phenobarbital has been researched along with Carbon Tetrachloride Poisoning in 106 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Carbon Tetrachloride Poisoning: Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 7.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "Biliary cirrhosis was induced by bile duct ligation, and micronodular cirrhosis by chronic exposure to phenobarbital/CCl4 in male rats." | 3.70 | The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. ( Clozel, M; Gerbes, AL; Reichen, J; Sägesser, H; Steiner, MJ, 1998) |
| " Hepatotoxic compounds such as CCl4, galactosamine and thioacetamide that cause hepatic necrosis and compounds such as hydrazine and ethionine that cause fatty liver all result in elevated urinary taurine levels in rats." | 3.69 | Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro. ( Timbrell, JA; Waterfield, CJ, 1996) |
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 3.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "05), area under the curve and terminal half-life were significantly increased (p < 0." | 1.29 | Indocyanine green pharmacokinetics in rats with progressive carbon tetrachloride-induced hepatocellular insufficiency. ( Delrat, P; Dupin, S; Houin, G; Le Quellec, A; Voigt, JJ, 1994) |
| " These results should be taken into consideration to determine the optimal CCl4 dosing schedule in the rat CCl4-induced cirrhosis model." | 1.29 | Mechanism of carbon tetrachloride autoprotection: an in vivo study based on 13C-aminopyrine and 13C-galactose breath tests. ( Brazier, JL; Géloën, A; Minaire, Y; Mion, F; Rousseau, M, 1994) |
| "Phenobarbital pretreatment decreased the in vivo t0." | 1.28 | Effect of phenobarbital treatment on carbon tetrachloride-mediated cytochrome P-450 loss and diene conjugate formation. ( Moody, DE, 1992) |
| " In retrograde perfusion under low oxygen supply with Ca2+, CCl4 produced essentially the same toxic manifestations as those observed in the anterograde perfusion." | 1.28 | Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats. ( Masuda, Y; Nakamura, Y, 1990) |
| "This augmented necrosis is averted by prolonged treatment with hyperbaric oxygen." | 1.27 | Effect of hyperoxia on liver necrosis induced by hepatotoxins. ( Marzella, L; Muhvich, K; Myers, RA, 1986) |
| "Rats treated with phenobarbital, which increases hepatic cytochrome P-450 content, or isoniazid, which does not increase hepatic cytochrome P-450 content, both metabolized more CCl4 than control rats as indicated by exhalation of greater quantities of CCl4 metabolites and by an increase in CCl4 toxicity." | 1.27 | Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450. ( Burk, RF; Hill, KE; Lane, JM, 1988) |
| " Liver and kidney samples were also taken at appropriate times after dosing and examined histologically for evidence of drug induced damage." | 1.26 | Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat. ( Clampitt, RB, 1978) |
| "The influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (CCl4) was investigated in a group of rhesus monkeys." | 1.25 | Protein deficiency in carbon tetrachloride-induced hepatic lesions. ( Deo, MG; Ramalingaswami, V; Roy, H, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 91 (85.85) | 18.7374 |
| 1990's | 14 (13.21) | 18.2507 |
| 2000's | 1 (0.94) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seawright, AA | 2 |
| McLean, AE | 6 |
| Chibowski, D | 4 |
| Siezieniewska, Z | 4 |
| Czarnecki, J | 4 |
| Pokora, J | 4 |
| Chodkowska, A | 4 |
| Ebel, RE | 1 |
| McGrath, EA | 1 |
| Poli, G | 1 |
| Cheeseman, K | 1 |
| Slater, TF | 1 |
| Dianzani, MU | 1 |
| Wainfan, E | 1 |
| Dizik, M | 1 |
| Balis, ME | 1 |
| Di Simplicio, P | 1 |
| Naldini, A | 1 |
| Bianco, MT | 1 |
| Yanagi, S | 1 |
| Sakamoto, M | 1 |
| Ninomiya, Y | 1 |
| Kamiya, T | 1 |
| Mahieu, P | 1 |
| Geubel, A | 1 |
| Rahier, J | 1 |
| Scailteur, V | 1 |
| Dieryck, JP | 1 |
| Lauwerys, R | 1 |
| Harris, RN | 2 |
| Anders, MW | 3 |
| Orrenius, S | 1 |
| Thor, H | 1 |
| Eklöw, L | 1 |
| Moldéus, P | 1 |
| Jones, DP | 1 |
| Takano, T | 1 |
| Tatematsu, M | 1 |
| Hasegawa, R | 1 |
| Imaida, K | 1 |
| Ito, N | 1 |
| Ugazio, G | 3 |
| Bosia, S | 1 |
| Cornaglia, E | 1 |
| Angelov, EP | 1 |
| Zalatnai, A | 2 |
| Lapis, K | 2 |
| Dupin, S | 1 |
| Delrat, P | 1 |
| Le Quellec, A | 1 |
| Voigt, JJ | 1 |
| Houin, G | 1 |
| Mion, F | 1 |
| Géloën, A | 1 |
| Rousseau, M | 1 |
| Brazier, JL | 1 |
| Minaire, Y | 1 |
| Chapman, KM | 1 |
| Prabhudesai, M | 1 |
| Erdman, JW | 1 |
| Timbrell, JA | 1 |
| Waterfield, CJ | 1 |
| Reichen, J | 2 |
| Gerbes, AL | 1 |
| Steiner, MJ | 1 |
| Sägesser, H | 1 |
| Clozel, M | 1 |
| Zimmermann, A | 1 |
| Zhao, D | 1 |
| Brandão, CG | 1 |
| Ferreira, HH | 1 |
| Piovesana, H | 1 |
| Polimeno, NC | 1 |
| Ferraz, JG | 1 |
| de Nucci, G | 1 |
| Pedrazzoli, J | 1 |
| Benakis, A | 1 |
| Corthay, J | 1 |
| Medilanski, P | 1 |
| Dormard, Y | 1 |
| Lévy, JC | 1 |
| Deo, MG | 1 |
| Roy, H | 1 |
| Ramalingaswami, V | 3 |
| McPhie, JL | 1 |
| Short, LT | 1 |
| Frimmer, M | 1 |
| Homann, J | 1 |
| Rufeger, U | 1 |
| Clampitt, RB | 1 |
| Litterst, CL | 2 |
| Mimnaugh, EG | 1 |
| Gram, TE | 2 |
| Watanabe, A | 1 |
| Katz, DI | 1 |
| Stenger, RJ | 4 |
| Johnson, EA | 3 |
| Datta, RK | 1 |
| Rice, J | 1 |
| Lee, YW | 1 |
| Wiebe, LI | 1 |
| Lindstrom, TD | 1 |
| Remmer, H | 2 |
| Awadallah, R | 3 |
| el-Dessoukey, EA | 3 |
| Tahani, HM | 2 |
| Mikhail, H | 1 |
| Zinat, HA | 1 |
| Kotb, NA | 1 |
| Nopanitaya, W | 1 |
| Grisham, JW | 1 |
| Carson, JL | 1 |
| Dotson, MM | 1 |
| Gans, JH | 1 |
| Abou-el-Makarem, MM | 1 |
| el-Gammal, H | 1 |
| Tsironis, AG | 1 |
| Mykoniatis, MG | 1 |
| Papacharalampous, NX | 2 |
| Shah, HC | 1 |
| Carlson, GP | 2 |
| Torrielli, MV | 2 |
| Lasierra, J | 1 |
| Barrao, F | 1 |
| Ceña, G | 1 |
| Aza, MJ | 1 |
| Morandeira, MJ | 1 |
| Barrao, ME | 1 |
| González-Gallego, J | 1 |
| Moody, DE | 1 |
| Sárosi, I | 1 |
| Rot, A | 1 |
| Lapsis, K | 1 |
| Wu, ZQ | 1 |
| Piché, D | 1 |
| Vallières, S | 1 |
| Huet, PM | 1 |
| Gascon-Barré, M | 1 |
| Masuda, Y | 2 |
| Nakamura, Y | 2 |
| d'Arville, CN | 1 |
| Le, M | 1 |
| Kloppel, TM | 1 |
| Simon, FR | 1 |
| Stenbäck, F | 1 |
| Saarni, HU | 1 |
| Rautio, A | 1 |
| Stengård, J | 1 |
| Sotaniemi, EA | 1 |
| Abe, H | 1 |
| Orita, M | 1 |
| Konishi, H | 1 |
| Arichi, S | 1 |
| Odashima, S | 1 |
| Marzella, L | 1 |
| Muhvich, K | 1 |
| Myers, RA | 1 |
| Yan, SQ | 1 |
| Liu, RL | 1 |
| Wang, J | 1 |
| Zhu, XY | 1 |
| Burk, RF | 1 |
| Hill, KE | 1 |
| Lane, JM | 1 |
| Driver, HE | 1 |
| McDanell, R | 1 |
| Tacchi-Bedford, AM | 1 |
| Makarananda, K | 1 |
| Fox, GA | 1 |
| Price, SC | 1 |
| Hinton, RH | 1 |
| Goeting, NL | 1 |
| Fleming, JS | 1 |
| Gallagher, P | 1 |
| Walmsely, BH | 1 |
| Karran, SJ | 1 |
| Rush, B | 1 |
| Merritt, MV | 1 |
| Kaluzny, M | 1 |
| Van Schoick, T | 1 |
| Brunden, MN | 1 |
| Ruwart, M | 1 |
| Radwan, P | 3 |
| Celiński, K | 3 |
| Danhof, M | 1 |
| Hisaoka, M | 1 |
| Levy, G | 1 |
| Horne, CH | 1 |
| Scott, CA | 1 |
| Busuttil, A | 1 |
| Macsween, RN | 1 |
| Platt, DS | 1 |
| Cockrill, BL | 1 |
| Nayak, NC | 2 |
| Chopra, P | 2 |
| Heni, N | 2 |
| Tuchweber, B | 2 |
| Werringloer, J | 1 |
| Kourounakis, P | 1 |
| Davis, DC | 1 |
| Schroeder, DH | 1 |
| Reagan, RL | 1 |
| Gillette, JR | 2 |
| Brodie, BB | 1 |
| Krishna, G | 1 |
| Reid, WD | 1 |
| Cho, AK | 1 |
| Roy, S | 1 |
| Suarez, KA | 1 |
| Fuller, GC | 1 |
| Fausto, N | 1 |
| Chenderovitch, J | 1 |
| Raizman, A | 1 |
| Infante, R | 1 |
| Tsironis, A | 1 |
| Breen, KJ | 1 |
| Shaw, J | 1 |
| Alvin, J | 1 |
| Henderson, GI | 1 |
| Hoyumpa, AM | 1 |
| Schenker, S | 1 |
| Pani, P | 1 |
| Gabriel, L | 1 |
| Gravela, E | 1 |
| Farber, TM | 1 |
| Van Loon, EJ | 1 |
| D'Acosta, N | 2 |
| Castro, JA | 3 |
| Díaz Gòmez, MI | 2 |
| de Ferreyra, EC | 2 |
| de Castro, CR | 2 |
| de Fenos, OM | 1 |
| Blinder, LV | 1 |
| Gasparian, SA | 1 |
| Maliugin, EF | 1 |
| Kliuchnikova, ZhI | 1 |
| Archakov, AI | 1 |
| Kröner, H | 1 |
| Schlag, P | 1 |
| Staib, W | 1 |
| Elek, S | 1 |
| Borsy, J | 1 |
| Maderspach, A | 1 |
| Polgári, I | 1 |
| Osváth, Z | 1 |
| Jámbor, E | 1 |
| Mantilla-Plata, B | 1 |
| Harbison, RD | 1 |
| Reynolds, ES | 1 |
| Ree, HJ | 1 |
| Moslen, MT | 1 |
| Hurwitz, A | 1 |
| Steele, DP | 1 |
| Mudie, AW | 1 |
| Bishop, R | 1 |
| Chen, FC | 1 |
| Cavanagh, JB | 1 |
| Ambre, JJ | 1 |
| Fischer, LJ | 1 |
| Vorne, M | 2 |
| Marshall, WJ | 1 |
| Poggioli, R | 1 |
| Baggio, G | 1 |
| Rao, KS | 1 |
| Glende, EA | 1 |
| Recknagel, RO | 1 |
| Miller, RA | 1 |
| Williamson, JN | 1 |
| Kovacs, K | 1 |
| Sasame, HA | 1 |
| Klinger, W | 1 |
| Müller, D | 1 |
| Tiller, R | 1 |
| Rudolph, G | 1 |
| Garner, RC | 2 |
| Robinson, SH | 1 |
| Read, AE | 1 |
| Glasson, B | 1 |
1 review available for phenobarbital and Carbon Tetrachloride Poisoning
| Article | Year |
|---|---|
The influence of diet on activation and inactivation of chemicals--evidence from animals and man.
Topics: 1,2-Dimethylhydrazine; Acetaminophen; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Co | 1986 |
105 other studies available for phenobarbital and Carbon Tetrachloride Poisoning
| Article | Year |
|---|---|
Induced susceptibility of sheep to carbon tetrachloride intoxication.
Topics: Animals; Bilirubin; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1967 |
[Effect of phenobarbital on the morphologic, histochemical and ultrastructural picture of the rat liver after chronic administration of CCl4].
Topics: Animals; Carbon Tetrachloride Poisoning; Drug Synergism; Enzyme Activation; Glucose-6-Phosphatase; L | 1984 |
CCl4-hepatotoxicity in the Mongolian gerbil: influence of monooxygenase system induction.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chlordec | 1984 |
The role of lipid peroxidation in CCl4-induced damage to liver microsomal enzymes: comparative studies in vitro using microsomes and isolated liver cells.
Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Glucose-6-Phosphatase; Glut | 1981 |
Increased activity of rat liver N2-guanine tRNA methyltransferase II in response to liver damage.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Escherichia coli; Ethionine; Female; | 1984 |
[Relation between glutathione and cytoplasmic protein sulfhydryl groups in the rat: a rapid procedure for analytical determination].
Topics: Animals; Carbon Tetrachloride Poisoning; Cytoskeletal Proteins; Glutathione; Hydrocarbons, Iodinated | 1984 |
Decrease in L-type pyruvate kinase activity in rat liver by some promoters of hepatocarcinogenesis.
Topics: Animals; Carbon Tetrachloride Poisoning; Carcinogens; Diethylnitrosamine; Isoenzymes; Isomerism; Liv | 1984 |
Potentiation of carbon-tetrachloride hepato-nephrotoxicity by phenobarbital in man, a case report.
Topics: Barbiturates; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug Synergism | 1983 |
Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.
Topics: 1-Propanol; Animals; Carbon Dioxide; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1981 |
Drug-stimulated H2O2 formation in hepatocytes. Possible toxicological implications.
Topics: Animals; Bromobenzenes; Carbon Tetrachloride Poisoning; Glutathione; Hydrogen Peroxide; Kinetics; Li | 1981 |
Effect of 2-propanol treatment on carbon tetrachloride metabolism and toxicity.
Topics: 1-Propanol; Alanine Transaminase; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachlo | 1981 |
Dose-response relationship for the promoting effect of phenobarbital on the induction of liver hyperplastic nodules in rats exposed to 2-fluorenylacetamide and carbon tetrachloride.
Topics: 2-Acetylaminofluorene; Animals; Carbon Tetrachloride Poisoning; Dose-Response Relationship, Drug; Dr | 1980 |
Experimental model of cirrhosis in rabbits exposed to carbon tetrachloride by inhalation.
Topics: Administration, Inhalation; Animals; Body Weight; Carbon Tetrachloride Poisoning; Hexobarbital; Live | 1995 |
[A selective decrease in cytochrome P450 in the liver microsomes of male rats following phenobarbital and 3-methylcholanthrene induction and acute tetrachloromethane poisoning].
Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Cytochromes | 1993 |
Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: delay or inhibition?
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1994 |
Indocyanine green pharmacokinetics in rats with progressive carbon tetrachloride-induced hepatocellular insufficiency.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Half-Life; Indocyanine Green; Liver; Liver Cir | 1994 |
Mechanism of carbon tetrachloride autoprotection: an in vivo study based on 13C-aminopyrine and 13C-galactose breath tests.
Topics: Alanine Transaminase; Aminopyrine; Animals; Aspartate Aminotransferases; Carbon Isotopes; Carbon Tet | 1994 |
Effects of acute ethanol doses or dietary phenobarbitol with carbon tetrachloride exposure on vitamin A status of rats.
Topics: Alcoholic Intoxication; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Inj | 1993 |
Changes in taurine as an indicator of hepatic dysfunction and biochemical perturbations. Studies in vivo and in vitro.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cells, Cultured; Clenbute | 1996 |
The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Bilirubin; Blood Pressure; Body Weight; Bosentan; Carbon | 1998 |
Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization.
Topics: Actins; Animals; Bile Ducts, Intrahepatic; Biomarkers; Blood Vessels; Capillaries; Carbon Tetrachlor | 1999 |
Development of an experimental model of liver cirrhosis in rabbits.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease Models, Ani | 2000 |
Hazards from chemicals: scientific questions and conflicts of interest.
Topics: Acetaminophen; Adult; Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Envir | 1979 |
[Liver extract effect on liver microsomal system and on an experimental model of intoxication].
Topics: Animals; Carbon Tetrachloride Poisoning; Enzyme Induction; Hexobarbital; Liver Extracts; Male; Micro | 1977 |
Protein deficiency in carbon tetrachloride-induced hepatic lesions.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Fatty Liver; Glucos | 1975 |
Hepatic prolyl hydroxylase activity in experimental cirrhosis.
Topics: Carbon Tetrachloride Poisoning; Coenzymes; Collagen; Hydroxyproline; Liver; Liver Cirrhosis, Experim | 1975 |
[Inhibition by diethyldithiocarbamate (DEDTC) of acute hepatotoxic effects induced by polyhalogenated hydrocarbons (PHHC)].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chloroform; Ditioca | 1976 |
Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Evaluation Studies | 1978 |
Comparative alterations in extrahepatic drug metabolism by factors known to affect hepatic activity.
Topics: Aminopyrine N-Demethylase; Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Carbon Tetrac | 1977 |
Microsomal hexose-6-phosphate dehydrogenase in injured liver.
Topics: Alcohol Oxidoreductases; Animals; Antigen-Antibody Reactions; Carbohydrate Dehydrogenases; Carbon Te | 1977 |
The effects of phenobarbital and 3,4-benzypyrene on microsomal cytochrome P-450 and NADPH-cytochrome C reductase in regenerating rat liver after partial hepatectomy or chemical injury.
Topics: Animals; Benzopyrenes; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytoc | 1977 |
Amphetamine metabolism in mice exposed chronically to phenobarbital and to phenobarbital with carbon tetrachloride.
Topics: Amphetamine; Animals; Carbon Tetrachloride Poisoning; Chromatography, Thin Layer; Feces; Male; Mice; | 1979 |
Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated rat hepatocytes.
Topics: Animals; Carbon Tetrachloride Poisoning; Glutathione; In Vitro Techniques; Kinetics; L-Lactate Dehyd | 1978 |
Microsomal enzymes inducers and serum minerals in carbon-tetrachloride hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Enzyme Induction; Enzyme Inhibitors; Liver; Male; Metals; M | 1978 |
Effect of drugs affecting microsomal enzymes on serum protein pattern and fat content of the liver.
Topics: Animals; Blood Proteins; Body Weight; Carbon Tetrachloride Poisoning; Lipids; Liver; Male; Phenobarb | 1978 |
Effect of phenobarbitone and propionyl-promazine on serum enzymes in carbon-tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Carbon Tetrachlori | 1978 |
Surface features of cirrhotic liver.
Topics: Animals; Carbon Tetrachloride Poisoning; Endothelium; Liver; Liver Cirrhosis, Experimental; Male; Mi | 1976 |
Diethylnitrosamine-induced changes in mouse liver morphology and function.
Topics: Animals; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Hexobarbital; Liver; Liver Neoplasms; M | 1976 |
Effect of phenobarbitone and indoxyl sulphate on biliary excretion of foreign organic compounds during administration of carbon tetrachloride.
Topics: Animals; Bile; Carbon Tetrachloride Poisoning; Indoles; Male; Phenobarbital; Phenolphthaleins; Rats | 1976 |
The effect of phenobarbital on the serum bilirubin level in normal and CCI-4 liver-damaged rats. Biochemical and histologic study.
Topics: Animals; Bilirubin; Blood Transfusion; Carbon Tetrachloride Poisoning; Colorimetry; Depression, Chem | 1975 |
Alteration by phenobarbital and 3-methyl-cholanthrene of functional and structural changes in rat liver due to carbon tetrachloride inhalation.
Topics: Amino Acids; Animals; Carbon Tetrachloride Poisoning; Endoplasmic Reticulum; Liver; Male; Methylchol | 1975 |
Biochemical aspects of the protective action of propyl gallate on liver injury in rats poisoned with carbon tetrachloride.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Temperature; | 1975 |
Changes of the fibrinolytic system in liver dysfunction: role of portal hypertension.
Topics: Amino Acid Sequence; Animals; Carbon Tetrachloride Poisoning; Fibrinolysis; Hemodynamics; Hypertensi | 1992 |
Effect of phenobarbital treatment on carbon tetrachloride-mediated cytochrome P-450 loss and diene conjugate formation.
Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Injections, Intraperitoneal | 1992 |
Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethylnitrosamine hepatocarcinogenesis in rats.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Diethylnitrosamine; Liver; Liver Cirr | 1991 |
Unimpaired induction of drug-metabolizing enzymes in hepatocytes isolated from rats with micronodular cirrhosis.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Biotransform | 1991 |
Effects of oxygen deficiency and calcium omission on carbon tetrachloride hepatotoxicity in isolated perfused livers from phenobarbital-pretreated rats.
Topics: Animals; Calcium; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Li | 1990 |
Alterations in the functional expression of receptors on cirrhotic rat hepatocytes.
Topics: Animals; Asialoglycoprotein Receptor; Carbon Tetrachloride Poisoning; Epidermal Growth Factor; ErbB | 1989 |
Oxidation of diethyldithiocarbamate to disulfiram by liver microsomal cytochrome P-450-containing monooxygenase system.
Topics: Animals; Carbon Tetrachloride Poisoning; Catalase; Cytochrome P-450 Enzyme System; Disulfiram; Ditio | 1989 |
Reversibility of rat liver cirrhosis by medroxyprogesterone acetate.
Topics: Animals; Carbon Tetrachloride Poisoning; Immunohistochemistry; Liver; Liver Cirrhosis, Experimental; | 1989 |
Effects of saikosaponin-d on enhanced CCl4-hepatotoxicity by phenobarbitone.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride Poisoning; Drug Synerg | 1985 |
Effect of hyperoxia on liver necrosis induced by hepatotoxins.
Topics: Acetaminophen; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cric | 1986 |
[First pass effect of gallanilide in rats].
Topics: Animals; Anti-Arrhythmia Agents; Carbon Tetrachloride Poisoning; Chloramphenicol; Drug Incompatibili | 1988 |
Inhibition of CCl4 metabolism by oxygen varies between isoenzymes of cytochrome P-450.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Isoen | 1988 |
Changes in plasma proteins in rats treated for short periods with hepatotoxins or with agents which induce cytochrome P450 isoenzymes.
Topics: 1-Propanol; Animals; Aroclors; Blood Proteins; Carbon Tetrachloride Poisoning; Chlorodiphenyl (54% C | 1987 |
Alterations in liver blood flow and reticuloendothelial function in progressive cirrhosis in the rat.
Topics: Animals; Carbon Tetrachloride Poisoning; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Ma | 1986 |
Studies on the mechanism of the protective action of 16,16-dimethylPGE2 in carbon tetrachloride induced acute hepatic injury in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Body Temperature; Breath Tests; Carbon Tetrachloride; Carbo | 1986 |
[Experimental examination of the influence of Imuran (azathioprine) on the content of hydroxyproline in perfusion fluid of isolated liver in healthy rats and after chronic CCl4 poisoning].
Topics: Animals; Azathioprine; Carbon Tetrachloride Poisoning; Drug Interactions; Hydroxyproline; In Vitro T | 1985 |
[Experimental examination of the interaction and inducing influence of Imuran (azathioprine) on healthy and injured parenchymatous cells of rat liver].
Topics: Animals; Azathioprine; Carbon Tetrachloride Poisoning; Drug Interactions; Enzyme Induction; Liver; P | 1985 |
[The influence of enzymatic induction on the content of hydroxyproline in perfusion fluid of isolated liver in healthy rats and in rats after chronic intoxication with CCl4].
Topics: Animals; Carbon Tetrachloride Poisoning; Chronic Disease; Drug Interactions; Enzyme Induction; Hydro | 1985 |
Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats.
Topics: Animals; Blood Proteins; Brain; Carbon Tetrachloride Poisoning; Cholestasis, Extrahepatic; Ethanol; | 1985 |
Effect of the production of experimental cirrhosis in rats on serum protein levels.
Topics: Alpha-Globulins; Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Chemical and Drug Induced | 1973 |
Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.
Topics: Alanine Transaminase; Amides; Animals; Anticholesteremic Agents; Barbiturates; Body Weight; Butyrate | 1967 |
The role of liver cell endoplasmic reticulum and microsomal enzymes in carbon tetrachloride toxicity: an in vivo study.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dietary Proteins; E | 1970 |
[Influencing of microsomal enzymes by carbon tetrachloride with and without phenobarbital pretreatment].
Topics: Aniline Compounds; Animals; Carbon Tetrachloride Poisoning; Cytochromes; Furaldehyde; Glucose-6-Phos | 1971 |
[Effect of carbon tetrachloride on endoplasmic enzymes in rat liver].
Topics: Aminopyrine; Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Choli | 1971 |
Effect of phenobarbital or pregnenolone-16alpha-carbonitrile (PCN) pretreatment on acute carbon tetrachloride hepatotoxicity in rats.
Topics: Animals; Carbon Tetrachloride Poisoning; Cattle; Chemical and Drug Induced Liver Injury; Cytochrome | 1974 |
A comparison of the effects of halothane and CCl 4 on the hepatic drug metabolizing system.
Topics: Aniline Compounds; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochromes; Dealk | 1971 |
Drug metabolism in man: past, present, and future.
Topics: Aerobiosis; Alkylating Agents; Allyl Compounds; Animals; Autoradiography; Bromine; Carbon Isotopes; | 1971 |
Mechanism of carbon tetrachloride hepatotoxicity. An in vivo study of its molecular basis in rats and monkeys.
Topics: Aniline Compounds; Animals; Biopsy; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver | 1972 |
Differential acute effects of phenobarbital and 3-methylcholanthrene pretreatment on CCl 4 -induced hepatotoxicity in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cytochro | 1972 |
Effect of phenobarbital and carbon tetrachloride on sodium dehydrocholate metabolism in the guinea-pig.
Topics: Animals; Carbon Tetrachloride Poisoning; Dehydrocholic Acid; Guinea Pigs; Phenobarbital; Secretory R | 1974 |
[The induction of liver cirrhosis in rats by simultaneous administration of carbon tetrachloride and phenobarbitone (author's transl)].
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Liver Cirrhosis; Male | 1973 |
Effect of experimental hepatic injury on the clearance of phenobarbital and paraldehyde.
Topics: Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bilirubin; Carbon Tetrachloride; Carbon | 1973 |
Further observation on the effects of 3-methylcholanthrene and phenobarbital on carbon tetrachloride hepatotoxicity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Cell Sur | 1973 |
Potentiation of CCl4-induced hepatotoxicity in the dog by chronic exposure to phenobarbital.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dr | 1973 |
Role of cytochrome P-450 in carbon tetrachloride activation and CCl 4-induced necrosis. Effect of inhibitors of heme synthesis. I. 3-Amino-1,2,4 triazole.
Topics: Animals; Carbon Isotopes; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enz | 1973 |
Irreversible binding of 14C from 14CCl4 to liver microsomal lipids and proteins from rats pretreated with compounds altering microsomal mixed-function oxygenase activity.
Topics: Animals; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Cystamine; Female; Lipid Metabolism; | 1973 |
[Use of enzyme tests for diagnosing the character of toxic liver damage and for controlling the effectiveness of chemotherapy for CCl-4 poisoning].
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug I | 1973 |
[Studies concerning the relationship between the release of enzymes and electrolyte shift in the liver (author's transl)].
Topics: Alanine Transaminase; Animals; Calcium; Carbon Tetrachloride Poisoning; Chloramphenicol; Dinitrophen | 1974 |
[The effect of clofibrate (ethyl-p-chlorophenoxy isobutyrate), M-451 (bis-p-chlorophenoxy-acetylurea) and phenobarbital on experimental liver damage in rats].
Topics: Animals; Carbon Tetrachloride Poisoning; Clofibrate; Cyanates; Ethionine; Hepatitis, Animal; Liver; | 1974 |
Effects of phenobarbital and SKF 525A pretreatment, sex, liver injury, and vehicle on delta9-tetrahydrocannabinol toxicity.
Topics: Animals; Brain Chemistry; Cannabis; Carbon Radioisotopes; Carbon Tetrachloride Poisoning; Chemical a | 1974 |
Modifying effect of 3-amino-1,2,4-triazole on phenobarbital-induced changes in rat liver.
Topics: Amitrole; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytochrom | 1972 |
Liver parenchymal cell injury. IX. Phenobarbital potentiation of endoplasmic reticulum denaturation following carbon tetrachloride.
Topics: Animals; Autoradiography; Calcium; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical and Dru | 1972 |
Effects of microsomal enzyme inducers on animals poisoned with hepatotoxins.
Topics: Alanine Transaminase; Animals; Barbiturates; Blood Proteins; Body Weight; Carbon Tetrachloride; Carb | 1972 |
The effect of diet and drugs on hepatic microsomal aminopyrine N-demethylase activity in vitro and susceptibility to carbon tetrachloride in sheep.
Topics: Aminopyrine; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; DDT; Diet; Dietary Prote | 1972 |
Factors affecting neurotoxicity by p-bromophenylacetylurea in rats.
Topics: Acetylcholinesterase; Age Factors; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemi | 1971 |
The effect of prednisolone and other factors on the catabolism of 5-fluorouracil in rats.
Topics: Animals; Autoradiography; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; Chemical | 1971 |
Effect of phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride-induced liver damage.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Clinical Enzyme Tests; Cytochromes; Enzyme Act | 1971 |
Determinants of toxicity.
Topics: Animals; Animals, Newborn; Binding Sites; Carbon Tetrachloride Poisoning; Cell Differentiation; Cyto | 1971 |
[Behavior of lipoproteins in hepatic steatosis].
Topics: Animals; Carbon Tetrachloride Poisoning; Fasting; Fatty Liver; Lipoproteins; Phenobarbital; Rats; Tr | 1971 |
Effect of partial liver resection and phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride induced liver damage.
Topics: Animals; Benzoates; Carbon Tetrachloride Poisoning; Cytochromes; Enzyme Induction; Hepatectomy; Hexo | 1971 |
The effect of cirrhosis of the liver on microsomal detoxications and cytochrome P-450.
Topics: Aminopyrine; Animals; Carbon Tetrachloride Poisoning; Cytochromes; Liver; Liver Cirrhosis, Experimen | 1969 |
[Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl-sorbitol (MSF). II. Influence of phenobarbital on sleep in animals with carbon tetrachloride poisoning].
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Furans; Phenobarbit | 1969 |
Effect of drug pretreatment on carbon tetrachloride-induced lipid peroxidation in rat liver microsomal lipids.
Topics: Animals; Carbon Tetrachloride Poisoning; Centrifugation; Chemical and Drug Induced Liver Injury; Lip | 1970 |
Effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Drug Synergism; Injections, Intraperi | 1970 |
Further observations upon the effects of phenobarbital pretreatment on the hepatotoxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Endoplasmic Reticul | 1971 |
Influence of phenobarbital and various steroids on CCl4 hepatotoxicity.
Topics: Animals; Carbon Tetrachloride Poisoning; Desoxycorticosterone; Drug Synergism; Estradiol; Ethylestre | 1971 |
Studies on the destruction of liver microsomal cytochrome P-450 by carbon tetrachloride administration.
Topics: Age Factors; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cytoch | 1968 |
[Bromsulphalein elimination from the blood and the activity of glutamate oxaloacetic transaminase and glutamate pyruvate transaminase in serum and liver homogenates of immature and adult rats after pretreatment with CCl4 or barbiturates].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Barbiturates; Carbon Tetrachloride Poiso | 1968 |
Toxicity of carbon tetrachloride.
Topics: Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Liver; Phenobarbital; Phenylbutazone; | 1969 |
Increased susceptibility to carbon tetrachloride poisoning in the rat after pretreatment with oral phenobarbitone.
Topics: Adipose Tissue; Animals; Bilirubin; Carbon Dioxide; Carbon Isotopes; Carbon Tetrachloride Poisoning; | 1969 |
Increased bilirubin formation from nonhemoglobin sources in rats with disorders of the liver.
Topics: Animals; Bilirubin; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Erythrop | 1969 |
Drugs and liver disease.
Topics: Biliary Tract Diseases; Bilirubin; Brain Diseases; Carbon Tetrachloride Poisoning; Chemical and Drug | 1969 |
[Services and perspectives of metabolic research on certain exogenous substances endowed with pharmacological activity].
Topics: Animals; Carbon Tetrachloride Poisoning; Humans; Microsomes; Pentobarbital; Pharmacology; Phenobarbi | 1965 |