phenobarbital has been researched along with Deficiency, Magnesium in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi." | 3.74 | Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. ( Brumback, AC; Dzhala, VI; Staley, KJ, 2008) |
| "Loreclezole was also shown to inhibit 'low Ca2+' and 'low Mg2+' epileptogenesis at similar concentrations to those active on inhibition." | 1.28 | In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus. ( Ashton, D; Willems, R, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, AJ | 1 |
| Jones, NA | 1 |
| Williams, CM | 1 |
| Stephens, GJ | 1 |
| Whalley, BJ | 1 |
| Dzhala, VI | 1 |
| Brumback, AC | 1 |
| Staley, KJ | 1 |
| Belknap, JK | 1 |
| Berg, JH | 1 |
| Ondrusek, G | 1 |
| Waddingham, S | 1 |
| Jooste, PL | 1 |
| Wolfswinkel, JM | 1 |
| Schoeman, JJ | 1 |
| Strydom, NB | 1 |
| Buck, DR | 1 |
| Mahoney, AW | 1 |
| Hendricks, DG | 1 |
| Katz, SH | 1 |
| Gerstman, I | 1 |
| Lautenbacher, HW | 1 |
| Hediger, ML | 1 |
| Ashton, D | 1 |
| Willems, R | 1 |
| Campbell, TC | 1 |
| Hayes, JR | 1 |
| Josephson, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Bumetanide for Newborn Seizures: A Phase I Study of Pharmacokinetics and Safety of Bumetanide for Neonatal Seizures[NCT00830531] | Phase 1 | 43 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenobarbital and Deficiency, Magnesium
| Article | Year |
|---|---|
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
8 other studies available for phenobarbital and Deficiency, Magnesium
| Article | Year |
|---|---|
Development of multi-electrode array screening for anticonvulsants in acute rat brain slices.
Topics: 4-Aminopyridine; Animals; Animals, Newborn; Anticonvulsants; Disease Models, Animal; Drug Evaluation | 2010 |
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
Topics: Animals; Anticonvulsants; Bumetanide; Chloride Channels; Chlorides; Drug Synergism; Drug Therapy, Co | 2008 |
Barbiturate withdrawal and magnesium deficiency in mice.
Topics: Animals; Barbiturates; Body Weight; Brain; Humans; Magnesium; Magnesium Deficiency; Male; Mice; Mice | 1978 |
Epileptic-type convulsions and magnesium deficiency.
Topics: Acclimatization; Adult; Chlorides; Epilepsy; Hot Temperature; Humans; Magnesium; Magnesium Deficienc | 1979 |
Preliminary report on the magnesium deficient rat as a model of epilepsy.
Topics: Age Factors; Animals; Disease Models, Animal; Epilepsy; Female; Magnesium Deficiency; Male; Phenobar | 1978 |
Letter: Failure to confirm anticonvulsant hypomagnesaemia.
Topics: Epilepsy; Humans; Magnesium Deficiency; Phenobarbital; Phenytoin | 1976 |
In vitro studies on the broad spectrum anticonvulsant loreclezole in the hippocampus.
Topics: Animals; Anticonvulsants; Calcium; Electric Stimulation; Epilepsy; Etomidate; gamma-Aminobutyric Aci | 1992 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |