phenobarbital has been researched along with Cardiac Hypertrophy in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenobarbital pretreatment did not substantially alter the time course of toxicity induced with 20 mg/l monocrotaline water." | 1.28 | Dose-response relationship in intoxication by the pyrrolizidine alkaloid monocrotaline. ( Hubbard, AK; Huxtable, RJ; Shubat, PJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kay, JM | 1 |
| Smith, P | 1 |
| Heath, D | 1 |
| Will, JA | 1 |
| Shubat, PJ | 1 |
| Hubbard, AK | 1 |
| Huxtable, RJ | 1 |
| Khaliq, SU | 1 |
3 other studies available for phenobarbital and Cardiac Hypertrophy
| Article | Year |
|---|---|
Effects of phenobarbitone, cinnarizine, and zoxazolamine on the development of right ventricular hypertrophy and hypertensive pulmonary vascular disease in rats treated with monocrotaline.
Topics: Animals; Cardiomegaly; Cinnarizine; Hypertension, Pulmonary; Male; Phenobarbital; Piperazines; Pyrro | 1976 |
Dose-response relationship in intoxication by the pyrrolizidine alkaloid monocrotaline.
Topics: Administration, Oral; Animals; Bronchoalveolar Lavage Fluid; Cardiomegaly; Dose-Response Relationshi | 1989 |
Protective effect of phenobarbitone against fulvine-induced hepatic damage and hypertensive pulmonary vascular disease in the rat.
Topics: Animals; Blood Pressure; Cardiomegaly; Chemical and Drug Induced Liver Injury; Female; Heart Ventric | 1973 |