phenobarbital has been researched along with Brain Ischemia in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 6 (31.58) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (10.53) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Nese, M | 1 |
| Riboli, G | 1 |
| Brighetti, G | 1 |
| Sassi, V | 1 |
| Camela, E | 1 |
| Caselli, G | 1 |
| Sassaroli, S | 1 |
| Borlimi, R | 1 |
| Aucoin, M | 1 |
| Cooley, K | 1 |
| Saunders, PR | 1 |
| Carè, J | 1 |
| Anheyer, D | 1 |
| Medina, DN | 1 |
| Cardozo, V | 1 |
| Remy, D | 1 |
| Hannan, N | 1 |
| Garber, A | 1 |
| Velayos, M | 1 |
| Muñoz-Serrano, AJ | 1 |
| Estefanía-Fernández, K | 1 |
| Sarmiento Caldas, MC | 1 |
| Moratilla Lapeña, L | 1 |
| López-Santamaría, M | 1 |
| López-Gutiérrez, JC | 1 |
| Li, J | 1 |
| Zhang, J | 1 |
| Shen, S | 1 |
| Zhang, B | 2 |
| Yu, WW | 1 |
| Toyoda, H | 1 |
| Huang, DQ | 1 |
| Le, MH | 1 |
| Nguyen, MH | 1 |
| Huang, R | 1 |
| Zhu, L | 1 |
| Wang, J | 6 |
| Xue, L | 1 |
| Liu, L | 2 |
| Yan, X | 2 |
| Huang, S | 1 |
| Li, Y | 6 |
| Xu, T | 1 |
| Li, C | 2 |
| Ji, F | 1 |
| Ming, F | 1 |
| Zhao, Y | 2 |
| Cheng, J | 1 |
| Wang, Y | 3 |
| Zhao, H | 1 |
| Hong, S | 1 |
| Chen, K | 2 |
| Zhao, XA | 1 |
| Zou, L | 1 |
| Sang, D | 1 |
| Shao, H | 1 |
| Guan, X | 1 |
| Chen, X | 2 |
| Chen, Y | 4 |
| Wei, J | 1 |
| Zhu, C | 1 |
| Wu, C | 1 |
| Moore, HB | 1 |
| Barrett, CD | 1 |
| Moore, EE | 1 |
| Jhunjhunwala, R | 1 |
| McIntyre, RC | 1 |
| Moore, PK | 1 |
| Hajizadeh, N | 1 |
| Talmor, DS | 1 |
| Sauaia, A | 1 |
| Yaffe, MB | 1 |
| Liu, C | 3 |
| Lin, Y | 1 |
| Dong, Y | 1 |
| Wu, Y | 1 |
| Bao, Y | 1 |
| Yan, H | 2 |
| Ma, J | 1 |
| Fernández-Cuadros, ME | 1 |
| Albaladejo-Florín, MJ | 1 |
| Álava-Rabasa, S | 1 |
| Usandizaga-Elio, I | 1 |
| Martinez-Quintanilla Jimenez, D | 1 |
| Peña-Lora, D | 1 |
| Neira-Borrajo, I | 1 |
| López-Muñoz, MJ | 1 |
| Rodríguez-de-Cía, J | 1 |
| Pérez-Moro, OS | 1 |
| Abdallah, M | 1 |
| Alsaleh, H | 1 |
| Baradwan, A | 1 |
| Alfawares, R | 1 |
| Alobaid, A | 1 |
| Rasheed, A | 1 |
| Soliman, I | 1 |
| Wendel Garcia, PD | 1 |
| Fumeaux, T | 1 |
| Guerci, P | 1 |
| Heuberger, DM | 1 |
| Montomoli, J | 2 |
| Roche-Campo, F | 1 |
| Schuepbach, RA | 1 |
| Hilty, MP | 1 |
| Poloni, TE | 1 |
| Carlos, AF | 1 |
| Cairati, M | 1 |
| Cutaia, C | 1 |
| Medici, V | 1 |
| Marelli, E | 1 |
| Ferrari, D | 1 |
| Galli, A | 1 |
| Bognetti, P | 1 |
| Davin, A | 1 |
| Cirrincione, A | 1 |
| Ceretti, A | 1 |
| Cereda, C | 1 |
| Ceroni, M | 1 |
| Tronconi, L | 1 |
| Vitali, S | 1 |
| Guaita, A | 1 |
| Leeds, JS | 1 |
| Raviprakash, V | 1 |
| Jacques, T | 1 |
| Scanlon, N | 1 |
| Cundall, J | 1 |
| Leeds, CM | 1 |
| Riva, A | 1 |
| Gray, EH | 1 |
| Azarian, S | 1 |
| Zamalloa, A | 1 |
| McPhail, MJW | 1 |
| Vincent, RP | 1 |
| Williams, R | 1 |
| Chokshi, S | 1 |
| Patel, VC | 1 |
| Edwards, LA | 1 |
| Alqarawi, W | 1 |
| Birnie, DH | 1 |
| Golian, M | 1 |
| Nair, GM | 1 |
| Nery, PB | 1 |
| Klein, A | 1 |
| Davis, DR | 1 |
| Sadek, MM | 1 |
| Neilipovitz, D | 1 |
| Johnson, CB | 1 |
| Green, MS | 1 |
| Redpath, C | 1 |
| Miller, DC | 1 |
| Beamer, P | 1 |
| Billheimer, D | 1 |
| Subbian, V | 1 |
| Sorooshian, A | 1 |
| Campbell, BS | 1 |
| Mosier, JM | 1 |
| Novaretti, JV | 1 |
| Astur, DC | 1 |
| Cavalcante, ELB | 1 |
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| Cohen, M | 1 |
| Huang, W | 1 |
| Li, T | 1 |
| Ling, Y | 1 |
| Qian, ZP | 1 |
| Zhang, YY | 1 |
| Huang, D | 1 |
| Xu, SB | 1 |
| Liu, XH | 1 |
| Xia, L | 1 |
| Yang, Y | 3 |
| Lu, SH | 1 |
| Lu, HZ | 1 |
| Zhang, R | 2 |
| Ma, JX | 1 |
| Tang, S | 1 |
| Li, CM | 1 |
| Wan, J | 1 |
| Wang, JF | 1 |
| Ma, JQ | 1 |
| Luo, JJ | 1 |
| Chen, HY | 2 |
| Mi, SL | 1 |
| Chen, SY | 1 |
| Su, YG | 1 |
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| Lopes, RMRM | 1 |
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| Nogueira, F | 1 |
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| Papachristou, DJ | 1 |
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| Wang, L | 3 |
| Yan, D | 1 |
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| Yang, K | 2 |
| Zhai, C | 1 |
| Yang, M | 1 |
| Lao, X | 1 |
| Sun, J | 1 |
| Ma, N | 1 |
| Wang, S | 1 |
| Ye, W | 1 |
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| Rahimi, S | 1 |
| Singh, MP | 1 |
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| Nakanishi, I | 1 |
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| Hamada, H | 1 |
| van der Boom, T | 1 |
| Gruppen, EG | 1 |
| Lefrandt, JD | 1 |
| Connelly, MA | 1 |
| Links, TP | 1 |
| Dullaart, RPF | 1 |
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| Bedlack, R | 1 |
| Mathews, D | 1 |
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| Leal, DB | 1 |
| de Andrade, CM | 1 |
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| Camacho-Ordóñez, A | 1 |
| Ortiz Bibriesca, DM | 1 |
| Estrada-Mena, FJ | 1 |
| Martin, BL | 1 |
| Thompson, LC | 1 |
| Kim, YH | 2 |
| Snow, SJ | 1 |
| Schladweiler, MC | 1 |
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| King, C | 1 |
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| Hazari, MS | 1 |
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| Goldfinger, LE | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Clinical Trial of Therapeutic Hypothermia During Transport for Hypoxic Ischemic Encephalopathy (HIE): Device-regulated Cooling Versus Standard Practice.[NCT01683383] | 101 participants (Actual) | Interventional | 2012-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants in target temperature range (33-34 C) anytime during transport (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) |
|---|---|
| Control (Standard Cooling) | 24 |
| Device (Servo-regulated Cooling) | 41 |
Percentage of participants in target range (33°-34°C) one hour after cooling initiation by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of participants (Number) |
|---|---|
| Control (Standard Cooling) | 8 |
| Device (Servo-regulated Cooling) | 28 |
The percentage of temperatures in the target range (33°-34°C) during transport after cooling initiation by the transport team. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Percentage of temperatures (Median) |
|---|---|
| Control (Standard Cooling) | 0 |
| Device (Servo-regulated Cooling) | 73 |
Time to the target temperature range (33°-34°C) from initiation of cooling by the transport team (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Minutes (Mean) |
|---|---|
| Control (Standard Cooling) | 63 |
| Device (Servo-regulated Cooling) | 44 |
The incidence, intervention and outcome of cardiac arrhythmia, major bleeding, altered skin integrity, pulmonary hypertension, device-related events, death, and other serious adverse events from the time of initiation of transport cooling to the time of completion will be monitored. (NCT01683383)
Timeframe: Participants will be followed for the duration of neonatal transport from the birth hospital to the cooling center, an expected average of 4 hours
| Intervention | Participants (Number) | |||||
|---|---|---|---|---|---|---|
| Cardiac arrhythmia | Major bleeding (pulmonary hemorrhage) | Altered skin integrity | Pulmonary hypertension | Device-related events | Death | |
| Control (Standard Cooling) | 0 | 0 | 0 | 0 | 0 | 6 |
| Device (Servo-regulated Cooling) | 0 | 1 | 0 | 0 | 2 | 9 |
4 reviews available for phenobarbital and Brain Ischemia
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Barbiturate therapy in the management of cerebral ischaemia.
Topics: Animals; Barbiturates; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dogs; Humans | 1982 |
Interventions for perinatal hypoxic-ischemic encephalopathy.
Topics: Animals; Asphyxia Neonatorum; Brain Damage, Chronic; Brain Ischemia; Calcium Channel Blockers; Excit | 1997 |
Pharmacologic considerations in the management of the asphyxiated newborn.
Topics: Asphyxia Neonatorum; Barbiturates; Brain; Brain Edema; Brain Ischemia; Free Radicals; Humans; Hypoxi | 1985 |
3 trials available for phenobarbital and Brain Ischemia
| Article | Year |
|---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
The effect of phenobarbital on cerebral blood flow in newborn infants with foetal distress.
Topics: Brain Ischemia; Cerebrovascular Circulation; Fetal Distress; Humans; Hypoxia, Brain; Infant, Newborn | 1994 |
Early high-dose phenobarbital treatment for prevention of hypoxic-ischemic brain damage in very low birth weight infants.
Topics: Brain Damage, Chronic; Brain Ischemia; Cerebral Hemorrhage; Developmental Disabilities; Drug Adminis | 1988 |
13 other studies available for phenobarbital and Brain Ischemia
| Article | Year |
|---|---|
Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia.
Topics: Animals; Animals, Newborn; Anticonvulsants; Azepines; Benzamides; Brain; Brain Ischemia; Brain-Deriv | 2015 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
High dose barbiturate therapy in neurosurgery and intensive care.
Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Criti | 1984 |
Pharmacologic protection against ischemic brain damage.
Topics: Adult; Animals; Arterial Occlusive Diseases; Barbiturates; Brain Injuries; Brain Ischemia; Cats; Cer | 1983 |
Factors affecting outcome in hypoxic-ischemic encephalopathy in term infants.
Topics: Adolescent; Adult; Brain Ischemia; Dexamethasone; Electroencephalography; Female; Follow-Up Studies; | 1983 |
The increase in extracellular potassium concentration in the ischemic brain in relation to the preischemic functional activity and cerebral metabolic rate.
Topics: Adenosine Triphosphate; Amphetamine; Animals; Bicuculline; Blood Pressure; Body Temperature; Brain I | 1980 |
Prognostic value of continuous electroencephalographic recording in full term infants with hypoxic ischaemic encephalopathy.
Topics: Brain Damage, Chronic; Brain Ischemia; Diagnosis, Computer-Assisted; Electroencephalography; Follow- | 1994 |
Increase in ubiquitin conjugates dependent on ischemic damage.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Gerbillinae; Immunoblotting; Male; Muramidase; Phen | 1993 |
Relationship between ischemic damage and concentrations of phenytoin and phenobarbital in the brain cortex of epileptic patients in vegetative state at death.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Autopsy; Brain Ischemia; Case-Control Studies; Cere | 1996 |
[Disorders of cerebral hemodynamics and their correction in epilepsy].
Topics: Brain Ischemia; Caffeine; Cerebrovascular Circulation; Epilepsy; Humans; Papaverine; Phenobarbital | 1979 |
[Changes in cerebral blood circulation and their correction in the interparoxysmal period of epilepsy].
Topics: Adolescent; Adult; Brain Ischemia; Caffeine; Cerebrovascular Circulation; Drug Therapy, Combination; | 1990 |
[Brain energy metabolism of cerebral ischemic mice and the effects of some drugs].
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Ginsenosides; Lactates; Lactic Acid; Male; M | 1989 |
Neonatal hypoxic-ischemic encephalopathy: current management practices.
Topics: Academic Medical Centers; Asphyxia Neonatorum; Brain Ischemia; Electroencephalography; Humans; Infan | 1988 |