phenobarbital has been researched along with Cytomegalic Inclusion Disease in 1 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Kraft, WK | 1 |
Dysart, K | 1 |
Greenspan, JS | 1 |
Gibson, E | 1 |
Kaltenbach, K | 1 |
Ehrlich, ME | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Buprenorphine for the Treatment of Neonatal Abstinence Syndrome[NCT00521248] | Phase 1 | 60 participants (Anticipated) | Interventional | 2004-04-30 | Completed | ||
Prospective Randomized Blinded Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)[NCT04455802] | Phase 3 | 0 participants (Actual) | Interventional | 2020-10-01 | Withdrawn (stopped due to termination of funding) | ||
A Randomized, Active-Control, Double-Blind, Double-Dummy Clinical Trial Comparing Sublingual Buprenorphine And Morphine Solution For The Treatment Of Neonatal Opioid Abstinence Syndrome[NCT01452789] | Phase 3 | 63 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
This endpoint will compare length of stay in the hospital (in days) using sublingual buprenorphine or morphine solution. (NCT01452789)
Timeframe: Duration of hospital stay is an expected average of 5 weeks.
Intervention | days (Median) |
---|---|
Sublingual Buprenorphine | 21 |
Oral Morphine | 33 |
This endpoint will compare length of treatment (in days) using sublingual buprenorphine or oral morphine solution. (NCT01452789)
Timeframe: Patients will be followed for the duration of hospital stay, an expected average of 5 weeks.
Intervention | days (Median) |
---|---|
Sublingual Buprenorphine | 15 |
Oral Morphine | 28 |
Adverse events will be collected, graded by severity, and assessed for causality referent to study drug. (NCT01452789)
Timeframe: Patients will be followed for the duration of hospital stay, an expected average of 5 weeks.
Intervention | Participants (Count of Participants) |
---|---|
Sublingual Buprenorphine | 7 |
Oral Morphine | 8 |
This endpoint will compare requirement number of patients who require use of supplemental phenobarbital. (NCT01452789)
Timeframe: Patients will be followed for the duration of hospital stay, an expected average of 5 weeks.
Intervention | participants (Number) |
---|---|
Sublingual Buprenorphine | 5 |
Oral Morphine | 7 |
1 trial available for phenobarbital and Cytomegalic Inclusion Disease
Article | Year |
---|---|
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |
Revised dose schema of sublingual buprenorphine in the treatment of the neonatal opioid abstinence syndrome.
Topics: Administration, Sublingual; Adult; Birth Weight; Buprenorphine; Cytomegalovirus Infections; Dose-Res | 2011 |