phenobarbital has been researched along with Cognition Disorders in 30 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "Children exposed during pregnancy to the anticonvulsant drugs phenytoin, phenobarbital, and carbamazepine as monotherapy and polytherapy have an increased frequency of midface and digit hypoplasia." | 3.73 | The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs. ( Coull, BA; Dorfman, J; Holmes, LB; Rosenberger, PB, 2005) |
| "Neurocognitive performances were evaluated in 9 children with different types of epilepsy prior to and at least 6 months after discontinuation of phenobarbital." | 3.69 | Discontinuation of phenobarbital in children: effects on neurocognitive behavior. ( Devoti, M; Riva, D, 1996) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Curcumin has shown antioxidant, anti-inflammatory and neuro-protective properties." | 1.36 | Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. ( Gupta, YK; Mehla, J; Reeta, KH, 2010) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 8 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Verrotti, A | 1 |
| Scaparrotta, A | 1 |
| Cofini, M | 1 |
| Chiarelli, F | 1 |
| Tiboni, GM | 1 |
| Saldarriaga, W | 1 |
| Lein, P | 1 |
| González Teshima, LY | 1 |
| Isaza, C | 1 |
| Rosa, L | 1 |
| Polyak, A | 1 |
| Hagerman, R | 1 |
| Girirajan, S | 1 |
| Silva, M | 1 |
| Tassone, F | 1 |
| Cumbo, E | 1 |
| Ligori, LD | 1 |
| Reeta, KH | 2 |
| Mehla, J | 1 |
| Gupta, YK | 2 |
| Markowitz, GJ | 1 |
| Kadam, SD | 1 |
| Smith, DR | 1 |
| Johnston, MV | 1 |
| Comi, AM | 1 |
| Zhang, LL | 1 |
| Zeng, LN | 1 |
| Li, YP | 1 |
| Pahuja, M | 1 |
| Kleekal, T | 1 |
| Tripathi, M | 1 |
| Rattka, M | 1 |
| Brandt, C | 2 |
| Löscher, W | 2 |
| Holmes, LB | 1 |
| Coull, BA | 1 |
| Dorfman, J | 1 |
| Rosenberger, PB | 1 |
| Karlov, VA | 1 |
| Gastens, AM | 1 |
| Bankstahl, JP | 1 |
| Somerville, ER | 1 |
| Bruni, J | 1 |
| Dam, M | 1 |
| Marescaux, C | 1 |
| Warter, JM | 1 |
| Micheletti, G | 1 |
| Rumbach, L | 1 |
| Coquillat, G | 1 |
| Kurtz, D | 1 |
| Branford, D | 1 |
| Collacott, RA | 1 |
| Riva, D | 1 |
| Devoti, M | 1 |
| Molyneux, ME | 1 |
| Camfield, CS | 1 |
| Chaplin, S | 1 |
| Doyle, AB | 1 |
| Shapiro, SH | 1 |
| Cummings, C | 1 |
| Camfield, PR | 1 |
| Kugoh, T | 1 |
| Hosokawa, K | 1 |
| Fishman, MA | 1 |
| Gallassi, R | 2 |
| Morreale, A | 2 |
| Di Sarro, R | 1 |
| Marra, M | 1 |
| Lugaresi, E | 1 |
| Baruzzi, A | 2 |
| Bigarella, MM | 1 |
| Mäder, MJ | 1 |
| Doro, MP | 1 |
| Gorz, AM | 1 |
| Marcourakis, T | 1 |
| Tsanaclis, L | 1 |
| Bittencourt, PR | 1 |
| Trimble, MR | 2 |
| Trimble, R | 1 |
| Lorusso, S | 1 |
| Stracciari, A | 1 |
| Procaccianti, G | 1 |
| Groh, CH | 1 |
| Rosenmayr, FW | 1 |
| Chédru, F | 1 |
| Geschwind, N | 1 |
| Hansotia, P | 1 |
| Wadia, NH | 1 |
| Zlotlow, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Diagnosis and Management of Patients With Epilepsy: Nationwide, Multicenter Study of Recordings for the Diagnosis and Management of Patients With Epilepsy and Treatment With Levetiracetam in Daily Clinical Practice in Greece[NCT02356731] | 450 participants (Actual) | Observational | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for phenobarbital and Cognition Disorders
| Article | Year |
|---|---|
Developmental neurotoxicity and anticonvulsant drugs: a possible link.
Topics: Animals; Anticonvulsants; Breast Feeding; Carbamazepine; Cognition Disorders; Developmental Disabili | 2014 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; | 1990 |
Anticonvulsant drugs and cognitive function: a review of the literature.
Topics: Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; Phenobarbital; Phe | 1987 |
3 trials available for phenobarbital and Cognition Disorders
| Article | Year |
|---|---|
Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Anticonvulsants; Case-Control Stud | 2010 |
Interaction profile of Zizyphus jujuba with phenytoin, phenobarbitone, and carbamazepine in maximal electroshock-induced seizures in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Chi-Square Distribution; Chromat | 2012 |
Side effects of phenobarbital in toddlers; behavioral and cognitive aspects.
Topics: Child Behavior Disorders; Child, Preschool; Clinical Trials as Topic; Cognition Disorders; Dose-Resp | 1979 |
23 other studies available for phenobarbital and Cognition Disorders
| Article | Year |
|---|---|
Phenobarbital use and neurological problems in FMR1 premutation carriers.
Topics: Cognition Disorders; DNA Mutational Analysis; Excitatory Amino Acid Antagonists; Family Health; Fema | 2016 |
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Brain; Carbamazepine; Cognition Disorder | 2010 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
The intrahippocampal kainate model of temporal lobe epilepsy revisited: epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Epilepsy, Temporal Lobe; Fema | 2013 |
The correlation of deficits in IQ with midface and digit hypoplasia in children exposed in utero to anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Face; Facie | 2005 |
[Epileptic encephalopathy].
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Cognition Disorders; Electroencephalography; Epilep | 2006 |
Predictors of pharmacoresistant epilepsy: pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cognition Disorders; Dis | 2008 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum | 1984 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
Comparison of community and institutional prescription of antiepileptic drugs for individuals with learning disabilities.
Topics: Adult; Ambulatory Care; Anticonvulsants; Cognition Disorders; Day Care, Medical; Drug Therapy, Combi | 1994 |
Discontinuation of phenobarbital in children: effects on neurocognitive behavior.
Topics: Adolescent; Anticonvulsants; Attention; Child; Cognition Disorders; Dose-Response Relationship, Drug | 1996 |
Impact of malaria on the brain and its prevention.
Topics: Africa; Animals; Anticonvulsants; Child, Preschool; Cognition Disorders; Humans; Malaria, Cerebral; | 2000 |
Mental dullness associated with left frontal continuous focal discharge.
Topics: Adult; Carbamazepine; Cognition Disorders; Electroencephalography; Epilepsy, Post-Traumatic; Frontal | 1977 |
Commentary: side effects of phenobarbital.
Topics: Child, Preschool; Cognition Disorders; Humans; Intelligence; Intelligence Tests; Phenobarbital; Seiz | 1979 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; | 1992 |
Cognitive functions of epileptic patients on monotherapy with phenobarbitone and healthy controls.
Topics: Adolescent; Adult; Cognition; Cognition Disorders; Epilepsy; Humans; Middle Aged; Neuropsychological | 1991 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
Withdrawal of phenobarbital and carbamazepine in epileptic patients: a preliminary neuropsychological report.
Topics: Adolescent; Adult; Carbamazepine; Cognition Disorders; Dose-Response Relationship, Drug; Female; Hum | 1986 |
[Isolated petit mal status epilepticus. A new epilepsy syndrome characterised by paroxysmal behavioural disturbances (author's transl)].
Topics: Benzodiazepinones; Child; Child Behavior Disorders; Cognition Disorders; Diagnosis, Differential; Di | 1974 |
Disorders of higher cortical functions in acute confusional states.
Topics: Acute Disease; Adult; Affect; Anesthesia, General; Art; Attention; Cognition Disorders; Electronarco | 1972 |
Temporal lobe epilepsy with "absences".
Topics: Adult; Cognition Disorders; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Methohe | 1971 |
Temporal lobe "spike focus" associated with confusion, complete amnesia and fugues in a paranoid schizophrenic.
Topics: Adult; Amnesia; Chlorpromazine; Cognition Disorders; Dissociative Disorders; Electroencephalography; | 1968 |