phenobarbital has been researched along with Crigler Najjar Syndrome in 37 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 8.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| "Crigler-Najjar syndrome (CN) type II is a congenital disease with unconjugated hyperbilirubinemia due to a deficiency of uridine 5'-diphospho-glucuronosyltransferase 1A1." | 7.83 | Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II. ( Hammann, F; Haschke, M; Krähenbühl, S; Kummer, O, 2016) |
| " We report the case of a Gly71-->Arg/Tyr486-->Asp homozygous mother of East Asian descent, who was treated with phototherapy during embryogenesis and with phenobarbital during the rest of the pregnancy." | 7.73 | Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II. ( Egberts, EH; Holstein, A; Lohse, P; Plaschke, A, 2005) |
| "The effect of phenobarbital treatment on bilirubin metabolism and bile secretion was studied in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis." | 7.66 | Effect of phenobarbital on serum and biliary parameters in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis. ( Malet, PF; Rosato, EF; Roy-Chowdhury, J; Shaw, L; Trotman, BW, 1983) |
| "A 37-year-old mother with CNS type II was treated with phenobarbital during her pregnancy and her bilirubin levels were monitored." | 4.85 | Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature. ( Koelbl, H; Kohlschmidt, N; Passuello, V; Puhl, AG; Skala, C; Steiner, E; Wirth, S, 2009) |
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 4.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| " Patients with Crigglar-Najjar syndrome type II respond to phenobarbital therapy which decreases their chances of getting bilirubinemia by 60-70% in 3 weeks." | 3.88 | Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth. ( Ameer, A; Attiq, H; Imran, M; Liaqat, A; Shahid, A, 2018) |
| "Crigler-Najjar syndrome (CN) type II is a congenital disease with unconjugated hyperbilirubinemia due to a deficiency of uridine 5'-diphospho-glucuronosyltransferase 1A1." | 3.83 | Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II. ( Hammann, F; Haschke, M; Krähenbühl, S; Kummer, O, 2016) |
| " We report the case of a Gly71-->Arg/Tyr486-->Asp homozygous mother of East Asian descent, who was treated with phototherapy during embryogenesis and with phenobarbital during the rest of the pregnancy." | 3.73 | Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II. ( Egberts, EH; Holstein, A; Lohse, P; Plaschke, A, 2005) |
| "The effect of phenobarbital treatment on bilirubin metabolism and bile secretion was studied in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis." | 3.66 | Effect of phenobarbital on serum and biliary parameters in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis. ( Malet, PF; Rosato, EF; Roy-Chowdhury, J; Shaw, L; Trotman, BW, 1983) |
| "Orlistat treatment increases fecal fat excretion and decreases plasma unconjugated bilirubin (UCB) concentrations in Gunn rats, the animal model for CN disease." | 2.73 | Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial. ( Hafkamp, AM; Nelisse-Haak, R; Oude Elferink, RP; Sinaasappel, M; Verkade, HJ, 2007) |
| "Clinically apparent jaundice is unusual in patients with beta-thalassemia major." | 1.36 | Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome. ( Aggarwal, V; Aneja, S; Fabiano, C; Sammarco, P; Seth, A; Sharma, S, 2010) |
| "Phenobarbital treatment of Gunn recipients of jejunal transplants from Wistar rats normalizes serum bilirubin levels." | 1.29 | The use of jejunal transplants to treat a genetic enzyme deficiency. ( Burgos, AA; Jaffe, BM; Martinez-Noack, M, 1996) |
| "The recognition that Gilbert's syndrome is a quite heterogeneous entity will allow a better understanding of the mode of inheritance of this disorder; its relationship to Crigler-Najjar type II disease also awaits further definition." | 1.27 | Familial unconjugated hyperbilirubinemia syndromes. ( Reichen, J, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (29.73) | 18.7374 |
| 1990's | 9 (24.32) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 9 (24.32) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Cozzi, L | 1 |
| Nuti, F | 1 |
| Degrassi, I | 1 |
| Civeriati, D | 1 |
| Paolella, G | 1 |
| Nebbia, G | 1 |
| Aronson, SJ | 1 |
| Veron, P | 1 |
| Collaud, F | 1 |
| Hubert, A | 1 |
| Delahais, V | 1 |
| Honnet, G | 1 |
| de Knegt, RJ | 1 |
| Junge, N | 1 |
| Baumann, U | 1 |
| Di Giorgio, A | 1 |
| D'Antiga, L | 1 |
| Ginocchio, VM | 1 |
| Brunetti-Pierri, N | 1 |
| Labrune, P | 1 |
| Beuers, U | 1 |
| Bosma, PJ | 2 |
| Mingozzi, F | 1 |
| Liaqat, A | 1 |
| Shahid, A | 1 |
| Attiq, H | 1 |
| Ameer, A | 1 |
| Imran, M | 1 |
| Gailite, L | 1 |
| Rots, D | 1 |
| Pukite, I | 1 |
| Cernevska, G | 1 |
| Kreile, M | 1 |
| Shi, X | 1 |
| Aronson, S | 1 |
| Khan, AS | 1 |
| Kummer, O | 1 |
| Hammann, F | 1 |
| Haschke, M | 1 |
| Krähenbühl, S | 1 |
| Rubio Gómez, I | 1 |
| López González, MF | 1 |
| Ibáñez Alcalde, MM | 1 |
| Cañabate Reche, F | 1 |
| Passuello, V | 1 |
| Puhl, AG | 1 |
| Wirth, S | 1 |
| Steiner, E | 1 |
| Skala, C | 1 |
| Koelbl, H | 1 |
| Kohlschmidt, N | 1 |
| Aggarwal, V | 1 |
| Seth, A | 1 |
| Sharma, S | 1 |
| Aneja, S | 1 |
| Sammarco, P | 1 |
| Fabiano, C | 1 |
| Holstein, A | 2 |
| Bryan, CS | 1 |
| Liu, WL | 1 |
| Li, F | 1 |
| He, ZX | 1 |
| Jiang, HY | 1 |
| Ai, R | 1 |
| Chen, XX | 1 |
| Huang, K | 1 |
| Plaschke, A | 1 |
| Lohse, P | 1 |
| Egberts, EH | 1 |
| Torres, M | 1 |
| Bruguera, M | 1 |
| Maruo, Y | 1 |
| Topaloglu, AK | 1 |
| Takahashi, H | 2 |
| Mori, A | 1 |
| Iwai, M | 1 |
| Duzovali, O | 1 |
| Yamamoto, K | 1 |
| Matui, K | 1 |
| Sato, H | 1 |
| Takeuchi, Y | 1 |
| Hafkamp, AM | 1 |
| Nelisse-Haak, R | 1 |
| Sinaasappel, M | 2 |
| Oude Elferink, RP | 1 |
| Verkade, HJ | 1 |
| Reichen, J | 1 |
| Trotman, BW | 1 |
| Shaw, L | 1 |
| Roy-Chowdhury, J | 1 |
| Malet, PF | 1 |
| Rosato, EF | 1 |
| Younossi, ZM | 1 |
| Foroozan, P | 1 |
| Rubaltelli, FF | 1 |
| Novello, A | 1 |
| Zancan, L | 1 |
| Vilei, MT | 1 |
| Muraca, M | 2 |
| Jaffe, BM | 1 |
| Burgos, AA | 1 |
| Martinez-Noack, M | 1 |
| Ciotti, M | 1 |
| Werlin, SL | 1 |
| Owens, IS | 1 |
| Jansen, PL | 2 |
| Ito, T | 1 |
| Katagiri, C | 1 |
| Ikeno, S | 1 |
| Nagata, N | 1 |
| Terakawa, N | 1 |
| Lee, WS | 1 |
| McKiernan, PJ | 1 |
| Beath, SV | 1 |
| Preece, MA | 1 |
| Baty, D | 1 |
| Kelly, DA | 1 |
| Burchell, B | 1 |
| Clarke, DJ | 1 |
| Plöchl, E | 1 |
| Hohenwallner, W | 1 |
| Wehinger, H | 1 |
| Gollan, JL | 2 |
| Huang, SN | 2 |
| Billing, B | 1 |
| Sherlock, S | 2 |
| Stiehl, A | 1 |
| Berk, PD | 1 |
| Martin, JF | 1 |
| Blaschke, TF | 1 |
| Scharschmidt, BF | 1 |
| Plotz, PH | 1 |
| Volodin, NN | 1 |
| Persico, M | 1 |
| Romano, M | 1 |
| Gentile, S | 1 |
| Mori, Y | 1 |
| Kimura, H | 1 |
| Suehiro, K | 1 |
| Naritomi, Y | 1 |
| Maeda, Y | 1 |
| Kusaba, T | 1 |
| Ishibashi, D | 1 |
| Pett, S | 1 |
| Mowat, AP | 1 |
| Duhamel, G | 1 |
| Blanckaert, N | 1 |
| Metreau, JM | 1 |
| Préaux, AM | 1 |
| Bouvry, M | 1 |
| Fevery, J | 1 |
| Berthelot, P | 1 |
| Scheig, R | 1 |
| Billing, BH | 1 |
5 reviews available for phenobarbital and Crigler Najjar Syndrome
| Article | Year |
|---|---|
Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
Topics: Adult; Bilirubin; Crigler-Najjar Syndrome; Female; Hearing Disorders; Humans; Infant; Infant, Newbor | 2009 |
[Crigler-Najjar syndrome].
Topics: Bilirubin; Calcium Phosphates; Chemotherapy, Adjuvant; Crigler-Najjar Syndrome; Diagnosis, Different | 2005 |
Diagnosis and management of Crigler-Najjar syndrome.
Topics: Animals; Bilirubin; Child; Crigler-Najjar Syndrome; Female; Humans; Kernicterus; Liver Transplantati | 1999 |
Phenobarbital following phototherapy for Crigler-Najjar syndrome type II with good fetal outcome: a case report.
Topics: Adult; Anticonvulsants; Crigler-Najjar Syndrome; Female; Humans; Infant, Newborn; Phenobarbital; Pho | 2001 |
[Congenital nonhemolytic hyperbilirubinemias].
Topics: Adolescent; Adult; Age Factors; Bilirubin; Child; Child, Preschool; Cholestasis; Chronic Disease; Cr | 1977 |
1 trial available for phenobarbital and Crigler Najjar Syndrome
| Article | Year |
|---|---|
Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial.
Topics: Adolescent; Adult; Anti-Obesity Agents; Bilirubin; Child; Combined Modality Therapy; Crigler-Najjar | 2007 |
31 other studies available for phenobarbital and Crigler Najjar Syndrome
| Article | Year |
|---|---|
Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity.
Topics: Bilirubin; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyperb | 2022 |
Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler-Najjar Syndrome.
Topics: Adolescent; Adult; Animals; Antibodies, Neutralizing; Antibodies, Viral; Bilirubin; Capsid; Child; C | 2019 |
Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth.
Topics: Adolescent; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyper | 2018 |
Case report: multiple UGT1A1 gene variants in a patient with Crigler-Najjar syndrome.
Topics: Adolescent; Crigler-Najjar Syndrome; Glucuronosyltransferase; Humans; Male; Mutation; Phenobarbital; | 2018 |
A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report.
Topics: Adolescent; Bilirubin; Codon, Terminator; Crigler-Najjar Syndrome; DNA Mutational Analysis; Exons; F | 2019 |
Reduction of hyperbilirubinemia with hypericum extract (St. John's Wort) in a patient with Crigler-Najjar syndrome type II.
Topics: Adult; Area Under Curve; Bilirubin; Crigler-Najjar Syndrome; Cytochrome P-450 CYP3A; Enzyme Inductio | 2016 |
[Phenobarbital in Crigler-Najjar syndrome type 1: A therapeutic option].
Topics: Crigler-Najjar Syndrome; Humans; Infant, Newborn; Male; Phenobarbital | 2016 |
Persistent jaundice in an infant with homozygous beta thalassemia due to co-inherited Crigler-Najjar syndrome.
Topics: beta-Thalassemia; Crigler-Najjar Syndrome; Erythrocyte Transfusion; Fatal Outcome; GABA Modulators; | 2010 |
Three consecutive pregnancies in a woman with Crigler-Najjar syndrome type II with good maternal and neonatal outcomes.
Topics: Adult; Anticonvulsants; Cesarean Section; Crigler-Najjar Syndrome; Female; Humans; Infant, Newborn; | 2011 |
Analysis of bilirubin UDP-glucuronosyltransferase gene mutations in an unusual Crigler-Najjar syndrome patient.
Topics: Anticonvulsants; Crigler-Najjar Syndrome; DNA Mutational Analysis; Exons; Glucuronosyltransferase; H | 2012 |
Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II.
Topics: Adult; Anticonvulsants; Crigler-Najjar Syndrome; Female; Follow-Up Studies; Humans; Infant, Newborn; | 2005 |
Crigler-Najjar syndrome type II caused by a homozygous triple mutation [T-3279G, A(TA)7TAA, and H39D] of UGT1A1.
Topics: Blotting, Western; Child; Crigler-Najjar Syndrome; Gene Expression Regulation, Enzymologic; Genetic | 2006 |
Familial unconjugated hyperbilirubinemia syndromes.
Topics: Animals; Bile Acids and Salts; Bilirubin; Crigler-Najjar Syndrome; Diagnosis, Differential; Disease | 1983 |
Effect of phenobarbital on serum and biliary parameters in a patient with Crigler-Najjar syndrome, type II and acquired cholestasis.
Topics: Adult; Bile; Cholestasis; Crigler-Najjar Syndrome; Humans; Hyperbilirubinemia, Hereditary; Liver Fun | 1983 |
Treatment of Crigler-Najjar type II with small-dose phenobarbital.
Topics: Adult; Atropine; Crigler-Najjar Syndrome; Drug Combinations; Female; Humans; Phenobarbital; Scopolam | 1995 |
Serum and bile bilirubin pigments in the differential diagnosis of Crigler-Najjar disease.
Topics: Administration, Oral; Bile; Bile Pigments; Bilirubin; Chromatography, High Pressure Liquid; Crigler- | 1994 |
The use of jejunal transplants to treat a genetic enzyme deficiency.
Topics: Animals; Bilirubin; Crigler-Najjar Syndrome; Disease Models, Animal; Jejunum; Phenobarbital; Rats; R | 1996 |
Delayed response to phenobarbital treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene.
Topics: Bilirubin; Crigler-Najjar Syndrome; Fluid Therapy; Glucuronosyltransferase; Humans; Hyperbilirubinem | 1999 |
Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy.
Topics: Bile Pigments; Bilirubin; Chromatography, High Pressure Liquid; Crigler-Najjar Syndrome; Diagnosis, | 2001 |
[Treatment of Crigler-Najjar's congenital familial non-hemolytic jaundice with kernicterus].
Topics: Crigler-Najjar Syndrome; Developmental Disabilities; Epilepsy; Female; Humans; Hyperbilirubinemia; H | 1978 |
Prolonged survival in three brothers with severe type 2 Crigler-Najjar syndrome. Ultrastructural and metabolic studies.
Topics: Bile Acids and Salts; Bile Pigments; Bilirubin; Crigler-Najjar Syndrome; Electroencephalography; Glu | 1975 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
Unconjugated hyperbilirubinemia. Physiologic evaluation and experimental approaches to therapy.
Topics: Adult; Albumins; Animals; Bilirubin; Crigler-Najjar Syndrome; Ethosuximide; Female; Gilbert Disease; | 1975 |
[Crigler-Najjar syndrome in an infant during the 1st year of life].
Topics: Crigler-Najjar Syndrome; Follow-Up Studies; Humans; Infant; Male; Phenobarbital; Phototherapy; Time | 1991 |
Responsiveness to phenobarbital in an adult with Crigler-Najjar disease associated with neurological involvement and skin hyperextensibility.
Topics: Adult; Bilirubin; Chromatography, High Pressure Liquid; Crigler-Najjar Syndrome; Epilepsy, Tonic-Clo | 1991 |
[A case of Crigler-Najjar syndrome of type II].
Topics: Adolescent; Bilirubin; Crigler-Najjar Syndrome; Glucuronosyltransferase; Humans; Liver; Male; Phenob | 1991 |
The differential diagnosis of Crigler-Najjar disease, types 1 and 2, by bile pigment analysis.
Topics: Bile; Bile Acids and Salts; Bile Pigments; Bilirubin; Child; Crigler-Najjar Syndrome; Diagnosis, Dif | 1991 |
Crigler-Najjar syndrome types I and II. Clinical experience--King's College Hospital 1972-1978. Phenobarbitone, phototherapy and liver transplantation.
Topics: Child; Child, Preschool; Crigler-Najjar Syndrome; Female; Humans; Hyperbilirubinemia, Hereditary; In | 1987 |
An unusual case of Crigler-Najjar disease in the adult. Classification into types I and II revisited.
Topics: Adult; Bile; Bile Acids and Salts; Bilirubin; Crigler-Najjar Syndrome; Glucuronosyltransferase; Huma | 1985 |
Neonatal jaundice.
Topics: Albumins; Bile Ducts; Bilirubin; Breast Feeding; Crigler-Najjar Syndrome; Erythroblastosis, Fetal; E | 1974 |
Proceedings: Prolonged survival in the Crigler-Najjar syndrome: ultrastructural and dietary studies.
Topics: Bilirubin; Cell Membrane; Crigler-Najjar Syndrome; Endoplasmic Reticulum; Glucose; Golgi Apparatus; | 1974 |