phenobarbital has been researched along with Cryptogenic Infantile Spasms in 32 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 7.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 3.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Interictal EEG showed hypsarrhythmia in 27 infants and multifocal spikes with normal or nearly normal background in 17 infants." | 2.70 | Infantile spasms: diagnosis and assessment of treatment response by video-EEG. ( Gaily, E; Granström, ML; Liukkonen, E; Paetau, R; Rekola, R, 2001) |
| " Therefore phenobarbitone does not have seem to have any significant effect on cerebral haemodynamics up to a dosage of 20 mg/kg, so that there is no apparent effect on the risk of cerebral haemorrhage." | 2.66 | [Doppler flow velocities in cerebral arteries in relation to intravenous phenobarbital in premature infants weighing between 500 and 1,500 g]. ( Jorch, G; Michel, E; Rabe, H; Rickers, E; Stöhr, G; Süllwald, A, 1988) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| "EEG revealed the typical pattern of hypsarrhythmia leading to the diagnosis of West syndrome." | 1.32 | Persistent hyperinsulinemic hypoglycemia presenting with a rare complication: West syndrome. ( Bideci, A; Camurdan, MO; Cinaz, P; Demirel, F; Serdaroğlu, A, 2004) |
| "Carbamazepine is a standard anticonvulsant in children and adults." | 1.31 | Carbamazepine in phenobarbital-nonresponders: experience with ten preterm infants. ( Bartmann, P; Elger, CE; Hoppen, T, 2001) |
| " Oral high-dose phenobarbital therapy was begun at a dosage of 15 mg/kg/day, and the seizures markedly decreased to 5-10 times per day and the epileptic discharges on electroencephalogram greatly decreased." | 1.31 | Oral high-dose phenobarbital therapy for early infantile epileptic encephalopathy. ( Kawada, Y; Noma, S; Ozawa, H; Sugai, K, 2002) |
| "The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG." | 1.29 | Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. ( Blennow, G; Hellström-Westas, L; Lindroth, M; Rosén, I; Svenningsen, NW, 1995) |
| "Lorazepam was given intravenously at 0." | 1.28 | Lorazepam in the treatment of refractory neonatal seizures. ( King, KC; Maytal, J; Novak, GP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (34.38) | 18.7374 |
| 1990's | 7 (21.88) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 7 (21.88) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Nishimoto, S | 1 |
| Shimakawa, S | 1 |
| Akira, A | 1 |
| Moraes Neto, R | 1 |
| Franklin, GL | 1 |
| Crippa, ACS | 1 |
| Sharawat, IK | 1 |
| Kasinathan, A | 1 |
| Sahu, JK | 1 |
| Sankhyan, N | 1 |
| Kosaka, T | 1 |
| Ohta, G | 1 |
| Kometani, H | 1 |
| Kawatani, M | 1 |
| Ohshima, Y | 1 |
| Chin, EM | 1 |
| Cohen, JS | 1 |
| Harris, J | 1 |
| Mori, T | 1 |
| Goji, A | 1 |
| Toda, Y | 1 |
| Ito, H | 1 |
| Mori, K | 1 |
| Kohmoto, T | 1 |
| Imoto, I | 1 |
| Kagami, S | 1 |
| Singh, D | 1 |
| Lau, M | 1 |
| Ayers, T | 1 |
| Singh, Y | 1 |
| Akingbola, O | 1 |
| Barbiero, L | 1 |
| Nelson, S | 1 |
| Velizarova, R | 1 |
| Gelisse, P | 1 |
| Pageaux, GP | 1 |
| Genton, P | 1 |
| Crespel, A | 1 |
| Vendrame, M | 1 |
| Guilhoto, LM | 1 |
| Loddenkemper, T | 1 |
| Gregas, M | 1 |
| Bourgeois, BF | 1 |
| Kothare, SV | 1 |
| Scher, MS | 1 |
| Alvin, J | 1 |
| Gaus, L | 1 |
| Minnigh, B | 1 |
| Painter, MJ | 1 |
| JABBOUR, JT | 1 |
| JIMENEZESPINOSA, L | 1 |
| BAIRD, HW | 1 |
| Camurdan, MO | 1 |
| Cinaz, P | 1 |
| Serdaroğlu, A | 1 |
| Bideci, A | 1 |
| Demirel, F | 1 |
| Dieterich, E | 1 |
| Walther, B | 1 |
| Goebel, B | 1 |
| Willis, J | 1 |
| Gould, JB | 1 |
| Hellström-Westas, L | 1 |
| Blennow, G | 1 |
| Lindroth, M | 1 |
| Rosén, I | 1 |
| Svenningsen, NW | 1 |
| Eriksson, K | 1 |
| Baer, M | 1 |
| Kilpinen, P | 1 |
| Koivikko, M | 1 |
| Hoppen, T | 1 |
| Elger, CE | 1 |
| Bartmann, P | 1 |
| Gaily, E | 1 |
| Liukkonen, E | 1 |
| Paetau, R | 1 |
| Rekola, R | 1 |
| Granström, ML | 1 |
| Ozawa, H | 1 |
| Kawada, Y | 1 |
| Noma, S | 1 |
| Sugai, K | 1 |
| Aucamp, AK | 1 |
| Speciali, GG | 1 |
| Lison, MP | 1 |
| Trompetter-van Woerden, ML | 1 |
| van der Zwan, A | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Dubowitz, LM | 1 |
| Bouza, H | 1 |
| Hird, MF | 1 |
| Jaeken, J | 1 |
| Vigevano, F | 1 |
| Di Capua, M | 1 |
| Fusco, L | 1 |
| Ricci, S | 1 |
| Sebastianelli, R | 1 |
| Lucchini, P | 1 |
| Maytal, J | 1 |
| Novak, GP | 1 |
| King, KC | 1 |
| Webb, R | 1 |
| Bobele, G | 1 |
| Hakeem, VF | 1 |
| Wallace, SJ | 1 |
| Jorch, G | 1 |
| Rickers, E | 1 |
| Rabe, H | 1 |
| Stöhr, G | 1 |
| Süllwald, A | 1 |
| Michel, E | 1 |
| Kortbeek, LH | 1 |
3 reviews available for phenobarbital and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
The pharmacological treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsies, | 1979 |
'Benign' familial neonatal convulsions.
Topics: Chromosome Aberrations; Chromosome Disorders; Female; Follow-Up Studies; Genes, Dominant; Humans; In | 1990 |
[Epilepsy in children].
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Fever; Humans; Infant; | 1974 |
4 trials available for phenobarbital and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Uncoupling of EEG-clinical neonatal seizures after antiepileptic drug use.
Topics: Anticonvulsants; Electroencephalography; Evoked Potentials; Female; Gestational Age; Humans; Infant, | 2003 |
Infantile spasms: diagnosis and assessment of treatment response by video-EEG.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Clobazam; Electroenceph | 2001 |
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica | 1977 |
[Doppler flow velocities in cerebral arteries in relation to intravenous phenobarbital in premature infants weighing between 500 and 1,500 g].
Topics: Birth Weight; Blood Flow Velocity; Cerebrovascular Circulation; Echoencephalography; Humans; Infant, | 1988 |
25 other studies available for phenobarbital and Cryptogenic Infantile Spasms
| Article | Year |
|---|---|
Response to: "Infantile spasms in Down syndrome responsive to phenobarbital".
Topics: Anticonvulsants; Down Syndrome; Humans; Phenobarbital; Spasms, Infantile | 2022 |
Infantile spasms in Down syndrome responsive to phenobarbital.
Topics: Anticonvulsants; Down Syndrome; Electroencephalography; Humans; Infant; Phenobarbital; Spasms, Infan | 2022 |
Response to Carbamazepine in KCNQ2 Related Early Infantile Epileptic Encephalopathy.
Topics: Carbamazepine; Electroencephalography; Exons; Genetic Predisposition to Disease; Humans; KCNQ2 Potas | 2019 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; | 2019 |
Vigabatrin as a Targeted Treatment of GABA
Topics: Animals; Anticonvulsants; Chromosomes, Human, Pair 9; Drug Substitution; Electroencephalography; Epi | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
De Novo Heterogeneous Mutations in SCN2A and GRIN2A Genes and Seizures With Ictal Vocalizations.
Topics: Anticonvulsants; Clonazepam; Diagnosis, Differential; Electroencephalography; Female; Fructose; Huma | 2016 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
Outcomes of epileptic spasms in patients aged less than 3 years: single-center United States experience.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Electroencephalography; Female; Humans; Infant; Male; | 2012 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
[THERAPY OF EPILEPSY].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Chlordiazepoxide; Epilepsy; Epilepsy, Temporal Lobe; H | 1964 |
CONVULSIONS IN INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Electroencephalography; Encephalitis; Epilepsy; Epilepsy, Absence; Epilepsy, | 1963 |
Persistent hyperinsulinemic hypoglycemia presenting with a rare complication: West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Congenital Hyperinsulinism; Diazoxide; Electroencephal | 2004 |
[Prognostication of neonates by compact polygraphy (author's transl)].
Topics: Cerebral Cortex; Electroencephalography; Evoked Potentials; Humans; Infant, Newborn; Phenobarbital; | 1981 |
Periodic alpha seizures with apnea in a newborn.
Topics: Alpha Rhythm; Female; Humans; Infant, Newborn; Infant, Postmature; Infant, Small for Gestational Age | 1980 |
Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Electroencephalography; Humans; Infant, Low | 1995 |
Effects of long barbiturate anaesthesia on eight children with severe epilepsy.
Topics: Anesthesia, General; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsies | 1993 |
Carbamazepine in phenobarbital-nonresponders: experience with ten preterm infants.
Topics: Administration, Oral; Anticonvulsants; Carbamazepine; Electroencephalography; Female; Follow-Up Stud | 2001 |
Oral high-dose phenobarbital therapy for early infantile epileptic encephalopathy.
Topics: Administration, Oral; Anticonvulsants; Dose-Response Relationship, Drug; Electroencephalography; Hum | 2002 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease.
Topics: Clonazepam; Electroencephalography; Female; gamma-Aminobutyric Acid; Humans; Infant, Newborn; Phenob | 1992 |
Sixth-month benign familial convulsions.
Topics: Electroencephalography; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Infant; Male; Phenob | 1992 |
Lorazepam in the treatment of refractory neonatal seizures.
Topics: Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female; Humans; Infant, Newbor | 1991 |
EEG monitoring of therapy for neonatal seizures.
Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog | 1990 |