phenobarbital has been researched along with Concussive Convulsion in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Maintenance dosage adjustments, when necessary, were based on serial plasma concentrations of the drug, sustained at between 5 and 30 micrograms/ml." | 1.28 | Phenobarbital in the prophylaxis of late posttraumatic seizures. ( Arrigo, A; Bonuccelli, U; Murri, L; Parenti, G; Rossi, G, 1992) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "Phenobarbital (PB) was tested for its efficacy in averting post-traumatic epilepsy (PTE) in patients with non-missile head injuries." | 1.26 | Phenobarbital prophylaxis of post traumatic epilepsy. ( Bonuccelli, U; Del Tacca, M; Lenzi, B; Murri, L; Parenti, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (78.95) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Temkin, NR | 1 |
| Schmidt, D | 1 |
| Baratz, R | 1 |
| Mesulam, MM | 1 |
| Karbowski, K | 1 |
| Murri, L | 2 |
| Parenti, G | 2 |
| Bonuccelli, U | 2 |
| Lenzi, B | 1 |
| Del Tacca, M | 1 |
| Kugoh, T | 1 |
| Hosokawa, K | 1 |
| McNaughton, FL | 1 |
| Rasmussen, T | 1 |
| Manaka, S | 1 |
| Jacobi, G | 1 |
| Arrigo, A | 1 |
| Rossi, G | 1 |
| Parsonage, M | 1 |
| Grand, W | 1 |
| Rapport, RL | 2 |
| Penry, JK | 2 |
| Popek, K | 3 |
| Rish, BL | 1 |
| Caveness, WF | 1 |
| Musil, F | 1 |
| Holub, V | 1 |
4 reviews available for phenobarbital and Concussive Convulsion
| Article | Year |
|---|---|
Preventing and treating posttraumatic seizures: the human experience.
Topics: Animals; Anticonvulsants; Brain Injuries; Drug Evaluation, Preclinical; Drug Therapy, Combination; E | 2009 |
[The post-traumatic epilepsy (author's transl)].
Topics: Brain Concussion; Brain Injuries; Brain Neoplasms; Carbamazepine; Diagnostic Errors; Electroencephal | 1981 |
[Post-traumatic epilepsy].
Topics: Brain Injuries; Carbamazepine; Child; Dose-Response Relationship, Drug; Electroencephalography; Epil | 1992 |
Pharmacoligic prophylaxis of posttraumatic epilepsy. A review.
Topics: Accidents, Traffic; Adolescent; Adult; Animals; Anticonvulsants; Drug Therapy, Combination; Epilepsy | 1972 |
1 trial available for phenobarbital and Concussive Convulsion
| Article | Year |
|---|---|
Cooperative prospective study on posttraumatic epilepsy: risk factors and the effect of prophylactic anticonvulsant.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chi-Square Distribution; Child; Epilepsy, Post-Traumatic | 1992 |
14 other studies available for phenobarbital and Concussive Convulsion
| Article | Year |
|---|---|
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Adult-onset stuttering treated with anticonvulsants.
Topics: Adult; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Epilepsy, Post-Traumatic; Female; H | 1981 |
Phenobarbital prophylaxis of post traumatic epilepsy.
Topics: Adolescent; Adult; Epilepsy, Post-Traumatic; Female; Humans; Male; Middle Aged; Phenobarbital | 1980 |
Mental dullness associated with left frontal continuous focal discharge.
Topics: Adult; Carbamazepine; Cognition Disorders; Electroencephalography; Epilepsy, Post-Traumatic; Frontal | 1977 |
Criteria for selection of patients for neurosurgical treatment.
Topics: Adolescent; Age Factors; Child; Electroencephalography; Encephalitis; Epilepsies, Partial; Epilepsy; | 1975 |
Phenobarbital in the prophylaxis of late posttraumatic seizures.
Topics: Adolescent; Adult; Child; Epilepsy, Post-Traumatic; Female; Humans; Male; Middle Aged; Phenobarbital | 1992 |
Epilepsy.
Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec | 1974 |
The significance of post-traumatic status epilepticus in childhood.
Topics: Age Factors; Cerebral Cortex; Child; Child, Preschool; Consciousness; Craniocerebral Trauma; Electro | 1974 |
[Prevention of post-traumatic epilepsy following serious brain injuries. Closing report summarizing results of the research done within the framework of the state plan of research in the years 1965-1969; edited by Z. Servít].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Injuries; Epilepsy, Post-Traumatic; Female; Humans; | 1972 |
Relation of prophylactic medication to the occurrence of early seizures following craniocerebral trauma.
Topics: Brain Edema; Brain Injuries; Dexamethasone; Epilepsy, Post-Traumatic; Humans; Military Medicine; Phe | 1973 |
A survey of attitudes toward the pharmacological prophylaxis of posttraumatic epilepsy.
Topics: Anticonvulsants; Attitude of Health Personnel; Craniocerebral Trauma; Epilepsy, Post-Traumatic; Huma | 1973 |
[Clinical attempt to prevent post-traumatic epilepsy following severe brain injuries in adults].
Topics: Adolescent; Adult; Aged; Brain Injuries; Dibenzazepines; Electroencephalography; Epilepsy; Epilepsy, | 1969 |
[Clinical attempt to prevent post-traumatic epilepsy in children].
Topics: Adolescent; Child; Child, Preschool; Craniocerebral Trauma; Electroencephalography; Epilepsy, Post-T | 1969 |
Draft instructions for preventive treatment of posttraumatic epilepsy.
Topics: Brain Injuries; Czechoslovakia; Electroencephalography; Epilepsy, Post-Traumatic; Humans; Hydantoins | 1969 |