phenobarbital has been researched along with Cell Transformation, Neoplastic in 67 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "BRCA1 driven triple negative breast cancer (TNBC) has been shown to arise from luminal progenitors yet little is known about how BRCA1 loss-of-function (LOF) and concomitant mutations affect the luminal progenitor cell state." | 1.62 | Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors. ( Bach, K; Caldas, C; Clarke, RB; Greenhalgh, AR; Halim, TYF; Howell, SJ; Kania, K; Khaled, WT; Lazarus, KA; Marioni, JC; Pensa, S; Pinaud, S; Shehata, M; Simões, BM; Stockis, J; Zarocsinceva, M, 2021) |
| "With phenobarbital treatment the total focal volume was 20% of the liver volume three weeks after PH, whereas the corresponding value in the case of 3-methylcholanthrene was only 1%." | 1.30 | Induced drug resistance inhibits selection of initiated cells and cancer development. ( Eriksson, LC; Rissler, P; Torndal, UB, 1997) |
| "Aneuploidy was also present, as expected, in 4 of 33 AHF in the animals placed on CD + PHB." | 1.28 | Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model. ( Cechner, RL; Hinrichsen, LI; Sudilovsky, O; Wang, JH; Whitacre, CM, 1990) |
| "The phenobarbital treatment became unnecessary when neoplastic nodules were present." | 1.27 | Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect. ( Barbason, H; Betz, EH; Rassenfosse, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (40.30) | 18.7374 |
| 1990's | 19 (28.36) | 18.2507 |
| 2000's | 14 (20.90) | 29.6817 |
| 2010's | 5 (7.46) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
| Authors | Studies |
|---|---|
| Phoon, YP | 1 |
| Chivukula, IV | 1 |
| Tsoi, YL | 1 |
| Kanatani, S | 1 |
| Uhlén, P | 1 |
| Kuiper, R | 1 |
| Lendahl, U | 1 |
| Bach, K | 1 |
| Pensa, S | 1 |
| Zarocsinceva, M | 1 |
| Kania, K | 1 |
| Stockis, J | 1 |
| Pinaud, S | 1 |
| Lazarus, KA | 1 |
| Shehata, M | 1 |
| Simões, BM | 1 |
| Greenhalgh, AR | 1 |
| Howell, SJ | 1 |
| Clarke, RB | 1 |
| Caldas, C | 1 |
| Halim, TYF | 1 |
| Marioni, JC | 1 |
| Khaled, WT | 1 |
| Okuda, Y | 1 |
| Kushida, M | 1 |
| Kikumoto, H | 1 |
| Nakamura, Y | 1 |
| Higuchi, H | 1 |
| Kawamura, S | 1 |
| Cohen, SM | 1 |
| Lake, BG | 1 |
| Yamada, T | 1 |
| Thomson, JP | 1 |
| Hunter, JM | 1 |
| Lempiäinen, H | 1 |
| Müller, A | 1 |
| Terranova, R | 1 |
| Moggs, JG | 1 |
| Meehan, RR | 1 |
| Klaunig, JE | 2 |
| Gehen, SC | 1 |
| Wang, Z | 1 |
| Klein, PJ | 1 |
| Billington, R | 1 |
| Phillips, JM | 2 |
| Burgoon, LD | 1 |
| Goodman, JI | 3 |
| Calvisi, DF | 1 |
| Wang, M | 1 |
| Halasi, M | 1 |
| Kabirov, K | 1 |
| Banerjee, A | 1 |
| Landolfi, J | 1 |
| Lyubimov, AV | 1 |
| Gartel, AL | 1 |
| Lupp, A | 1 |
| Danz, M | 1 |
| Müller, D | 1 |
| Kaledin, VI | 1 |
| Il'nitskaia, SI | 1 |
| Baginskaia, NV | 1 |
| Kholodar', AV | 1 |
| Obut, TA | 1 |
| Groos, J | 1 |
| Kopp-Schneider, A | 1 |
| Chakraborty, T | 2 |
| Chatterjee, A | 2 |
| Saralaya, MG | 1 |
| Chatterjee, M | 2 |
| Yamamoto, Y | 1 |
| Negishi, M | 1 |
| Maronpot, RR | 1 |
| Swamy, AH | 1 |
| Rana, B | 1 |
| Shyamsundar, A | 1 |
| Sakakima, Y | 1 |
| Hayakawa, A | 1 |
| Nagasaka, T | 1 |
| Nakao, A | 1 |
| Zhao, X | 1 |
| Zhang, JJ | 1 |
| Wang, X | 1 |
| Bu, XY | 1 |
| Lou, YQ | 1 |
| Zhang, GL | 1 |
| Yadav, AS | 1 |
| Bhatnagar, D | 1 |
| Moore, MA | 1 |
| Hacker, HJ | 1 |
| Kunz, HW | 1 |
| Bannasch, P | 1 |
| Becker, FF | 2 |
| Hozumi, M | 1 |
| Mori, H | 1 |
| Furuya, K | 1 |
| Williams, GM | 2 |
| Nesnow, S | 1 |
| Leavitt, S | 1 |
| Garland, H | 1 |
| Vaughan, TO | 1 |
| Hyatt, B | 1 |
| Montgomery, L | 1 |
| Cudak, C | 1 |
| Kokunai, T | 1 |
| Taomoto, K | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Barbason, H | 1 |
| Rassenfosse, C | 1 |
| Betz, EH | 1 |
| Lindahl, R | 1 |
| Evces, S | 1 |
| Sheng, WL | 1 |
| Sherman, CD | 1 |
| Portier, CJ | 1 |
| Chiao, C | 1 |
| Zhang, Y | 1 |
| Kaufman, DG | 1 |
| Kaufmann, WK | 1 |
| Neveu, MJ | 1 |
| Hully, JR | 1 |
| Babcock, KL | 1 |
| Hertzberg, EL | 1 |
| Nicholson, BJ | 1 |
| Paul, DL | 1 |
| Pitot, HC | 4 |
| Santoni-Rugiu, E | 1 |
| Preisegger, KH | 1 |
| Kiss, A | 1 |
| Audolfsson, T | 1 |
| Shiota, G | 1 |
| Schmidt, EV | 1 |
| Thorgeirsson, SS | 3 |
| Rissler, P | 1 |
| Torndal, UB | 1 |
| Eriksson, LC | 1 |
| Osanai, M | 1 |
| Ogawa, K | 1 |
| Lee, GH | 1 |
| Christensen, JG | 1 |
| Goldsworthy, TL | 1 |
| Cattley, RC | 1 |
| Sanders, S | 1 |
| Im, YH | 1 |
| Kim, HT | 1 |
| Kim, IY | 1 |
| Factor, VM | 1 |
| Hahm, KB | 1 |
| Anzano, M | 1 |
| Jang, JJ | 1 |
| Flanders, K | 1 |
| Haines, DC | 1 |
| Sizeland, A | 1 |
| Kim, SJ | 1 |
| Isenberg, JS | 1 |
| Kamendulis, LM | 1 |
| Ackley, DC | 1 |
| Smith, JH | 1 |
| Pugh, G | 1 |
| Lington, AW | 1 |
| McKee, RH | 1 |
| Idoine, JB | 1 |
| Elliott, JM | 1 |
| Wilson, MJ | 1 |
| Weisburger, EK | 1 |
| Marx, JL | 1 |
| Saeter, G | 1 |
| Seglen, PO | 1 |
| Stenius, U | 1 |
| Rubin, K | 1 |
| Gullberg, D | 1 |
| Högberg, J | 1 |
| Decloitre, F | 2 |
| Lafarge-Frayssinet, C | 3 |
| Martin, M | 2 |
| Frayssinet, C | 3 |
| Maruyama, H | 1 |
| Tanaka, T | 1 |
| Jirtle, RL | 1 |
| Meyer, SA | 1 |
| Gebhardt, R | 1 |
| Fitzke, H | 1 |
| Fausel, M | 1 |
| Eisenmann-Tappe, I | 1 |
| Mecke, D | 1 |
| Wang, JH | 1 |
| Hinrichsen, LI | 1 |
| Whitacre, CM | 1 |
| Cechner, RL | 1 |
| Sudilovsky, O | 1 |
| Roberfroid, M | 1 |
| Préat, V | 1 |
| Ouldelhkim, M | 1 |
| Nizard, C | 1 |
| Mesnil, M | 1 |
| Yamasaki, H | 1 |
| Kirsch-Volders, M | 2 |
| Deleener, A | 2 |
| Lans, M | 2 |
| de Gerlache, J | 2 |
| Yeoh, G | 1 |
| Porter, I | 1 |
| Arcus, M | 1 |
| Douglas, A | 1 |
| Glauert, HP | 1 |
| Hanigan, M | 1 |
| Miyazaki, M | 1 |
| Handa, Y | 1 |
| Suzuki, Y | 1 |
| Sato, J | 1 |
| Russell, JJ | 1 |
| Staffeldt, EF | 1 |
| Wright, BJ | 1 |
| Prapuolenis, A | 1 |
| Carnes, BA | 1 |
| Peraino, C | 3 |
| McClain, RM | 1 |
| Posch, RC | 1 |
| Bosakowski, T | 1 |
| Armstrong, JM | 1 |
| Ward, JM | 1 |
| Diwan, BA | 1 |
| Ohshima, M | 1 |
| Hu, H | 1 |
| Schuller, HM | 1 |
| Rice, JM | 1 |
| Sivak, A | 1 |
| Tu, AS | 1 |
| Grosso, LE | 1 |
| Goldsworthy, T | 1 |
| Vesselinovitch, SD | 1 |
| Trosko, JE | 1 |
| Chang, CC | 1 |
| Fry, RJ | 1 |
| Staffeldt, E | 1 |
| Benedict, WF | 1 |
| Gielen, JE | 1 |
| Nebert, DW | 1 |
| Paschke, M | 1 |
| Schwanitz, F | 1 |
5 reviews available for phenobarbital and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
[Chemoprevention of carcinogenesis].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; Cyclic AMP; DNA, Neoplas | 1983 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver.
Topics: Adenosine Triphosphatases; Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitros | 1985 |
Genetics and epigenetics of neoplasia: facts and theories.
Topics: Age Factors; Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Cells, Cul | 1985 |
Single-hit versus multi-hit concept of hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Age Factors; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylni | 1985 |
62 other studies available for phenobarbital and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Notch activation in the mouse mammary luminal lineage leads to ductal hyperplasia and altered partitioning of luminal cell subtypes.
Topics: Animals; Cell Transformation, Neoplastic; Epithelial Cells; Female; Hyperplasia; Mammary Glands, Ani | 2020 |
Time-resolved single-cell analysis of Brca1 associated mammary tumourigenesis reveals aberrant differentiation of luminal progenitors.
Topics: Animals; BRCA1 Protein; Breast Neoplasms; Cell Communication; Cell Differentiation; Cell Transformat | 2021 |
Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
Topics: Androstanes; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; C | 2017 |
Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver.
Topics: 5-Methylcytosine; Animals; Carcinogens; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme Sys | 2013 |
Mechanism of 1,3-dichloropropene-induced rat liver carcinogenesis.
Topics: Adenoma, Liver Cell; Allyl Compounds; Animals; Biomarkers, Tumor; Cell Proliferation; Cell Transform | 2015 |
The constitutive active/androstane receptor facilitates unique phenobarbital-induced expression changes of genes involved in key pathways in precancerous liver and liver tumors.
Topics: Animals; Apoptosis; Cell Cycle; Cell Transformation, Neoplastic; Constitutive Androstane Receptor; D | 2009 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; | 2011 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
Evaluation of 2-year-old intrasplenic fetal liver tissue transplants in rats.
Topics: Animals; beta-Naphthoflavone; Biomarkers, Tumor; Cell Differentiation; Cell Transformation, Neoplast | 2003 |
[Effect of phenobarbital and thyroxine on hepatocarcinogenesis initiated in mice by nitrosoethylurea and diethylnitrosamine].
Topics: Alkylating Agents; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Ethylnitrosourea; F | 2005 |
Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Glutathione S-Transfer | 2006 |
Chemopreventive effect of vanadium in a rodent model of chemical hepatocarcinogenesis: reflections in oxidative DNA damage, energy-dispersive X-ray fluorescence profile and metallothionein expression.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Chemoprevention; Deoxyguanosi | 2006 |
Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.
Topics: Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplastic; Constitutive Androstane | 2007 |
Molecular basis of vanadium-mediated inhibition of hepatocellular preneoplasia during experimental hepatocarcinogenesis in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Cell Proliferation; Cell Transformation, Neoplastic; | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Effect of berberine on hepatocyte proliferation, inducible nitric oxide synthase expression, cytochrome P450 2E1 and 1A2 activities in diethylnitrosamine- and phenobarbital-treated rats.
Topics: Animals; Anticarcinogenic Agents; Berberine; Carcinogens; Cell Proliferation; Cell Transformation, N | 2008 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocyte | 2007 |
Enhancement of NNM-induced carcinogenesis in the rat liver by phenobarbital: a combined morphological and enzyme histochemical approach.
Topics: Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Synergism; Liver; Live | 1983 |
The direct and indirect effects of promoters may depend upon the nature of the initiated cell.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; DN | 1983 |
Enhanced survival and absence of progressive growth of transplanted rat liver altered eosinophilic foci and neoplastic nodules in phenobarbital-treated rats.
Topics: Animals; Carcinogens; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Eosine Yellowis | 1983 |
Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts.
Topics: Animals; Aroclors; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Cell Division; C | 1981 |
[Effect of tumor promoting agents on the in vitro malignant transformation of the fetal rat brain cells exposed in utero to ethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Drug Intera | 1984 |
Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Diethylnitrosamine; Hepatectomy; Liver N | 1983 |
Expression of the tumor aldehyde dehydrogenase phenotype during 2-acetylaminofluorene-induced rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Cell Transformatio | 1982 |
Quantitative analysis of multiple phenotype enzyme-altered foci in rat hepatocarcinogenesis experiments: the multipath/multistage model.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Female; Live | 1995 |
Derivation of phenobarbital-responsive immortal rat hepatocytes.
Topics: Animals; Carcinogenicity Tests; Cell Line, Transformed; Cell Transformation, Neoplastic; DNA Replica | 1995 |
Multiple mechanisms are responsible for altered expression of gap junction genes during oncogenesis in rat liver.
Topics: Animals; Blotting, Northern; Cell Transformation, Neoplastic; Connexin 26; Connexin 43; Connexins; D | 1994 |
Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model.
Topics: Animals; Apoptosis; Cell Division; Cell Transformation, Neoplastic; Gene Expression Regulation, Neop | 1996 |
Induced drug resistance inhibits selection of initiated cells and cancer development.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Transformation, Neoplastic; Drug Resistance, Neopl | 1997 |
Phenobarbital causes apoptosis in conditionally immortalized mouse hepatocytes depending on deregulated c-myc expression: characterization of an unexpected effect.
Topics: Animals; Antigens, Polyomavirus Transforming; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cell | 1997 |
Dysregulation of apoptosis by c-myc in transgenic hepatocytes and effects of growth factors and nongenotoxic carcinogens.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Bleomycin; Carcinogens; Cell Transformation, Neop | 1999 |
Promotion of hepatocarcinogenesis by phenobarbital in c-myc/TGF-alpha transgenic mice.
Topics: Animals; Apoptosis; bcl-X Protein; Carcinogens; Cell Transformation, Neoplastic; Crosses, Genetic; G | 2000 |
Heterozygous mice for the transforming growth factor-beta type II receptor gene have increased susceptibility to hepatocellular carcinogenesis.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diethylnitrosamine; Female; Gene Dosage; Gene | 2001 |
Operational reversibility is a key aspect of carcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Diethylhexyl Phthalate; Gap Junctions; Humans; Liver; Mice | 2001 |
Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents.
Topics: Animals; Body Weight; Cell Communication; Cell Transformation, Neoplastic; Diet; Diethylhexyl Phthal | 2001 |
Rat liver cells in culture: effect of storage, long-term culture, and transformation on some enzyme levels.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Cell Division; Cell Line; Cell Transform | 1976 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Tumor promoters: carcinogenesis gets more complicated.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cocarcinogenesis; Dietary Fats; Epidermal Gro | 1978 |
gamma-Glutamyltranspeptidase-positive rat hepatocytes are protected from GSH depletion, oxidative stress and reversible alterations of collagen receptors.
Topics: Animals; Biomarkers, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Diethylnitro | 1990 |
Modifications of microfilaments and microtubules induced by two hepatic tumor promoters, phenobarbital and biliverdin in non-transformed and transformed hepatic cell lines.
Topics: Actin Cytoskeleton; Actins; Animals; Bilirubin; Biliverdine; Cell Line; Cell Line, Transformed; Cell | 1990 |
Effects of the peroxisome proliferator di(2-ethylhexyl)phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital.
Topics: 2-Acetylaminofluorene; Adenosine Triphosphate; Alkaline Phosphatase; Animals; Cell Transformation, N | 1990 |
Liver tumor promotion: effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-beta 1 expression.
Topics: Animals; Binding, Competitive; Cell Transformation, Neoplastic; Diethylnitrosamine; Epidermal Growth | 1991 |
Influence of hormones and drugs on glutathione-S-transferase levels in primary culture of adult rat hepatocytes.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Glutathione Transferase; Hormones; Liver; | 1990 |
Nuclear DNA content of altered hepatic foci in a rat liver carcinogenesis model.
Topics: Aneuploidy; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Choline; Diethylnitrosamine; Dis | 1990 |
[Concept of tumor promoters in hepatocarcinogenesis].
Topics: Bile Acids and Salts; Carcinogens; Cell Transformation, Neoplastic; Humans; Hydrocarbons, Chlorinate | 1990 |
Modulation of neoplastic development: concepts and examples.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Diet; Enzyme Induction; Hepatectomy; Liver Ne | 1990 |
[Oncogenes and tumor promotion].
Topics: Animals; Bilirubin; Biliverdine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Gene | 1990 |
[Modification of the cellular cytoskeleton and hepatic tumor promotion].
Topics: Animals; Biliverdine; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; L | 1990 |
[Role of junctional intercellular communication in hepatic carcinogenesis in rats].
Topics: Animals; Cell Communication; Cell Transformation, Neoplastic; Cells, Cultured; Intercellular Junctio | 1990 |
Increased silver stainability of metaphase chromosomes from rat hepatocytes during in vivo hepatocarcinogenesis.
Topics: Animals; Cell Transformation, Neoplastic; Chromosomes; Diethylnitrosamine; Liver Neoplasms; Metaphas | 1985 |
Transformation of cultured fetal rat liver cells by MDAB and phenobarbital. Morphological, biochemical and immunocytochemical characterization of cell lines.
Topics: Animals; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Culture Te | 1989 |
Tumor phenotype and susceptibility to progression as an expression of subpopulations of initiated murine cells.
Topics: alpha-Fetoproteins; Animals; Cell Transformation, Neoplastic; Diethylnitrosamine; Disease Susceptibi | 1985 |
Promotion of 3'-methyl-4-dimethylaminoazobenzene-initiated adult rat liver cells to malignant state by phenobarbital in culture.
Topics: Animals; Cell Cycle; Cell Transformation, Neoplastic; Epithelium; gamma-Glutamyltransferase; Liver; | 1986 |
Effects of rat strain, diet composition, and phenobarbital on hepatic gamma-glutamyl transpeptidase histochemistry and on the induction of altered hepatocyte foci and hepatic tumors by diethylnitrosamine.
Topics: Animals; Cell Transformation, Neoplastic; Diet; gamma-Glutamyltransferase; Liver; Liver Neoplasms; P | 1987 |
Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital.
Topics: Animals; Body Weight; Cell Transformation, Neoplastic; Eating; Female; Male; Nitrosamines; Organ Siz | 1988 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh | 1986 |
Use of rodent hepatocytes for metabolic activation in transformation assays.
Topics: 2-Acetylaminofluorene; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cell Cycle; Cell L | 1985 |
Nucleolar changes during the first steps of experimental hepatocarcinogenesis in rats.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride; Cell Nucleolus; Cell Transformation, Neoplasti | 1985 |
Role of tumor promotion in affecting the multi-hit nature of carcinogenesis.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cell Transformation, Neoplastic; Fema | 1985 |
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Topics: Acetates; Amides; Animals; Autoradiography; Carcinoma, Hepatocellular; Cell Division; Cell Transform | 1971 |
Polycyclic hydrocarbon-produced toxicity, transformation, and chromosomal aberrations as a function of aryl hydrocarbon hydroxylase activity in cell cultures.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chromosome Ab | 1972 |
[Pretesting of drugs using lower and higher plants. II. Effect of phenazetin and various substances frequently combined with it, on the shape and growth of Micrasterias americana].
Topics: Antineoplastic Agents; Biological Assay; Caffeine; Cell Division; Cell Transformation, Neoplastic; D | 1971 |