phenobarbital has been researched along with Chromosomal Translocation in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is an effective anti-epileptic medication often used for long-term control of seizure disorders that has been implicated in hematological toxicities, including rare reports of myelodysplasia and acute leukemia." | 1.35 | Translocation-positive acute myeloid leukemia associated with valproic acid therapy. ( Ben-Ezra, J; Massey, GV; Riley, RS; Russell, EC; Williams, DC, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, DC | 1 |
| Massey, GV | 1 |
| Russell, EC | 1 |
| Riley, RS | 1 |
| Ben-Ezra, J | 1 |
| Sargent, LM | 1 |
| Sattler, GL | 1 |
| Roloff, B | 1 |
| Xu, YH | 1 |
| Sattler, CA | 1 |
| Meisner, L | 1 |
| Pitot, HC | 1 |
| Zijlstra, JA | 1 |
| Vogel, EW | 1 |
3 other studies available for phenobarbital and Chromosomal Translocation
| Article | Year |
|---|---|
Translocation-positive acute myeloid leukemia associated with valproic acid therapy.
Topics: Acute Disease; Anticonvulsants; Cell Differentiation; Cell Division; Child, Preschool; Chromosomes, | 2008 |
Ploidy and specific karyotypic changes during promotion with phenobarbital, 2,5,2',5'-tetrachlorobiphenyl, and/or 3,4,3'4'-tetrachlorobiphenyl in rat liver.
Topics: Animals; Carcinogens; Cell Division; Chromosome Aberrations; Chromosome Deletion; Chromosome Disorde | 1992 |
Influence of metabolic factors on the mutagenic effectiveness of cyclophosphamide in Drosophila melanogaster.
Topics: Animals; Aroclors; Benzimidazoles; Biotransformation; Chlorodiphenyl (54% Chlorine); Cyclophosphamid | 1989 |