phenobarbital has been researched along with Carcinoma in 14 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Following chronic treatment, altered hepatic foci and adenomas were classified as: small-cell, heterogeneous basophilic lesions (spontaneous or tetrachlorodibenzo-p-dioxin-induced); large-cell, homogeneous basophilic lesions (WY-14,643-induced); acidophilic lesions (phenobarbital- or chlordane-induced)." | 3.70 | Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice. ( Anderson, SP; Cattley, RC; Christensen, JG; Corton, JC; Fox, TR; Goldsworthy, TL; Gonzales, AJ; Healy, LN; Malarkey, DE; Romach, EH, 1999) |
| "To investigate the role of monomethyltriazenes as the active metabolites of antitumor dimethyltriazenes, the in vivo simultaneous treatment with an inducer (phenobarbital, PB) or an inhibitor (carbon tetrachloride, CCl4) of hepatic drug metabolism was examined in mice bearing Lewis lung carcinoma." | 3.67 | Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes. ( Giraldi, T; Lassiani, L; Perissin, L; Sava, G; Zorzet, S, 1988) |
| " Dose-response studies of the capacity of 7,8-BF to inhibit DMBA tumor initiation revealed that 7,8-BF was an effective inhibitor at 2." | 1.26 | The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation. ( Berry, DL; Digiovanni, J; Juchau, MR; Slaga, TJ; Thompson, S; Viaje, A, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KATO, R | 1 |
| FRONTINO, G | 1 |
| VASSANELLI, P | 1 |
| Page, JL | 1 |
| Strom, SC | 1 |
| Omiecinski, CJ | 1 |
| Richards, GE | 1 |
| Brewer, ED | 1 |
| Conley, SB | 1 |
| Saldana, LR | 1 |
| Christensen, JG | 1 |
| Romach, EH | 1 |
| Healy, LN | 1 |
| Gonzales, AJ | 1 |
| Anderson, SP | 1 |
| Malarkey, DE | 1 |
| Corton, JC | 1 |
| Fox, TR | 1 |
| Cattley, RC | 1 |
| Goldsworthy, TL | 1 |
| Slaga, TJ | 1 |
| Thompson, S | 1 |
| Berry, DL | 1 |
| Digiovanni, J | 1 |
| Juchau, MR | 1 |
| Viaje, A | 1 |
| Lijinsky, W | 1 |
| Kovatch, RM | 1 |
| Thomas, BJ | 1 |
| Kraupp-Grasl, B | 1 |
| Huber, W | 1 |
| Putz, B | 1 |
| Gerbracht, U | 1 |
| Schulte-Hermann, R | 1 |
| Diwan, BA | 4 |
| Hagiwara, A | 1 |
| Ward, JM | 3 |
| Rice, JM | 4 |
| Lubet, RA | 1 |
| Nims, RW | 1 |
| Klaunig, JE | 2 |
| Weghorst, CM | 1 |
| Henneman, JR | 1 |
| Ohshima, M | 2 |
| Shirai, T | 1 |
| Masuda, A | 1 |
| Imaida, K | 1 |
| Ogiso, T | 1 |
| Ito, N | 1 |
| Sava, G | 1 |
| Zorzet, S | 1 |
| Perissin, L | 1 |
| Giraldi, T | 1 |
| Lassiani, L | 1 |
| Pereira, MA | 1 |
| Herren-Freund, SL | 1 |
| Ruch, RJ | 1 |
| Hu, H | 1 |
| Schuller, HM | 1 |
14 other studies available for phenobarbital and Carcinoma
| Article | Year |
|---|---|
Phenobarbital markedly increases liver weight in Walker carcinosarcoma bearing rats.
Topics: Animals; Carcinoma; Carcinoma 256, Walker; Carcinosarcoma; Liver; Phenobarbital; Rats | 1963 |
Regulation of the human cathepsin E gene by the constitutive androstane receptor.
Topics: Amino Acid Motifs; Carcinoma; Cathepsin E; Cells, Cultured; Constitutive Androstane Receptor; Gene E | 2007 |
Combined hypothyroidism and hypoparathyroidism in an infant after maternal 131I administration.
Topics: Carcinoma; Female; Humans; Hypocalcemia; Hypoparathyroidism; Hypothyroidism; Infant; Infant, Newborn | 1981 |
Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.
Topics: Adenoma; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Carcinogens; Carcinoma; Carr | 1999 |
The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzopyrene Hydroxylase; Carcinoma; D | 1977 |
The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Diethylnitrosamine; Drug Interactions; Female; Hepatectomy | 1992 |
Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver.
Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Carcinoma; Female; gamma-Glutamyltransferase; Liver; | 1990 |
Effects of sodium salts of phenobarbital and barbital on development of bladder tumors in male F344/NCr rats pretreated with either N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-nitrosobutyl-4-hydroxybutylamine.
Topics: Animals; Barbital; Barbiturates; Butylhydroxybutylnitrosamine; Carcinoma; Cocarcinogenesis; FANFT; M | 1989 |
Lack of promoting effect of clonazepam on the development of N-nitrosodiethylamine-initiated hepatocellular tumors in mice is correlated with its inability to inhibit cell-to-cell communication in mouse hepatocytes.
Topics: Adenoma; Aminopyrine N-Demethylase; Animals; Carcinogens; Carcinoma; Cell Communication; Clonazepam; | 1989 |
Promotion by sodium barbital of renal cortical and transitional cell tumors, but not intestinal tumors, in F344 rats given methyl(acetoxymethyl)nitrosamine, and lack of effect of phenobarbital, amobarbital, or barbituric acid on development of either rena
Topics: Adenoma; Amobarbital; Animals; Barbital; Barbiturates; Carcinogens; Carcinoma; Carcinoma, Renal Cell | 1989 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Effects of an inducer and an inhibitor of hepatic metabolism on the antitumor action of dimethyltriazenes.
Topics: Animals; Antineoplastic Agents; Biotransformation; Carbon Tetrachloride; Carcinoma; Liver; Lung Neop | 1988 |
Effect of phenobarbital on the development of liver tumors in juvenile and adult mice.
Topics: Adenoma; Age Factors; Animals; Carcinoma; Diethylnitrosamine; DNA; Liver Neoplasms, Experimental; Ma | 1986 |
Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro.
Topics: Adenoma; Animals; Carcinogens; Carcinoma; Cell Transformation, Neoplastic; Cells, Cultured; Diethylh | 1986 |