phenobarbital has been researched along with Deficiency, Factor II in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methaqualone pretreatment did not affect warfarin-induced hypoprothrombinemia, whereas phenobarbital-pretreated animals showed a 32 to 64% reduction in response to the anticoagulant." | 1.26 | Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia. ( Herczeg, T; Mathur, PP; Reavey-Cantwell, NH; Smyth, RD, 1976) |
| "Antipyrine has been used as a model drug to investigate the effects of liver disease on drug metabolism in man." | 1.25 | Determinants of serum antipyrine half-lives in patients with liver disease. ( Branch, RA; Herbert, CM; Read, AE, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HARRISON, GA | 1 |
| ROSEN, M | 1 |
| GOODALL, P | 1 |
| Mathur, PP | 1 |
| Smyth, RD | 1 |
| Herczeg, T | 1 |
| Reavey-Cantwell, NH | 1 |
| Shojania, AM | 1 |
| Grewar, D | 1 |
| Shetty, SN | 1 |
| Himes, JA | 1 |
| Edds, GT | 1 |
| Solomon, GE | 1 |
| Hilgartner, MW | 1 |
| Kutt, H | 1 |
| Reynolds, JW | 1 |
| Branch, RA | 1 |
| Herbert, CM | 1 |
| Read, AE | 1 |
| MacDonald, MG | 1 |
| Robinson, DS | 1 |
1 review available for phenobarbital and Deficiency, Factor II
| Article | Year |
|---|---|
The use of drugs in influencing human fetal metabolism.
Topics: Adrenocortical Hyperfunction; Animals; Blood Transfusion, Intrauterine; Congenital Hypothyroidism; E | 1974 |
7 other studies available for phenobarbital and Deficiency, Factor II
| Article | Year |
|---|---|
HAEMORRHAGIC COMPLICATIONS DURING THE TREATMENT OF TETANUS.
Topics: Amobarbital; Child; Chloramphenicol; Chlorpromazine; Diphenhydramine; Hematuria; Hemolysis; Hydrocor | 1964 |
Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Enzyme Induction; Hexobarbital; Hypoprothro | 1976 |
Hypoprothrombinemic hemorrhage due to cholestyramine therapy.
Topics: Bile Duct Diseases; Child, Preschool; Cholestyramine Resin; Female; Hemorrhage; Humans; Hypoprothrom | 1986 |
Effect of phenobarbital on bishydroxycoumarin plasma concentrations and hypoprothrombinemic responses in sheep.
Topics: Administration, Oral; Animals; Dicumarol; Drug Interactions; Female; Hypoprothrombinemias; Injection | 1972 |
Phenobarbital-induced coagulation defects in cats.
Topics: Alanine Transaminase; Animals; Animals, Newborn; Blood Coagulation; Blood Coagulation Disorders; Cat | 1974 |
Determinants of serum antipyrine half-lives in patients with liver disease.
Topics: Adult; Alkaline Phosphatase; Antipyrine; Aspartate Aminotransferases; Bilirubin; Half-Life; Hepatiti | 1973 |
Clinical observations of possible barbiturate interference with anticoagulation.
Topics: Adolescent; Adult; Aged; Anticoagulants; Barbiturates; Coumarins; Enzyme Induction; Female; Hemorrha | 1968 |