phenobarbital and Coma
phenobarbital has been researched along with Coma in 64 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 9.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| " We report 3 women, aged 20, 20 and 28 and a man aged 24 with psychogenic status epilepticus admitted to an intensive care unit and treated by induction of phenobarbital coma when other antiepileptic medication failed." | 7.70 | [Phenobarbital coma for psychogenic status epilepticus]. ( Kramer, U; Neufeld, MY; Taliansky, A, 2000) |
| "Doxepin is a tricyclic antidepressant from the group of dibenzoxepines." | 5.38 | [Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study]. ( Kołodziej, M; Krajewska, A; Majewska, M; Szponar, J, 2012) |
| "Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression." | 5.30 | A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria. ( Abdel Baki, SG; Birbeck, GL; Capparelli, EV; Dzinjalamala, FK; Gardiner, JC; Herman, ST; Mallewa, M; Postels, DG; Seydel, KB; Taylor, TE; Toto, NM, 2019) |
| "She was comatose, hypotensive and in acute renal failure with crystalluria." | 5.27 | Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion. ( de Jong, W; Seldenrijk, R; van Dijk, A; van Heijst, AN, 1983) |
| " Therapeutic coma induction with midazolam, thiopentone, phenobarbitone or propofol is indicated when conventional antiepileptics fail to abort seizure." | 4.98 | High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature. ( Chakrabarty, B; Gulati, S; Jauhari, P; Lodha, R; Sankar, J; Sondhi, V, 2018) |
| "To report a case of hyperammonemia without hepatic dysfunction as a possible cause of lethargy, stupor, and coma in a woman after valproic acid (VPA) administration, and discuss the possible different mechanisms of ammonia elevation and coma." | 4.78 | Valproate-induced coma: case report and literature review. ( Clavería, LE; Coria, F; Duarte, J; Fernandez, E; Macias, S, 1993) |
| " We describe a patient with phenobarbital-induced hypersensitivity syndrome who revealed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with limbic encephalitis during the course of the disease." | 3.74 | Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome. ( Fukuhara, M; Kano, Y; Sakuma, K; Shiohara, T, 2008) |
| " We report 3 women, aged 20, 20 and 28 and a man aged 24 with psychogenic status epilepticus admitted to an intensive care unit and treated by induction of phenobarbital coma when other antiepileptic medication failed." | 3.70 | [Phenobarbital coma for psychogenic status epilepticus]. ( Kramer, U; Neufeld, MY; Taliansky, A, 2000) |
| " The results indicate that (1) neurodiagnostic tests such as electroencephalograms and radionuclide scanning reconfirmed clinically determined brain death in only one half to two thirds of patients; (2) electrocerebral silence in the absence of barbiturates, hypothermia, or cerebral malformations during 24 hours was confirmatory of brain death if the clinical findings remained unchanged; (3) absence of radionuclide uptake associated with initial electrocerebral silence was associated with brain death; (4) term infants clinically brain dead for 2 days and preterm infants brain dead for 3 days did not survive despite electroencephalogram or cerebral blood flow status; and (5) phenobarbital levels greater than 25 micrograms/mL may suppress electroencephalographic activity in this age group." | 3.67 | Brain death in the newborn. ( Ashwal, S; Schneider, S, 1989) |
| "Enuresis is a common problem often treated effectively with imipramine hydrochloride." | 3.66 | Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981) |
| "The present studies evaluated the effect of phenobarbital, pentobarbital, and thiopental at concentrations comparable to those attained during therapeutic barbiturate-induced coma, on in vitro mitogen-induced lymphocyte activation." | 3.66 | Barbiturate inhibition of lymphocyte function. Differing effects of various barbiturates used to induce coma. ( Frenkel, E; Hill, SA; Kikuchi, K; Lipsky, P; Neuwelt, EA, 1982) |
| "Doxepin is a tricyclic antidepressant from the group of dibenzoxepines." | 1.38 | [Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study]. ( Kołodziej, M; Krajewska, A; Majewska, M; Szponar, J, 2012) |
| "Phenobarbital was detected in the blood." | 1.35 | [Intoxication with an unknown sedative substance]. ( Bodmer, M; Christ, A; Liechti, ME, 2008) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "Coma blisters are self-limited lesions that occur in the setting of coma of various causes, but are most commonly associated with barbiturate overdose." | 1.28 | Coma blisters: report and review. ( Dunn, C; Grossman, ME; Held, JL; Kohn, SR; Silvers, DN; Spitz, J, 1990) |
| "Seventeen had Glasgow Coma Scales of 3 to 4 and 23 scales of 5 to 7." | 1.27 | Early prediction of outcome after severe head injury in children. ( Pfenninger, J, 1984) |
| "She was comatose, hypotensive and in acute renal failure with crystalluria." | 1.27 | Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion. ( de Jong, W; Seldenrijk, R; van Dijk, A; van Heijst, AN, 1983) |
| "The second case occurred subsequent to cardiopulmonary arrest with unfavorable outcome." | 1.27 | Alpha-pattern coma in childhood and adolescence. ( Kaplan, AM; Lersch, DR, 1984) |
| "Six children who remained in deep coma after immersion accidents in fresh water received therapy to maintain normal intracranial pressure (ICP)." | 1.26 | Intensive care after fresh water immersion accidents in children. ( Pfenninger, J; Sutter, M, 1982) |
| "A 41-year-old man in deep coma after drug overdosage showed electroencephalographic activity of alpha frequency." | 1.26 | Recovery from drug-induced alpha coma. ( Furukawa, T; Inaki, K; Kuroiwa, Y, 1981) |
| "Both patients experienced decreases in coma, but both of them bled after treatment." | 1.26 | The treatment of severe drug intoxication with charcoal hemoperfusion in series with hemodialysis. ( Bentley, C; Kjellstrand, CM, 1979) |
Research
Studies (64)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (68.75) | 18.7374 |
| 1990's | 7 (10.94) | 18.2507 |
| 2000's | 8 (12.50) | 29.6817 |
| 2010's | 4 (6.25) | 24.3611 |
| 2020's | 1 (1.56) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kohara, S | 1 |
| Kamijo, Y | 1 |
| Seki, S | 1 |
| Hasegawa, E | 1 |
| Birbeck, GL | 1 |
| Herman, ST | 1 |
| Capparelli, EV | 1 |
| Dzinjalamala, FK | 1 |
| Abdel Baki, SG | 1 |
| Mallewa, M | 1 |
| Toto, NM | 1 |
| Postels, DG | 1 |
| Gardiner, JC | 1 |
| Taylor, TE | 1 |
| Seydel, KB | 1 |
| Gulati, S | 1 |
| Sondhi, V | 1 |
| Chakrabarty, B | 1 |
| Jauhari, P | 1 |
| Lodha, R | 1 |
| Sankar, J | 1 |
| Matsumoto, H | 1 |
| Umakoshi, K | 1 |
| Kikuchi, S | 1 |
| Takeba, J | 1 |
| Aibiki, M | 1 |
| Bodmer, M | 1 |
| Christ, A | 1 |
| Liechti, ME | 1 |
| Wakamoto, H | 1 |
| Nakamura, Y | 1 |
| Ebihara, T | 1 |
| Tokuda, K | 1 |
| Ohmori, H | 1 |
| Kołodziej, M | 1 |
| Majewska, M | 1 |
| Krajewska, A | 1 |
| Szponar, J | 1 |
| FROMMEL, E | 1 |
| RADOUCO-THOMAS, C | 1 |
| STOIMENOV, I | 1 |
| LOLOVA, Kh | 1 |
| VANDAM, LD | 1 |
| COLLINS, WL | 1 |
| WARTER, J | 1 |
| MANTZ, JM | 1 |
| METAIS, P | 1 |
| HAMMANN, B | 1 |
| KURTZ, D | 1 |
| CELESIA, GG | 1 |
| ANDERMANN, F | 1 |
| MULLAN, D | 1 |
| PLATTS, M | 1 |
| RIDGWAY, B | 1 |
| RIZZUTO, VJ | 1 |
| INGLESBY, TV | 1 |
| GRACE, WJ | 1 |
| KASPERLIK, A | 1 |
| SASAKI, K | 1 |
| SAITO, S | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Lal, R | 1 |
| Faiz, S | 1 |
| Garg, RK | 1 |
| Baweja, KS | 1 |
| Guntupalli, J | 1 |
| Finkel, KW | 1 |
| Kenny, JM | 1 |
| Chipolombwe, MJ | 1 |
| Molyneux, E | 1 |
| Sakuma, K | 1 |
| Kano, Y | 1 |
| Fukuhara, M | 1 |
| Shiohara, T | 1 |
| Goulon, M | 1 |
| Nouailhat, F | 1 |
| Lévy-Alcover, MA | 1 |
| Dordain, G | 1 |
| Johanson, WG | 1 |
| Greene, AS | 1 |
| Cromie, WJ | 1 |
| Pfenninger, J | 2 |
| González, J | 1 |
| Abraham-Jalil, A | 1 |
| Mota Hernández, F | 1 |
| Lezama, C | 1 |
| van Heijst, AN | 1 |
| de Jong, W | 1 |
| Seldenrijk, R | 1 |
| van Dijk, A | 1 |
| Lersch, DR | 1 |
| Kaplan, AM | 1 |
| Seghieri, G | 1 |
| De Giorgio, LA | 1 |
| Innocenti, F | 1 |
| Pettiná, G | 1 |
| Zolfanelli, F | 1 |
| Apicella, P | 1 |
| Salmoiraghi, L | 1 |
| Carabellese, G | 1 |
| Neuwelt, EA | 1 |
| Kikuchi, K | 1 |
| Hill, SA | 1 |
| Lipsky, P | 1 |
| Frenkel, E | 1 |
| Sutter, M | 1 |
| Kuroiwa, Y | 1 |
| Furukawa, T | 1 |
| Inaki, K | 1 |
| Hume, AL | 1 |
| Cant, BR | 1 |
| Albertson, TE | 1 |
| Fisher, CJ | 1 |
| Shragg, TA | 1 |
| Baselt, RC | 1 |
| Lin, JL | 1 |
| Lim, PS | 1 |
| Mirski, MA | 1 |
| Williams, MA | 1 |
| Hanley, DF | 1 |
| Duarte, J | 1 |
| Macias, S | 1 |
| Coria, F | 1 |
| Fernandez, E | 1 |
| Clavería, LE | 1 |
| Söylemezoğlu, O | 1 |
| Bakkaloğlu, A | 1 |
| Yiğit, S | 1 |
| Saatçi, U | 1 |
| Taliansky, A | 1 |
| Kramer, U | 1 |
| Neufeld, MY | 1 |
| Palmer, BF | 1 |
| Bentley, C | 1 |
| Kjellstrand, CM | 1 |
| Martí Viaño, JL | 1 |
| Sellés, J | 1 |
| Orts, A | 1 |
| Marco, J | 1 |
| Vega, F | 1 |
| Esplugues, J | 1 |
| Bondoli, A | 1 |
| Magalini, SI | 1 |
| Barbi, S | 1 |
| Rodola, F | 1 |
| Abballe, C | 1 |
| Aoki, N | 1 |
| Sutton, D | 1 |
| Dunn, C | 1 |
| Held, JL | 1 |
| Spitz, J | 1 |
| Silvers, DN | 1 |
| Grossman, ME | 1 |
| Kohn, SR | 1 |
| de Boer, WB | 1 |
| Kendall, PA | 1 |
| Breheny, FX | 1 |
| Ashwal, S | 1 |
| Schneider, S | 1 |
| Schneider, D | 1 |
| Engelmann, L | 1 |
| Tanaka, T | 1 |
| Tomita, Y | 1 |
| Nishimura, S | 1 |
| Goldberg, MJ | 1 |
| Berlinger, WG | 1 |
| Park, GD | 1 |
| Wroblewski, BA | 1 |
| Garvin, WH | 1 |
| Hancock, BW | 1 |
| Derr, RF | 1 |
| Zieve, L | 1 |
| Ernest, C | 1 |
| Hirsch, JF | 1 |
| Metzger, J | 1 |
| Chahinian, P | 1 |
| Leblanc, J | 1 |
| Godeau, P | 1 |
| Karch, SB | 1 |
| Grohme, S | 1 |
| Schneider, H | 1 |
| Masshoff, W | 1 |
| Carroll, BJ | 1 |
| Fournier, E | 1 |
| Kaloyanova, F | 1 |
| Treich, I | 1 |
| Capelle, N | 1 |
| Sampson, D | 1 |
| Harasymiv, I | 1 |
| Hensley, WJ | 1 |
| Spehlman, R | 1 |
| Colley, B | 1 |
| Landesman, LM | 1 |
| Milner, G | 1 |
| Lous, P | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Safety and Feasibility Study of Enteral Levetiracetam vs. Phenobarbital for Seizure Control in Pediatric Cerebral Malaria[NCT01982812] | Phase 2 | 44 participants (Actual) | Interventional | 2014-01-31 | Completed | ||
| A Dose-Escalation, Safety And Feasibility Study Of Enteral Levetiracetam For Seizure Control In Pediatric Cerebral Malaria[NCT01660672] | Phase 1/Phase 2 | 7 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Mean Time From Admission to BCS >/= 4
"The mean time in hours from admission until the subject reaches Blantyre Coma Scale of greater than or equal to 4. Participants who died are excluded from this analysis.~The Blantyre Coma Score has ranges from 0-5 based upon the a sum of the following 3 domains- Eye movement~1 - Watches or follows 0 - Fails to watch or follow~Best motor response 2 - Localizes painful stimulus 1 - Withdraws limb from painful stimulus 0 - No response or inappropriate response~Best verbal response 2 - Cries appropriately with pain, or, if verbal, speaks~1 - Moan or abnormal cry with pain 0 - No vocal response to pain" (NCT01982812)
Timeframe: 7 days
| Intervention | hours of coma from admission (Mean) |
|---|---|
| Oral Levetiracetam | 35.4 |
| Comparison Group | 34.6 |
Minutes With Seizure on EEG
Comparing LVT to standard AED the number of minutes spent in seizure per cEEG in the 72 hours after treatment allocation. (NCT01982812)
Timeframe: 72 hours
| Intervention | minutes with seizure (Mean) |
|---|---|
| Oral Levetiracetam | 165.2 |
| Comparison Group | 464.8 |
Required Additional AED
Additional AEDs required (including for breakthrough seizures in LVT group) during admission for seizure control (yes/no) (NCT01982812)
Timeframe: 7 days
| Intervention | Participants requiring additional AEDs (Number) |
|---|---|
| Oral Levetiracetam | 18 |
| Comparison Group | 18 |
Sequelae
"Neurologic outcome in 3 categories--~Neurologically intact at discharge~Neurologic sequelae at discharge--specifically new sensory or motor deficits, ongoing seizures, or behavioral abnormalities based upon a physician examination at discharge~Died during admission, never discharged" (NCT01982812)
Timeframe: 7 days
| Intervention | participants (Number) | ||
|---|---|---|---|
| Neurologically intact at discharge | Neurologic sequelae at discharge | Died during admission | |
| Comparison Group | 14 | 2 | 5 |
| Oral Levetiracetam | 19 | 3 | 1 |
Freedom From Seizure
Number of subjects free of seizure at 24 hours after initiation of treatment (NCT01660672)
Timeframe: 24 hours
| Intervention | individuals (Number) |
|---|---|
| LEVETIRACETAM | 7 |
Mean Time to Return to a BCS Score Greater Than or Equal to 4
Mean time from admission to a BCS score greater than or equal to 4. The BCS (Blantyre Coma Scale) is a 0-5 scale measuring motor response, verbal response and eye movement assessing the severity of coma in children with cerebral malaria. Lower scores correspond to more profound coma. (NCT01660672)
Timeframe: 7 days
| Intervention | hours (Mean) |
|---|---|
| LEVETIRACETAM | 35.3 |
Number of Participants Requiring AED During Admission
Number of participants who required AEDS during admission(including for breakthrough seizures in the LVT group) during admission. (NCT01660672)
Timeframe: 7 days
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 6 |
Number of Participants With Neurologic Sequelae at Discharge
Number of participants with neurologic sequelae at discharge (NCT01660672)
Timeframe: day 7
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 2 |
Number of Subjects Exposed to Phenobarbitone Prior to Enrollment
Pre-enrollment exposure to phenobarbitone may impact LVT efficacy, and analysis base on this characteristic will be evaluated. (NCT01660672)
Timeframe: 0 hour
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 3 |
Number of Subjects With Retinopathy at Enrollment
Retinopathy status may impact LVT efficacy and subject status will be analyzed based on this characteristic. (NCT01660672)
Timeframe: Upon admission
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 4 |
Range of Plasma Concentration of LVT Across All Individuals
Range of plasma LVT concentrations will be determined through HPLC method at eight timepoints post administration to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 72 hours
| Intervention | mcg/ml (Mean) |
|---|---|
| LEVETIRACETAM | 35 |
Toxicity Related to LVT
Toxicity including vomiting, aspiration, complications related to the NGT, laboratory parameters at 24 hours and 1 week post LVT administration, and an overall acute case fatality rate significantly above the consistent historical ward average for CM. Pk studies to evaluate LVT absorption and elimination in pediatric CM. (NCT01660672)
Timeframe: 1 week
| Intervention | participants (Number) |
|---|---|
| LEVETIRACETAM | 0 |
Reviews
2 reviews available for phenobarbital and Coma
| Article | Year |
|---|---|
High dose phenobarbitone coma in pediatric refractory status epilepticus; a retrospective case record analysis, a proposed protocol and review of literature.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Protocols; Coma; Drug Resistance; Fem | 2018 |
Valproate-induced coma: case report and literature review.
Topics: Ammonia; Coma; Epilepsy, Complex Partial; Female; Humans; Middle Aged; Phenobarbital; Phenytoin; Val | 1993 |
Trials
2 trials available for phenobarbital and Coma
| Article | Year |
|---|---|
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Coma; Cross-Over Studies; | 2019 |
Activated charcoal in phenobarbital overdose.
Topics: Adult; Charcoal; Coma; Drug Administration Schedule; Humans; Phenobarbital | 1985 |
Other Studies
60 other studies available for phenobarbital and Coma
| Article | Year |
|---|---|
Poisoning by abnormally high blood phenobarbital concentration treated with extracorporeal therapy.
Topics: Blood Gas Analysis; Charcoal; Coma; Humans; Male; Middle Aged; Norepinephrine; Phenobarbital | 2023 |
[BIS values were useful on the evaluation of consciousness recovery in acute Vegetamin-A poisoning: report of a case].
Topics: Acute Disease; Adult; Charcoal; Chlorpromazine; Coma; Consciousness Monitors; Drug Combinations; Ene | 2014 |
[Intoxication with an unknown sedative substance].
Topics: Coma; Diagnosis, Differential; Half-Life; Humans; Hypnotics and Sedatives; Male; Metabolic Clearance | 2008 |
Reversible coma associated with prolonged high-dose phenobarbital therapy in bilateral Sturge-Weber syndrome.
Topics: Anticonvulsants; Brain; Causality; Cerebrovascular Disorders; Coma; Consciousness; Contraindications | 2009 |
[Prolonged toxic coma and anisocoria secondary to doxepin, lorazepam and phenobarbital poisoning--case study].
Topics: Antidepressive Agents, Tricyclic; Coma; Complex Mixtures; Doxepin; Drug Overdose; Drug Synergism; Hu | 2012 |
[Effects of phenobarbital, acylureas and diphenylhydantoin on coma during electric epileptic crisis in guinea pig. II..].
Topics: Anticonvulsants; Barbiturates; Coma; Electricity; Epilepsy; Guinea Pigs; Phenobarbital; Phenytoin; S | 1953 |
[Hypoglycemic coma induced by small doses of insulin in the treatment of psychiatric diseases; combination of insulin with luminal and caffeine. I].
Topics: Caffeine; Coma; Convulsive Therapy; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Mental Disor | 1957 |
Recovery from acute phenobarbital intoxication after prolonged coma.
Topics: Barbiturates; Coma; Drug-Related Side Effects and Adverse Reactions; Phenobarbital; Psychoses, Subst | 1963 |
[Prolonged coma (10 days) due to massive phenobarbital (25 g) poisoning: prolonged apnea (4 days); artificial respiration. Recovery].
Topics: Apnea; Barbiturates; Cardiac Glycosides; Cell Respiration; Chloroform; Coma; Humans; Phenobarbital; | 1963 |
SOME OBSERVATIONS ON THE ELECTROGRAPHIC CORRELATES OF THE DECEREBRATE ATTACK.
Topics: Child; Coma; Decerebrate State; Electroencephalography; Epilepsy; Humans; Hypoxia, Brain; Infusions, | 1964 |
BARBITURATE INTOXICATION.
Topics: Amobarbital; Barbiturates; Coma; Diagnosis; Electrocardiography; Hypnotics and Sedatives; Hypoxia, B | 1965 |
PROBENECID (BENEMID) INTOXICATION WITH STATUS EPILEPTICUS.
Topics: Coma; Drug Therapy; Epilepsy; Gout; Phenobarbital; Phenytoin; Poisoning; Probenecid; Status Epilepti | 1965 |
[STABILITY OF THE INTERNAL ENVIRONMENT IN THE TREATMENT OF BARBITURATE POISONING (APROPOS OF A CASE OF LUMINAL POISONING WITH COMA LASTING 10 DAYS)].
Topics: Barbiturates; Coma; Phenobarbital; Toxicology | 1964 |
[Changes in substances related to gamma-aminobutyric acid in various parts of the rabbit brain during phenobarbital coma and megimide awakening].
Topics: Amino Acids; Animals; Bemegride; Brain; Brain Chemistry; Central Nervous System Stimulants; Coma; ga | 1962 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Use of continuous venovenous hemodiafiltration in a case of severe phenobarbital poisoning.
Topics: Coma; Drug Overdose; Hemodiafiltration; Humans; Hypnotics and Sedatives; Hypotension; Male; Middle A | 2006 |
A case of repeated coma in an 8-year-old boy.
Topics: Anticonvulsants; Child; Coma; Humans; Male; Phenobarbital; Porphyria, Acute Intermittent; Recurrence | 2007 |
Syndrome of inappropriate secretion of antidiuretic hormone associated with limbic encephalitis in a patient with drug-induced hypersensitivity syndrome.
Topics: Acyclovir; Aged; Anticonvulsants; Antiviral Agents; Coma; Drug Hypersensitivity; Encephalitis; Epile | 2008 |
[Toxic coma with autonomic sideration, with a favorable outcome].
Topics: Adult; Amobarbital; Body Temperature; Brain; Cardiovascular System; Chlorpromazine; Coma; Diazepam; | 1967 |
Massive phenobarbital ingestion with survival.
Topics: Adult; Coma; Female; Humans; Phenobarbital; Radiography, Thoracic | 1967 |
Treatment of imipramine overdose in children.
Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat | 1981 |
Early prediction of outcome after severe head injury in children.
Topics: Adolescent; Blood Coagulation Tests; Brain Death; Brain Injuries; Child; Child, Preschool; Coma; Dex | 1984 |
[Phenobarbital poisoning].
Topics: Coma; Combined Modality Therapy; Humans; Infant; Male; Phenobarbital; Pulmonary Edema | 1983 |
Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.
Topics: Aged; Charcoal; Coma; Female; Half-Life; Hemoperfusion; Humans; Kinetics; Phenobarbital; Phenylethyl | 1983 |
Alpha-pattern coma in childhood and adolescence.
Topics: Adolescent; Age Factors; Alpha Rhythm; Child; Child, Preschool; Coma; Heart Arrest; Humans; Infant; | 1984 |
[Description of a case of a syndrome similar to Reye's syndrome in a male adult undergoing treatment with valproic acid and phenobarbital].
Topics: Adult; Brain Diseases; Coma; Epilepsy, Tonic-Clonic; Fever; Humans; Male; Muscle Rigidity; Phenobarb | 1982 |
[Our experience with intensive therapy of some cases of infantile encephalitis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Coma; Dexamethasone; Encephalitis; | 1981 |
Barbiturate inhibition of lymphocyte function. Differing effects of various barbiturates used to induce coma.
Topics: Barbiturates; Blood Proteins; Cell Division; Coma; Humans; Lymphocyte Activation; Lymphocytes; Mitog | 1982 |
Intensive care after fresh water immersion accidents in children.
Topics: Accidents; Child; Child, Preschool; Coma; Critical Care; Female; Fresh Water; Humans; Hypothermia, I | 1982 |
Recovery from drug-induced alpha coma.
Topics: Adult; Alpha Rhythm; Chlorpromazine; Coma; Diazepam; Humans; Male; Phenobarbital; Suicide, Attempted | 1981 |
Central somatosensory conduction after head injury.
Topics: Adolescent; Adult; Body Temperature Regulation; Brain Injuries; Brain Stem; Child; Coma; Dominance, | 1981 |
A prolonged severe intoxication after ingestion of phenytoin and phenobarbital.
Topics: Adult; Coma; Confusion; Female; Gastric Lavage; Humans; Nystagmus, Pathologic; Phenobarbital; Phenyt | 1981 |
Continuous arteriovenous hemoperfusion in acute poisoning.
Topics: Adult; Aged; Arteriovenous Shunt, Surgical; Coma; Fatal Outcome; Female; Hemodynamics; Hemoperfusion | 1994 |
Prolonged pentobarbital and phenobarbital coma for refractory generalized status epilepticus.
Topics: Adolescent; Coma; Electrocardiography; Humans; Male; Pentobarbital; Phenobarbital; Status Epilepticu | 1995 |
Haemodialysis treatment in phenobarbital intoxication in infancy.
Topics: Coma; Humans; Infant; Male; Phenobarbital; Poisoning; Renal Dialysis | 1993 |
[Phenobarbital coma for psychogenic status epilepticus].
Topics: Adult; Anticonvulsants; Coma; Female; Humans; Male; Phenobarbital; Psychophysiologic Disorders; Stat | 2000 |
Effectiveness of hemodialysis in the extracorporeal therapy of phenobarbital overdose.
Topics: Adult; Anticonvulsants; Charcoal; Coma; Drug Overdose; Female; Humans; Hypnotics and Sedatives; Phen | 2000 |
The treatment of severe drug intoxication with charcoal hemoperfusion in series with hemodialysis.
Topics: Adolescent; Adult; Charcoal; Coma; Female; Hematoma; Hemoperfusion; Humans; Male; Metabolic Clearanc | 1979 |
[Antagonism of barbituric coma by stimulating products. Experimental study].
Topics: Animals; Body Weight; Choline; Coma; Cytidine Diphosphate Choline; Female; Glycolates; Injections, I | 1978 |
Distribution of free amino acids in coma due to acute barbiturate poisoning in guinea pigs.
Topics: Amino Acids; Animals; Brain; Coma; Energy Metabolism; Guinea Pigs; Male; Phenobarbital | 1979 |
Infantile acute encephalopathy with combined symmetrical hypodensities in the thalami and the putamen on computed tomography.
Topics: Acute Disease; Brain Diseases; Coma; Follow-Up Studies; Glycerol; Humans; Infant; Male; Necrosis; Ph | 1992 |
Alpha coma--comment.
Topics: Alpha Rhythm; Barbiturates; Carbon Monoxide Poisoning; Coma; Humans; Phenobarbital | 1990 |
Coma blisters: report and review.
Topics: Adult; Blister; Coma; Humans; Male; Phenobarbital | 1990 |
Alpha coma and barbiturate poisoning.
Topics: Alpha Rhythm; Barbiturates; Carbon Monoxide Poisoning; Coma; Drug Overdose; Electroencephalography; | 1989 |
Brain death in the newborn.
Topics: Apnea; Brain; Brain Death; Brain Stem; Cerebrovascular Circulation; Coma; Electroencephalography; Hu | 1989 |
[Sense and nonsense in barbiturate-induced functional paralysis for the protective and therapeutic decrease in cerebral oxygen requirements].
Topics: Brain; Cerebral Hemorrhage; Cerebral Infarction; Coma; Hemodynamics; Humans; Oxygen Consumption; Phe | 1988 |
[Electroencephalographic rhythms of alpha frequency in a comatose patient with adrenoleukodystrophy--the spectrum analysis of alpha wave in EEG and the electrophysiological studies of alpha-coma].
Topics: Adrenoleukodystrophy; Alpha Rhythm; Child; Coma; Diffuse Cerebral Sclerosis of Schilder; Humans; Mal | 1986 |
Once-daily administration of phenobarbital in adults. Clinical efficacy and benefit.
Topics: Adult; Brain Injuries; Coma; Female; Humans; Male; Middle Aged; Phenobarbital; Seizures | 1985 |
Acute barbiturate poisoning in young epileptics.
Topics: Adolescent; Child; Coma; Epilepsy, Tonic-Clonic; Female; Humans; Male; Phenobarbital; Substance-Rela | 1974 |
Adenylate energy charge: relation to guanylate energy charge and the adenylate kinase equilibrium constant.
Topics: Adenine Nucleotides; Adenosine Monophosphate; Ammonia; Animal Nutritional Physiological Phenomena; A | 1972 |
[Bilateral hypoplasia of the internal carotid with persistance of an admirable network. Apropos of a case in an adult].
Topics: Adult; Blood Flow Velocity; Carotid Arteries; Carotid Artery, Internal; Cerebral Angiography; Collat | 1973 |
Methsuximide overdose. Delayed onset of profound coma.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Central Nervous System; Coma; Drug Synergism; Ele | 1973 |
[Encephalopathies in vita reducta].
Topics: Adult; Aged; Brain; Brain Death; Brain Injuries; Carbon Monoxide Poisoning; Cerebellum; Cerebral Cor | 1969 |
Barbiturate overdosage: presentation with focal neurological signs.
Topics: Adult; Alcoholism; Amobarbital; Barbiturates; Basilar Artery; Bromides; Cerebral Hemorrhage; Coma; C | 1969 |
[Application of gas chromatography to the identification and determination of barbiturate derivatives in the blood during acute poisoning].
Topics: Amobarbital; Barbiturates; Chemistry, Clinical; Chromatography, Gas; Coma; Humans; Methods; Methylat | 1970 |
Gas chromatographic assay of underivatized 5,5-diphenylhydantoin (dilantin) in plasma extracts.
Topics: Carbamazepine; Chloroform; Chromatography, Gas; Coma; Epilepsy; Humans; Hydrogen-Ion Concentration; | 1971 |
Effect of diazepam (Valium) on experimental seizures in unanesthetized cat.
Topics: Animals; Cats; Cerebral Cortex; Coma; Diazepam; Electroencephalography; Light; Pentylenetetrazole; P | 1968 |
[A case of severe acute poisoning by Bellaspon].
Topics: Adult; Atropa belladonna; Coma; Ergotamine; Female; Humans; Phenobarbital; Plants, Medicinal; Plants | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine | 1968 |
Elimination of barbiturates.
Topics: Adult; Amobarbital; Barbiturates; Coma; Female; Humans; Pentobarbital; Phenobarbital; Thiopental | 1966 |