phenobarbital has been researched along with Choline Deficiency in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (73.68) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konstandi, M | 1 |
| Segos, D | 1 |
| Galanopoulou, P | 1 |
| Theocharis, S | 1 |
| Zarros, A | 1 |
| Lang, MA | 1 |
| Marselos, M | 1 |
| Liapi, C | 1 |
| Bachman, AN | 1 |
| Kamendulis, LM | 1 |
| Goodman, JI | 1 |
| DeAngelo, AB | 1 |
| Garrett, CT | 1 |
| Queral, AE | 1 |
| Ghoshal, AK | 1 |
| Farber, E | 1 |
| Abanobi, SE | 1 |
| Lombardi, B | 3 |
| Shinozuka, H | 2 |
| Counts, JL | 1 |
| Sarmiento, JI | 1 |
| Harbison, ML | 1 |
| Downing, JC | 1 |
| McClain, RM | 1 |
| Goodman, JL | 1 |
| Saito, R | 2 |
| Estes, LW | 1 |
| Francis, KT | 1 |
| Hamrick, ME | 1 |
| Smith, RC | 1 |
| Greim, H | 1 |
| Czygan, P | 1 |
| Garro, AJ | 1 |
| Hutterer, F | 1 |
| Schaffner, F | 1 |
| Popper, H | 1 |
| Mezey, E | 1 |
| Potter, JJ | 1 |
| Brandes, D | 1 |
| Saeter, G | 1 |
| Seglen, PO | 1 |
| Chandar, N | 1 |
| Janosky, JE | 1 |
| Gupta, C | 1 |
| Hattori, A | 1 |
| Betschart, JM | 1 |
| Virji, MA | 1 |
| Sarma, DS | 1 |
| Rao, PM | 1 |
| Rajalakshmi, S | 1 |
| de Camargo, JL | 1 |
| Punyarit, P | 1 |
| Newberne, PM | 1 |
| Ariyoshi, T | 2 |
| Remmer, H | 3 |
| Elies, W | 1 |
| Heni, N | 1 |
| Sorrell, MF | 1 |
| Tuma, DJ | 1 |
| Noffsinger, JK | 1 |
| Barak, AJ | 1 |
| Takabatake, E | 1 |
2 reviews available for phenobarbital and Choline Deficiency
| Article | Year |
|---|---|
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Liver tumour promotion by chemicals: models and mechanisms.
Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarb | 1986 |
17 other studies available for phenobarbital and Choline Deficiency
| Article | Year |
|---|---|
Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart | 2009 |
Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency.
Topics: Animals; Cells, Cultured; Choline Deficiency; DNA; DNA Methylation; Ethanolamines; GC Rich Sequence; | 2006 |
Inhibition of phenobarbital and dietary choline deficiency promoted preneoplastic lesions in rat liver by environmental contaminant di(2-ethylhexyl)phthalate.
Topics: Animals; Choline Deficiency; Diet; Diethylhexyl Phthalate; gamma-Glutamyltransferase; Liver Neoplasm | 1984 |
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens.
Topics: Animals; Choline Deficiency; DNA; Liver Neoplasms, Experimental; Male; Methionine; Methylation; Phen | 1984 |
Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.
Topics: Animals; Cell Division; Choline; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver Neopl | 1982 |
Cell proliferation and global methylation status changes in mouse liver after phenobarbital and/or choline-devoid, methionine-deficient diet administration.
Topics: Animals; Carcinogens; Cell Division; Choline Deficiency; Cocarcinogenesis; Diet; DNA; Liver; Liver N | 1996 |
Reduced response to phenobarbital by the liver of rats fed a choline-deficient diet.
Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Lipid Metabolism; Liver; Male; Microsco | 1975 |
Drug metabolism in choline-deficient rats.
Topics: Animals; Choline Deficiency; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; In Vitro T | 1975 |
Cytochrome P-450 in the activation and inactivation of carcinogens.
Topics: Animals; Aroclors; Biotransformation; Carcinogens; Choline Deficiency; Cytochrome P-450 Enzyme Syste | 1975 |
Effects of a choline-deficient diet on the induction of drug- and ethanol-metabolizing enzymes and on the alteration of rates of ethanol degradation by ethanol and phenobarbital.
Topics: Animals; Choline Deficiency; Diet; Enzyme Induction; Ethanol; Kinetics; Lipid Metabolism; Liver; Mal | 1975 |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment | 1990 |
Modulation of epidermal growth factor receptors in rat hepatocytes by two liver tumor-promoting regimens, a choline-deficient and a phenobarbital diet.
Topics: Animals; Choline Deficiency; Epidermal Growth Factor; ErbB Receptors; Liver; Liver Neoplasms, Experi | 1988 |
Early stages of nodular transformation of the B6C3F1 mouse liver induced by choline deficiency.
Topics: Animals; Choline Deficiency; Hepatectomy; Hypertrophy; Liver; Male; Mice; Mice, Inbred Strains; Orga | 1985 |
[Effect of phenobarbital and diphenylhydantoin on different lipid fractions of liver].
Topics: Animals; Choline Deficiency; Ethanol; Fatty Liver; Liver; Phenobarbital; Phenytoin; Phospholipids; R | 1968 |
[Effect of various drugs on lipid content and drug metabolizing enzymes in rat liver following experimentally induced fatty degeneration].
Topics: Animals; Choline Deficiency; Enzyme Induction; Fatty Liver; Lipid Metabolism; Liver; Male; Microsome | 1970 |
Phenobarbital-induced fatty livers in the rat.
Topics: Animals; Cholesterol; Choline; Choline Deficiency; Dietary Fats; Dietary Proteins; Fatty Liver; Inje | 1973 |
Drug metabolism in ethanol-induced fatty liver.
Topics: Animals; Body Weight; Choline Deficiency; Cytochromes; Endoplasmic Reticulum; Ethanol; Fatty Liver; | 1970 |