phenobarbital has been researched along with Cholestasis, Intrahepatic in 23 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cholestasis, Intrahepatic: Impairment of bile flow due to injury to the HEPATOCYTES; BILE CANALICULI; or the intrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 5.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| "Depending on the underlying disease state resulting in cholestasis, phenobarbital, ursodiol, bile sequestering agents, and opioid antagonists appear to be most effective for treating pruritus related to intrahepatic cholestasis." | 4.84 | Treatment of cholestatic pruritus in children. ( Cies, JJ; Giamalis, JN, 2007) |
| "A comprehensive literature search was conducted in MEDLINE (1966-July 2002) using the following MeSH terms: pregnancy, itching, intrahepatic cholestasis, cholestyramine, ursodeoxycholic acid, and phenobarbital." | 4.81 | Treatment of itching associated with intrahepatic cholestasis of pregnancy. ( Boothby, LA; Jenkins, JK, 2002) |
| "The elimination of caffeine from plasma and the excretion of the main metabolites of metamizol (noramidopyrinemethanesulphonate sodium) into the urine were determined in healthy pregnant women (weeks 30-38 of pregnancy) and in patients with intrahepatic cholestasis in pregnancy (weeks 28-39 of pregnancy)." | 3.67 | [The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions]. ( Ortweiler, W; Peiker, G; Siegert, C; Splinter, FK; Traeger, A, 1987) |
| "Lithocholic acid (LCA) was used to induce intrahepatic cholestasis." | 1.35 | Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis. ( Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL, 2008) |
| "Phenobarbital was administered to 22 patients before imaging." | 1.29 | Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice. ( Ben-Haim, S; Brown, BP; Johnson, J; Kao, SC; Seabold, JE; Tran, D, 1995) |
| "Benign recurrent intrahepatic cholestasis is characterized by attacks of cholestasis." | 1.28 | Benign recurrent intrahepatic cholestasis. A report of 26 cases. ( Benhamou, JP; Brenard, R; Geubel, AP, 1989) |
| "The itching was relieved in five of the seven cases during the first week of treatment, but after that the symptom tended to reappear." | 1.26 | Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine. ( Heikkinen, J; Jänne, O; Mäentausta, O; Ylöstalo, P, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (60.87) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beilke, LD | 2 |
| Aleksunes, LM | 1 |
| Olson, ER | 1 |
| Besselsen, DG | 2 |
| Klaassen, CD | 1 |
| Dvorak, K | 1 |
| Cherrington, NJ | 2 |
| Jenkins, JK | 1 |
| Boothby, LA | 1 |
| Saratikov, AS | 1 |
| Novozheeva, TP | 1 |
| Akhmedzhanov, RR | 1 |
| Cies, JJ | 1 |
| Giamalis, JN | 1 |
| Cheng, Q | 1 |
| Kulkarni, S | 1 |
| Slitt, AL | 1 |
| Becker, M | 2 |
| von Bergmann, K | 1 |
| Rotthauwe, HW | 2 |
| Leiss, O | 1 |
| Stiehl, A | 2 |
| Czygan, P | 1 |
| Fröhling, W | 1 |
| Kommerell, B | 1 |
| Senn, M | 1 |
| Rodés, J | 1 |
| Rozman, C | 1 |
| Panés, J | 1 |
| Querol, FX | 1 |
| Bruguera, M | 1 |
| Back, P | 2 |
| Heikkinen, J | 1 |
| Mäentausta, O | 1 |
| Ylöstalo, P | 1 |
| Jänne, O | 1 |
| Richter, E | 1 |
| Breimer, DD | 1 |
| Zilly, W | 1 |
| Ben-Haim, S | 1 |
| Seabold, JE | 1 |
| Kao, SC | 1 |
| Johnson, J | 1 |
| Tran, D | 1 |
| Brown, BP | 1 |
| Sigl, B | 1 |
| Lachgar, T | 1 |
| Touil, Y | 1 |
| Deschamps, JP | 1 |
| Miguet, JP | 1 |
| Vuitton, D | 1 |
| Joanne, C | 1 |
| Allemand, H | 1 |
| Carayon, P | 1 |
| Bechtel, P | 1 |
| Gisselbrecht, H | 1 |
| Javitt, NB | 1 |
| Fukumoto, Y | 1 |
| Okita, K | 1 |
| Yasunaga, M | 1 |
| Konishi, T | 1 |
| Yamasaki, T | 1 |
| Ando, M | 1 |
| Shirasawa, H | 1 |
| Fuji, T | 1 |
| Takemoto, T | 1 |
| Brenard, R | 1 |
| Geubel, AP | 1 |
| Benhamou, JP | 1 |
| Ortweiler, W | 1 |
| Peiker, G | 1 |
| Siegert, C | 1 |
| Splinter, FK | 1 |
| Traeger, A | 1 |
| Kuoppala, T | 1 |
| Tuimala, R | 1 |
| Parviainen, M | 1 |
| Koskinen, T | 1 |
| Bunch, SE | 1 |
| Conway, MB | 1 |
| Center, SA | 1 |
| Castleman, WL | 1 |
| Baldwin, BH | 1 |
| Hornbuckle, WE | 1 |
| Tennant, BC | 1 |
3 reviews available for phenobarbital and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Treatment of itching associated with intrahepatic cholestasis of pregnancy.
Topics: Adult; Antipruritics; Cholagogues and Choleretics; Cholestasis, Intrahepatic; Female; Humans; Phenob | 2002 |
Treatment of cholestatic pruritus in children.
Topics: Antipruritics; Child; Cholagogues and Choleretics; Cholestasis, Extrahepatic; Cholestasis, Intrahepa | 2007 |
Cholestatic liver disease and its management.
Topics: Cholestasis, Intrahepatic; Colchicine; Humans; Phenobarbital; Pruritus; Ursodeoxycholic Acid | 1989 |
1 trial available for phenobarbital and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
A new therapeutic trial of secretin in the treatment of intrahepatic cholestasis.
Topics: Adult; Aged; Bilirubin; Cholestasis, Intrahepatic; Clinical Trials as Topic; Drainage; Female; Gluca | 1989 |
19 other studies available for phenobarbital and Cholestasis, Intrahepatic
| Article | Year |
|---|---|
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Rec | 2009 |
Efficiency of enzyme-inducing agents in rats with intrahepatic cholestasis.
Topics: 1-Naphthylisothiocyanate; Animals; Barbiturates; Benzhydryl Compounds; Bilirubin; Cholestasis, Intra | 2002 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytopro | 2008 |
Effects of phenobarbital on biliary lipid metabolism in children with chronic intrahepatic cholestasis.
Topics: Bile; Bile Acids and Salts; Bile Ducts, Intrahepatic; Bilirubin; Child; Child, Preschool; Cholestasi | 1984 |
Bile acids and their sulphated and glucuronidated derivatives in bile, plasma, and urine of children with intrahepatic cholestasis: effects of phenobarbital treatment.
Topics: Bile; Bile Acids and Salts; Child; Child, Preschool; Cholestasis, Intrahepatic; Female; Glucuronates | 1980 |
[Cure of a case of childhood intrahepatic cholestasis using phenobarbital and cholestyramine].
Topics: Calcium; Child, Preschool; Cholestasis, Intrahepatic; Cholestyramine Resin; Female; Growth Disorders | 1983 |
Phenobarbital-induced alterations of bile acid metabolism in cases of intrahepatic cholestasis.
Topics: Adolescent; Adult; Bile Acids and Salts; Child; Child, Preschool; Cholestasis, Intrahepatic; Female; | 1982 |
Serum bile acid levels in intrahepatic cholestasis of pregnancy during treatment with phenobarbital or cholestyramine.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholestasis, Intrahepatic; Cholestyramine Resin; Cholic | 1982 |
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobar | 1980 |
[Treatment of cholestatic liver diseases with phenobarbital and ursodeoxycholic acid].
Topics: Cholestasis, Intrahepatic; Cystic Fibrosis; Female; Humans; Liver Diseases; Liver Function Tests; Ma | 1993 |
Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice.
Topics: Aniline Compounds; Biliary Atresia; Cholestasis, Intrahepatic; Female; Glycine; Hepatitis; Humans; I | 1995 |
[Pathogenesis and therapy of pruritus in pregnancy].
Topics: Animals; Cholestasis, Intrahepatic; Cholestyramine Resin; Female; Histamine H1 Antagonists; Humans; | 1994 |
[The drug hypersensitivity syndrome or DRESS syndrome to phenobarbital].
Topics: Aged; Anticonvulsants; Cholestasis, Intrahepatic; Drug Eruptions; Edema; Eosinophilia; Epilepsy; Fem | 2001 |
[Hepatic drug metabolism in patients with intrahepatic cholestasis (author's transl)].
Topics: Adolescent; Adult; Aged; Antipyrine; Cholestasis, Intrahepatic; Female; Humans; Liver; Male; Middle | 1979 |
Benign recurrent intrahepatic cholestasis. A report of 26 cases.
Topics: Adult; Cholestasis, Intrahepatic; Cholestyramine Resin; Female; Humans; Male; Phenobarbital; Plasmap | 1989 |
Therapeutic use of phenobarbital in intrahepatic cholestasis. Inductions in bile acid metabolism.
Topics: Bile Acids and Salts; Cholestasis, Intrahepatic; Humans; Phenobarbital | 1987 |
[The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions].
Topics: Biotransformation; Caffeine; Cholestasis, Intrahepatic; Cytochrome P-450 Enzyme System; Female; Huma | 1987 |
Vitamin D and mineral metabolism in intrahepatic cholestasis of pregnancy.
Topics: Bile Acids and Salts; Calcifediol; Calcitriol; Cholestasis, Intrahepatic; Cholestyramine Resin; Drug | 1986 |
Toxic hepatopathy and intrahepatic cholestasis associated with phenytoin administration in combination with other anticonvulsant drugs in three dogs.
Topics: Animals; Anticonvulsants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Dog Dis | 1987 |