |
| Pick, CG | 7 |
| Weizman, R | 1 |
| Gavish, M | 3 |
| Ihemelandu, EC | 1 |
| Weizman, A | 2 |
| Fares, F | 2 |
| Kanner, BI | 1 |
| Rogel-Fuchs, Y | 2 |
| Zahalka, EA | 2 |
| Zangar, RC | 2 |
| Springer, DL | 2 |
| Buhler, DR | 2 |
| Woldt, E | 1 |
| Nelson, J | 1 |
| Bedard, M | 1 |
| Delaney-Black, V | 1 |
| Jaiswal, AK | 3 |
| Bhattacharya, SK | 2 |
| Zahalka, EH | 1 |
| Rehavi, M | 1 |
| Newman, ME | 4 |
| Abu-Roumi, M | 3 |
| Koch, S | 1 |
| Jäger-Roman, E | 1 |
| Lösche, G | 1 |
| Nau, H | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Silverman, WF | 3 |
| Steingart, RA | 4 |
| Ventegodt, S | 1 |
| Hilden, J | 1 |
| Zachau-Christiansen, B | 1 |
| Barg, J | 1 |
| Maslaton, J | 1 |
| Nesher, M | 1 |
| Dessens, AB | 2 |
| Cohen-Kettenis, PT | 2 |
| Mellenbergh, GJ | 2 |
| vd Poll, N | 1 |
| Koppe, JG | 2 |
| Boer, K | 2 |
| Jones, AM | 1 |
| Singh, Y | 1 |
| Singh, M | 2 |
| Adachi, M | 1 |
| Ai, Y | 1 |
| Maeda, E | 1 |
| Singh, KP | 1 |
| van De Poll, NE | 1 |
| Barron, S | 1 |
| Awad, Y | 1 |
| Assencio-Ferreira, VJ | 1 |
| Abraham, R | 1 |
| Veiga, JC | 1 |
| Santos, KC | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Livezey, GT | 1 |
| Smith, CV | 1 |
| McCrary, JA | 1 |
| Novak, RF | 1 |
| Primiano, T | 1 |
| Trombka, D | 2 |
| Bolognesi, C | 1 |
| Parrini, M | 1 |
| Aiello, C | 1 |
| Rossi, L | 1 |
| van der Pol, MC | 1 |
| Hadders-Algra, M | 1 |
| Huisjes, HJ | 1 |
| Touwen, BC | 1 |
| Dorn, LD | 1 |
| Sedowofia, SK | 1 |
| Innes, J | 1 |
| Peter, A | 1 |
| Alleva, E | 1 |
| Clayton, RM | 1 |
| Laxer, U | 1 |
| Rice, JM | 1 |
| Rehm, S | 1 |
| Donovan, PJ | 1 |
| Perantoni, AO | 1 |
| Fulroth, R | 1 |
| Phillips, B | 1 |
| Durand, DJ | 1 |
| Rayburn, W | 1 |
| Donn, S | 1 |
| Compton, A | 1 |
| Piehl, E | 1 |
| Abel, EL | 1 |
| Tan, SE | 1 |
| Subramanian, M | 1 |
| Baum, M | 1 |
| Garrett, KM | 1 |
| Sobrian, SK | 1 |
| Nandedkar, AK | 1 |
| Jacobson, CD | 1 |
| Antolick, LL | 1 |
| Scholey, R | 1 |
| Uemura, E | 1 |
| Vorhees, CV | 1 |
| Statter, M | 1 |
| Ben Shachar, D | 1 |
| Youdim, MB | 1 |
| Iser-Strenger, C | 1 |
| Fujii, T | 1 |
| Ohtaki, Y | 1 |
| Nakanishi, H | 1 |
| Morimoto, S | 1 |
| Hayashi, K | 1 |
| Yamamoto, N | 1 |
| Takagi, S | 1 |
| Alleva, FR | 1 |
| Seth, PK | 1 |
| Balazs, T | 1 |
| Martin, JC | 1 |
| Martin, DC | 1 |
| Mackler, B | 1 |
| Grace, R | 1 |
| Shores, P | 1 |
| Chao, S | 1 |
| Kleinberger, N | 1 |
| Wanich, A | 1 |
| Macmahon, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Randomized Clinical Trial of Antenatal Phenobarbital in the Prevention of Neonatal Intracranial Hemorrhage[NCT00009620] | Phase 3 | 610 participants (Actual) | Interventional | 1993-02-28 | Completed | ||
| Follow-up Visit of High Risk Infants[NCT00009633] | 68,000 participants (Anticipated) | Observational | 1993-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for phenobarbital and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, | 2019 |
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
[Withdrawal in newborns after exposure to psychotropic medications during pregnancy].
Topics: Anticonvulsants; Female; Humans; Infant, Newborn; Male; Neonatal Abstinence Syndrome; Phenobarbital; | 2012 |
Long-lasting effects of early barbiturates on central nervous system and behavior.
Topics: Animals; Barbiturates; Behavior, Animal; Brain; Cell Differentiation; Drug Tolerance; Enzyme Inducti | 1983 |
Gender dimorphism in brain.
Topics: Androgens; Animals; Animals, Newborn; Aromatase; Birds; Brain; Cricetinae; Dronabinol; Female; Ferre | 1986 |
7 trials available for phenobarbital and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Neurodevelopmental outcome of premature infants after antenatal phenobarbital exposure.
Topics: Anticonvulsants; Central Nervous System; Child Development; Female; Fetus; Humans; Infant; Infant, N | 2002 |
Effects of phenobarbital and multiple-dose corticosteroids on developmental outcome at age 7 years.
Topics: Adrenal Cortex Hormones; Child; Child Behavior; Child Development; Dose-Response Relationship, Drug; | 2003 |
Antenatal phenobarbital therapy and neonatal outcome. II: Neurodevelopmental outcome at 36 months.
Topics: Anticonvulsants; Body Height; Body Weight; Cerebral Hemorrhage; Child Development; Child, Preschool; | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
[Delayed effects of prenatal exposure to phenobarbital on intelligence--Phenemal].
Topics: Adult; Anticonvulsants; Double-Blind Method; Female; Humans; Intelligence; Intelligence Tests; Male; | 1996 |
Does perinatal phenobarbital exposure affect developmental outcome at age 2?
Topics: Adult; Anticonvulsants; Central Nervous System Depressants; Cerebral Hemorrhage; Chi-Square Distribu | 1999 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
85 other studies available for phenobarbital and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposur | 2022 |
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc | 2022 |
Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report.
Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; F | 2017 |
Comparison of the long-term behavioral effects of neonatal exposure to retigabine or phenobarbital in rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Cognition; Dose-R | 2016 |
Congenital abnormalities of 88 children born to mothers who attempted suicide with phenobarbital during pregnany: the use of a disaster epidemiological model for the evaluation of drug teratogenicity.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Case-Control Studies; Cohort Studies; Dose-Response | 2009 |
Therapeutic strategies to avoid long-term adverse outcomes of neonatal antiepileptic drug exposure.
Topics: Animals; Animals, Newborn; Anticonvulsants; Corpus Striatum; Female; Humans; Lamotrigine; Mental Pro | 2010 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile | 2011 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Phenobarbital-induced alterations in the sexual differentiation of the female rat: reversal by hydroxyurea and cycloheximide.
Topics: Animals; Cycloheximide; Estrous Cycle; Female; Fertility; Hydroxyurea; Phenobarbital; Pregnancy; Pre | 1982 |
Chronic prenatal exposure to phenobarbital and long-term behavior effects on mice offspring.
Topics: Animals; Anticonvulsants; Female; Hindlimb; Locomotion; Male; Mice; Motor Activity; Phenobarbital; P | 2004 |
Nicotine therapy in adulthood reverses the synaptic and behavioral deficits elicited by prenatal exposure to phenobarbital.
Topics: Animals; Behavior, Animal; Biomarkers; Brain Stem; Carbachol; Cerebral Cortex; Cytosol; Female; Hemi | 2005 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
Mechanism-based approaches for the reversal of drug neurobehavioral teratogenicity.
Topics: Animals; Behavior, Animal; Chickens; Disease Models, Animal; Female; Heroin; Hippocampus; Mice; Phen | 2006 |
Unilateral multicystic dysplastic kidney in infants exposed to antiepileptic drugs during pregnancy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Follow-Up Studies; Humans; Infant, Newborn; Matern | 2007 |
Neonatal extrapyramidal movements. Neonatal withdrawal due to maternal citalopram and ondansetron use.
Topics: Adult; Anti-Anxiety Agents; Basal Ganglia Diseases; Citalopram; Female; Humans; Infant, Newborn; Lor | 2008 |
Responsiveness of cerebral and hepatic cytochrome P450s in rat offspring prenatally exposed to lindane.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cytochrome P-450 Enzyme System; Enzyme Induction | 2008 |
Effects of prenatal maternal injections of phenobarbital on brain neurotransmitters and behavior of young C57 mice.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Female; Mice; Mice, Inbred C57BL; Neurotran | 1981 |
[Histochemical appearance of gamma-glutamyltranspeptidase in the rat liver after transplacental exposure to diethylnitrosamine and postnatal administration of phenobarbital].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Histo | 1984 |
Delayed effects of drug exposure during pregnancy: reproductive function.
Topics: Animals; Anticonvulsants; Estrus; Female; Fertility; Luteinizing Hormone; Male; Phenobarbital; Pheny | 1983 |
Behavioral effects of phenobarbitone II. Effects in nursing female mice.
Topics: Animals; Behavior, Animal; Female; Lactation; Male; Maternal Behavior; Mice; Phenobarbital; Pregnanc | 1983 |
Absence of behavioral effects of intrauterine phenobarbital exposure in rats.
Topics: Animals; Behavior, Animal; Exploratory Behavior; Female; Nervous System; Phenobarbital; Pregnancy; P | 1984 |
Lack of promotion effect of phenobarbital on pulmonary tumorigenesis in ddy mice initiated by transplacental exposure to 1-ethyl-1-nitrosourea.
Topics: Animals; Ethylnitrosourea; Female; Lung; Lung Neoplasms; Male; Mice; Nitrosourea Compounds; Phenobar | 1984 |
Prenatal maternal phenobarbital increases reactivity and retards habituation of mature offspring to environmental stimuli.
Topics: alpha-Methyltyrosine; Animals; Brain Chemistry; Dopamine; Environment; Female; Habituation, Psychoph | 1981 |
Brain maturation following administration of phenobarbital, phenytoin, and sodium valproate to developing rats or to their dams: effects on synthesis of brain myelin and other subcellular membrane proteins.
Topics: Animals; Anticonvulsants; Brain; Female; Intracellular Membranes; Membrane Proteins; Myelin Proteins | 1982 |
Perinatal development of cytochrome P-450, NADPH-cytochrome c reductase and ethoxycoumarin deethylase in rat liver nuclear membranes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Li | 1982 |
Prenatal phenobarbital treatment and temperature-controlling dopamine receptors.
Topics: Animals; Apomorphine; Body Temperature Regulation; Brain; Clonidine; Dose-Response Relationship, Dru | 1983 |
Congenital radial nerve pressure palsy.
Topics: Female; Humans; Infant, Newborn; Male; Nerve Compression Syndromes; Paralysis; Phenobarbital; Pregna | 1983 |
Effect of prenatal exposure to phenobarbital on the development of monoamine oxidase and glucocorticoids.
Topics: Adrenal Cortex; Aging; Animals; Body Weight; Corticosterone; Female; Glucocorticoids; Growth; Liver; | 1983 |
Morphological alterations in the medial preoptic area after prenatal administration of phenobarbital.
Topics: Animals; Brain; Female; Male; Mice; Mice, Inbred Strains; Organ Size; Phenobarbital; Pregnancy; Pren | 1982 |
Reproductive dysfunction in female offspring after prenatal exposure to phenobarbital: critical period of action.
Topics: Animals; Estradiol; Estrus; Female; Fertility; Male; Phenobarbital; Pregnancy; Prenatal Exposure Del | 1981 |
Reproductive dysfunction in male rats following prenatal exposure to phenobarbital.
Topics: Animals; Body Weight; Estrus; Female; Luteinizing Hormone; Male; Phenobarbital; Pregnancy; Prenatal | 1980 |
In utero exposure to phenobarbital and intelligence deficits in adult men.
Topics: Adult; Anticonvulsants; Case-Control Studies; Cognition; Cohort Studies; Denmark; Double-Blind Metho | 1995 |
GTPase activity in mouse hippocampus membranes following prenatal exposure to heroin and phenobarbital.
Topics: Animals; Carbachol; Cell Membrane; Enzyme Activation; Female; GTP Phosphohydrolases; Guanosine Triph | 1995 |
Neonatal narcotic withdrawal in Hong Kong Chinese.
Topics: Asian People; Case-Control Studies; Chlorpromazine; Female; Hong Kong; Humans; Infant, Newborn; Narc | 1994 |
A mouse model of early social interactions after prenatal drug exposure: a genetic investigation.
Topics: Animals; Exploratory Behavior; Female; Genetics, Behavioral; Genotype; Grooming; Interpersonal Relat | 1994 |
Prenatal and neonatal pharmacologic stress on early behavior and sexual maturation in the hamster.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Animals, Newborn; Behavior, Animal; Cricetinae | 1994 |
Effects of chronic prenatal, neonatal and adult exposure to barbiturates on mitochondrial benzodiazepine receptors in mouse testis.
Topics: Animals; Animals, Newborn; Female; Injections, Subcutaneous; Isoquinolines; Male; Mice; Mitochondria | 1994 |
Effect of maternal phenobarbital consumption on muscle development in mice.
Topics: Animals; Female; Male; Mice; Muscle Development; Muscles; Organ Size; Phenobarbital; Pregnancy; Pren | 1993 |
Hippocampal gamma-aminobutyric acid and benzodiazepine receptors after early phenobarbital exposure.
Topics: Animals; Female; Hippocampus; Male; Mice; Phenobarbital; Pregnancy; Prenatal Exposure Delayed Effect | 1993 |
Reversal of early phenobarbital-induced cholinergic and related behavioral deficits by neuronal grafting.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Behavior, Animal; Brain; Female; Hippocampus; Histo | 1994 |
Alterations in cytochrome P-450 levels in adult rats following neonatal exposure to xenobiotics.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aging; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; | 1993 |
Effect of prenatal undernutrition and phenobarbitone administration on discrimination learning and passive avoidance behaviour in rats.
Topics: Animals; Avoidance Learning; Discrimination Learning; Female; Nutrition Disorders; Phenobarbital; Pr | 1996 |
Alterations in hippocampal hemicholinium-3 binding and related behavioural and biochemical changes after prenatal phenobarbitone exposure.
Topics: Animals; Behavior, Animal; Choline; Female; Hippocampus; Male; Maze Learning; Mice; Phenobarbital; P | 1995 |
Inositol phosphate formation in mice prenatally exposed to drugs: relation to muscarinic receptors and postreceptor effects.
Topics: Animals; Carbachol; Female; GTP-Binding Proteins; Heroin; In Vitro Techniques; Inositol Phosphates; | 1996 |
Neural grafting as a tool for the study and reversal of neurobehavioral birth defects.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Cell Transplantation; Congenital Abnormalit | 1996 |
[Phenemal to pregnant women and children's intelligence and quality of life 31-33 years later].
Topics: Adult; Female; Follow-Up Studies; Humans; Hypnotics and Sedatives; Intelligence; Maternal-Fetal Exch | 1997 |
Pre- and postsynaptic alterations in the septohippocampal cholinergic innervations after prenatal exposure to drugs.
Topics: Animals; Biological Transport; Carbachol; Cholinergic Fibers; Enzyme Activation; Female; Heroin; Hip | 1998 |
Prenatal exposure to anticonvulsants and psychosexual development.
Topics: Anticonvulsants; Cross-Sectional Studies; Female; Follow-Up Studies; Gender Identity; Humans; Male; | 1999 |
Effect of prenatal diazepam, phenobarbital, haloperidol and fluoxetine exposure on foot shock induced aggression in rats.
Topics: Aggression; Animals; Diazepam; Drug Evaluation, Preclinical; Electroshock; Female; Fluoxetine; Halop | 1998 |
[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Fatal Outcome; Female; Humans; Infant; Infant, | 1999 |
Effect of phenobarbitone administration to pregnant rats on anxiety in offsprings.
Topics: Animals; Anxiety; Brain; Exploratory Behavior; Female; Male; Maze Learning; Phenobarbital; Pregnancy | 1999 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
Neurobehavioral damage to cholinergic systems caused by prenatal exposure to heroin or phenobarbital: cellular mechanisms and the reversal of deficits by neural grafts.
Topics: Animals; Behavior, Animal; Choline O-Acetyltransferase; Excitatory Amino Acid Antagonists; Female; F | 2000 |
Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits.
Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Carbachol; Carrier Proteins; Choline O-Acet | 2000 |
[Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report].
Topics: Adult; Anticonvulsants; Cranial Sutures; Craniosynostoses; Female; Humans; Infant; Phenobarbital; Pr | 2001 |
Prenatal exposure to phenobarbital and quantifiable alterations in the electroencephalogram of adult rat offspring.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Phenobarbita | 1992 |
Changes in adult metabolism of aflatoxin B1 in rats neonatally exposed to diethylstilbestrol. Alterations in alpha-class glutathione S-transferases.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aflatoxin B1; Animals; Biotransformation; Blotting, Western; Dieth | 1992 |
Hippocampal cholinergic alterations and related behavioral deficits after early exposure to phenobarbital.
Topics: Animals; Animals, Newborn; Behavior, Animal; Carbachol; Choline O-Acetyltransferase; Female; Hippoca | 1992 |
DNA damage induced by 7,12-dimethylbenz[a]anthracene in the liver and the mammary gland of rats exposed to polycyclic aromatic hydrocarbon enzyme inducers during perinatal life.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Aroclors; DNA Damage; Enzyme Induction; | 1991 |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Central Nervous System; Child; Child De | 1991 |
Effects of prenatal treatment with phenobarbital.
Topics: Animals; Female; Follow-Up Studies; Gonadal Steroid Hormones; Humans; Longitudinal Studies; Male; Ph | 1990 |
Effect of prenatal and neonatal chronic exposure to phenobarbital on central and peripheral benzodiazepine receptors.
Topics: Aging; Animals; Brain; Female; Flunitrazepam; Male; Mice; Muscimol; Phenobarbital; Pregnancy; Prenat | 1990 |
Differential effects of prenatal exposure to phenobarbital on the behaviour and neurochemistry of CBA and C57BL/6J mice.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Brain Chemistry; Cells, Cultured; Female; | 1989 |
Dopaminergic denervation reverses behavioral deficits induced by prenatal exposure to phenobarbital.
Topics: Animals; Cholinergic Fibers; Dopamine; Female; Hippocampus; Hydroxydopamines; Learning Disabilities; | 1989 |
Comparative transplacental carcinogenesis by directly acting and metabolism-dependent alkylating agents in rodents and nonhuman primates.
Topics: Alkylating Agents; Animals; Brain Neoplasms; Carcinogens; Choriocarcinoma; Diethylnitrosamine; Eryth | 1989 |
Perinatal outcome of infants exposed to cocaine and/or heroin in utero.
Topics: Cocaine; Drug Synergism; Female; Fetal Growth Retardation; Heroin; Humans; Infant, Newborn; Microcep | 1989 |
Oral phenobarbital given antenatally to reduce neonatal intraventricular hemorrhage. A comparison between maternal and umbilical cord serum levels at delivery.
Topics: Administration, Oral; Cerebral Hemorrhage; Female; Fetal Blood; Humans; Infant, Newborn; Labor, Obst | 1989 |
Effects of delta 9-tetrahydrocannabinol, phenobarbital, and their combination on pregnancy and offspring in rats.
Topics: Animals; Body Weight; Dronabinol; Drug Combinations; Female; Litter Size; Phenobarbital; Pregnancy; | 1987 |
[Sensitivity of rat hepatocytes to phenobarbital after a single dose of N-nitrosodiethylamine in the embryonal and postnatal period or after partial hepatectomy].
Topics: Animals; Diethylnitrosamine; Enzyme Induction; Female; gamma-Glutamyltransferase; Hepatectomy; Hyper | 1987 |
Effects of prenatal phenobarbital on benzodiazepine receptor development.
Topics: Animals; Brain; Cerebellum; Diencephalon; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |
Neuron transplantation reverses phenobarbital-induced behavioral birth defects in mice.
Topics: Acetylcholine; Animals; Behavior, Animal; Female; Hippocampus; Locus Coeruleus; Mice; Norepinephrine | 1988 |
The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus.
Topics: Aging; Animals; Body Weight; Dendrites; Female; Hippocampus; Phenobarbital; Pregnancy; Prenatal Expo | 1988 |
Fetal anticonvulsant exposure: effects on behavioral and physical development.
Topics: Animals; Anticonvulsants; Female; Humans; Learning; Memory; Motor Activity; Oxazoles; Phenobarbital; | 1986 |
Studies on noradrenergic alterations in relation to early phenobarbital-induced behavioral changes.
Topics: Animals; Behavior, Animal; Cell Count; Female; Hippocampus; Locus Coeruleus; Male; Mice; Norepinephr | 1987 |
Normal zinc and iron concentrations in mice after early exposure to phenobarbital.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Female; Hippocampus; Iron; Liver; Male; Mice; Ph | 1987 |
Alterations in mice dopamine receptor characteristics after early exposure to phenobarbital.
Topics: Animals; Animals, Newborn; Apomorphine; Corpus Striatum; Drug Synergism; Female; Mice; Motor Activit | 1986 |
Alterations in the thermic response to chlorpromazine in rats exposed prenatally to central nervous system depressants.
Topics: Animals; Body Temperature; Central Nervous System Depressants; Chlorpromazine; Drug Interactions; Et | 1986 |
Phenobarbital during pregnancy in mouse and man.
Topics: Animals; Brain Chemistry; Diet; Female; Humans; Kinetics; Litter Size; Mice; Motor Activity; Phenoba | 1986 |
Delayed development of reproductive functions and alteration of dopamine receptor binding in hypothalamus of rats exposed prenatally to phenytoin and phenobarbital.
Topics: Animals; Female; Hypothalamus; Male; Phenobarbital; Phenytoin; Pregnancy; Prenatal Exposure Delayed | 1986 |
Maternal barbiturate administration and offspring response to shock.
Topics: Animals; Avoidance Learning; Body Weight; Brain; Conditioning, Operant; Electroshock; Female; Humans | 1985 |
Early phenobarbital-induced alterations in hippocampal acetylcholinesterase activity and behavior.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Brain Diseases; Butyrylcholinesterase; Cerebellum; | 1985 |
Prenatal versus neonatal long-term effect of phenobarbital on mouse microsomal drug-oxidizing system.
Topics: Animals; Animals, Newborn; Brain; Enzyme Induction; Female; Fetus; Gestational Age; Mice; Microsomes | 1985 |
Phenobarbital: epidemiological evidence.
Topics: Brain Neoplasms; Child; Female; Fetus; Follow-Up Studies; Humans; Lung Neoplasms; Male; Neoplasms; P | 1985 |