phenobarbital has been researched along with Cholelithiasis in 28 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cholelithiasis: Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Six patients with cholesterol cholelithiasis were studied before and after 3 weeks treatment with phenobarbital, 120 mg/day." | 7.65 | The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis. ( Hepner, GW, 1976) |
| "Six patients with cholesterol cholelithiasis were studied before and after 3 weeks treatment with phenobarbital, 120 mg/day." | 3.65 | The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis. ( Hepner, GW, 1976) |
| "Phenobarbital alone has been useful, so far, in the treatment of cholesterol gallstones." | 1.25 | Barbituates and biliary function. ( Capron, JP; Erlinger, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 28 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| ARECCO, F | 1 |
| SOLARI, E | 1 |
| Hirayama, C | 1 |
| Kishimoto, Y | 1 |
| Zak, RA | 1 |
| Marks, JW | 2 |
| Schoenfield, LJ | 5 |
| Dederer, IuM | 1 |
| Bouchier, IA | 2 |
| Lagarriga, J | 2 |
| Gil, D | 1 |
| Méndez, N | 1 |
| Cohen, J | 1 |
| Rubio, A | 1 |
| González, VM | 1 |
| López, G | 1 |
| Nottle, PD | 1 |
| Hughes, E | 1 |
| Capron, JP | 1 |
| Erlinger, S | 1 |
| Sherman, JH | 1 |
| Bonorris, GG | 3 |
| Chung, A | 2 |
| Coyne, MJ | 3 |
| Redinger, RN | 2 |
| Paumgartner, G | 1 |
| Vlahcevic, ZR | 1 |
| Gregory, DH | 1 |
| Swell, L | 1 |
| Tompkins, RK | 1 |
| Miller, NE | 1 |
| Ginsberg, RL | 1 |
| Garnick, MB | 1 |
| Hepner, GW | 1 |
| Menghini, G | 1 |
| Pallotta, B | 1 |
| Goldstein, LI | 2 |
| Lahana, D | 1 |
| Pedersen, L | 1 |
| Morrissey, KP | 1 |
| Sturdevant, RA | 1 |
| Klapdor, R | 1 |
| Schliewe, J | 1 |
| Valerius, H | 1 |
| Bell, GD | 1 |
| Black, M | 1 |
| Perrett, RD | 1 |
| Carter, AE | 1 |
9 reviews available for phenobarbital and Cholelithiasis
| Article | Year |
|---|---|
[Effects of alcohol and medication on bile acid metabolism].
Topics: Animals; Bile Acids and Salts; Cholelithiasis; Cholesterol, HDL; Clofibrate; Contraceptives, Oral; C | 1984 |
Current status of chenodeoxycholic acid (chenodiol) therapy of cholesterol gallstones.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholesterol, Diet | 1983 |
[Dissolution of gallstones: reality and prospects].
Topics: Adult; Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Female; Human | 1980 |
The medical treatment of gallstones.
Topics: Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholic Acids; Gallstones; | 1980 |
[What is reliable in the internal therapy of the gallstone trouble?].
Topics: Bile; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Clofibrate; Diet; Dose-Response Relationsh | 1975 |
Part II. The systemic treatment of gallstones.
Topics: Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholecystectomy; Cho | 1976 |
[Medical treatment of gallstones].
Topics: Ascorbic Acid; Chenodeoxycholic Acid; Cholelithiasis; Female; Fusidic Acid; Humans; Male; Middle Age | 1975 |
Current concepts of gallstone formation.
Topics: Animals; Bile; Bile Acids and Salts; Cholecystectomy; Cholelithiasis; Cholesterol; Cholestyramine Re | 1975 |
Medical therapy for gallstones.
Topics: Administration, Oral; Bile; Bile Acids and Salts; Bilirubin; Calcium; Chemical and Drug Induced Live | 1974 |
4 trials available for phenobarbital and Cholelithiasis
| Article | Year |
|---|---|
Current status of chenodeoxycholic acid (chenodiol) therapy of cholesterol gallstones.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cholesterol, Diet | 1983 |
Gallstone dissolution by chenodeoxycholic acid and phenobarbital.
Topics: Chenodeoxycholic Acid; Cholelithiasis; Clinical Trials as Topic; Double-Blind Method; Drug Synergism | 1978 |
Treatment of gallstones with chenodeoxycholic acid and phenobarbital.
Topics: Adult; Aged; Bile; Biopsy; Chenodeoxycholic Acid; Cholelithiasis; Clinical Trials as Topic; Drug The | 1975 |
Effect of chenodeoxycholic acid and phenobarbital on the rate-limiting enzymes of hepatic cholesterol and bile acid synthesis in patients with gallstones.
Topics: Bile; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Female; Humans; Hydr | 1976 |
16 other studies available for phenobarbital and Cholelithiasis
| Article | Year |
|---|---|
[Parasympathicolytic effects of a delayed-absorption combination of belladonna and phenylethylbarbituric acid].
Topics: Atropa belladonna; Barbiturates; Cholecystitis; Cholelithiasis; Coronary Disease; Gastroenterology; | 1963 |
[Biliary lithiasis and cholesterolemia. Experimental study in the hamster].
Topics: Animals; Cholelithiasis; Cholesterol; Cholesterol, Dietary; Cricetinae; Gallbladder; Liver; Male; Me | 1982 |
Gallstones: operate, dissolve or leave alone?
Topics: Butyrates; Chenodeoxycholic Acid; Cholagogues and Choleretics; Cholecystectomy; Cholelithiasis; Drug | 1981 |
Barbituates and biliary function.
Topics: Adenosine Triphosphatases; Animals; Bile; Bile Acids and Salts; Biliary Tract; Bilirubin; Cholelithi | 1975 |
The effects of phenobarbital on biliary lipid metabolism in cholesterol gallstone subjects.
Topics: Adult; Aged; Bile; Bile Acids and Salts; Cholecystography; Cholelithiasis; Cholesterol; Feces; Femal | 1979 |
Editorial: Phenobarbital and cholesterol gallstone dissolution.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Haplorhini; Human | 1976 |
Phenobarbital, bile acid metabolism, and cholesterol cholelithiasis.
Topics: Adult; Bile Acids and Salts; Cholelithiasis; Cholesterol; Female; Humans; Male; Middle Aged; Phenoba | 1977 |
Effect of phenobarbital on biliary lipid metabolism in normal man.
Topics: Administration, Oral; Adult; Bile; Bile Acids and Salts; Cholelithiasis; Cholesterol; Female; Humans | 1977 |
The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis.
Topics: Adult; Aged; Aminopyrine; Bile; Bile Acids and Salts; Cholelithiasis; Cholesterol; Female; Humans; K | 1976 |
Marked increase in serum levels of liver enzymes in patients receiving chenic acid and phenobarbital for gallstone dissolution.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Chenodeoxycholic Acid; Chol | 1976 |
Medical treatment of gallstones.
Topics: Animals; Arteriosclerosis; Bile; Chenodeoxycholic Acid; Cholelithiasis; Cholestasis; Cholesterol; Di | 1975 |
[Mechanisms of bile secretion in mini-pigs (author's transl)].
Topics: Animals; Bile; Bile Acids and Salts; Cholecystectomy; Cholecystokinin; Cholelithiasis; Cholestasis; | 1975 |
The effect of phenobarbital on cholesterol gallstones in hamsters.
Topics: Animals; Bile; Bilirubin; Body Weight; Cholelithiasis; Cholesterol; Cricetinae; Diet; Glucuronosyltr | 1973 |
Pathophysiology of Cholelithiasis.
Topics: Animals; Bile; Bile Acids and Salts; Calculi; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol; Cr | 1974 |
The present position concerning gallstone dissolution.
Topics: Animals; Bile Acids and Salts; Chenodeoxycholic Acid; Cholelithiasis; Cholesterol, Dietary; Cholesty | 1974 |
Hepatic bilirubin UDP-glucuronyl transferase activity and cytochrome P450 content in a surgical population, and the effects of preoperative drug therapy.
Topics: Bilirubin; Biopsy; Cholelithiasis; Cytochrome P-450 Enzyme System; Enzyme Induction; Hexosyltransfer | 1973 |