phenobarbital has been researched along with Chromosome-Defective Micronuclei in 5 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An increased number of chromosomal aberrations were observed after pre-treatment with PB." | 1.37 | N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital. ( Aiub, CA; Eckl, P; Felzenszwalb, I; Ferreira, F; Gadermaier, G; Oliveira, I; Ribeiro Pinto, LF, 2011) |
| " The results of all these studies, when compared with controls, showed that PB has both genotoxic and cytotoxic potential in apparently increasing intensity at longer periods of chronic feeding in mice, which would warrant due consideration in its long-term use on human subjects." | 1.32 | Assessment of the genotoxic and cytotoxic potential of an anti-epileptic drug, phenobarbital, in mice: a time course study. ( Biswas, SJ; Khuda-Bukhsh, AR; Pathak, S, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aiub, CA | 1 |
| Gadermaier, G | 1 |
| Oliveira, I | 1 |
| Felzenszwalb, I | 1 |
| Ferreira, F | 1 |
| Ribeiro Pinto, LF | 1 |
| Eckl, P | 1 |
| Biswas, SJ | 1 |
| Pathak, S | 2 |
| Khuda-Bukhsh, AR | 2 |
| Kumar Das, J | 1 |
| Jyoti Biswas, S | 1 |
| Van Goethem, F | 1 |
| Ghahroudi, MA | 1 |
| Castelain, P | 1 |
| Kirsch-Volders, M | 1 |
| Ejchart, A | 1 |
| Koziorowska, J | 1 |
5 other studies available for phenobarbital and Chromosome-Defective Micronuclei
| Article | Year |
|---|---|
N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: effects of cytochrome P450 induction by phenobarbital.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinogens; Cell Death; Cells, Cultured; Chromosome Aberrat | 2011 |
Assessment of the genotoxic and cytotoxic potential of an anti-epileptic drug, phenobarbital, in mice: a time course study.
Topics: Administration, Oral; Animals; Anticonvulsants; Bone Marrow Cells; Chromosome Aberrations; Humans; K | 2004 |
Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Lipid Peroxidation; Liver; Lycopodium; Male; | 2006 |
Frequency and DNA content of micronuclei in rat parenchymal liver cells during experimental hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleus; Diethylnitrosamine; DNA; Liver; | 1993 |
Strain-dependent differences in mutagenicity and genotoxicity of cyclophosphamide in mice.
Topics: Animals; Bone Marrow; Chromosomes; Cyclophosphamide; Cytochrome P-450 Enzyme System; Liver; Mice; Mi | 1993 |