Page last updated: 2024-11-02

phenobarbital and Choline Deficiency

phenobarbital has been researched along with Choline Deficiency in 19 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199014 (73.68)18.7374
1990's3 (15.79)18.2507
2000's2 (10.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Konstandi, M1
Segos, D1
Galanopoulou, P1
Theocharis, S1
Zarros, A1
Lang, MA1
Marselos, M1
Liapi, C1
Bachman, AN1
Kamendulis, LM1
Goodman, JI1
DeAngelo, AB1
Garrett, CT1
Queral, AE1
Ghoshal, AK1
Farber, E1
Abanobi, SE1
Lombardi, B3
Shinozuka, H2
Counts, JL1
Sarmiento, JI1
Harbison, ML1
Downing, JC1
McClain, RM1
Goodman, JL1
Saito, R2
Estes, LW1
Francis, KT1
Hamrick, ME1
Smith, RC1
Greim, H1
Czygan, P1
Garro, AJ1
Hutterer, F1
Schaffner, F1
Popper, H1
Mezey, E1
Potter, JJ1
Brandes, D1
Saeter, G1
Seglen, PO1
Chandar, N1
Janosky, JE1
Gupta, C1
Hattori, A1
Betschart, JM1
Virji, MA1
Sarma, DS1
Rao, PM1
Rajalakshmi, S1
de Camargo, JL1
Punyarit, P1
Newberne, PM1
Ariyoshi, T2
Remmer, H3
Elies, W1
Heni, N1
Sorrell, MF1
Tuma, DJ1
Noffsinger, JK1
Barak, AJ1
Takabatake, E1

Reviews

2 reviews available for phenobarbital and Choline Deficiency

ArticleYear
Cell biology of hepatocarcinogenesis.
    Critical reviews in oncogenesis, 1990, Volume: 1, Issue:4

    Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N

1990
Liver tumour promotion by chemicals: models and mechanisms.
    Cancer surveys, 1986, Volume: 5, Issue:4

    Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarb

1986

Other Studies

17 other studies available for phenobarbital and Choline Deficiency

ArticleYear
Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response.
    Journal of applied toxicology : JAT, 2009, Volume: 29, Issue:2

    Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart

2009
Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 90, Issue:2

    Topics: Animals; Cells, Cultured; Choline Deficiency; DNA; DNA Methylation; Ethanolamines; GC Rich Sequence;

2006
Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalate.
    Cancer letters, 1984, Volume: 23, Issue:3

    Topics: Animals; Choline Deficiency; Diet; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver Neoplasm

1984
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens.
    Carcinogenesis, 1984, Volume: 5, Issue:10

    Topics: Animals; Choline Deficiency; DNA; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Phen

1984
Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.
    Cancer research, 1982, Volume: 42, Issue:2

    Topics: Animals; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neopl

1982
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
    Carcinogenesis, 1996, Volume: 17, Issue:6

    Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver N

1996
Reduced response to phenobarbital by the liver of rats fed a choline-deficient diet.
    Biochimica et biophysica acta, 1975, Jan-13, Volume: 381, Issue:1

    Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Lipid Metabolism; Liver; Male; Microsco

1975
Drug metabolism in choline-deficient rats.
    Research communications in chemical pathology and pharmacology, 1975, Volume: 10, Issue:4

    Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; In Vitro T

1975
Cytochrome P-450 in the activation and inactivation of carcinogens.
    Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00

    Topics: Animals; Aroclors; Biotransformation; Carcinogens; Choline Deficiency; Cytochrome P-450 Enzyme Syste

1975
Effects of a choline-deficient diet on the induction of drug- and ethanol-metabolizing enzymes and on the alteration of rates of ethanol degradation by ethanol and phenobarbital.
    Biochemical pharmacology, 1975, Nov-01, Volume: 24, Issue:21

    Topics: Animals; Choline Deficiency; Diet; Enzyme Induction; Ethanol; Kinetics; Lipid Metabolism; Liver; Mal

1975
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
    Research communications in chemical pathology and pharmacology, 1990, Volume: 69, Issue:2

    Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment

1990
Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.
    Cancer research, 1988, Mar-01, Volume: 48, Issue:5

    Topics: Animals; Choline Deficiency; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Neoplasms, Experi

1988
Early stages of nodular transformation of the B6C3F1 mouse liver induced by choline deficiency.
    Toxicologic pathology, 1985, Volume: 13, Issue:1

    Topics: Animals; Choline Deficiency; Hepatectomy; Hypertrophy; Liver; Male; Mice; Mice, Inbred Strains; Orga

1985
[Effect of phenobarbital and diphenylhydantoin on different lipid fractions of liver].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1968, Volume: 260, Issue:2

    Topics: Animals; Choline Deficiency; Ethanol; Fatty Liver; Liver; Phenobarbital; Phenytoin; Phospholipids; R

1968
[Effect of various drugs on lipid content and drug metabolizing enzymes in rat liver following experimentally induced fatty degeneration].
    Naunyn-Schmiedebergs Archiv fur Pharmakologie, 1970, Volume: 266, Issue:4

    Topics: Animals; Choline Deficiency; Enzyme Induction; Fatty Liver; Lipid Metabolism; Liver; Male; Microsome

1970
Phenobarbital-induced fatty livers in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 143, Issue:3

    Topics: Animals; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Liver; Inje

1973
Drug metabolism in ethanol-induced fatty liver.
    Life sciences, 1970, Apr-08, Volume: 9, Issue:7

    Topics: Animals; Body Weight; Choline Deficiency; Cytochromes; Endoplasmic Reticulum; Ethanol; Fatty Liver;

1970