phenobarbital has been researched along with Critical Illness in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| " Further research is needed to identify an optimal dosing strategy for TSCU patients at high risk for severe AWS." | 1.91 | Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients. ( Chau, T; Chuang, L; Goldenberg-Sandau, A; Igneri, L; Pham, C; Sensenig, R; Solomon, D, 2023) |
| "Retrospective pilot population pharmacokinetic analysis." | 1.56 | Rapid Increase in Clearance of Phenobarbital in Neonates on Extracorporeal Membrane Oxygenation: A Pilot Retrospective Population Pharmacokinetic Analysis. ( Knibbe, CAJ; Krekels, EHJ; Michaličková, D; Pokorná, P; Slanař, O; Tibboel, D, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 3 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ware, LR | 1 |
| Schuler, BR | 1 |
| Goodberlet, MZ | 1 |
| Marino, KK | 1 |
| Lupi, KE | 1 |
| DeGrado, JR | 1 |
| Pham, C | 1 |
| Goldenberg-Sandau, A | 1 |
| Sensenig, R | 1 |
| Chau, T | 1 |
| Igneri, L | 1 |
| Solomon, D | 1 |
| Chuang, L | 1 |
| Michaličková, D | 1 |
| Pokorná, P | 1 |
| Tibboel, D | 1 |
| Slanař, O | 1 |
| Knibbe, CAJ | 1 |
| Krekels, EHJ | 1 |
| Gagnon, DJ | 1 |
| Fontaine, GV | 1 |
| Riker, RR | 1 |
| Fraser, GL | 1 |
| Dixit, D | 1 |
| Endicott, J | 1 |
| Burry, L | 1 |
| Ramos, L | 1 |
| Yeung, SY | 1 |
| Devabhakthuni, S | 1 |
| Chan, C | 1 |
| Tobia, A | 1 |
| Bulloch, MN | 1 |
| Smetana, KS | 1 |
| Cook, AM | 1 |
| Bastin, ML | 1 |
| Oyler, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenobarbital Versus Ativan for Refractory Alcohol Withdrawal Treatment in the Intensive Care Unit[NCT04156464] | Phase 4 | 142 participants (Anticipated) | Interventional | 2020-07-06 | Recruiting | ||
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for phenobarbital and Critical Illness
| Article | Year |
|---|---|
Repurposing Valproate, Enteral Clonidine, and Phenobarbital for Comfort in Adult ICU Patients: A Literature Review with Practical Considerations.
Topics: Administration, Oral; Administration, Sublingual; Adult; Clonidine; Critical Illness; Drug Repositio | 2017 |
Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients.
Topics: Baclofen; Benzodiazepines; Critical Illness; Dexmedetomidine; Ethanol; Humans; Length of Stay; Pheno | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
3 other studies available for phenobarbital and Critical Illness
| Article | Year |
|---|---|
Evaluation of Dexmedetomidine as an Adjunct to Phenobarbital for Alcohol Withdrawal in Critically Ill Patients.
Topics: Adult; Alcoholism; Benzodiazepines; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics a | 2023 |
Phenobarbital for the Management of Alcohol Withdrawal Syndrome in Critically Ill, Surgical-Trauma Patients.
Topics: Alcoholism; Benzodiazepines; Critical Illness; Humans; Phenobarbital; Retrospective Studies; Substan | 2023 |
Rapid Increase in Clearance of Phenobarbital in Neonates on Extracorporeal Membrane Oxygenation: A Pilot Retrospective Population Pharmacokinetic Analysis.
Topics: Adult; Critical Illness; Drug Monitoring; Extracorporeal Membrane Oxygenation; Humans; Infant, Newbo | 2020 |