phenobarbital has been researched along with Cholangitis in 8 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cholangitis: Inflammation of the biliary ductal system (BILE DUCTS); intrahepatic, extrahepatic, or both.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 5.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| " Except for the patients with cholestatic hepatitis, in whom marked cholestasis was virtually the only abnormality in liver biopsy specimens, serum bilirubin and bile acid concentrations were diminished during therapy, the hepatic clearance of sulfobromophthalein and 131-I-rose bengal was variably enhanced, and there was relief from pruritus." | 3.65 | Phenobarbital effects in cholestatic liver diseases. ( Bloomer, JR; Boyer, JL, 1975) |
| "Phenobarbital (PB) has a reputation for safety, and it is commonly believed that PB-related increases in serum aminotransferase levels do not indicate or predict the development of significant chronic liver disease." | 1.34 | Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients. ( Di Mizio, G; Gambardella, A; Labate, A; Perna, A; Quattrone, A; Ricci, P, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Di Mizio, G | 1 |
| Gambardella, A | 1 |
| Labate, A | 1 |
| Perna, A | 1 |
| Ricci, P | 1 |
| Quattrone, A | 1 |
| Stiehl, A | 1 |
| Brunner, G | 1 |
| Bloomer, JR | 1 |
| Boyer, JL | 1 |
| Golladay, ES | 1 |
| Slezak, JW | 1 |
| Seibert, JJ | 1 |
| Stillman, AE | 1 |
| Earnest, DL | 1 |
| Woolfenden, JM | 1 |
| Gips, CH | 1 |
| Kühn, HA | 1 |
| Richter, E | 1 |
1 review available for phenobarbital and Cholangitis
| Article | Year |
|---|---|
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholan | 1970 |
7 other studies available for phenobarbital and Cholangitis
| Article | Year |
|---|---|
Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: an autopsy report of two patients.
Topics: Adult; Anticonvulsants; Autopsy; Chemical and Drug Induced Liver Injury; Cholangitis; Chromatography | 2007 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
[Therapy of the chronic destructive, non-purulent cholangitis (primary biliary cirrhosis)].
Topics: Azathioprine; Calcium; Cholangitis; Cholestyramine Resin; Clofibrate; Humans; Hypercholesterolemia; | 1976 |
Phenobarbital effects in cholestatic liver diseases.
Topics: Adult; Bile Ducts, Intrahepatic; Bilirubin; Chenodeoxycholic Acid; Child; Child, Preschool; Cholangi | 1975 |
Intractable cholangitis due to conduit obstruction.
Topics: Anti-Bacterial Agents; Biliary Atresia; Child; Cholangitis; Clinical Protocols; Humans; Methylpredni | 1990 |
Hepatobiliary scintigraphy for cholestasis in congenital hepatic fibrosis. Diagnosis and treatment.
Topics: Bile Ducts, Intrahepatic; Child; Cholangitis; Cholestasis; Dehydrocholic Acid; Gentamicins; Humans; | 1985 |
Reflections on the treatment of itch in primary biliary cirrhosis.
Topics: Adult; Azathioprine; Child, Preschool; Cholangitis; Cholestyramine Resin; Female; Humans; Phenobarbi | 1973 |