phenobarbital has been researched along with Cardiomegaly in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital pretreatment did not substantially alter the time course of toxicity induced with 20 mg/l monocrotaline water." | 1.28 | Dose-response relationship in intoxication by the pyrrolizidine alkaloid monocrotaline. ( Hubbard, AK; Huxtable, RJ; Shubat, PJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kay, JM | 1 |
| Smith, P | 1 |
| Heath, D | 1 |
| Will, JA | 1 |
| Shubat, PJ | 1 |
| Hubbard, AK | 1 |
| Huxtable, RJ | 1 |
| Khaliq, SU | 1 |
3 other studies available for phenobarbital and Cardiomegaly
| Article | Year |
|---|---|
Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.
Topics: Animals; Cardiomegaly; Cinnarizine; Hypertension, Pulmonary; Male; Phenobarbital; Piperazines; Pyrro | 1976 |
Dose-response relationship in intoxication by the pyrrolizidine alkaloid monocrotaline.
Topics: Administration, Oral; Animals; Bronchoalveolar Lavage Fluid; Cardiomegaly; Dose-Response Relationshi | 1989 |
Protective effect of phenobarbitone against fulvine-induced hepatic damage and hypertensive pulmonary vascular disease in the rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Chemical and Drug Induced Liver Injury; Female; Heart Ventric | 1973 |