phenobarbital has been researched along with Complications, Pregnancy in 170 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure." | 7.85 | Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017) |
| "When tramadol is used during pregnancy, there is a serious risk for neonatal abstinence syndrome." | 7.79 | [Neonatal abstinence syndrome after maternal use of tramadol]. ( de Wit, D; Koomen-Botman, I, 2013) |
| " We report the case of a Gly71-->Arg/Tyr486-->Asp homozygous mother of East Asian descent, who was treated with phototherapy during embryogenesis and with phenobarbital during the rest of the pregnancy." | 7.73 | Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II. ( Egberts, EH; Holstein, A; Lohse, P; Plaschke, A, 2005) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Serum bile acid concentrations were followed in 29 patients with cholestasis of pregnancy treated for pruritus with either phenobarbital or cholestyramine." | 7.66 | Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy. ( Laatikainen, T, 1978) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 7.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 7.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 5.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| " The mothers received methadone (n=22), slow-release oral morphine (n=17) or buprenorphine (n=14) throughout pregnancy." | 5.12 | Management of neonatal abstinence syndrome in neonates born to opioid maintained women. ( Baewert, A; Ebner, N; Fischer, G; Jagsch, R; Peternell, A; Rohrmeister, K; Thau, K; Winklbaur, B, 2007) |
| "A 37-year-old mother with CNS type II was treated with phenobarbital during her pregnancy and her bilirubin levels were monitored." | 4.85 | Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature. ( Koelbl, H; Kohlschmidt, N; Passuello, V; Puhl, AG; Skala, C; Steiner, E; Wirth, S, 2009) |
| "A comprehensive literature search was conducted in MEDLINE (1966-July 2002) using the following MeSH terms: pregnancy, itching, intrahepatic cholestasis, cholestyramine, ursodeoxycholic acid, and phenobarbital." | 4.81 | Treatment of itching associated with intrahepatic cholestasis of pregnancy. ( Boothby, LA; Jenkins, JK, 2002) |
| "Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure." | 3.85 | Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017) |
| "When tramadol is used during pregnancy, there is a serious risk for neonatal abstinence syndrome." | 3.79 | [Neonatal abstinence syndrome after maternal use of tramadol]. ( de Wit, D; Koomen-Botman, I, 2013) |
| "To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with carbamazepine, lamotrigine, phenobarbital, or valproate." | 3.79 | Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F, 2013) |
| " We report the case of a Gly71-->Arg/Tyr486-->Asp homozygous mother of East Asian descent, who was treated with phototherapy during embryogenesis and with phenobarbital during the rest of the pregnancy." | 3.73 | Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II. ( Egberts, EH; Holstein, A; Lohse, P; Plaschke, A, 2005) |
| "Exposed subjects were adult men born at the largest hospital in Copenhagen between 1959 and 1961 who were exposed to phenobarbital during gestation via maternal medical treatment and whose mothers had no history of a central nervous system disorder and no treatment during pregnancy with any other psychopharmacological drug." | 3.69 | In utero exposure to phenobarbital and intelligence deficits in adult men. ( Mortensen, EL; Reinisch, JM; Rubin, DB; Sanders, SA, 1995) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| " Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy." | 3.68 | Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990) |
| "The elimination of caffeine from plasma and the excretion of the main metabolites of metamizol (noramidopyrinemethanesulphonate sodium) into the urine were determined in healthy pregnant women (weeks 30-38 of pregnancy) and in patients with intrahepatic cholestasis in pregnancy (weeks 28-39 of pregnancy)." | 3.67 | [The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions]. ( Ortweiler, W; Peiker, G; Siegert, C; Splinter, FK; Traeger, A, 1987) |
| "We report the case of a 19-year-old Laotian patient affected by fulminant hepatitis during the third trimester of her pregnancy after a 1-month administration of quinidine phenylethylbarbiturate." | 3.67 | Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report. ( Benhamou, JP; Bernuau, J; Bourlière, M; Rueff, B, 1988) |
| "Two cases concerning newborn infants whose mothers used phencyclidine (PCP) during pregnancy are described." | 3.66 | Neonatal manifestations of maternal phencyclidine (PCP) abuse. ( Bosu, SK; Modaniou, HD; Strauss, AA, 1981) |
| "Birth defects associated with phenytoin and phenobarbital taken during pregnancy include craniofacial and limb deformities." | 3.66 | Fetal hydantoin syndrome in triplets. A unique experiment of nature. ( Bustamante, SA; Stumpff, LC, 1978) |
| "Serum bile acid concentrations were followed in 29 patients with cholestasis of pregnancy treated for pruritus with either phenobarbital or cholestyramine." | 3.66 | Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy. ( Laatikainen, T, 1978) |
| "The aim of the study was to compare the effect of phenobarbital given to pregnant rabbits and of epileptic seizures on the course of pregnancy, the physical state, and central nervous system development of newborns." | 3.66 | [Comparison of the transplacental effect of luminal and epileptic seizures in pregnant rabbits on the development of the fetal nervous system]. ( Bryłko-Chmielik, J; Dambska, M; Danielewicz-Kotowicz, A; Dydyk, L; Maślińska, D; Onyszkiewicz, J, 1979) |
| "An epileptic patient whose seizures were controlled with carbamazepine and primidone was followed throughout pregnancy and lactation." | 3.66 | Carbamazepine levels in pregnancy and lactation. ( Blake, DA; Freeman, JM; Luff, RD; Niebyl, JR, 1979) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Plasma anticonvulsant levels were followed during pregnancy in 11 epileptic women taking phenytoin and/or phenobarbital or a drug metabolized in the body to phenobarbital." | 3.65 | Plasma anticonvulsant concentrations during pregnancy. ( Eadie, MJ; Edwards, VE; Lander, CM; Tyrer, JH, 1977) |
| "Three families are described in which each of the mothers took trimethadione during pregnancy." | 3.65 | The fetal trimethadione syndrome. ( Hanson, JW; Mellman, WJ; Neiderer, B; Zackai, EH, 1975) |
| ", raise the possibility that fetal damage previously attributed to phenytoin and other anticonvulsant drugs, principally phenobarbitone, may be due to epilepsy itself." | 3.65 | Anticonvulsants and parental epilepsy in the development of birth defects. ( Hartz, SC; Heinonen, OP; Mitchell, AA; Monson, RR; Rosenberg, L; Shapiro, S; Siskind, V; Slone, D, 1976) |
| "Maternal demographics, pregnancy complications, antenatal management, and route of delivery did not differ between the phenobarbital group (n = 50) and the placebo group (n = 60)." | 2.67 | Antenatal phenobarbital for the prevention of periventricular and intraventricular hemorrhage: a double-blind, randomized, placebo-controlled, multihospital trial. ( Hale, K; Kaempf, JW; Molina, R; Pantoja, AF; Porreco, R; Rosenberg, AA, 1990) |
| " Further, this scoring system has been used by relating it to the dosage schedule of phenobarbital or paregoric as part of an ongoing research project designed to test the comparative usefulness of recommended treatments for neonates with abstinence symptoms." | 2.64 | Assessment and treatment of abstinence in the infant of the drug-dependent mother. ( Connaughton, JF; Emich, JP; Finnegan, LP; Kron, RE, 1975) |
| "When opioid misuse rises in the United States, pregnant women and their neonates are affected." | 2.61 | Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome. ( Jones, HE; Kraft, WK, 2019) |
| "Only trimethadione has been convincingly linked to fetal malformation." | 2.36 | The pregnant epileptic: a review and recommendations. ( Fenichel, GM; McLain, LW; Montouris, GD, 1979) |
| "Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0." | 1.72 | Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "Phenobarbital levels were higher in symptomatic infants than asymptomatic infants, although the difference was not statistically significant." | 1.37 | Infants born to mothers under phenobarbital treatment: correlation between serum levels and clinical features of neonates. ( Antichi, E; Cardiello, V; Carducci, C; Catenazzi, P; D'Antuono, A; Piras, A; Pozzoli, G; Romagnoli, C; Scorrano, A; Zuppa, AA, 2011) |
| " Experimental studies in pregnant rabbits using Primatene in both low and high dosage resulted in limb reduction defects and other malformations in a significant number of the offspring compared with controls." | 1.31 | Association of sympathomimetic drugs with malformations. ( Drut, RM; Gilbert-Barness, E, 2000) |
| "With the diagnosis of neonatal Graves' disease established, both twins were treated with propranolol (2 mg/kg." | 1.30 | [Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism]. ( Grüters, A; Hüfner, M; Lakomek, M; Roth, C; Siggelkow, H, 1997) |
| "Maternal drug addiction has increased in an alarming way over the last ten years." | 1.28 | [Newborn infant of drug-addicted mother: maternal, perinatal, neonatal aspects, and neonatal abstinence syndrome]. ( Arcas Cruz, R; Comas Mastmitja, L; Cruz Hernández, M; Figueras Aloy, J; Jiménez González, R; Vilanova Juanola, JM, 1991) |
| "Sixty-three infants with neonatal seizures were studied in terms of etiology, seizure type, electroencephalograms, and outcome." | 1.27 | Neonatal seizures: a reappraisal. ( Nogen, AG, 1984) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "Status epilepticus is a serious emergency that rarely complicates the management of the pregnant patient with seizure disorders." | 1.27 | Status epilepticus in pregnancy. A case report. ( Fougner, AC; Seltzer, VL; Wilson, SJ, 1985) |
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 1.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| "Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations." | 1.26 | Neonatal seizures associated with narcotic withdrawal. ( Herzlinger, RA; Kandall, SR; Vaughan, HG, 1977) |
| "A daily dosage of 100 mg phenobarbitone administered orally to pregnant women for three days or more immediately before delivery has reduced the various mortality rates for low-birth-weight infants by 50% or more." | 1.26 | Decrease in the mortality rates for low-birth-weight infants after phenobarbitone treatment. ( Trolle, D, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 120 (70.59) | 18.7374 |
| 1990's | 23 (13.53) | 18.2507 |
| 2000's | 13 (7.65) | 29.6817 |
| 2010's | 12 (7.06) | 24.3611 |
| 2020's | 2 (1.18) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, X | 1 |
| Wang, Y | 1 |
| Zhang, Y | 1 |
| Song, C | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Xia, L | 1 |
| Ma, L | 1 |
| Jiang, W | 1 |
| MacMillan, KDL | 1 |
| Kaplan, YC | 1 |
| Demir, O | 1 |
| Erol, S | 1 |
| Ozcan, B | 1 |
| Celik, IH | 1 |
| Bas, AY | 1 |
| Demirel, N | 1 |
| Tomson, T | 2 |
| Battino, D | 3 |
| Bonizzoni, E | 2 |
| Craig, J | 2 |
| Lindhout, D | 4 |
| Perucca, E | 2 |
| Sabers, A | 2 |
| Thomas, SV | 1 |
| Vajda, F | 2 |
| Jones, HE | 1 |
| Kraft, WK | 1 |
| de Wit, D | 1 |
| Koomen-Botman, I | 1 |
| Barroso, FV | 1 |
| Araujo Júnior, E | 1 |
| Guazelli, CA | 1 |
| Santana, EF | 1 |
| Rolo, LC | 1 |
| Martins, Mda G | 1 |
| Moron, AF | 1 |
| Lau, C | 1 |
| Watson, H | 1 |
| Cheong, J | 1 |
| Vanya, M | 1 |
| Devosa, I | 1 |
| Szok, D | 1 |
| Bártfai, G | 1 |
| Winklbaur, B | 2 |
| Kopf, N | 1 |
| Ebner, N | 2 |
| Jung, E | 1 |
| Thau, K | 2 |
| Fischer, G | 2 |
| Passuello, V | 1 |
| Puhl, AG | 1 |
| Wirth, S | 1 |
| Steiner, E | 1 |
| Skala, C | 1 |
| Koelbl, H | 1 |
| Kohlschmidt, N | 1 |
| Holstein, A | 2 |
| Bryan, CS | 1 |
| Zuppa, AA | 1 |
| Carducci, C | 1 |
| Scorrano, A | 1 |
| Antichi, E | 1 |
| Catenazzi, P | 1 |
| Piras, A | 1 |
| Pozzoli, G | 1 |
| Cardiello, V | 1 |
| D'Antuono, A | 1 |
| Romagnoli, C | 1 |
| Abdel-Latif, ME | 1 |
| Oei, J | 1 |
| Craig, F | 1 |
| Lui, K | 1 |
| Bokhari, A | 1 |
| Coull, BA | 2 |
| Holmes, LB | 2 |
| Jenkins, JK | 1 |
| Boothby, LA | 1 |
| Melchior, JC | 1 |
| Svensmark, O | 1 |
| Trolle, D | 2 |
| LAWRENCE, A | 1 |
| JABBOUR, JT | 1 |
| RYDER, RJ | 1 |
| MARX, GF | 1 |
| SCHEINBERG, L | 1 |
| ROMNEY, SL | 1 |
| NEWILL, RG | 1 |
| Yaris, F | 1 |
| Kadioglu, M | 1 |
| Kesim, M | 1 |
| Ulku, C | 1 |
| Yaris, E | 1 |
| Kalyoncu, NI | 1 |
| Plaschke, A | 1 |
| Lohse, P | 1 |
| Egberts, EH | 1 |
| Rohrmeister, K | 1 |
| Baewert, A | 1 |
| Jagsch, R | 1 |
| Peternell, A | 1 |
| Eadie, MJ | 2 |
| Fukuda, T | 1 |
| Fukushima, Y | 1 |
| Kuroki, Y | 1 |
| Hiilesmaa, VK | 1 |
| Teramo, K | 1 |
| Granström, ML | 1 |
| Bardy, AH | 1 |
| Schmidt, D | 1 |
| Damasio, H | 1 |
| Nogen, AG | 1 |
| Pearl, KN | 1 |
| Dickens, S | 1 |
| Latham, P | 1 |
| Traggis, DG | 1 |
| Maunz, DL | 1 |
| Baroudy, R | 1 |
| Philbert, A | 1 |
| Dam, M | 2 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Tabuchi, T | 1 |
| Wagatsuma, T | 1 |
| Nakazawa, Y | 1 |
| Fabris, C | 1 |
| Prandi, GM | 1 |
| Berardi, V | 1 |
| Santoro, MA | 1 |
| Martano, C | 1 |
| Mombrò, M | 1 |
| Zenk, KE | 1 |
| Cohen, MS | 1 |
| Ostergaard, GZ | 1 |
| Pedersen, SE | 1 |
| Shaw, D | 1 |
| Frohlich, J | 1 |
| Wittmann, BA | 1 |
| Willms, M | 1 |
| Srinivasan, G | 1 |
| Seeler, RA | 1 |
| Tiruvury, A | 1 |
| Pildes, RS | 1 |
| Heikkinen, J | 1 |
| Mäentausta, O | 1 |
| Ylöstalo, P | 1 |
| Jänne, O | 1 |
| Glade, G | 1 |
| Saccar, CL | 1 |
| Pereira, GR | 1 |
| Bossi, L | 1 |
| Assael, BM | 1 |
| Avanzini, G | 1 |
| Caccamo, ML | 1 |
| Canger, R | 1 |
| Como, ML | 1 |
| Pifarotti, G | 1 |
| de Giambattista, M | 1 |
| Franceschetti, S | 1 |
| Marini, A | 1 |
| Pardi, G | 1 |
| Porro, MG | 1 |
| Rovei, V | 1 |
| Sanjuan, M | 1 |
| Soffientini, ME | 1 |
| Spina, S | 1 |
| Spreafico, R | 1 |
| Bale, JF | 1 |
| Allen, RW | 1 |
| Hulme, J | 1 |
| Wyman, ML | 1 |
| Strauss, AA | 1 |
| Modaniou, HD | 1 |
| Bosu, SK | 1 |
| Nau, H | 4 |
| Rating, D | 2 |
| Häuser, I | 1 |
| Jäger, E | 1 |
| Koch, S | 2 |
| Helge, H | 2 |
| Reinisch, JM | 1 |
| Sanders, SA | 1 |
| Mortensen, EL | 1 |
| Rubin, DB | 1 |
| Stiehl, A | 2 |
| Yerby, MS | 4 |
| Sigl, B | 1 |
| Barnes, ER | 1 |
| Thompson, DF | 1 |
| Jäger-Roman, E | 1 |
| Lösche, G | 1 |
| Thorp, JA | 1 |
| Neimark, M | 1 |
| Poskin, M | 1 |
| Roth, C | 1 |
| Siggelkow, H | 1 |
| Grüters, A | 1 |
| Hüfner, M | 1 |
| Lakomek, M | 1 |
| Renzulli, P | 1 |
| Tuchschmid, P | 1 |
| Eich, G | 1 |
| Fanconi, S | 1 |
| Schwöbel, MG | 1 |
| Gilbert-Barness, E | 1 |
| Drut, RM | 1 |
| Dessens, AB | 1 |
| Cohen-Kettenis, PT | 1 |
| Mellenbergh, GJ | 1 |
| Koppe, JG | 1 |
| van De Poll, NE | 1 |
| Boer, K | 1 |
| Harvey, EA | 1 |
| Huntington, KB | 1 |
| Khoshbin, S | 1 |
| Hayes, AM | 1 |
| Ryan, LM | 1 |
| Ito, T | 1 |
| Katagiri, C | 1 |
| Ikeno, S | 1 |
| Takahashi, H | 1 |
| Nagata, N | 1 |
| Terakawa, N | 1 |
| Laskowska, M | 1 |
| Leszczyńska-Gorzelak, B | 1 |
| Oleszczuk, J | 1 |
| Zackai, EH | 1 |
| Mellman, WJ | 1 |
| Neiderer, B | 1 |
| Hanson, JW | 2 |
| Smith, DW | 1 |
| Shapiro, S | 1 |
| Hartz, SC | 1 |
| Siskind, V | 1 |
| Mitchell, AA | 1 |
| Slone, D | 1 |
| Rosenberg, L | 1 |
| Monson, RR | 1 |
| Heinonen, OP | 1 |
| Visner, GH | 1 |
| Huisjes, HJ | 2 |
| Elshove, J | 2 |
| Stambaugh, JE | 1 |
| Hemphill, DM | 1 |
| Wainer, IW | 1 |
| Schwartz, I | 1 |
| Margaria, E | 1 |
| Palieri Furlan, L | 1 |
| Marioni, A | 1 |
| Magro, M | 1 |
| Lovera, C | 1 |
| Gaetti, MT | 1 |
| Carotti, G | 1 |
| Vianelli, P | 1 |
| Pellegrini, L | 1 |
| Bini, PL | 1 |
| Scalseggi, V | 1 |
| Dambska, M | 1 |
| Bryłko-Chmielik, J | 1 |
| Danielewicz-Kotowicz, A | 1 |
| Dydyk, L | 1 |
| Maślińska, D | 1 |
| Onyszkiewicz, J | 1 |
| Himaya, A | 1 |
| Pathak, SM | 1 |
| Nuyens, AJ | 1 |
| Krzaniak, S | 1 |
| Taylor, GO | 1 |
| Melvin, GR | 1 |
| Aceto, T | 1 |
| Barlow, J | 1 |
| Munson, D | 1 |
| Wierda, D | 1 |
| Ghodse, AH | 1 |
| Reed, JL | 1 |
| Mack, JW | 1 |
| Montouris, GD | 1 |
| Fenichel, GM | 1 |
| McLain, LW | 1 |
| Diehl, LW | 1 |
| Friis, ML | 1 |
| Trebbin, WM | 1 |
| Lander, CM | 1 |
| Edwards, VE | 1 |
| Tyrer, JH | 1 |
| Ramsay, RE | 1 |
| Strauss, RG | 1 |
| Wilder, BJ | 1 |
| Willmore, LJ | 1 |
| Madden, JD | 1 |
| Vesterhus, P | 1 |
| Johannessen, SI | 1 |
| Bustamante, SA | 1 |
| Stumpff, LC | 1 |
| Laatikainen, T | 1 |
| Niebyl, JR | 1 |
| Blake, DA | 1 |
| Freeman, JM | 1 |
| Luff, RD | 1 |
| Mygind, KI | 1 |
| Christiansen, J | 1 |
| Wolf, SM | 1 |
| Herzlinger, RA | 1 |
| Kandall, SR | 2 |
| Vaughan, HG | 1 |
| Anderson, RC | 1 |
| Kullander, S | 1 |
| Finnegan, LP | 5 |
| Kron, RE | 5 |
| Connaughton, JF | 2 |
| Emich, JP | 2 |
| Moreno, JA | 1 |
| Zelson, C | 3 |
| Kaplan, SL | 1 |
| Litt, M | 3 |
| Phoenix, MD | 2 |
| Biale, Y | 1 |
| Lewenthal, H | 1 |
| Aderet, NB | 1 |
| Annegers, JF | 2 |
| Elveback, LR | 2 |
| Hauser, WA | 2 |
| Kurland, LT | 2 |
| Eng, D | 1 |
| Omtzigt, JG | 1 |
| Cornel, MC | 1 |
| Leavitt, A | 1 |
| Erickson, DM | 1 |
| McCormick, KB | 1 |
| Loewenson, RB | 1 |
| Sells, CJ | 2 |
| Benedetti, TJ | 1 |
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| Julian, C | 1 |
| Legras, C | 1 |
| Magaudda, A | 1 |
| Guerrini, R | 1 |
| Genton, P | 1 |
| Soulayrol, S | 1 |
| Giraud, N | 1 |
| Mesdjian, E | 1 |
| Trentin, G | 1 |
| Meinardi, H | 1 |
| Meijer, JW | 1 |
| Kattner, E | 1 |
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| Izumi, M | 1 |
| Okada, H | 1 |
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| Phadke, V | 1 |
| Anand, AJ | 1 |
| Patel, RB | 1 |
| Deshpande, DV | 1 |
| van der Pol, MC | 1 |
| Hadders-Algra, M | 1 |
| Touwen, BC | 1 |
| Arcas Cruz, R | 1 |
| Figueras Aloy, J | 1 |
| Vilanova Juanola, JM | 1 |
| Comas Mastmitja, L | 1 |
| Jiménez González, R | 1 |
| Cruz Hernández, M | 1 |
| Wilkins, JR | 1 |
| McLaughlin, JA | 1 |
| Sinks, TH | 1 |
| Kosnik, EJ | 1 |
| Holder, M | 1 |
| Majewski, F | 1 |
| Lenard, HG | 1 |
| Kaempf, JW | 1 |
| Porreco, R | 1 |
| Molina, R | 1 |
| Hale, K | 1 |
| Pantoja, AF | 1 |
| Rosenberg, AA | 1 |
| Sutton, LR | 1 |
| Hinderliter, SA | 1 |
| Friel, PN | 1 |
| McCormick, K | 1 |
| Koerner, M | 1 |
| Van Allen, M | 1 |
| Leavitt, AM | 1 |
| Yerby, JA | 1 |
| Piccione, E | 1 |
| Ticconi, C | 1 |
| Cennamo, M | 1 |
| Bertollini, R | 1 |
| Källen, B | 1 |
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| Robert, E | 1 |
| Bourlière, M | 1 |
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| Thomas, D | 1 |
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| Tuimala, R | 1 |
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| Makaveeva, V | 1 |
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| Levy, RH | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessing the Effects of Auricular Acupressure on Newborn Behaviors and Withdrawal Signs in Newborns With Neonatal Abstinence Syndrome: A Pilot Study[NCT03890562] | 12 participants (Actual) | Interventional | 2019-09-04 | Completed | |||
| Donor Human Milk for Infants With Neonatal Abstinence Syndrome[NCT02182973] | 12 participants (Actual) | Observational | 2014-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in head circumference from day 1 to day 14 (cm/wk) (NCT02182973)
Timeframe: 2 weeks
| Intervention | cm/wk (Mean) |
|---|---|
| Donor Human Milk | 0.4 |
| Historical Control | 0.6 |
Minimum score:0; Maximum score 13. Higher scores mean more GI distress (NCT02182973)
Timeframe: 2 weeks
| Intervention | Percentage of participants (Number) |
|---|---|
| Donor Human Milk | 39 |
| Historical Controls | 61 |
Change in weight from study day 1 to study day 14 (grams/day) Weight day 14 - weight day 1 divided by 14 (NCT02182973)
Timeframe: 2 weeks
| Intervention | grams/day (Mean) |
|---|---|
| Donor Human Milk | 19.1 |
| Historical Control | 20.5 |
22 reviews available for phenobarbital and Complications, Pregnancy
| Article | Year |
|---|---|
Neonatal Abstinence Syndrome: Review of Epidemiology, Care Models, and Current Understanding of Outcomes.
Topics: Analgesics, Opioid; Breast Feeding; Buprenorphine; Female; Humans; Hypnotics and Sedatives; Infant, | 2019 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Analgesia, Opioids, and Other Drug Use During Pregnancy and Neonatal Abstinence Syndrome.
Topics: Analgesia, Obstetrical; Analgesics; Analgesics, Opioid; Breast Feeding; Buprenorphine; Buprenorphine | 2019 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
Treating pregnant women dependent on opioids is not the same as treating pregnancy and opioid dependence: a knowledge synthesis for better treatment for women and neonates.
Topics: Buprenorphine; Diagnosis, Dual (Psychiatry); Female; GABA Modulators; Humans; Infant, Newborn; Menta | 2008 |
Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
Topics: Adult; Bilirubin; Crigler-Najjar Syndrome; Female; Hearing Disorders; Humans; Infant; Infant, Newbor | 2009 |
Treatment of itching associated with intrahepatic cholestasis of pregnancy.
Topics: Adult; Antipruritics; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Female; Humans; Phenob | 2002 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
Drug management of adult vascular headaches (migraine and cluster headache): Part II--Prevention and attacks.
Topics: Adult; Amitriptyline; Belladonna Alkaloids; Cluster Headache; Cyproheptadine; Drug Combinations; Erg | 1984 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
[The newborn infant of the drug-dependent mother. Review of literature and personal case reports].
Topics: Adult; Female; Fetal Diseases; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1980 |
An overview of perinatal clinical pharmacology.
Topics: Abnormalities, Drug-Induced; Analgesics; Bupivacaine; Carbamazepine; Chloramphenicol; Diazepam; Digo | 1981 |
Drug abuse in pregnancy: fetal ad neonatal effects.
Topics: Alcoholism; Birth Weight; Chlorpromazine; Diazepam; Female; Fetus; Humans; Infant, Newborn; Infant, | 1982 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
Phenobarbital following phototherapy for Crigler-Najjar syndrome type II with good fetal outcome: a case report.
Topics: Adult; Anticonvulsants; Crigler-Najjar Syndrome; Female; Humans; Infant, Newborn; Phenobarbital; Pho | 2001 |
[Dysmorphisms and psychomotor retardation in infants of mothers treated with anticonvulsants in pregnancy].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy, Tonic-Clonic; Female; Fetus; Humans; | 1979 |
Disturbances of bile acid metabolism in cholestasis.
Topics: Bile Acids and Salts; Bile Ducts; Cholestasis; Cholestyramine Resin; Deoxycholic Acid; Disease Model | 1977 |
The effect of maternal narcotic addiction on the newborn infant.
Topics: Abnormalities, Drug-Induced; Breast Feeding; Female; Fertility; Heroin Dependence; Humans; Infant Mo | 1977 |
The pregnant epileptic: a review and recommendations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Kine | 1979 |
[Findings in newborn infants following drug abuse or drug weaning in the mother].
Topics: Abnormalities, Drug-Induced; Adult; Female; Fetal Growth Retardation; Heroin Dependence; Humans; Inf | 1991 |
[Problems of neurological drug therapy in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antiparkinson Agents; Carbamazepine; Chelating Agents; | 1989 |
In utero disease and the newborn infant.
Topics: Acid-Base Equilibrium; Acidosis; Amniotic Fluid; Animals; Bilirubin; Birth Weight; Electrocardiograp | 1970 |
7 trials available for phenobarbital and Complications, Pregnancy
| Article | Year |
|---|---|
Management of neonatal abstinence syndrome in neonates born to opioid maintained women.
Topics: Adult; Apgar Score; Female; Gestational Age; Humans; Infant, Newborn; Male; Methadone; Morphine; Neo | 2007 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Maternal oxygen desaturation with intravenous magnesium therapy.
Topics: Female; Humans; Injections, Intravenous; Magnesium Sulfate; Oxygen; Phenobarbital; Pregnancy; Pregna | 1997 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
A potentially toxic drug interaction between pethidine (meperidine) and phenobarbitone.
Topics: Adult; Brain Neoplasms; Drug Synergism; Drug Therapy, Combination; Female; Half-Life; Humans; Meperi | 1977 |
Assessment and treatment of abstinence in the infant of the drug-dependent mother.
Topics: Clinical Trials as Topic; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenoba | 1975 |
Antenatal phenobarbital for the prevention of periventricular and intraventricular hemorrhage: a double-blind, randomized, placebo-controlled, multihospital trial.
Topics: Adult; Apgar Score; Cerebral Hemorrhage; Cerebral Ventricles; Colorado; Double-Blind Method; Female; | 1990 |
141 other studies available for phenobarbital and Complications, Pregnancy
| Article | Year |
|---|---|
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc | 2022 |
Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report.
Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; F | 2017 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
[Neonatal abstinence syndrome after maternal use of tramadol].
Topics: Adult; Analgesics, Opioid; Female; Humans; Infant, Newborn; Neonatal Abstinence Syndrome; Opioid-Rel | 2013 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Com | 2013 |
Perinatal outcomes from the use of antiepileptic drugs during pregnancy: a case-control study.
Topics: Adult; Anticonvulsants; Apgar Score; Case-Control Studies; Congenital Abnormalities; Epilepsy; Femal | 2015 |
Poor neonatal adaptation following in-utero exposure to quetiapine and lamotrigine.
Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Hypothyroidism; Infant, Newborn; Infa | 2015 |
Three consecutive pregnancies in a woman with Crigler-Najjar syndrome type II with good maternal and neonatal outcomes.
Topics: Adult; Anticonvulsants; Cesarean Section; Crigler-Najjar Syndrome; Female; Humans; Infant, Newborn; | 2011 |
Infants born to mothers under phenobarbital treatment: correlation between serum levels and clinical features of neonates.
Topics: Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Hospitals, University; Humans; Infant, New | 2011 |
Profile of infants born to drug-using mothers: a state-wide audit.
Topics: Australian Capital Territory; Breast Feeding; Congenital Abnormalities; Female; Hospitalization; Hos | 2013 |
Effect of prenatal exposure to anticonvulsant drugs on dermal ridge patterns of fingers.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Dermatogly | 2002 |
Placental transfer of phenobarbitone in epileptic women, and elimination in newborns.
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; | 1967 |
ANTI-EPILEPTIC DRUGS AND THE FOETUS.
Topics: Barbiturates; Epilepsy; Female; Fetal Diseases; Fetus; Phenobarbital; Phenytoin; Pregnancy; Pregnanc | 1963 |
THE INFANT WITH EPILEPSY.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Birth Injuries; Classific | 1963 |
HAEMORRHAGE ASSOCIATED WITH THROMBOCYTOPENIA IN MEGALOBLASTIC ANAEMIA.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Blood Platelet Disorders; Drug Therapy; Epilepsy; | 1964 |
ANESTHETIC MANAGEMENT OF THE PARTURIENT WITH INTRACRANIAL TUMOR.
Topics: Anesthesia; Anesthesia, Endotracheal; Anesthesia, Spinal; Anesthetics; Angiography; Brain Neoplasms; | 1964 |
NOCTURNAL EPILEPSY AND HYPOGLYCAEMIA.
Topics: Anticonvulsants; Child; Circadian Rhythm; Delayed-Action Preparations; Drug Therapy; Electroencephal | 1964 |
Barbexaclone use in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Phen | 2004 |
Successful photo-and phenobarbital therapy during pregnancy in a woman with Crigler-Najjar syndrome type II.
Topics: Adult; Anticonvulsants; Crigler-Najjar Syndrome; Female; Follow-Up Studies; Humans; Infant, Newborn; | 2005 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit | 1983 |
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Topics: Carbamazepine; Congenital Abnormalities; Epilepsy; Female; Fetal Death; Folic Acid; Humans; Phenobar | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Neonatal seizures: a reappraisal.
Topics: Age Factors; Anticonvulsants; Electroencephalography; Female; Humans; Hypoxia; Infant, Newborn; Isch | 1984 |
Functional palatal incompetence in the fetal anticonvulsant syndrome.
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy; Female; Humans; Male; Maternal-Fetal Exchan | 1984 |
Splenic hemorrhage in a neonate of a mother on anticonvulsant therapy.
Topics: Female; Hemorrhage; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Co | 1984 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
Neonatal effects of maternal clomipramine treatment.
Topics: Acidosis, Respiratory; Clomipramine; Cyanosis; Depressive Disorder; Female; Humans; Infant, Newborn; | 1982 |
A prospective study of 18 patients with cholestasis of pregnancy.
Topics: Adolescent; Adult; Amniotic Fluid; Bile Acids and Salts; Cholestasis; Cholestyramine Resin; Drug The | 1982 |
Maternal anticonvulsant therapy and hemorrhagic disease of the newborn.
Topics: Adult; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1982 |
Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis, Intrahepatic; Cholestyramine Resin; Cholic | 1982 |
Cimetidine in pregnancy: apparent transient liver impairment in the newborn.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Cimetidine; Fema | 1980 |
Plasma levels and clinical effects of antiepileptic drugs in pregnant epileptic patients and their newborns.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenyt | 1980 |
Anterior spinal artery syndrome during the postpartum period.
Topics: Adult; Cerebral Hemorrhage; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange | 1981 |
Neonatal manifestations of maternal phencyclidine (PCP) abuse.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Mater | 1981 |
Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
Topics: Adult; Aminopyrine; Cytochrome P-450 Enzyme System; Epilepsy; Female; Half-Life; Humans; Hydroxylati | 1980 |
In utero exposure to phenobarbital and intelligence deficits in adult men.
Topics: Adult; Anticonvulsants; Case-Control Studies; Cognition; Cohort Studies; Denmark; Double-Blind Metho | 1995 |
[Treatment of cholestatic liver diseases with phenobarbital and ursodeoxycholic acid].
Topics: Cholestasis, Intrahepatic; Cystic Fibrosis; Female; Humans; Liver Diseases; Liver Function Tests; Ma | 1993 |
[Pathogenesis and therapy of pruritus in pregnancy].
Topics: Animals; Cholestasis, Intrahepatic; Cholestyramine Resin; Female; Histamine H1 Antagonists; Humans; | 1994 |
Antenatal phenobarbital to prevent or minimize intraventricular hemorrhage in the low-birthweight neonate.
Topics: Cerebral Hemorrhage; Cerebral Ventricles; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; | 1993 |
[Neonatal Basedow's disease in twins from a mother with severe T3 hyperthyroidism].
Topics: Adrenergic beta-Antagonists; Adult; Antithyroid Agents; Autoantibodies; Developmental Disabilities; | 1997 |
Early vitamin K deficiency bleeding after maternal phenobarbital intake: management of massive intracranial haemorrhage by minimal surgical intervention.
Topics: Anticonvulsants; Cesarean Section; Epilepsy, Generalized; Female; Hematoma, Subdural; Humans; Infant | 1998 |
Association of sympathomimetic drugs with malformations.
Topics: Adult; Aerosols; Animals; Asthma; Drug Combinations; Ephedrine; Female; Humans; Hypnotics and Sedati | 2000 |
Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems.
Topics: Adult; Anticonvulsants; Cephalometry; Cognition; Cross-Sectional Studies; Epilepsy; Female; Follow-U | 2000 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
The fetal trimethadione syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anthropometry; Child, Preschool; Developmental | 1975 |
The fetal hydantoin syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Child, Preschool; Developmental Di | 1975 |
Anticonvulsants and parental epilepsy in the development of birth defects.
Topics: Abnormalities, Drug-Induced; Congenital Abnormalities; Epilepsy; Female; Finland; Follow-Up Studies; | 1976 |
Letter: Anticonvulsants and fetal malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Phenobarbital; Phenytoin; Pr | 1976 |
[Endogenous intoxications of pregnancy: jaundice of pregnancy].
Topics: Adult; Arginine; Bicarbonates; Cholestasis; Cholestyramine Resin; Dextrans; Fatty Liver; Female; Glu | 1979 |
[Comparison of the transplacental effect of luminal and epileptic seizures in pregnant rabbits on the development of the fetal nervous system].
Topics: Anencephaly; Animals; Brain Stem; Cerebral Cortex; Epilepsy, Tonic-Clonic; Female; Fetal Growth Reta | 1979 |
The effect of various drugs on maternal serum cystine aminopeptidase.
Topics: Adolescent; Adult; Aminopeptidases; Cystinyl Aminopeptidase; Diazepam; Female; Humans; In Vitro Tech | 1977 |
Iatrogenic congenital goiter and hypothyroidism with respiratory distress in a newborn.
Topics: Asthma; Congenital Hypothyroidism; Ephedrine; Female; Goiter; Humans; Hypothyroidism; Infant, Newbor | 1978 |
[Anticonvulsants and simultaneous medication - a problem in pregnancy (author's transl)].
Topics: Adult; Anticonvulsants; Antiemetics; Dihydroergotamine; Drug Combinations; Drug Interactions; Drug T | 1977 |
Epilepsy among parents of children with facial clefts.
Topics: Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Humans; Male; Parents; Phenobarbital; Ph | 1979 |
Hemodialysis and pregnancy.
Topics: Acute Kidney Injury; Adolescent; Adult; Chloral Hydrate; Female; Glutethimide; Humans; Infant, Newbo | 1979 |
American Academy of Pediatrics Committee on Drugs: anticonvulsants and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1979 |
Plasma anticonvulsant concentrations during pregnancy.
Topics: Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications | 1977 |
Status epilepticus in pregnancy: effect of phenytoin malabsorption on seizure control.
Topics: Administration, Oral; Adult; Female; Humans; Intestinal Absorption; Phenobarbital; Phenytoin; Postpa | 1978 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
[Neonatal abstinence syndrome in children whose mothers were treated for epilepsy during pregnancy].
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1978 |
Fetal hydantoin syndrome in triplets. A unique experiment of nature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Face; Female; Growth Disorder | 1978 |
Effect of cholestyramine and phenobarbital on pruritus and serum bile acid levels in cholestasis of pregnancy.
Topics: Adult; Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis; Cholestyramine Resin; Cholic Acids; | 1978 |
Carbamazepine levels in pregnancy and lactation.
Topics: Adult; Carbamazepine; Epilepsy, Temporal Lobe; Female; Fetal Blood; Fetus; Humans; Lactation; Milk, | 1979 |
Phenytoin and phenobarbitone plasma clearance during pregnancy.
Topics: Adult; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Female; Human | 1976 |
The effectiveness of phenobarbital in the prevention of recurrent febrile convulsions in children with and without a history of pre-, peri- and postnatal abnormalities.
Topics: Child; Child, Preschool; Female; Follow-Up Studies; Humans; Obstetric Labor Complications; Phenobarb | 1977 |
Neonatal seizures associated with narcotic withdrawal.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Pregnanc | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadio | 1976 |
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines; | 1976 |
[Use of phenobarbital in the management of pruritus associated with cholestatic jaundice of pregnancy].
Topics: Administration, Oral; Biliary Tract Diseases; Drug Evaluation; Female; Humans; Jaundice; Phenobarbit | 1975 |
Neonatal abstinence syndrome: assessment and management.
Topics: Administration, Oral; Antidiarrheals; Central Nervous System; Diazepam; Digestive System; Female; He | 1975 |
Acute management of neonatal addiction.
Topics: Antidiarrheals; Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant | 1975 |
The assessment of behavioral change in infants undergoing narcotic withdrawal: comparative data from clinical and objective methods.
Topics: Arousal; Attention; Central Nervous System; Female; Heroin Dependence; Humans; Infant, Newborn; Infa | 1975 |
Congenital malformations due to anticonvulsive drugs.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Ord | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Epilepsy anticonvulsants and malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cleft Lip; Cleft Palate; Epilepsy; Female; Heart Defec | 1975 |
Decrease in the mortality rates for low-birth-weight infants after phenobarbitone treatment.
Topics: Birth Weight; Female; Fetal Death; Humans; Infant Mortality; Infant, Newborn; Infant, Premature; Phe | 1976 |
Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male; Methadone; Opium; Phenob | 1976 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Epilepsy and craniofacial abnormalities.
Topics: Abnormalities, Drug-Induced; Adult; Cleft Lip; Cleft Palate; Epilepsy, Tonic-Clonic; Female; Humans; | 1991 |
Antiepileptic medication in pregnancy: late effects on the children's central nervous system development.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Central Nervous System; Child; Child De | 1991 |
[Newborn infant of drug-addicted mother: maternal, perinatal, neonatal aspects, and neonatal abstinence syndrome].
Topics: Adult; Chlorpromazine; Female; Humans; Infant, Low Birth Weight; Infant, Newborn; Neonatal Abstinenc | 1991 |
Parental occupation and intracranial neoplasms of childhood: anecdotal evidence from a unique occupational cancer cluster.
Topics: Adolescent; Barbiturates; Brain Neoplasms; Case-Control Studies; Child; Child, Preschool; Electronic | 1991 |
[Hypoplasia of the nails and end phalanges as a sequela of prenatal barbiturate exposure].
Topics: Abnormalities, Drug-Induced; Child, Preschool; Epilepsy, Tonic-Clonic; Female; Fingers; Humans; Male | 1990 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1990 |
Pharmacokinetics of anticonvulsants in pregnancy: alterations in plasma protein binding.
Topics: Adult; Anticonvulsants; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Maternal-Fetal Exch | 1990 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
Quinidine phenylethylbarbiturate-induced fulminant hepatitis in a pregnant woman. A case report.
Topics: Adult; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Humans; Phenobarbital; Pre | 1988 |
Infants of drug-addicted mothers.
Topics: Acquired Immunodeficiency Syndrome; Female; Humans; Infant; Infant, Newborn; Neonatal Abstinence Syn | 1988 |
[The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions].
Topics: Biotransformation; Caffeine; Cholestasis, Intrahepatic; Cytochrome P-450 Enzyme System; Female; Huma | 1987 |
Vitamin D and mineral metabolism in intrahepatic cholestasis of pregnancy.
Topics: Bile Acids and Salts; Calcifediol; Calcitriol; Cholestasis, Intrahepatic; Cholestyramine Resin; Drug | 1986 |
[Acute poisoning and pregnancy].
Topics: Acute Disease; Adolescent; Adult; Female; Humans; Mushroom Poisoning; Nitrazepam; Phenobarbital; Pre | 1986 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Anticonvulsant use during pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetal Death; Humans; Phenobarbital; | 1985 |
Status epilepticus in pregnancy. A case report.
Topics: Adolescent; Diazepam; Female; Humans; Infusions, Parenteral; Phenobarbital; Phenytoin; Pregnancy; Pr | 1985 |
Congenital malformations among infants born to epileptic women.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Congenital Abnormalities; England; Epilepsy; F | 1973 |
Chorea gravidarum.
Topics: Adolescent; Adult; Chorea; Emotions; Female; Humans; Phenobarbital; Pregnancy; Pregnancy Complicatio | 1966 |
Phenobarbitone and the neonate.
Topics: Female; Humans; Infant, Newborn; Jaundice, Neonatal; Maternal-Fetal Exchange; Phenobarbital; Pregnan | 1969 |
Neonatal haemorrhage following maternal anticonvulsant therapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Male; Phenobarbital; Phenytoin; P | 1970 |
Digital hypoplasia and anticonvulsants during gestation: a teratogenic syndrome?
Topics: Abnormalities, Drug-Induced; Epilepsy, Tonic-Clonic; Female; Fingers; Hand; Humans; Infant, Newborn; | 1974 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Blood Coagulation Disorders; Epilepsy; Female; Human | 1971 |
The effect of a methadone treatment program upon pregnant heroin addicts and their newborn infants.
Topics: Adult; Birth Weight; Blood Glucose; Calcium; Female; Fetus; Gestational Age; Heroin Dependence; Huma | 1974 |
Effects of prenatal meprobamate and chlordiazepoxide hydrochloride on human embryonic and fetal development.
Topics: Abnormalities, Drug-Induced; Aluminum; Anxiety; Child, Preschool; Chlordiazepoxide; Embryo, Mammalia | 1974 |
Do anticonvulsants have a teratogenic effect?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Cleft Palate; Congenital | 1974 |
Sympodia.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abnormalities, Severe Teratoid; Autopsy; Epile | 1974 |
Effects of age, sex, obesity, and pregnancy on plasma diphenylhydantoin levels.
Topics: Adolescent; Adult; Age Factors; Analysis of Variance; Chromatography, Gas; Dose-Response Relationshi | 1974 |
A medical and social survey of 231 children with seizures.
Topics: Adolescent; Attitude to Health; Child; Child Behavior Disorders; Child, Preschool; Electroencephalog | 1972 |
Barbiturate withdrawal syndrome in a passively addicted infant.
Topics: Cesarean Section; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Infant, Newborn; I | 1972 |
Rare diseases, old drug, new knowledge.
Topics: Animals; Bilirubin; Epilepsy; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Newborn, Diseases | 1973 |
Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Child; Congenital Abnormalities; Drug S | 1973 |
Transplacental passage of primidone.
Topics: Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; Labor, Obstetric; Maternal-Fetal | 1973 |
Neonatal hyperthyroidism.
Topics: Adult; Body Weight; Breast Diseases; Diarrhea; Digitalis Glycosides; Female; Graves Disease; Humans; | 1973 |
The teratological effects of anticonvulsants and the effects on pregnancy and birth.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cleft Lip; Cleft Palate; Cyclohe | 1973 |
Observations on the sudden death of infants born to addicted mothers.
Topics: Adult; Death, Sudden; Female; Heroin Dependence; Humans; Infant; Infant Mortality; Infant, Newborn; | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
[Letter: Teratogenic hazards in antiepileptic therapy].
Topics: Abnormalities, Drug-Induced; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital; Phenytoin; Preg | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
The effect of phenobarbital on intrahepatic cholestasis of pregnancy.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Bilirubin; Blood Pro | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Letter: Anticonvulsant drugs and congenital abnormalities.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Fetus; Fingers; Humans; Infant; Nail | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Maternal barbiturate utilization and neonatal withdrawal symptomatology.
Topics: Anticonvulsants; Apgar Score; Barbiturates; Epilepsy; Female; Gestational Age; Heroin; Humans; Infan | 1972 |
Phenobarbital and alkaline phosphatase: a preliminary report.
Topics: Alkaline Phosphatase; Animals; Female; Humans; Hypophosphatasia; Liver; Phenobarbital; Pregnancy; Pr | 1972 |
Observations on heroin and methadone withdrawal in the newborn.
Topics: Adolescent; Adult; Apgar Score; Birth Weight; Female; Heroin; Humans; Infant, Newborn; Infant, Newbo | 1971 |
[Detection and prognosis of the neonatal mal according to the electroclinical study of 150 cases].
Topics: Cerebral Hemorrhage; Cerebrovascular Disorders; Congenital Abnormalities; Electroencephalography; Ep | 1969 |
[Late cutaneous porphyria with sclerodermic syndrome revealed by taking estrogens, barbiturates and estro-progestational hormones].
Topics: Adult; Amenorrhea; Chemical and Drug Induced Liver Injury; Female; Humans; Lynestrenol; Mestranol; P | 1969 |
Heroin withdrawal syndrome.
Topics: Chlorpromazine; Female; Heroin; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal E | 1970 |
Role of posture in sodium, water, and potassium homeostasis of an abnormal pregnancy.
Topics: Adolescent; Aminohippuric Acids; Blood Pressure; Creatinine; Diet Therapy; Diuresis; Female; Glomeru | 1970 |
Phenobarbital for neonatal jaundice.
Topics: Bilirubin; Eclampsia; Epilepsy; Female; Humans; Infant, Newborn; Infant, Premature; Jaundice, Neonat | 1970 |
P henobarbital-Dilantin treatment of the intrauterine patient.
Topics: Enzyme Induction; Epilepsy; Erythroblastosis, Fetal; Female; Fetal Diseases; Humans; Infant, Newborn | 1970 |
Maternal folate deficiency and pregnancy wastage. IV. Effects of folic acid supplements, anticonvulsants, and oral contraceptives.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Anemia, Macrocytic; Anemia, Sickle Cell; Anemia, | 1971 |
[Congenital abnormalities, cleft lip and cleft palate in particular, in children of epileptic mothers].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Cleft Lip; Cleft Palate; Epilepsy; Fema | 1971 |
[Severe neonatal avitaminosis K in 2 infants born of a mother treated with anticonvulsants].
Topics: Adult; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Preg | 1968 |
[On the problem of the treatment of cerebral epilepsy during pregnancy, labor and puerperium].
Topics: Anticonvulsants; Delivery, Obstetric; Epilepsy; Female; Humans; Obstetric Labor Complications; Pheno | 1968 |
Pheochromocytoma associated with pregnancy. Specialty team management and review.
Topics: Adrenal Gland Neoplasms; Adult; Anesthesia, Intravenous; Female; Fetal Death; Humans; Hypertension; | 1969 |
Transplacental effects of drugs in mice.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Male; Maternal-Fetal Exchange; Methylcell | 1965 |