phenobarbital has been researched along with Carcinoma, Hepatocellular in 106 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 7.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 5.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 5.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| " In this study, the efficacy and toxicity of protocatechuic acid intercalated in zinc aluminum-layered double hydroxide nanoparticles (PCA-ZnAl) against diethylnitrosamine/phenobarbital (DEN/PB)-induced hepatocellular carcinoma (HCC) in BALB/c mice was evaluated." | 3.91 | Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. ( Barahuie, F; Fakurazi, S; Gani, SA; Hussein, MZ; Kura, AU; Muhammad, SA, 2019) |
| "The ability of diethylnitrosamine (DENA) to initiate and phenobarbital to promote altered-hepatocyte foci and hepatocellular carcinomas in C3H and C3B6F1 (C3H x C57BL/6) mice was compared to the extent of cell proliferation." | 3.68 | Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation. ( Pereira, MA, 1993) |
| "Exposure of female hepatitis B virus transgenic mice of lineage 50-4, which display liver injury secondary to overexpression of the gene for the large envelope polypeptide of hepatitis B virus, to the hepatocarcinogens aflatoxin and diethylnitrosamine produced more rapid and extensive evidence of nodule formation and oval cell proliferation, as well as the development of adenomas and primary hepatocellular carcinomas, than was seen in transgenic mice not exposed to carcinogens." | 3.68 | Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. ( Chisari, FV; Dunsford, HA; Hunt, JM; Sell, S, 1991) |
| "05% in the diet) for 6 months following a single dose of diethylnitrosamine (5 to 10 mg/kg) given within 24 hours after partial hepatectomy resulted in a marked increase in the number of enzyme-altered foci in the liver as well as in the production of hepatocellular carcinomas." | 3.65 | The natural history of neoplasia. Newer insights into an old problem. ( Pitot, HC, 1977) |
| "Administration of 40 ppm diethylnitrosamine (DENA) in the drinking water for 10 weeks to male Fischer rats led to hepatocellular carcinoma in 100 percent with metastasis to the lung in 40 percent, of the animals living for the full experimental period of 20 weeks." | 3.65 | Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression. ( Madison, RM; Viguera, C; Ward, JM; Weisburger, EK; Weisburger, JH, 1975) |
| "Within the cells of the liver and tumors, gallium is found in lysosomes, and rough endoplasmic reticulum." | 2.36 | Mechanisms of localization of gallium-67 in tumors. ( Larson, SM, 1978) |
| "Phenobarbital treated mice showed damped corticosterone levels and a less stable 24 hours activity rhythm as well as an increase in activity during the light phase, reminiscent of sleep disruption." | 1.62 | Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model. ( Ali, AAH; Hassan, SA; Jänicke, RU; Korf, HW; Pfeffer, M; Sohn, D; von Gall, C; Yassine, M, 2021) |
| " Overall, while chronic administration of the model CAR activator NaPB results in both hepatocellular adenoma and carcinoma in the low spontaneous liver tumour incidence C57BL/10J mouse strain, only 40 % of the liver tumours evaluated in this study had β-catenin mutations." | 1.56 | Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. ( Foster, A; Jones, HB; Kalaitzi, K; Lake, BG; Orton, TC; Sidaway, JE, 2020) |
| "Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC)." | 1.48 | Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis. ( Dozmorov, M; Fisher, PB; Ghosh, S; Jariwala, N; Lai, Z; Mendoza, RG; Mukhopadhyay, ND; Robertson, CL; Sarkar, D; Subler, MA; Windle, JJ, 2018) |
| "Phenobarbital (PB) is a cytochrome P450 (CYP) 2B inducer, and piperonyl butoxide (PBO) is a CYP1A/2B inducer." | 1.39 | Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide. ( Akane, H; Itahashi, M; Mitsumori, K; Morita, R; Nakane, F; Shibutani, M; Shiraki, A; Suzuki, K; Yafune, A, 2013) |
| "Group-II animals were kept untreated as hepatocellular carcinoma control." | 1.39 | Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats. ( Jhala, M; Joseph, JP; Kumar, P; Raval, SK; Sadariya, KA, 2013) |
| "A genetic basis of hepatocellular carcinoma (HCC) has been well-established and major signaling pathways, such as p53, Wnt-signaling, transforming growth factor-β (TGF-β) and Ras pathways, have been identified to be essential to HCC development." | 1.37 | Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. ( Galle, PR; Hansen, T; Kanzler, S; Longerich, T; Maass, T; Mann, A; Schirmacher, P; Strand, D; Teufel, A; Thieringer, FR, 2011) |
| "Ursolic acid is a natural triterpenoid widely found in food, medicinal herbs, apple peel and other products it has been extensively studied for its anticancer and antioxidant properties." | 1.35 | Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. ( Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D, 2009) |
| "Hepatocellular adenomas and hepatocellular carcinomas also show a very low density of beta1-ARs, extensive areas completely devoid of beta1-ARs being mingled with areas showing a weak immunostaining." | 1.33 | Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats. ( Cardani, R; Zavanella, T, 2005) |
| "The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
| "In gene therapy for hepatocellular carcinoma (HCC), gene transfer is efficient for small tumors, but not for large tumors." | 1.31 | Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters. ( Eto, Y; Futagawa, Y; Ohashi, T; Okamoto, T; Shiba, H, 2001) |
| "Primary hepatocellular carcinoma (HCC) is probably one of the most common fatal forms of liver cancer." | 1.30 | Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor. ( Adam, R; Anjo, A; Blazsek, I; Legras, S; Marion, S; Misset, JL; Reynes, M; Thièry, JP, 1999) |
| " Transfected cells were dosed with several known inducers of CYP3A4 and the levels of SPAP were measured." | 1.30 | A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. ( Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM, 1999) |
| "Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks." | 1.30 | Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999) |
| "It is concluded, that HepG2 hepatoma cells behave similar to the normal hepatocytes in terms of ALDH regulation and can be used for studies on the activity of ALDH as modified by added xenobiotics." | 1.27 | Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes. ( Marselos, M; Michalopoulos, G; Strom, SC, 1987) |
| "In the spectrum of hepatomas studied, 16alpha-hydroxylase activity was significantly decreased in parallel with the increase in hepatoma growth rate." | 1.26 | Metabolism of estrogens in hepatomas of different growth rates. ( Abul-Hajj, YJ; Morris, HP, 1977) |
| "Amount of cytochrome P-450 in hepatoma tissues also showed similar values as that in hyperplastic nodules." | 1.26 | Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats. ( Fukumoto, Y; Noda, K; Okita, K; Takemoto, T, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (37.74) | 18.7374 |
| 1990's | 23 (21.70) | 18.2507 |
| 2000's | 17 (16.04) | 29.6817 |
| 2010's | 22 (20.75) | 24.3611 |
| 2020's | 4 (3.77) | 2.80 |
| Authors | Studies |
|---|---|
| Kauffmann, HM | 1 |
| Schrenk, D | 1 |
| Kiuchi, Y | 1 |
| Suzuki, H | 1 |
| Hirohashi, T | 1 |
| Tyson, CA | 1 |
| Sugiyama, Y | 1 |
| Li, S | 1 |
| Li, Y | 1 |
| Sun, H | 1 |
| Jiang, Y | 1 |
| Pan, K | 1 |
| Su, Y | 1 |
| Bu, N | 1 |
| Sidaway, JE | 1 |
| Orton, TC | 1 |
| Kalaitzi, K | 1 |
| Jones, HB | 1 |
| Foster, A | 1 |
| Lake, BG | 2 |
| Hassan, SA | 1 |
| Ali, AAH | 1 |
| Yassine, M | 1 |
| Sohn, D | 1 |
| Pfeffer, M | 1 |
| Jänicke, RU | 1 |
| Korf, HW | 1 |
| von Gall, C | 1 |
| El Miniawy, HM | 1 |
| Ahmed, KA | 1 |
| Mansour, SA | 1 |
| Khattab, MM | 1 |
| Okuda, Y | 1 |
| Kushida, M | 1 |
| Kikumoto, H | 1 |
| Nakamura, Y | 1 |
| Higuchi, H | 1 |
| Kawamura, S | 1 |
| Cohen, SM | 1 |
| Yamada, T | 1 |
| Robertson, CL | 1 |
| Mendoza, RG | 1 |
| Jariwala, N | 1 |
| Dozmorov, M | 1 |
| Mukhopadhyay, ND | 1 |
| Subler, MA | 1 |
| Windle, JJ | 1 |
| Lai, Z | 1 |
| Fisher, PB | 1 |
| Ghosh, S | 1 |
| Sarkar, D | 1 |
| Pathak, S | 4 |
| Catanzaro, R | 1 |
| Vasan, D | 1 |
| Marotta, F | 1 |
| Chabria, Y | 1 |
| Jothimani, G | 1 |
| Verma, RS | 1 |
| Ramachandran, M | 1 |
| Khuda-Bukhsh, AR | 5 |
| Banerjee, A | 4 |
| Gani, SA | 1 |
| Muhammad, SA | 1 |
| Kura, AU | 1 |
| Barahuie, F | 1 |
| Hussein, MZ | 1 |
| Fakurazi, S | 1 |
| Morita, R | 1 |
| Yafune, A | 1 |
| Shiraki, A | 1 |
| Itahashi, M | 1 |
| Akane, H | 1 |
| Nakane, F | 1 |
| Suzuki, K | 1 |
| Shibutani, M | 1 |
| Mitsumori, K | 4 |
| Joseph, JP | 1 |
| Raval, SK | 1 |
| Sadariya, KA | 1 |
| Jhala, M | 1 |
| Kumar, P | 1 |
| Tekin, N | 1 |
| Ustuner, MC | 1 |
| Akyuz, F | 1 |
| Ozbayer, CS | 1 |
| Aydın, O | 1 |
| Benkli, K | 1 |
| Burukoglu, D | 1 |
| Degirmenci, I | 1 |
| Ozden, H | 1 |
| Omura, K | 2 |
| Uehara, T | 2 |
| Morikawa, Y | 2 |
| Hayashi, H | 2 |
| Minami, K | 2 |
| Kanki, M | 2 |
| Yamada, H | 2 |
| Ono, A | 2 |
| Urushidani, T | 2 |
| Lu, M | 1 |
| Wu, J | 1 |
| He, F | 1 |
| Wang, XL | 1 |
| Li, C | 1 |
| Chen, ZN | 1 |
| Bian, H | 1 |
| Delgado, E | 1 |
| Okabe, H | 1 |
| Preziosi, M | 1 |
| Russell, JO | 1 |
| Alvarado, TF | 1 |
| Oertel, M | 1 |
| Nejak-Bowen, KN | 1 |
| Zhang, Y | 1 |
| Monga, SP | 1 |
| Kobayashi, K | 1 |
| Hashimoto, M | 1 |
| Honkakoski, P | 1 |
| Negishi, M | 2 |
| Hussein, UK | 1 |
| Mahmoud, HM | 1 |
| Farrag, AG | 1 |
| Bishayee, A | 1 |
| Groll, N | 2 |
| Kollotzek, F | 1 |
| Goepfert, J | 1 |
| Joos, TO | 2 |
| Schwarz, M | 3 |
| Braeuning, A | 3 |
| Petrikat, T | 1 |
| Vetter, S | 1 |
| Wenz, C | 1 |
| Dengjel, J | 1 |
| Gretzmeier, C | 1 |
| Weiss, F | 1 |
| Poetz, O | 1 |
| Lambert, CB | 2 |
| Spire, C | 2 |
| Claude, N | 2 |
| Guillouzo, A | 2 |
| Renaud, MP | 1 |
| Nesnow, S | 1 |
| Ward, W | 1 |
| Moore, T | 1 |
| Ren, H | 1 |
| Hester, SD | 1 |
| Kakehashi, A | 1 |
| Inoue, M | 1 |
| Wei, M | 1 |
| Fukushima, S | 2 |
| Wanibuchi, H | 1 |
| Gayathri, R | 1 |
| Priya, DK | 1 |
| Gunassekaran, GR | 1 |
| Sakthisekaran, D | 3 |
| Maass, T | 1 |
| Thieringer, FR | 1 |
| Mann, A | 1 |
| Longerich, T | 1 |
| Schirmacher, P | 1 |
| Strand, D | 1 |
| Hansen, T | 1 |
| Galle, PR | 1 |
| Teufel, A | 1 |
| Kanzler, S | 1 |
| Biswas, SJ | 2 |
| Roy-Karmakar, S | 1 |
| Boujedaini, N | 1 |
| Belon, P | 1 |
| Karmakar, SR | 2 |
| Singh, Y | 1 |
| Rignall, B | 1 |
| Buchmann, A | 1 |
| Hammad, S | 1 |
| Othman, A | 1 |
| von Recklinghausen, I | 1 |
| Godoy, P | 1 |
| Hoehme, S | 1 |
| Drasdo, D | 1 |
| Hengstler, JG | 1 |
| Calvisi, DF | 1 |
| Kamino, H | 1 |
| Moore, R | 1 |
| Wang, M | 1 |
| Halasi, M | 1 |
| Kabirov, K | 1 |
| Landolfi, J | 1 |
| Lyubimov, AV | 1 |
| Gartel, AL | 1 |
| Rossmanith, W | 1 |
| Chabicovsky, M | 1 |
| Grasl-Kraupp, B | 1 |
| Peter, B | 1 |
| Schausberger, E | 1 |
| Schulte-Hermann, R | 1 |
| Thirunavukkarasu, C | 2 |
| THERET, C | 1 |
| CONNEY, AH | 1 |
| BURNS, JJ | 1 |
| FOUTS, JR | 3 |
| POTTER, VR | 1 |
| HART, LG | 1 |
| ADAMSON, RH | 1 |
| MORRIS, HP | 5 |
| Cardani, R | 1 |
| Zavanella, T | 1 |
| Kumar Das, J | 1 |
| Jyoti Biswas, S | 1 |
| Zhang, Q | 1 |
| Bae, Y | 1 |
| Kemper, JK | 1 |
| Kemper, B | 1 |
| Itoh, T | 1 |
| Moto, M | 1 |
| Kuroiwa, Y | 1 |
| Sakai, H | 1 |
| Sakakima, Y | 1 |
| Hayakawa, A | 1 |
| Nagasaka, T | 1 |
| Nakao, A | 1 |
| Olsavsky, KM | 1 |
| Page, JL | 1 |
| Johnson, MC | 1 |
| Zarbl, H | 1 |
| Strom, SC | 2 |
| Omiecinski, CJ | 1 |
| Bhattacharjee, N | 1 |
| Das, JK | 1 |
| Choudhury, SC | 1 |
| Banerjee, P | 1 |
| Paul, S | 1 |
| Premkumar, K | 1 |
| Sheriff, AK | 1 |
| Wiebel, FJ | 1 |
| Kiefer, F | 1 |
| Murdia, US | 1 |
| Ward, JM | 2 |
| Vesell, ES | 1 |
| Duthu, GS | 1 |
| Nestor, MS | 1 |
| Berliner, JA | 1 |
| Philpot, RM | 1 |
| Hankinson, O | 1 |
| Williams, GM | 1 |
| Gebhardt, R | 1 |
| Sirma, H | 1 |
| Stenbäck, F | 1 |
| Chasserot-Golaz, S | 1 |
| Beck, G | 1 |
| Venetianer, A | 1 |
| Bergelson, S | 1 |
| Pinkus, R | 1 |
| Daniel, V | 1 |
| Rosenberg, DW | 1 |
| Leff, T | 1 |
| Pereira, MA | 2 |
| Doostdar, H | 1 |
| Grant, MH | 1 |
| Melvin, WT | 1 |
| Wolf, CR | 1 |
| Burke, MD | 1 |
| Dubois, M | 1 |
| Plaisance, H | 1 |
| Thomé, JP | 1 |
| Kremers, P | 1 |
| Thièry, JP | 1 |
| Blazsek, I | 1 |
| Legras, S | 1 |
| Marion, S | 1 |
| Reynes, M | 1 |
| Anjo, A | 1 |
| Adam, R | 1 |
| Misset, JL | 1 |
| Ogg, MS | 1 |
| Williams, JM | 1 |
| Tarbit, M | 1 |
| Goldfarb, PS | 1 |
| Gray, TJ | 1 |
| Gibson, GG | 1 |
| McClain, RM | 2 |
| Rice, JM | 1 |
| Hagiwara, A | 1 |
| Miyata, E | 1 |
| Tamano, S | 1 |
| Sano, M | 1 |
| Masuda, C | 1 |
| Funae, Y | 1 |
| Ito, N | 1 |
| Shirai, T | 1 |
| Kolluri, S | 1 |
| Elbirt, KK | 1 |
| Bonkovsky, HL | 1 |
| Watanabe, T | 1 |
| Sugie, S | 1 |
| Okamoto, K | 1 |
| Rahman, KM | 1 |
| Ushida, J | 1 |
| Mori, H | 1 |
| Shiba, H | 1 |
| Okamoto, T | 1 |
| Futagawa, Y | 1 |
| Ohashi, T | 1 |
| Eto, Y | 1 |
| Pitot, HC | 3 |
| Barsness, L | 1 |
| Goldsworthy, T | 1 |
| Kitagawa, T | 1 |
| Clemmesen, J | 1 |
| Owens, IS | 2 |
| Nebert, DW | 1 |
| Weisburger, JH | 1 |
| Madison, RM | 1 |
| Viguera, C | 1 |
| Weisburger, EK | 1 |
| Williams, MT | 1 |
| Gaylor, JL | 2 |
| Swenson, DH | 1 |
| Lin, JK | 1 |
| Miller, EC | 2 |
| Miller, JA | 2 |
| Gessner, T | 1 |
| Nishizumi, M | 1 |
| Abul-Hajj, YJ | 1 |
| Okita, K | 1 |
| Noda, K | 1 |
| Fukumoto, Y | 1 |
| Takemoto, T | 1 |
| Wislocki, PG | 1 |
| McCoy, EC | 1 |
| Rosenkranz, HS | 1 |
| Larson, SM | 1 |
| McLean, AE | 1 |
| Driver, HE | 1 |
| Sutherland, IA | 1 |
| Belisario, MA | 1 |
| Arena, AR | 1 |
| Pecce, R | 1 |
| Borgia, R | 1 |
| Staiano, N | 1 |
| De Lorenzo, F | 1 |
| Vorce, RL | 1 |
| Goodman, JI | 1 |
| Sell, S | 1 |
| Hunt, JM | 1 |
| Dunsford, HA | 1 |
| Chisari, FV | 1 |
| Visser, O | 1 |
| van den Berg, JW | 1 |
| Koole-Lesuis, H | 1 |
| Voortman, G | 1 |
| Wilson, JH | 1 |
| Saeter, G | 2 |
| Seglen, PO | 2 |
| Fandrey, J | 1 |
| Seydel, FP | 1 |
| Siegers, CP | 1 |
| Jelkmann, W | 1 |
| Schwarze, PE | 1 |
| Herren-Freund, SL | 1 |
| Kaufmann, WK | 1 |
| MacKenzie, SA | 1 |
| Kaufman, DG | 1 |
| Rolin-Limbosch, S | 1 |
| Moens, W | 1 |
| Szpirer, C | 1 |
| Marselos, M | 1 |
| Michalopoulos, G | 1 |
| Miyake, Y | 1 |
| Rogers, LA | 1 |
| Peraino, C | 3 |
| Fry, RJ | 3 |
| Kunz, W | 1 |
| Schaude, G | 1 |
| Thomas, C | 1 |
| Staffeldt, E | 2 |
| Robinson, SH | 1 |
| Rugstad, HE | 1 |
| Yannoni, C | 1 |
| Tashjian, AH | 1 |
| Emmelot, P | 1 |
| Bos, CJ | 1 |
| Feinstein, RN | 1 |
| Cameron, EC | 1 |
| Phillips, JL | 1 |
| Benedict, WF | 1 |
| Gielen, JE | 1 |
| Niwa, A | 1 |
| Bebert, DW | 1 |
| Galotti, T | 1 |
| D'Amico, E | 1 |
| Marchese, E | 1 |
| Bompiani, R | 1 |
| Terranova, T | 1 |
| Russo, M | 1 |
| Jackson, SH | 1 |
| Epstein, RA | 1 |
6 reviews available for phenobarbital and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Regulation of gene expression by CAR: an update.
Topics: Active Transport, Cell Nucleus; Animals; Biotransformation; Carcinoma, Hepatocellular; Cholesterol; | 2015 |
A mechanistic relationship between thyroid follicular cell tumours and hepatocellular neoplasms in rodents.
Topics: Adenocarcinoma, Follicular; Animals; Carcinogens; Carcinoma, Hepatocellular; Environmental Pollutant | 1999 |
Mechanisms of localization of gallium-67 in tumors.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Gallium; Gallium Radioisotopes; G | 1978 |
Liver tumour promotion by phenobarbital: comparison of rat and human studies.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Epilepsy; Humans; Liver Neoplasms; Liver Neoplasms, | 1992 |
Cell biology of hepatocarcinogenesis.
Topics: Animals; Antioxidants; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, N | 1990 |
Mouse liver tumors and microsomal enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Cell Communication; Cocarcinogenesis; DNA Damage; Humans; Liver | 1990 |
100 other studies available for phenobarbital and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene.
Topics: 2-Acetylaminofluorene; Animals; Binding Sites; Carcinoma, Hepatocellular; Cisplatin; Clofibrate; Clo | 1998 |
cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Blotting, Northern; Caco-2 Cells; Carcinoma, | 1998 |
Mulberry fruit polysaccharides alleviate diethylnitrosamine/phenobarbital-induced hepatocarcinogenesis in vivo: the roles of cell apoptosis and inflammation.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Hepatocellular; Diethylnitrosamine; Fruit; Gene Ex | 2021 |
Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital.
Topics: Adenoma; Animals; beta Catenin; Carcinoma, Hepatocellular; Constitutive Androstane Receptor; Female; | 2020 |
Relationship between locomotor activity rhythm and corticosterone levels during HCC development, progression, and treatment in a mouse model.
Topics: Activity Cycles; Animals; Behavior, Animal; Biomarkers; Carcinoma, Hepatocellular; Chronotherapy; Ci | 2021 |
In vivo antitumour potential of camel's milk against hepatocellular carcinoma in rats and its improvement of cisplatin renal side effects.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Camelus; Carcinoma, Hepatocellular; Cisplatin; Dieth | 2017 |
Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin.
Topics: Androstanes; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; C | 2017 |
Astrocyte Elevated Gene-1 Regulates Macrophage Activation in Hepatocellular Carcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Move | 2018 |
Benefits of aged garlic extract in modulating toxicity biomarkers against p-dimethylaminoazobenzene and phenobarbital induced liver damage in
Topics: Animals; Biomarkers; Blood Glucose; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Catalase | 2020 |
Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Disease Models, Animal; | 2019 |
Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Cytochrome P-450 CYP1A1; Depression, Chemica | 2013 |
Anti cancerous efficacy of Ayurvedic milk extract of Semecarpus anacardium nuts on hepatocellular carcinoma in Wistar rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; L | 2013 |
Apoptotic effects of dipyrido [3,2-a:2',3'-c] phenazine (dppz) Au(III) complex against diethylnitrosamine/phenobarbital induced experimental hepatocarcinogenesis in rats.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Diethylnitrosamine; DNA Fragme | 2014 |
Detection of initiating potential of non-genotoxic carcinogens in a two-stage hepatocarcinogenesis study in rats.
Topics: Acetaminophen; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Animal; DNA D | 2014 |
Comprehensive analysis of DNA methylation and gene expression of rat liver in a 2-stage hepatocarcinogenesis model.
Topics: Animals; Carcinogenesis; Carcinogens; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, | 2014 |
Cell expression patterns of CD147 in N-diethylnitrosamine/phenobarbital-induced mouse hepatocellular carcinoma.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Basigin; Carcinogens; Carcinoma, H | 2015 |
Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Carcinogenesis; Carcinoma, Hepatocellul | 2015 |
Chemoprevention of Diethylnitrosamine-Initiated and Phenobarbital-Promoted Hepatocarcinogenesis in Rats by Sulfated Polysaccharides and Aqueous Extract of Ulva lactuca.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Diethyln | 2015 |
Phenobarbital inhibits calpain activity and expression in mouse hepatoma cells.
Topics: Animals; Calpain; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Dose-Response Rel | 2016 |
Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro.
Topics: Animals; Anticonvulsants; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Constitutive An | 2016 |
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells.
Topics: Adenosine Triphosphate; Carcinoma, Hepatocellular; Cell Line, Tumor; Cluster Analysis; Cytochrome P- | 2009 |
Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Gene Expression Profiling; Gene Expressi | 2009 |
Discrimination of tumorigenic triazole conazoles from phenobarbital by transcriptional analyses of mouse liver gene expression.
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Fungicides, Industr | 2009 |
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Proliferation; Diethylnitrosamine; Gene Expression Regulati | 2009 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, | 2009 |
Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis.
Topics: Alkylating Agents; Animals; Anticonvulsants; Blotting, Western; Carcinoma, Hepatocellular; Diethylni | 2011 |
Chelidonium majus 30C and 200C in induced hepato-toxicity in rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Carcinoma, Hepatocellular; Chelidonium; Chromosome Ab | 2010 |
Anti-carcinogenic potentials of a plant extract (Hydrastis canadensis): I. Evidence from in vivo studies in mice (Mus musculus).
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Chromosome Aberrations; Female; Hydrastis; Lipid Pe | 2010 |
Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.
Topics: Animals; beta Catenin; Carcinogens; Carcinoma, Hepatocellular; Cell Proliferation; Cell Separation; | 2010 |
Of mice and men: the nonrandom genomic instability in hepatocarcinogenesis.
Topics: Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diethylnitrosamine; Genes, myc; | 2011 |
Role of a novel CAR-induced gene, TUBA8, in hepatocellular carcinoma cell lines.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Constitutive Androstane Recep | 2011 |
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Carcinoma, Hepat | 2012 |
Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control.
Topics: Activins; Adenoma; Alternative Splicing; Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell | 2002 |
Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors.
Topics: Animals; Biomarkers; Blood Proteins; Carcinoma, Hepatocellular; Diethylnitrosamine; Glycoproteins; H | 2003 |
[Effects of gardenal and chlorpromazine 4560 R. P. on histology of hepatomas induced by 2-acetamino fluorene].
Topics: Animals; Carcinoma, Hepatocellular; Chlorpromazine; Fluorenes; Histological Techniques; Liver Neopla | 1957 |
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
Topics: Aminopyrine; Androgens; Benzopyrenes; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Ethionine; | 1963 |
FACTORS AFFECTING HEPATIC MICROSOMAL ENZYME SYSTEMS INVOLVED IN DRUG METABOLISM.
Topics: Alloxan; Aminopyrine; Carcinoma, Hepatocellular; Chlordan; Chlorpromazine; Codeine; Hexobarbital; Ja | 1963 |
BIOCHEMISTRY OF REGULATION OF ENZYME ACTIVITY AND SYNTHESIS. SESSION CHAIRMAN'S COMMENTS.
Topics: Adenosine Triphosphate; Biochemistry; Carcinoma, Hepatocellular; Feedback; Liver; Liver Neoplasms; M | 1963 |
THE STIMULATION OF DRUG METABOLISM IN VARIOUS RAT HEPATOMAS.
Topics: Aminopyrine; Aniline Compounds; Benzoates; Blood; Carcinoma, Hepatocellular; Chlordan; Hexobarbital; | 1965 |
Decreased density of beta1-adrenergic receptors in preneoplastic and neoplastic liver lesions of F344 rats.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Immunohistochemistry; Liver Neoplasm | 2005 |
Protective potentials of a potentized homeopathic drug, Lycopodium-30, in ameliorating azo dye induced hepatocarcinogenesis in mice.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Hepatocellular; Lipid Peroxidation; Liver; Lycopodium; Male; | 2006 |
Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.
Topics: Animals; Base Sequence; Binding Sites; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line | 2006 |
The initiation activity of norfloxacin does not result in the induction of hepatocellular tumors in rats.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Carcinogenicity Tests; Carcinogens; Carcinoma, | 2007 |
Prevention of hepatocarcinogenesis with phosphatidylcholine and menaquinone-4: in vitro and in vivo experiments.
Topics: Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transforma | 2007 |
Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues.
Topics: Adolescent; Adult; Aged; Antigens, Differentiation; Biomarkers; Blotting, Western; Carcinoma, Hepato | 2007 |
Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogens; Carcinoma, Hepatocellular; Chr | 2007 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Phenobarbital induces cytochrome P-450- and cytochrome P-448-dependent monooxygenases in rat hepatoma cells.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 Enzym | 1984 |
Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms.
Topics: Adenoma; Aging; Animals; Carcinoma, Hepatocellular; Disease Susceptibility; Eosine Yellowish-(YS); g | 1983 |
Complex, dynamically interacting host factors that affect the disposition of drugs and carcinogens.
Topics: Animals; Antipyrine; Carcinogens; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Enzyme | 1982 |
Characterization of NADPH-cytochrome P-450 reductase in a mouse hepatoma cell line.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Carcinoma, Hepatocellular; Cell Line; En | 1983 |
Non-linearity of neoplastic conversion induced in rat liver by low exposures to diethylnitrosamine.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Dose-Response Relationship, Drug; D | 1993 |
Biotransformation of 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) in rat hepatoma variants.
Topics: Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme Syst | 1993 |
Induction of AP-1 (Fos/Jun) by chemical agents mediates activation of glutathione S-transferase and quinone reductase gene expression.
Topics: Arsenates; Arsenites; Base Sequence; Binding Sites; Carcinoma, Embryonal; Carcinoma, Hepatocellular; | 1994 |
Regulation of cytochrome P450 in cultured human colonic cells.
Topics: Adenocarcinoma; Animals; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; beta-Naphthoflavone; Carcinoma | 1993 |
Comparison in C3H and C3B6F1 mice of the sensitivity to diethylnitrosamine-initiation and phenobarbital-promotion to the extent of cell proliferation.
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cell Division; Diethylnitrosamine; Female; Liver; Liver | 1993 |
The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells.
Topics: Benz(a)Anthracenes; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme | 1993 |
Hierarchical cluster analysis of environmental pollutants through P450 induction in cultured hepatic cells.
Topics: 7-Alkoxycoumarin O-Dealkylase; Analysis of Variance; Animals; Antibody Specificity; Benz(a)Anthracen | 1996 |
Hepatocellular carcinoma cell lines from diethylnitrosamine phenobarbital-treated rats. Characterization and sensitivity to endothall, a protein serine/threonine phosphatase-2A inhibitor.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma, Hepatocellular; Cell Cycle; Chick Embryo; Colonic Neopla | 1999 |
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.
Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofi | 1999 |
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo | 1999 |
Heme biosynthesis in a chicken hepatoma cell line (LMH): comparison with primary chick embryo liver cells (CELC).
Topics: 5-Aminolevulinate Synthetase; Animals; Carcinoma, Hepatocellular; Chick Embryo; Chickens; Enzyme Ind | 1999 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Efficient and cancer-selective gene transfer to hepatocellular carcinoma in a rat using adenovirus vector with iodized oil esters.
Topics: Adenoviridae; Alkylating Agents; Animals; Anticonvulsants; beta-Galactosidase; Carcinoma, Hepatocell | 2001 |
The natural history of neoplasia. Newer insights into an old problem.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Diet | 1977 |
Biochemical characterisation of stages of hepatocarcinogenesis after a single dose of diethylnitrosamine.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; gamma-Glu | 1978 |
Letter: Phenobarbitone, liver tumours, and thorotrast.
Topics: Adenoma, Bile Duct; Aged; Carcinoma, Hepatocellular; Denmark; Epilepsy; Female; Humans; Liver Neopla | 1975 |
Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.
Topics: Animals; Benzopyrenes; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; E | 1975 |
Modification of diethylnitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.
Topics: Animals; Antilymphocyte Serum; Carcinoma, Hepatocellular; Diethylnitrosamine; Hydroxyurea; Immunosup | 1975 |
Characterization of microsomal methyl sterol demethylase in two Morris hepatomas.
Topics: Animals; Buffers; Carcinoma, Hepatocellular; Cholesterol; Cholestyramine Resin; Cyanides; Cytochrome | 1976 |
Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.
Topics: Aflatoxins; Animals; Carcinogens; Carcinoma, Hepatocellular; DNA; Intestine, Small; Kidney; Liver; L | 1977 |
A comparison of steroid glucuronlytransferases of rat liver and hepatoma, and effects of phenobarbitone and 3-methylcholanthrene induction.
Topics: Animals; Carcinoma, Hepatocellular; Enzyme Induction; Estradiol; Estrone; Glucuronosyltransferase; K | 1976 |
Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital.
Topics: Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Drug Synergism; Liver Neoplasms; Male; Neopl | 1976 |
Metabolism of estrogens in hepatomas of different growth rates.
Topics: Animals; Carcinoma, Hepatocellular; Cell Division; Enzyme Activation; Estrogens; Kinetics; Liver; Li | 1977 |
Cytochrome P-450 in hyperplastic liver nodules during hepatocarcinogenesis with N-2-fluorenylacetamide in rats.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Cytochrome P-450 Enzyme System; Hyperplas | 1976 |
Carcinogenic and mutagenic activities of safrole, 1'-hydroxysafrole, and some known or possible metabolites.
Topics: Animals; Animals, Newborn; Carcinogens; Carcinoma, Hepatocellular; Dioxoles; Female; Liver; Liver Ne | 1977 |
The stability of events in the natural history of neoplasia.
Topics: Animals; Carcinoma, Hepatocellular; Humans; Liver; Liver Neoplasms; Mammary Neoplasms, Experimental; | 1977 |
Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2.
Topics: Carcinoma, Hepatocellular; Enzyme Induction; Humans; Liver Neoplasms; Methylcholanthrene; Mutagens; | 1991 |
Hypomethylation of ras oncogenes in chemically induced and spontaneous B6C3F1 mouse liver tumors.
Topics: Animals; Carcinoma, Hepatocellular; Chloroform; DNA, Neoplasm; Gene Expression Regulation, Neoplasti | 1991 |
Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice.
Topics: Adenoma; Aflatoxins; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Female; Gene Expression | 1991 |
Porphyrin synthesis by human hepatocytes and HepG2 cells--effects of enzyme inducers and delta-aminolevulinic acid.
Topics: Aminolevulinic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Cytochrome P-450 Enzyme System; Dim | 1991 |
Role of cytochrome P450 in the control of the production of erythropoietin.
Topics: Carcinoma, Hepatocellular; Cobalt; Cysteamine; Cytochrome P-450 Enzyme System; Ditiocarb; Erythropoi | 1990 |
Liver tumor promoters stimulate growth of transplanted hepatocellular carcinomas.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Hepatectomy; | 1990 |
Effect of phenobarbital on the gamma-glutamyltranspeptidase activity and the remodeling of nodules induced by the initiation-selection model.
Topics: 2-Acetylaminofluorene; Animals; Carcinoma, Hepatocellular; Diethylnitrosamine; Disease Models, Anima | 1985 |
Factors influencing the initiation by gamma rays of hepatocarcinogenesis in the rat.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle; Cells, Cultured; DNA Repair; Dose-Response Relations | 1987 |
Effects of tumour promoters on metabolic cooperation between human hepatoma cells.
Topics: Carcinogens; Carcinoma, Hepatocellular; Cell Communication; Cell Line; Humans; Hypoxanthine Phosphor | 1986 |
Effect of phenobarbital and 3-methylcholanthrene on aldehyde dehydrogenase activity in cultures of HepG2 cells and normal human hepatocytes.
Topics: Aldehyde Dehydrogenase; Aldehydes; Benzaldehydes; Carcinoma, Hepatocellular; Cells, Cultured; Liver; | 1987 |
Abnormal microsomal cytochromes and electron transport in Morris hepatomas.
Topics: Animals; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Cytochrome P-450 Enzyme System; C | 1974 |
The effect of phenobarbital on drug metabolic enzyme activity, ultrastructure and growth of a "minimal deviation" hepatoma (Morris 7800).
Topics: Animals; Carcinoma, Hepatocellular; Endoplasmic Reticulum; Hexobarbital; Liver; Liver Neoplasms; Mal | 1967 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7535.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Fluorenes; Glucosephosp | 1968 |
[The effect of phenobarbital and halogenated hydrocarbons on nitrosamine carcinogenesis].
Topics: Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Hepatocellular; Drug Synergism; Halothane; H | 1969 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7635.
Topics: Acetates; Amides; Animals; Carcinoma, Hepatocellular; Fluorenes; Liver Neoplasms; Neoplasms, Experim | 1969 |
Labeled bilirubin production by a clonal strain of rat hepatoma cells.
Topics: Animals; Bilirubin; Carbon Isotopes; Carcinoma, Hepatocellular; Clone Cells; Fibroblasts; Glycine; I | 1971 |
Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
Topics: Acetates; Amides; Animals; Autoradiography; Carcinoma, Hepatocellular; Cell Division; Cell Transform | 1971 |
Studies on plasma membranes. XV. A sex difference in alkaline phosphatase activities of plasma membranes isolated from rat liver.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Calcium; Carcinogens; Carcinoma, Hepatocellular; Ca | 1971 |
Aldehyde dehydrogenase activity in a rat hepatoma.
Topics: Acetamides; Acrylamides; Aldehydes; Animals; Carcinoma, Hepatocellular; Electrophoresis; Fluorenes; | 1972 |
Carbohydrate composition of rat hepatocyte nuclear membrane as compared to normal, Morris hepatoma 7800, and phenobarbital-induced microsomal membranes.
Topics: Animals; Carbohydrates; Carcinoma, Hepatocellular; Cell Nucleus; Chromatography, Gas; Galactosamine; | 1973 |
Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture. IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver.
Topics: Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinoma, Hepatocellular; Cell Line; Cricetinae; Culture | 1973 |
Energy coupling and extramitochondrial electron transport in slices of Morris hepatoma 3924 A.
Topics: Aminopyrine; Animals; Antimycin A; Biological Transport; Carcinoma, Hepatocellular; Cyanides; Dinitr | 1974 |
The metabolic effects of nonvolatile anesthetics on mammalian hepatoma cells in vitro. I. Inhibition of cell replication.
Topics: Amobarbital; Anesthetics, Local; Animals; Barbiturates; Carcinoma, Hepatocellular; Cell Count; Cell | 1971 |