phenobarbital has been researched along with Cocarcinogenesis in 106 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cocarcinogenesis: The combination of two or more different factors in the production of cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In previous studies, we found that male D2B6F1 mice fed phenobarbital (PB) for 53 weeks following N-nitrosodiethylamine (NDEA) initiation developed a high (70-80%) incidence of malignant hepatoblastomas." | 3.69 | Further evidence for promoter-dependent development of hepatoblastoma in the mouse. ( Diwan, BA; Henneman, JR; Rice, JM, 1995) |
| "05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
| "An increased number of chromosomal aberrations were observed after pre-treatment with PB." | 1.37 | N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF, 2011) |
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| "Ciprofibrate treatment did not increase the number or volume of altered hepatic foci (putative preneoplastic lesions)." | 1.28 | Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis. ( Clark, TD; Glauert, HP, 1989) |
| "Phenobarbital alone did not produce any apparent amount of foci in liver." | 1.27 | The effect of pre- and post-treatment with phenobarbital on the extent of gamma-glutamyl transpeptidase positive foci induced in rat liver by N-nitrosomorpholine. ( Bannasch, P; Kunz, W; Schwarz, M, 1983) |
| "Nafenopin treatment suppressed the development of foci at all time points, such that less hepatic lesions were seen than in animals which received only diethylnitrosamine." | 1.27 | Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver. ( Bentley, P; Bieri, F; Fröhlich, E; Stäubli, W; Waechter, F, 1984) |
| " Chronic administration of dose levels of PB below 0." | 1.27 | The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration. ( Campbell, HA; Goldsworthy, T; Pitot, HC, 1984) |
| ") at 4 weeks of age with N-nitrosodiethylamine (DEN) at a dosage of 80 mg/kg." | 1.27 | Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice. ( Lynch, P; Ohshima, M; Riggs, C; Ward, JM, 1984) |
| "The phenobarbital treatment became unnecessary when neoplastic nodules were present." | 1.27 | Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect. ( Barbason, H; Betz, EH; Rassenfosse, C, 1983) |
| "When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
| "025% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for two weeks combined with partial hepatectomy at the end of the first week and followed by long-term treatment with phenobarbital (PB) or 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from week 3 to week 86 resulted in dose-dependent development of liver and thyroid neoplastic and preneoplastic lesions." | 1.27 | Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion. ( Asamoto, M; Inoue, T; Ito, N; Nagao, M; Ogiso, T; Tsuda, H, 1988) |
| "The dose-response of diethylnitrosamine (DENA) initiation of hepatocarcinogenesis was determined in infant Balb/c male mice with and without subsequent phenobarbital treatment." | 1.27 | Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion. ( Klaunig, JE; Pereira, MA; Ruch, RJ; Weghorst, CM, 1988) |
| "Choline was not effective in inhibiting the development of lung metastases in either case." | 1.27 | Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats. ( Hoover, KL; Poirier, LA; Shivapurkar, N, 1986) |
| "Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
| "The dose-response relationship was determined in rats for the enhancement by phenobarbital of diethylnitrosamine (DENA)-initiated neoplastic nodules and hepatocellular carcinomas." | 1.27 | Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver. ( Herren-Freund, SL; Long, RE; Pereira, MA, 1986) |
| " A simple two-stage model of rat hepatocarcinogenesis with a single ip dose of diethylnitrosamine (DEN) as the initiator and sodium phenobarbitone or ethanol given in the drinking-water for 12-18 months as the promoter was used to investigate dose-response relationships for initiation and promotion." | 1.27 | Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol. ( Driver, HE; McLean, AE, 1986) |
| " A direct dose-response relationship in induction of thyroid tumors was found in both male and female rats." | 1.27 | Sex differential and dose dependence of phenobarbital-promoting activity in N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats. ( Hiasa, Y; Kitahori, Y; Konishi, N; Lin, JC; Shimoyama, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (67.92) | 18.7374 |
| 1990's | 24 (22.64) | 18.2507 |
| 2000's | 6 (5.66) | 29.6817 |
| 2010's | 4 (3.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braeuning, A | 1 |
| Parzefall, W | 1 |
| Freiler, C | 1 |
| Lorenz, O | 1 |
| Koudelka, H | 1 |
| Riegler, T | 1 |
| Nejabat, M | 1 |
| Kainzbauer, E | 1 |
| Grasl-Kraupp, B | 2 |
| Schulte-Hermann, R | 3 |
| Aiub, CA | 1 |
| Gadermaier, G | 1 |
| Oliveira, I | 1 |
| Felzenszwalb, I | 1 |
| Ferreira, F | 1 |
| Ribeiro Pinto, LF | 1 |
| Eckl, P | 1 |
| Schmid, A | 1 |
| Rignall, B | 1 |
| Pichler, BJ | 1 |
| Schwarz, M | 4 |
| Fukushima, S | 6 |
| Wanibuchi, H | 1 |
| Morimura, K | 1 |
| Wei, M | 1 |
| Nakae, D | 1 |
| Konishi, Y | 2 |
| Tsuda, H | 7 |
| Takasuka, N | 1 |
| Imaida, K | 4 |
| Shirai, T | 6 |
| Tatematsu, M | 3 |
| Tsukamoto, T | 1 |
| Hirose, M | 3 |
| Furukawa, F | 3 |
| Bursch, W | 1 |
| Chabicovsky, M | 1 |
| Wastl, U | 1 |
| Bukowska, K | 1 |
| Taper, H | 2 |
| Hokaiwado, N | 1 |
| Asamoto, M | 5 |
| Ogawa, K | 2 |
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Shinozuka, H | 2 |
| Lombardi, B | 3 |
| Capouya, ER | 1 |
| Lindahl, R | 2 |
| Novicki, DL | 1 |
| Jirtle, RL | 2 |
| Michalopoulos, G | 1 |
| Herren, SL | 1 |
| Pereira, MA | 5 |
| Bannasch, P | 1 |
| Kunz, W | 3 |
| Stäubli, W | 1 |
| Bentley, P | 1 |
| Bieri, F | 1 |
| Fröhlich, E | 1 |
| Waechter, F | 1 |
| Goldsworthy, T | 2 |
| Campbell, HA | 1 |
| Pitot, HC | 15 |
| Ohde, G | 1 |
| Schuppler, J | 1 |
| Timmermann-Trosiener, I | 1 |
| Kunz, HW | 1 |
| Tennekes, HA | 1 |
| Port, RE | 1 |
| Schwartz, M | 1 |
| Lorke, D | 1 |
| Schaude, G | 2 |
| Nesnow, S | 1 |
| Leavitt, S | 1 |
| Garland, H | 1 |
| Vaughan, TO | 1 |
| Hyatt, B | 1 |
| Montgomery, L | 1 |
| Cudak, C | 1 |
| Yamasaki, H | 1 |
| Sakata, T | 1 |
| Kurata, Y | 3 |
| Tamano, S | 3 |
| Ito, N | 14 |
| Ward, JM | 6 |
| Ohshima, M | 4 |
| Lynch, P | 1 |
| Riggs, C | 1 |
| Toyoda, K | 2 |
| Kokubo, T | 1 |
| Takahashi, M | 2 |
| Hayashi, Y | 2 |
| Malvaldi, G | 1 |
| Chieli, E | 1 |
| Saviozzi, M | 1 |
| Barbieri, O | 1 |
| Rossi, L | 1 |
| Cabral, JR | 1 |
| Santi, L | 1 |
| Moran, S | 2 |
| Sirica, AE | 1 |
| Weeks, J | 1 |
| Barbason, H | 1 |
| Rassenfosse, C | 1 |
| Betz, EH | 1 |
| Nakanishi, K | 3 |
| Hagiwara, A | 3 |
| Tennekes, H | 1 |
| Abanobi, SE | 1 |
| Stevens, FJ | 1 |
| Peraino, C | 2 |
| Allen, B | 1 |
| Boynton, AL | 1 |
| Whitfield, JF | 1 |
| Deguchi, T | 1 |
| Diwan, BA | 6 |
| Henneman, JR | 1 |
| Rice, JM | 6 |
| Merlino, GT | 1 |
| Dragan, YP | 3 |
| Hully, J | 1 |
| Crow, R | 1 |
| Mass, M | 1 |
| Manjeshwar, S | 1 |
| Laconi, E | 1 |
| Sheikh, A | 1 |
| Rao, PM | 2 |
| Rajalakshmi, S | 2 |
| Sarma, DS | 2 |
| Andersen, ME | 1 |
| Mills, JJ | 1 |
| Fox, TR | 1 |
| Goldsworthy, TL | 3 |
| Conolly, RB | 1 |
| Birnbaum, LS | 1 |
| Reisenbichler, H | 1 |
| Chari, RS | 1 |
| Boyer, IJ | 1 |
| Klaunig, JE | 4 |
| Laufer, C | 1 |
| Koleske, AJ | 1 |
| Drinkwater, N | 1 |
| Wada, S | 2 |
| Kato, T | 2 |
| Mutai, M | 1 |
| Ozaki, K | 1 |
| Yamaguchi, S | 2 |
| Kim, DJ | 1 |
| Baba-Toriyama, H | 1 |
| Counts, JL | 1 |
| Sarmiento, JI | 1 |
| Harbison, ML | 1 |
| Downing, JC | 1 |
| McClain, RM | 2 |
| Goodman, JL | 1 |
| Okada, N | 1 |
| Honda, A | 1 |
| Kawabata, M | 1 |
| Yajima, N | 1 |
| Hikita, H | 1 |
| Nuwaysir, EF | 1 |
| Vaughan, J | 1 |
| Babcock, K | 1 |
| Haas, MJ | 1 |
| Moennikes, O | 1 |
| Buchmann, A | 2 |
| Romualdi, A | 1 |
| Ott, T | 1 |
| Werringloer, J | 1 |
| Willecke, K | 1 |
| Watson, RE | 1 |
| Goodman, JI | 1 |
| Murasaki, G | 1 |
| Miyata, Y | 1 |
| Marx, JL | 1 |
| Hendrich, S | 3 |
| Leveston, AO | 1 |
| Hasegawa, R | 3 |
| Dong, JM | 1 |
| Kilianska, Z | 1 |
| Fukuda, K | 1 |
| Chiu, JF | 1 |
| Saeter, G | 1 |
| Seglen, PO | 1 |
| Xu, YH | 2 |
| Maronpot, R | 1 |
| Beer, DG | 1 |
| Neveu, MJ | 1 |
| Yamada, M | 1 |
| Hanausek-Walaszek, M | 1 |
| Del Rio, M | 1 |
| Adams, AK | 1 |
| Saito, R | 1 |
| Chandar, N | 1 |
| Janosky, JE | 1 |
| Thamavit, W | 1 |
| Masuko, T | 1 |
| Hashimoto, Y | 1 |
| Nagase, S | 1 |
| Goodspeed, D | 1 |
| Dunn, T | 1 |
| Maronpot, RR | 1 |
| Glauert, HP | 4 |
| Lee, MS | 1 |
| King, CM | 1 |
| Hei, TK | 1 |
| Sudilovsky, O | 1 |
| Hosoda, K | 1 |
| Hirose, K | 1 |
| Hanigan, M | 1 |
| Préat, V | 1 |
| de Gerlache, J | 2 |
| Lans, M | 2 |
| Roberfroid, M | 1 |
| Leonard, TB | 1 |
| Adams, T | 1 |
| Popp, JA | 1 |
| Haugen, DA | 1 |
| Carnes, BA | 1 |
| Reilly, CA | 1 |
| Springer, DL | 1 |
| Mahlum, DD | 1 |
| Clark, TD | 1 |
| Makino, T | 1 |
| Obara, T | 1 |
| Ura, H | 1 |
| Kinugasa, T | 1 |
| Kobayashi, H | 1 |
| Takahashi, S | 1 |
| Wolf, CR | 1 |
| Oesch, F | 1 |
| Robertson, LW | 1 |
| Masuda, A | 1 |
| Ogiso, T | 2 |
| Inoue, T | 1 |
| Nagao, M | 1 |
| Rizvi, TA | 1 |
| Kennan, W | 1 |
| Ruch, RJ | 2 |
| Weghorst, CM | 2 |
| Tanaka, T | 1 |
| Mori, H | 1 |
| Williams, GM | 1 |
| Malaveille, C | 1 |
| Brun, G | 1 |
| Park, SS | 1 |
| Gelboin, HV | 1 |
| Bartsch, H | 1 |
| Jang, JJ | 1 |
| Yamashita, K | 1 |
| Sato, S | 1 |
| Kononenko, LI | 1 |
| Grabovaia, AR | 1 |
| Bykorez, AI | 2 |
| Osipova, LA | 1 |
| Vinarchuk, MP | 1 |
| Khranovskaia, LN | 1 |
| Shivapurkar, N | 1 |
| Hoover, KL | 1 |
| Poirier, LA | 1 |
| Cavaliere, A | 1 |
| Bufalari, A | 1 |
| Vitali, R | 1 |
| Herren-Freund, SL | 2 |
| Long, RE | 1 |
| Kitagawa, T | 1 |
| Driver, HE | 1 |
| McLean, AE | 1 |
| Knutsen, GL | 1 |
| Dragani, TA | 1 |
| Manenti, G | 1 |
| Galliani, G | 1 |
| Della Porta, G | 1 |
| Deleener, A | 1 |
| Kirsch-Volders, M | 1 |
| Schmähl, D | 1 |
| Hiasa, Y | 1 |
| Kitahori, Y | 1 |
| Konishi, N | 1 |
| Shimoyama, T | 1 |
| Lin, JC | 1 |
| Timchalk, C | 1 |
| Charles, AK | 1 |
| Abraham, R | 1 |
9 reviews available for phenobarbital and Cocarcinogenesis
| Article | Year |
|---|---|
Tumor promotion--mechanisms and implication to risk estimation.
Topics: Animals; Carcinogens; Cell Communication; Cell Differentiation; Cocarcinogenesis; Humans; Mutagens; | 1984 |
Properties of incomplete carcinogens and promoters in hepatocarcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Hepate | 1982 |
Quantitative aspects of drug-mediated tumour promotion in liver and its toxicological implications.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Do | 1982 |
Receptor-mediated toxicity and implications for risk assessment.
Topics: Animals; Cell Division; Cocarcinogenesis; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; D | 1994 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Mouse liver tumors and microsomal enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Cell Communication; Cocarcinogenesis; DNA Damage; Humans; Liver | 1990 |
Strain-dependent effects of phenobarbital on liver tumor promotion in inbred mice.
Topics: Adenoma; Animals; Biotransformation; Cocarcinogenesis; Diethylnitrosamine; Disease Susceptibility; F | 1990 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Liver tumour promotion by chemicals: models and mechanisms.
Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarb | 1986 |
97 other studies available for phenobarbital and Cocarcinogenesis
| Article | Year |
|---|---|
Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?
Topics: Animals; Carcinogens; Cell Proliferation; Cocarcinogenesis; Constitutive Androstane Receptor; Humans | 2014 |
Superoxide deficiency attenuates promotion of hepatocarcinogenesis by cytotoxicity in NADPH oxidase knockout mice.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Ethanol; Female; Liver; Liver Neoplasms, Experimental | 2015 |
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrat | 2011 |
Quantitative analysis of the growth kinetics of chemically induced mouse liver tumors by magnetic resonance imaging.
Topics: Animal Use Alternatives; Animals; Cocarcinogenesis; Diethylnitrosamine; Early Detection of Cancer; I | 2012 |
Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.
Topics: Animals; Biomarkers; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Synergism | 2003 |
Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility.
Topics: Animals; Apoptosis; Carcinogens; Cell Differentiation; Cell Proliferation; Cocarcinogenesis; Diethyl | 2005 |
Transgenic disruption of gap junctional intercellular communication enhances early but not late stage hepatocarcinogenesis in the rat.
Topics: Alkylating Agents; Animals; Animals, Genetically Modified; Cell Communication; Cocarcinogenesis; Con | 2005 |
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
Topics: Animals; Body Weight; Choline; Cocarcinogenesis; Diet; Diethylnitrosamine; gamma-Glutamyltransferase | 1980 |
Changes in gamma-glutamyltransferase activity during N-2-fluorenylacetamide-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diet; gamma-Glutamyltransferase; Histocytochemistr | 1983 |
Establishment of two rat hepatoma cell strains produced by a carcinogen initiation, phenobarbital promotion protocol.
Topics: Animals; Cell Line; Cell Separation; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase | 1983 |
Tumor promotion in rat liver.
Topics: Animals; Carcinogens; Cocarcinogenesis; gamma-Glutamyltransferase; Liver Neoplasms; Liver Neoplasms, | 1983 |
The effect of pre- and post-treatment with phenobarbital on the extent of gamma-glutamyl transpeptidase positive foci induced in rat liver by N-nitrosomorpholine.
Topics: Animals; Cocarcinogenesis; Drug Interactions; gamma-Glutamyltransferase; Liver; Male; Nitrosamines; | 1983 |
Inhibitory effect of nafenopin upon the development of diethylnitrosamine-induced enzyme-altered foci within the rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Epoxide Hydrolases; gamma-Glutamyltransferase; Liver; | 1984 |
The natural history and dose-response characteristics of enzyme-altered foci in rat liver following phenobarbital and diethylnitrosamine administration.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Female; gamma-Gluta | 1984 |
Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumor promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin.
Topics: Animals; Autoradiography; Cell Division; Cocarcinogenesis; DNA; Female; gamma-Glutamyltransferase; H | 1981 |
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
Topics: Adenosine Triphosphatases; Animals; Biotransformation; Carcinogens; Cocarcinogenesis; Dieldrin; Dose | 1983 |
Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts.
Topics: Animals; Aroclors; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cell Division; C | 1981 |
Modification of N-methyl-N-nitrosourea initiated carcinogenesis in the rat by subsequent treatment with antioxidants, phenobarbital and ethinyl estradiol.
Topics: Animals; Antioxidants; Cocarcinogenesis; Ethinyl Estradiol; Male; Methylnitrosourea; Neoplasms, Expe | 1984 |
Di(2-ethylhexyl)phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice.
Topics: Animals; Cocarcinogenesis; Diethylhexyl Phthalate; Diethylnitrosamine; Liver; Liver Neoplasms; Lung; | 1984 |
[Establishment of test methods for examining promoters of hepatocarcinogenesis--promoting effects of phenobarbital, butylated hydroxytoluene and barbital].
Topics: Animals; Barbital; Barbiturates; Butylated Hydroxytoluene; Cocarcinogenesis; Diethylnitrosamine; Liv | 1984 |
Promotive effects of thiobenzamide on liver carcinogenesis.
Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobar | 1983 |
Carcinogenic effects induced in Wistar rats by combined treatment with technical-grade dichlorodiphenyltrichloroethane and sodium phenobarbital.
Topics: Animals; Body Weight; Cocarcinogenesis; DDT; Diet; Female; Liver Neoplasms, Experimental; Male; Phen | 1983 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver N | 1983 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.
Topics: Animals; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neopl | 1982 |
Development of a model to simulate the characteristics of rat liver tumor promotion by phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cocarcinogenesis; Liver Neoplasms; Mathematics; Models, | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Sequential 2-acetylaminofluorene--phenobarbital exposure induces a cytosolic aldehyde dehydrogenase during rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Oxidoreductases; Animals; Cocarcinogenesis; Drug Administration Sche | 1982 |
Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Calcium; Cell Cycle; Cells, Cultured; Cocarcinogenesis; DNA; Liver; Phenobarbital; Phorbol | 1980 |
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; gamma-Glutamyltrans | 1995 |
Further evidence for promoter-dependent development of hepatoblastoma in the mouse.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Hepatoblastoma; Liver Neoplasms, Experimental | 1995 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Glutathione Transfe | 1994 |
In vitro and in vivo response of hepatocytes from hepatic nodules to the mitoinhibitory effects of phenobarbital.
Topics: Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 1994 |
Transforming growth factor-beta receptors type I, II and III in phenobarbital-promoted rat liver tumors.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Down-Regulation; Gene Expression Regulation, Neoplast | 1994 |
Selective induction of DNA synthesis in mouse preneoplastic and neoplastic hepatic lesions after exposure to phenobarbital.
Topics: Adenoma, Liver Cell; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA, Neoplasm; Liver; Liver Neop | 1993 |
Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.
Topics: Albumins; Animals; Benzo(a)pyrene; Cocarcinogenesis; Disease Models, Animal; Female; Glutathione Tra | 1993 |
Modifying influence of swine-serum-induced liver fibrosis on development of preneoplastic lesions in rat liver.
Topics: 2-Acetylaminofluorene; Animals; Blood; Chemical and Drug Induced Liver Injury; Cocarcinogenesis; Deo | 1996 |
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver N | 1996 |
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; DNA; Drug Synergism; Lac Op | 1997 |
The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage.
Topics: Actins; Animals; Apoptosis; Cell Count; Cell Division; Cocarcinogenesis; Eating; Fasting; Female; Ge | 1998 |
Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Connexins; Crosses, Genetic; Diethylnitrosamine; Drug Synerg | 2000 |
Effects of phenobarbital on DNA methylation in GC-rich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosine; DNA; DNA Methylation; Genetic Predisposition to Di | 2002 |
Enhancing effect of inducers of liver microsomal enzymes on induction of hyperplastic liver nodules by N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Enzyme Induction; Hyperplasia; Liver; Liver Neopla | 1979 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
The appearance of hepatoma-associated chromosomal non-histone proteins in rat liver after a single dose of 3'-MDAB followed by treatment of phenobarbital.
Topics: alpha-Fetoproteins; Animals; Biomarkers, Tumor; Cell Nucleus; Chromatin; Chromosomal Proteins, Non-H | 1990 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Proto-oncogene and gap-junction protein expression in rodent liver neoplasms.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gene Expression Re | 1990 |
Lack of enhancing effects of fenvalerate and esfenvalerate on induction of preneoplastic glutathione S-transferase placental form positive liver cell foci in rats.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Diethylnitrosamine; Enzyme Induction; Glutathione | 1990 |
Structural and immunological identity of p65 tumor-associated factors from rat and mouse hepatocarcinomas.
Topics: 2-Acetylaminofluorene; Animals; Antibodies, Neoplasm; Biomarkers, Tumor; Carrier Proteins; Cocarcino | 1990 |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment | 1990 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Strain differences in susceptibility to 2-acetylaminofluorene and phenobarbital promotion of hepatocarcinogenesis: immunohistochemical analysis of cytochrome P-450 isozyme induction by 2-acetylaminofluorene and phenobarbital.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine | 1989 |
Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis.
Topics: Animals; Base Sequence; Cocarcinogenesis; Diet; Diethylnitrosamine; DNA; Female; gamma-Glutamyltrans | 1989 |
Effects of sodium salts of phenobarbital and barbital on development of bladder tumors in male F344/NCr rats pretreated with either N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-nitrosobutyl-4-hydroxybutylamine.
Topics: Animals; Barbital; Barbiturates; Butylhydroxybutylnitrosamine; Carcinoma; Cocarcinogenesis; FANFT; M | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
Different responses to phenobarbital promotion in the development of gamma-glutamyltranspeptidase-positive foci in the liver of rats initiated with diethylnitrosamine, N-hydroxy-2-acetyl-aminofluorene and aflatoxin B1.
Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyl | 1985 |
Effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Dietary Carbohydrates; DNA; Female; gamma-Glutamyltransferas | 1985 |
The quantitative analysis and stability of histochemical markers of altered hepatic foci in rat liver following initiation by diethylnitrosamine administration and promotion with phenobarbital.
Topics: Adenosine Triphosphatases; Animals; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltran | 1985 |
Promoting effects of phenobarbital and 3'-methyl-4-dimethylaminoazobenzene on the appearance of gamma-glutamyltranspeptidase positive foci in rat liver pretreated with varying doses of diethylnitrosamine.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Ex | 1985 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Comparative analysis of the effect of phenobarbital, dichlorodiphenyltrichloroethane, butylated hydroxytoluene and nafenopin on rat hepatocarcinogenesis.
Topics: Animals; Butylated Hydroxytoluene; Cocarcinogenesis; DDT; gamma-Glutamyltransferase; Liver Neoplasms | 1986 |
Dinitrotoluene isomer-specific enhancement of the expression of diethylnitrosamine-initiated hepatocyte foci.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dinitrobenzenes; Dose-Response Relationship, Drug; ga | 1986 |
Phenotypically selective promotion of diethylnitrosamine-initiated altered hepatocyte foci by dietary phenobarbital or a topically applied coal-derived organic mixture in male and female rats.
Topics: Administration, Topical; Animals; Coal; Cocarcinogenesis; Female; gamma-Glutamyltransferase; Iron; L | 1987 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell | 1989 |
Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis.
Topics: Animals; Clofibrate; Clofibric Acid; Cocarcinogenesis; Diet; Dose-Response Relationship, Drug; Femal | 1989 |
Effects of phenobarbital and secondary bile acids on liver, gallbladder, and pancreas carcinogenesis initiated by N-nitrosobis (2-hydroxypropyl)amine in hamsters.
Topics: Adenoma, Bile Duct; Animals; Bile Acids and Salts; Cocarcinogenesis; Cricetinae; Deoxycholic Acid; E | 1986 |
Polychlorinated biphenyls, classified as either phenobarbital- or 3-methylcholanthrene-type inducers of cytochrome P-450, are both hepatic tumor promoters in diethylnitrosamine-initiated rats.
Topics: Animals; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enzyme Induction; Fem | 1986 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.
Topics: 2-Acetylaminofluorene; Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Hepatectomy; Liv | 1988 |
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
Topics: Animals; Cocarcinogenesis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; L | 1988 |
Dose-response relationship of diethylnitrosamine-initiated tumors in neonatal balb/c mice: effect of phenobarbital promotion.
Topics: Adenoma; Animals; Animals, Newborn; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship | 1988 |
Enhancement of dimethylnitrosamine-initiated hepatocarcinogenesis in hamsters by subsequent administration of carbon tetrachloride but not phenobarbital or p,p'-dichlorodiphenyltrichloroethane.
Topics: Animals; Carbon Tetrachloride; Cocarcinogenesis; Cricetinae; DDT; Dimethylnitrosamine; Liver Neoplas | 1987 |
A monoclonal antibody against cytochrome P-450 enhances mutagen activation of N-nitrosodimethylamine by mouse liver S9: studies on the mode of action.
Topics: Animals; Antibodies, Monoclonal; Cocarcinogenesis; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxid | 1987 |
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne | 1988 |
[The use of a primary culture of liver cells from rat embryos subjected to transplacental exposure to N-nitrosodiethylamine for the study of hepatocarcinogenesis promoters].
Topics: Animals; Carcinogens; Cells, Cultured; Cocarcinogenesis; Diethylnitrosamine; Female; Liver; Liver Ne | 1987 |
Strain and species effects on the inhibition of hepatocyte intercellular communication by liver tumor promoters.
Topics: Animals; Carcinogens; Cell Communication; Cells, Cultured; Cocarcinogenesis; DDT; Dieldrin; Liver; L | 1987 |
Effect of the age of B6C3F1 mice on phenobarbital promotion of diethylnitrosamine-initiated liver tumors.
Topics: Adenoma; Aging; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Mice; Mice, In | 1987 |
[Characteristics of hepatocarcinogenesis after single exposure of synchronized cells of the regenerating liver to N-nitrosodiethylamine and subsequent administration of phenobarbital].
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; Liver Regenerat | 1987 |
Effect of methionine and choline on liver tumor promotion by phenobarbital and DDT in diethylnitrosamine-initiated rats.
Topics: Adenocarcinoma; Animals; Choline; Cocarcinogenesis; DDT; Diethylnitrosamine; Liver Neoplasms; Lung N | 1986 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Carcinogenicity and cocarcinogenicity test of phenobarbital sodium in adult BALB/c mice.
Topics: Animals; Cocarcinogenesis; Female; Hydrazines; Liver Neoplasms, Experimental; Lung Neoplasms; Male; | 1986 |
Dose-response relationship of phenobarbital promotion of diethylnitrosamine initiated tumors in rat liver.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Liver Neoplasms, Ex | 1986 |
Promoting and anticarcinogenic effects of phenobarbital and DDT in the rat hepatocarcinogenesis.
Topics: Animals; Cocarcinogenesis; DDT; Drug Interactions; Liver Neoplasms, Experimental; Male; Methyldimeth | 1986 |
An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological Assay; Butylated Hydroxyanisole; Carcinogens; | 1985 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |
Dose-response relationships for initiation of rat liver tumours by diethylnitrosamine and promotion by phenobarbitone or alcohol.
Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Dose-Response Relationship, Drug; Enzyme Induction; E | 1986 |
Effect of subsequent treatment of chloroform or phenobarbital on the incidence of liver and lung tumors initiated by ethylnitrosourea in 15 day old mice.
Topics: Animals; Chloroform; Cocarcinogenesis; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; L | 1985 |
Promoting effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene in mouse hepatocarcinogenesis.
Topics: Adenoma; Animals; Cocarcinogenesis; Diethylnitrosamine; DNA; Female; Liver Neoplasms, Experimental; | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Critical remarks on the validity of promoting effects in human carcinogenesis.
Topics: Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Humans; Neoplasms; Phenobarbital | 1985 |
Sex differential and dose dependence of phenobarbital-promoting activity in N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Female; Male; Nitrosamines | 1985 |
Comparative changes in rat liver cytosolic proteins by mirex, diethylnitrosamine, and dimethylnitrosamine exposure.
Topics: Animals; Carcinogens; Cocarcinogenesis; Cytosol; Diethylnitrosamine; Dimethylnitrosamine; Female; In | 1985 |