phenobarbital has been researched along with Constitutional Liver Dysfunction in 41 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 8.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| "Several mutations of bilirubin uridine diphosphate-glucuronosyltransferase gene (UGT1A1) have been reported in patients with unconjugated hyperbilirubinemia." | 4.12 | Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity. ( Civeriati, D; Cozzi, L; Degrassi, I; Nebbia, G; Nuti, F; Paolella, G, 2022) |
| " Patients with Crigglar-Najjar syndrome type II respond to phenobarbital therapy which decreases their chances of getting bilirubinemia by 60-70% in 3 weeks." | 3.88 | Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth. ( Ameer, A; Attiq, H; Imran, M; Liaqat, A; Shahid, A, 2018) |
| "An oral tolerance test using a 25-mg dose of ursodeoxycholic acid was carried out in 46 patients with constitutional hyperbilirubinemias: 26 with Gilbert's syndrome, 9 with Dubin-Johnson syndrome, 7 with Rotor Syndrome, 3 with constitutional indocyanine green intolerance, and 1 with Crigler-Najjar syndrome type II; they were compared with 14 healthy control subjects." | 3.66 | Ursodeoxycholic acid oral tolerance test in patients with constitutional hyperbilirubinemias and effect of phenobarbital. ( Iida, S; Makino, I; Ohkubo, H; Okuda, K, 1981) |
| "Salicylamide glucuronide (SAMG) in 0-6 and 6-12 hours-urine specimens was determined after oral administration of salicylamide in 7 normal volunteers (NV), in 51 cases of various liver diseases and hyperbilirubinemias, and in 19 cases after drug administration, to predict the in vivo drug metabolism in man and its change by drugs." | 3.65 | Salycylamide glucuronide formation in liver disease and its change by drugs. ( Adachi, Y; Wakisaka, G; Yamamoto, T, 1975) |
| "Neonatal hyperbilirubinemia is frequent and severe in Japanese newborns." | 1.33 | Neonatal hyperbilirubinemia and the bilirubin uridine diphosphate-glucuronosyltransferase gene: the common -3263T > G mutation of phenobarbital response enhancer module is not associated with the neonatal hyperbilirubinemia in Japanese. ( Aikawa, S; Akaba, K; Hayasaka, K; Kanai, M; Kijima, K; Kurachi, H; Sasaki, A; Shirahata, E; Tezuka, N; Umetsu, K, 2005) |
| "The recognition that Gilbert's syndrome is a quite heterogeneous entity will allow a better understanding of the mode of inheritance of this disorder; its relationship to Crigler-Najjar type II disease also awaits further definition." | 1.27 | Familial unconjugated hyperbilirubinemia syndromes. ( Reichen, J, 1983) |
| "Phenobarbital treatment resulted in significant increases in serum GGT activity (p less than 0." | 1.26 | Effects of phenobarbital on unconjugated bilirubin clearance, gamma-glutamyltranspeptidase and urinary d-glucaric acid in patients with Gilbert's syndrome. ( Hirayama, C; Kawasaki, H; Kimura, N; Murawaki, Y, 1982) |
| "Phenobarbital treatment significantly reduced the level of unconjugated serum bilirubin in patients with acute hepatitis or Gilbert's syndrome, but without any difference within these two groups of patients." | 1.26 | Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests. ( Hardt, F; Juhl, E; Thomsen, HF, 1981) |
| "In 16 patients suffering from Gilbert's syndrome, there was a decrease in the level of serum bilirubin, and increase of D-glucuric-acid output in urine and bromsulphophthalein transport maximum following the treatment of this drug given in 150 mg/day orally for three weeks." | 1.26 | Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat. ( Gógl, A; Klinger, W; Müller, D; Ruzsa, C; Simon, K; Vezekényi, Z, 1979) |
| "The pathophysiology of Gilbert's syndrome was studied by investigating the metabolism of the drug tolbutamide, which is metabolised by the liver but does not undergo glucuronidation." | 1.26 | Alteration of drug metabolism in Gilbert's syndrome. ( Carulli, N; Ferrari, A; Manenti, F; Mauro, E; Ponz de Leon, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (70.73) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 5 (12.20) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Cozzi, L | 1 |
| Nuti, F | 1 |
| Degrassi, I | 1 |
| Civeriati, D | 1 |
| Paolella, G | 1 |
| Nebbia, G | 1 |
| Liaqat, A | 1 |
| Shahid, A | 1 |
| Attiq, H | 1 |
| Ameer, A | 1 |
| Imran, M | 1 |
| Garg, PK | 1 |
| Kumar, A | 1 |
| Teckchandani, N | 1 |
| Hadke, NS | 1 |
| Ismail, AQ | 1 |
| Gandhi, A | 1 |
| El-Shimy, N | 1 |
| Kanai, M | 1 |
| Kijima, K | 1 |
| Shirahata, E | 1 |
| Sasaki, A | 1 |
| Akaba, K | 1 |
| Umetsu, K | 1 |
| Tezuka, N | 1 |
| Kurachi, H | 1 |
| Aikawa, S | 1 |
| Hayasaka, K | 1 |
| Costa, E | 1 |
| Vieira, E | 1 |
| Dos Santos, R | 1 |
| Torres, M | 1 |
| Bruguera, M | 1 |
| Kawasaki, H | 1 |
| Murawaki, Y | 1 |
| Kimura, N | 1 |
| Hirayama, C | 1 |
| Narang, AP | 1 |
| Datta, DV | 1 |
| Reichen, J | 1 |
| Cruz, NS | 1 |
| Alváez, RG | 1 |
| Trelles, JB | 1 |
| Ohkubo, H | 1 |
| Okuda, K | 1 |
| Iida, S | 1 |
| Makino, I | 1 |
| Iwańczak, F | 1 |
| Prandota, J | 1 |
| Thomsen, HF | 1 |
| Hardt, F | 1 |
| Juhl, E | 1 |
| Beckh, K | 1 |
| Orrett, FA | 1 |
| Lee, WS | 1 |
| McKiernan, PJ | 1 |
| Beath, SV | 1 |
| Preece, MA | 1 |
| Baty, D | 1 |
| Kelly, DA | 1 |
| Burchell, B | 1 |
| Clarke, DJ | 1 |
| Mechkov, G | 1 |
| Dimov, D | 1 |
| Iordanova, Iu | 1 |
| Adachi, Y | 2 |
| Wakisaka, G | 1 |
| Yamamoto, T | 2 |
| Kuwahara, I | 1 |
| Wehinger, H | 1 |
| Schenk, J | 1 |
| Gentile, S | 1 |
| Porcellini, M | 1 |
| Foglia, F | 1 |
| Coltorti, M | 1 |
| Gógl, A | 1 |
| Simon, K | 1 |
| Müller, D | 1 |
| Klinger, W | 1 |
| Ruzsa, C | 1 |
| Vezekényi, Z | 1 |
| Goresky, CA | 1 |
| Gordon, ER | 1 |
| Shaffer, EA | 1 |
| Paré, P | 1 |
| Carassavas, D | 1 |
| Aronoff, A | 1 |
| Nusinovici, V | 1 |
| Darnis, F | 1 |
| Levy, VG | 1 |
| Caroli, J | 1 |
| Bock, KW | 1 |
| Lovisetto, P | 2 |
| Giorcelli, W | 2 |
| Actis, GC | 2 |
| Biarese, V | 2 |
| Stiehl, A | 1 |
| Kirshenbaum, G | 1 |
| Shames, DM | 1 |
| Schmid, R | 1 |
| Carulli, N | 1 |
| Ponz de Leon, M | 1 |
| Mauro, E | 1 |
| Manenti, F | 1 |
| Ferrari, A | 1 |
| Fevery, J | 1 |
| Berk, PD | 2 |
| Martin, JF | 1 |
| Blaschke, TF | 2 |
| Scharschmidt, BF | 2 |
| Plotz, PH | 1 |
| Bode, JC | 1 |
| Sinaasappel, M | 1 |
| Jansen, PL | 1 |
| Vasil'ev, VS | 1 |
| Tsyrkunov, VM | 1 |
| Bogutskiĭ, MI | 1 |
| Bushma, MI | 1 |
| Abakumov, GZ | 1 |
| Eselev, MM | 1 |
| Stsepuro, PG | 1 |
| Rodkey, FL | 1 |
| Collison, HA | 1 |
| Waggoner, JG | 1 |
| Jézéquel, AM | 1 |
| Koch, M | 1 |
| Orlandi, F | 1 |
| Del Ninno, E | 1 |
| Tornaghi, G | 1 |
| Tripodi, A | 1 |
| Colombo, M | 1 |
3 reviews available for phenobarbital and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
[Crigler-Najjar syndrome].
Topics: Bilirubin; Calcium Phosphates; Chemotherapy, Adjuvant; Crigler-Najjar Syndrome; Diagnosis, Different | 2005 |
[Congenital nonhemolytic hyperbilirubinemias].
Topics: Adolescent; Adult; Age Factors; Bilirubin; Child; Child, Preschool; Cholestasis; Chronic Disease; Cr | 1977 |
[Hepatic-cell enzyme induction using phenobarbital: applications to the treatment of jaundice].
Topics: Bile Acids and Salts; Bilirubin; Cholestasis; Chronic Disease; Enzyme Induction; Gilbert Disease; Hu | 1976 |
3 trials available for phenobarbital and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
Comparison of in-vivo and in-vitro drug metabolism in patients with Gilbert's syndrome.
Topics: Adult; Antipyrine; Bilirubin; Clinical Trials as Topic; Female; Gilbert Disease; Humans; Hyperbiliru | 1982 |
[Effectiveness of phenobarbital, ziksorin and cordiamine in the treatment of non-conjugated hyperbilirubinemia].
Topics: Adolescent; Adult; Benzhydryl Compounds; Bilirubin; Clinical Trials as Topic; Drug Therapy, Combinat | 1989 |
[The use of optimal doses of phenobarbital in the treatment of Gilbert's syndrome].
Topics: Adult; Clinical Trials as Topic; Female; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Ma | 1988 |
35 other studies available for phenobarbital and Constitutional Liver Dysfunction
| Article | Year |
|---|---|
Gilbert or Crigler-Najjar syndrome? Neonatal severe unconjugated hyperbilirubinemia with P364L UGT1A1 homozygosity.
Topics: Bilirubin; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyperb | 2022 |
Crigler-Najjar Syndrome Type II Diagnosed in a Patient with Jaundice Since Birth.
Topics: Adolescent; Crigler-Najjar Syndrome; Female; Gilbert Disease; Glucuronosyltransferase; Humans; Hyper | 2018 |
Hereditary spherocytosis coexisting with Gilbert's syndrome: a diagnostic dilemma.
Topics: Adolescent; Bilirubin; Caloric Restriction; Diagnosis, Differential; Gilbert Disease; Humans; Hyperb | 2008 |
Intractable neonatal jaundice due to hereditary spherocytosis and Gilbert's syndrome.
Topics: Diagnosis, Differential; Female; GABA Modulators; Gilbert Disease; Humans; Infant, Newborn; Jaundice | 2011 |
Neonatal hyperbilirubinemia and the bilirubin uridine diphosphate-glucuronosyltransferase gene: the common -3263T > G mutation of phenobarbital response enhancer module is not associated with the neonatal hyperbilirubinemia in Japanese.
Topics: Asian People; Gene Frequency; Gilbert Disease; Glucuronosyltransferase; Humans; Infant, Newborn; Jap | 2005 |
The polymorphism c.-3279T>G in the phenobarbital-responsive enhancer module of the bilirubin UDP-glucuronosyltransferase gene is associated with Gilbert syndrome.
Topics: Adolescent; Adult; Enhancer Elements, Genetic; Female; Gilbert Disease; Glucuronosyltransferase; Hum | 2005 |
Effects of phenobarbital on unconjugated bilirubin clearance, gamma-glutamyltranspeptidase and urinary d-glucaric acid in patients with Gilbert's syndrome.
Topics: Adult; Bilirubin; Female; gamma-Glutamyltransferase; Gilbert Disease; Glucaric Acid; Humans; Hyperbi | 1982 |
Familial unconjugated hyperbilirubinemia syndromes.
Topics: Animals; Bile Acids and Salts; Bilirubin; Crigler-Najjar Syndrome; Diagnosis, Differential; Disease | 1983 |
[Gilbert's disease. Presentation of 2 cases].
Topics: Adolescent; Bilirubin; Bone Marrow; Child; Energy Intake; Female; Gilbert Disease; Humans; Hyperbili | 1982 |
Ursodeoxycholic acid oral tolerance test in patients with constitutional hyperbilirubinemias and effect of phenobarbital.
Topics: Administration, Oral; Adult; Deoxycholic Acid; Female; Gilbert Disease; Humans; Hyperbilirubinemia, | 1981 |
[Gilbert's syndrome. Diagnostic difficulties and successful use of the luminal test].
Topics: Adolescent; Bilirubin; Child; Diagnosis, Differential; Female; Gilbert Disease; Humans; Hyperbilirub | 1980 |
Diagnosis of Gilbert's syndrome. Reliability of the caloric restriction and phenobarbital stimulation tests.
Topics: Acute Disease; Adolescent; Adult; Bilirubin; Diagnosis, Differential; Energy Intake; Fasting; Female | 1981 |
[Does hyperbilirubinemia in Meulengracht disease (Gilbert syndrome) need treatment?].
Topics: Adult; Bilirubin; Female; Gilbert Disease; Humans; Hyperbilirubinemia; Male; Phenobarbital | 1994 |
The role of reduced calorie intake test in diagnosing Gilbert syndrome--a case report.
Topics: Adult; Bilirubin; Energy Intake; Gilbert Disease; Humans; Male; Phenobarbital | 1993 |
Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy.
Topics: Bile Pigments; Bilirubin; Chromatography, High Pressure Liquid; Crigler-Najjar Syndrome; Diagnosis, | 2001 |
[Proceedings: Serum gamma-glutamyl tranapeptidase activity after the induction and inhibition of liver microsomal enzymes in nonconjugated hyperbilirubinemia].
Topics: Enzyme Induction; Enzyme Repression; gamma-Glutamyltransferase; Gilbert Disease; Humans; Hyperbiliru | 1976 |
Salycylamide glucuronide formation in liver disease and its change by drugs.
Topics: Adolescent; Adult; Aged; Barbiturates; Bilirubin; Child; Female; Gilbert Disease; Glucuronates; Hepa | 1975 |
Effects of bucolome and related barbiturate derivatives on the displacement of bilirubin from plasma albumin in vivo and in vitro.
Topics: Animals; Barbiturates; Bilirubin; Gilbert Disease; Hyperbilirubinemia; In Vitro Techniques; Male; Ph | 1979 |
[Hyperbilirubinemias; diagnostic and therapeutic aspects].
Topics: Adult; Bilirubin; Diagnosis, Differential; Gilbert Disease; Hemolysis; Humans; Hyperbilirubinemia; I | 1979 |
[Mechanisms of detecting organic cholephilic anions in man: comparative studies on plasma depuration of rifamycin-SV. Interference of nicotinic acid and phenobarbital].
Topics: Adolescent; Adult; Female; Gilbert Disease; Humans; Liver; Male; Metabolic Clearance Rate; Nicotinic | 1979 |
Enzyme-inductive effect of a hypolipidemic compound N-bis-(p-chlorophenoxy)-acetyl-urea in man and rat.
Topics: Adolescent; Adult; Animals; Chemical Phenomena; Chemistry; Clofibrate; Clofibric Acid; Cytochrome P- | 1979 |
Definition of a conjugation of dysfunction in Gilbert's syndrome: studies of the handling of bilirubin loads and of the pattern of bilirubin conjugates secreted in bile.
Topics: Adolescent; Adult; Bile; Bile Pigments; Bilirubin; Fasting; Female; Gilbert Disease; Humans; Hyperbi | 1978 |
[Conjugation of bilirubin--enzymatic aspects].
Topics: Bilirubin; Gilbert Disease; Glucuronates; Glucuronosyltransferase; Humans; Microsomes, Liver; Phenob | 1976 |
[Gilbert's jaundice. Current clinico-nosographic, physiopathological and therapeutic aspects. III. Therapeutic action of enzyme inductors with reference to unconjugated bilirubin icterus].
Topics: Adult; Enzyme Induction; Female; Gilbert Disease; Glucuronates; Humans; Hyperbilirubinemia, Heredita | 1977 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
An expanded model of bilirubin kinetics: effect of feeding, fasting, and phenobarbital in Gilbert's syndrome.
Topics: Adult; Bilirubin; Eating; Fasting; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Kinetics | 1976 |
[Gilbert's jaundice. Current clinico-nosographical, physiopathological and therapeutic aspects. Note II. The phenomenon of enzyme induction at the level of the liver].
Topics: Amino Acids; Animals; Enzyme Induction; Gilbert Disease; Humans; Hyperbilirubinemia, Hereditary; Liv | 1976 |
Alteration of drug metabolism in Gilbert's syndrome.
Topics: Adult; Animals; Cytoplasm; Gilbert Disease; Half-Life; Humans; Hyperbilirubinemia, Hereditary; Liver | 1976 |
Conjugation of bilirubin--pathophysiological aspects.
Topics: Bilirubin; Fasting; Gilbert Disease; Glutethimide; Hyperbilirubinemia; Nicotinic Acids; Obesity; Phe | 1976 |
Unconjugated hyperbilirubinemia. Physiologic evaluation and experimental approaches to therapy.
Topics: Adult; Albumins; Animals; Bilirubin; Crigler-Najjar Syndrome; Ethosuximide; Female; Gilbert Disease; | 1975 |
[The therapeutic possibilities in Gilbert's disease].
Topics: Combined Modality Therapy; Gilbert Disease; Glucose; Humans; Hyperbilirubinemia; Phenobarbital; Ultr | 1992 |
The differential diagnosis of Crigler-Najjar disease, types 1 and 2, by bile pigment analysis.
Topics: Bile; Bile Acids and Salts; Bile Pigments; Bilirubin; Child; Crigler-Najjar Syndrome; Diagnosis, Dif | 1991 |
Drugs and the liver. I. Effects of glutethimide and phenobarbital on hepatic bilirubin clearance, plasma bilirubin turnover and carbon monoxide production in man.
Topics: Bilirubin; Carbon Monoxide; Carbon Radioisotopes; Chromium Radioisotopes; Female; Gilbert Disease; G | 1974 |
A morphometric study of the endoplasmic reticulum in human hepatocytes. Correlation between morphological and biochemical data in subjects under treatment with certain drugs.
Topics: Biopsy; Carbon Radioisotopes; Cell Membrane; Cell Nucleus; Cholesterol; Diazepam; Endoplasmic Reticu | 1974 |
[The d-glucaric acid test in the evaluation of the inductive properties of phenobarbital and spironalactone].
Topics: Adipates; Adolescent; Adult; Bilirubin; Enzyme Induction; Female; Gilbert Disease; Humans; Hyperbili | 1974 |