phenobarbital has been researched along with Deficiency, Protein in 18 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital treatment (80 mg/kg x day) stimulates 5 alpha-reduction of cortisol per g of microsomes almost twofold." | 1.26 | Effect of alcohol on microsomal cortisol 4en-5 alpha-reductase in the liver of rats fed on a standard or low protein diet. ( Bode, C; Bode, JC; Martini, GA, 1978) |
| "The influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (CCl4) was investigated in a group of rhesus monkeys." | 1.25 | Protein deficiency in carbon tetrachloride-induced hepatic lesions. ( Deo, MG; Ramalingaswami, V; Roy, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deo, MG | 1 |
| Roy, H | 1 |
| Ramalingaswami, V | 2 |
| Bode, C | 1 |
| Martini, GA | 1 |
| Bode, JC | 1 |
| Venera, GD | 1 |
| Morisoli, LS | 1 |
| Rodriguez Garay, EA | 1 |
| Sachan, DS | 1 |
| Singh, Y | 1 |
| Chaudhary, VK | 1 |
| Bhatnagar, R | 1 |
| Misra, UK | 1 |
| Campbell, TC | 3 |
| Hayes, JR | 3 |
| Mgbodile, MU | 2 |
| Peraino, C | 1 |
| Lamar, C | 1 |
| Pitot, HC | 1 |
| Chopra, P | 1 |
| Roy, S | 1 |
| Nayak, NC | 1 |
| Patel, JM | 1 |
| Pawar, SS | 1 |
| Adlard, BP | 1 |
| Lester, RG | 1 |
| Lathe, GH | 1 |
| Cuparencu, B | 1 |
| Grosu, L | 1 |
| Marshall, WJ | 2 |
| McLean, AE | 4 |
| Magee, PN | 1 |
2 reviews available for phenobarbital and Deficiency, Protein
| Article | Year |
|---|---|
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
Microsomes, metabolism and toxicity.
Topics: Animals; Barbiturates; Biotransformation; Carbon Tetrachloride; DDT; Enzyme Induction; Female; Hexob | 1969 |
16 other studies available for phenobarbital and Deficiency, Protein
| Article | Year |
|---|---|
Protein deficiency in carbon tetrachloride-induced hepatic lesions.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Glucos | 1975 |
Effect of alcohol on microsomal cortisol 4en-5 alpha-reductase in the liver of rats fed on a standard or low protein diet.
Topics: Animals; Dietary Proteins; Ethanol; Hydrocortisone; Male; Microsomes, Liver; Oxidoreductases; Phenob | 1978 |
Degradation of parathion to p-nitrophenol by livers of rats treated with phenobarbital.
Topics: Animals; Caseins; Dietary Proteins; Liver; Nitrophenols; Parathion; Phenobarbital; Protein Deficienc | 1978 |
Effects of low and high protein diets on the induction of microsomal drug-metabolizing enzymes in rat liver.
Topics: Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Diet; Dietary Proteins; DNA; Enzyme I | 1975 |
Mixed function oxidases in response to quality and quantity of dietary protein.
Topics: Animals; Caseins; Dietary Proteins; Liver; Lysine; Male; Membrane Lipids; Mixed Function Oxygenases; | 1988 |
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizng enzyme system. II. Effect of enzyme kinetics and electron transport system.
Topics: Aniline Compounds; Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductase | 1973 |
Studies on the induction and repression of enzymes in rat liver. IV. Effects of cortisone and phenobarbital.
Topics: Animals; Cortisone; Dietary Carbohydrates; Enzyme Repression; Hydro-Lyases; Liver; Phenobarbital; Pr | 1966 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
Activities of phenobarbital induced liver microsomal enzymes in rats fed protein- and fat-free diets.
Topics: Aniline Compounds; Animals; Deficiency Diseases; Dietary Fats; Enzyme Induction; Male; Microsomes, L | 1972 |
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system. I. Effect on substrate interaction with cytochrome P-450.
Topics: Appetite; Body Weight; Cytochrome P-450 Enzyme System; Dietary Proteins; Enzyme Induction; Kinetics; | 1973 |
The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin.
Topics: Animals; Bile Acids and Salts; Bilirubin; Body Weight; Depression, Chemical; Edetic Acid; In Vitro T | 1969 |
[Effect of some drugs with predominantly central nervous action on the assimilation and dissimilation of proteins].
Topics: Amphetamine; Animals; Barbiturates; Liver; Myocardium; Phenobarbital; Picrotoxin; Protein Deficiency | 1972 |
The effect of nutrition and hormonal status on cytochrome P-450 and its induction.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Amino Acids; Aminopyrine; Animals; Castration; Cytochromes; | 1969 |
The effect of protein deficiency and microsomal enzyme induction by DDT and phenobarbitone on the acute toxicity of chloroform and a pyrrolizidine alkaloid, retrorsine.
Topics: Alkaloids; Animals; Carbon Tetrachloride; Chloroform; DDT; Enzyme Induction; Heterocyclic Compounds; | 1970 |
Increased renal carcinogenesis by dimethyl nitrosamine in protein deficient rats.
Topics: Animals; DDT; Enzyme Induction; Kidney Neoplasms; Male; Microsomes, Liver; Neoplasms, Experimental; | 1970 |
The effect of oral phenobarbitone on hepatic microsomal cytochrome P-450 and demethylation activity in rats fed normal and low protein diets.
Topics: Animals; Caseins; Injections, Intraperitoneal; Liver; Male; Microsomes; Organ Size; Phenobarbital; P | 1969 |