phenobarbital has been researched along with Colonic Neoplasms in 13 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 5.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 1.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schuetz, EG | 1 |
| Beck, WT | 1 |
| Schuetz, JD | 1 |
| Fang, WF | 2 |
| Strobel, HW | 3 |
| Newaz, SN | 1 |
| Bolanowska, W | 1 |
| Gessner, T | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Jacomino, M | 1 |
| Shukla, P | 1 |
| Henning, SJ | 1 |
| Spinardi, AL | 1 |
| Kaneno, R | 1 |
| Rodrigues, MA | 1 |
| Salvadori, DM | 1 |
| Rocha, NS | 1 |
| Barbisan, LF | 1 |
| Ribeiro, LR | 1 |
| de Camargo, JL | 1 |
| Thièry, JP | 1 |
| Blazsek, I | 1 |
| Legras, S | 1 |
| Marion, S | 1 |
| Reynes, M | 1 |
| Anjo, A | 1 |
| Adam, R | 1 |
| Misset, JL | 1 |
| Bibby, MC | 1 |
| Phillips, RM | 1 |
| Double, JA | 1 |
| Hammond, DK | 1 |
| Chabot, GG | 1 |
| Bissery, MC | 1 |
| Gouyette, A | 1 |
| Ito, N | 1 |
| McLean, AE | 1 |
| Driver, HE | 1 |
| McDanell, R | 1 |
| Tacchi-Bedford, AM | 1 |
2 reviews available for phenobarbital and Colonic Neoplasms
| Article | Year |
|---|---|
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogen | 1986 |
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
11 other studies available for phenobarbital and Colonic Neoplasms
| Article | Year |
|---|---|
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, No | 1996 |
Effects of cyclophosphamide and polycyclic aromatic hydrocarbons on cell growth and mixed-function oxidase activity in a human colon tumor cell line.
Topics: Adenocarcinoma; Anthracenes; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Biotransformation; Ce | 1982 |
Metabolism of the carcinogen 1,2-dimethylhydrazine by isolated human colon microsomes and human colon tumor cells in culture.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Adult; Biotransformation; Carcinogens; Cells, Cultured; Colon | 1983 |
Drug interactions with acetaminophen: effects of phenobarbital, prednisone and 5-fluorouracil in normal and tumor-bearing rats.
Topics: Acetaminophen; Animals; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Galactosamine; I | 1980 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Use of amphotropic retroviral vectors for gene transfer in human colon carcinoma cells.
Topics: 3T3 Cells; Acetylcysteine; Animals; Caco-2 Cells; Colonic Neoplasms; Culture Media; Gene Transfer Te | 1997 |
Natural killer activity in a medium-term multi-organ bioassay for carcinogenesis.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Animals; Biological Assay; Carcinogenicity Tests; Carc | 1999 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neopla | 1999 |
The relationship between tissue levels of flavone acetic acid (NSC 347512) and site dependent anti-tumour activity in murine colon tumours.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Biological Availability; Colonic Neoplasms; Drug Scr | 1991 |
Human colon tumor cell line LS174T drug metabolizing system.
Topics: Animals; Cell Line; Colonic Neoplasms; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Cytoch | 1990 |
Flavone acetic acid (LM-975; NSC-347512) activation to cytotoxic species in vivo and in vitro.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cells, Cultured; Colonic Neoplasms; Dose-Response Re | 1989 |