phenobarbital has been researched along with Brain Injuries in 43 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 5.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| " The present study investigated the postmortem brain mRNA and immunohistochemical expressions of matrix metalloproteases (MMPs), claudin5 (CLDN5), and aquaporins (AQPs) in forensic autopsy cases of carbon monoxide (n = 14), METH (n = 21), and phenobarbital (n = 17) intoxication, compared with mechanical asphyxia (n = 15), brain injury (n = 11), non-brain injury (n = 21), and sharp instrument injury (n = 15) cases." | 3.80 | Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication. ( Guan, DW; Ishikawa, T; Maeda, H; Michiue, T; Wang, Q; Zhu, BL, 2014) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| " In order to use these effectively, the critical care nurse must be aware of the indications and controversies surrounding their use, the patho-physiologic conditions that impact on the disposition, and appropriate dosing and monitoring of these agents in the critical care setting." | 2.38 | Anticonvulsants: pharmacotherapeutic issues in the critically ill patient. ( Dupuis, RE; Miranda-Massari, J, 1991) |
| "It is the recommended drug for the treatment of seizures in term neonates." | 2.37 | [Phenobarbital in newborn infants. Overview]. ( Staudt, F, 1984) |
| " Based on the available data it seems that one may postulate the following conclusions: (1) that the distribution factors as well as changes in drug elimination capacities seem to play a role, perhaps with differing relative importance, during each of the maturational periods; (2) that the physicochemical properties of a drug and its dosage, as well as changes in the volume of distribution in children, in the course of certain disease states may have a significant effect on kinetics of drug disposition in the body; (3) that systemic clearance, a model independent parameter, rather than elimination half-life, a hybrid pharmacokinetic parameter, more accurately reflects elimination of some drugs from the body; (4) that each drug and every clinical situation may require the evaluation of the direct effect on pharmacokinetic processes, since general principles may not always apply; (5) that drug disposition studies should also be performed, if possible, on patients under actual clinical situations and receiving the usual therapeutic regime, and (6) that the half-life of colistin is independent of postnatal age which should serve as a warning not to generalize about drug excretion in the young infant." | 2.37 | Clinical pharmacokinetics of changes in drug elimination in children. ( Prandota, J, 1985) |
| "Survivors of neonatal seizures are at risk for developmental delay, epilepsy, and further neurological comorbidities." | 1.51 | Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury. ( Brady, J; Cabassa Miskimen, AC; Ghosh, S; Kang, PB; Robinson, MA; Weiss, M; Zou, B, 2019) |
| "Seizures are common in infants with HIE undergoing TH and may worsen outcome." | 1.48 | The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat. ( Aronowitz, E; Hutton, A; Krishna, S; Moore, H; Vannucci, SJ, 2018) |
| "Seventeen had Glasgow Coma Scales of 3 to 4 and 23 scales of 5 to 7." | 1.27 | Early prediction of outcome after severe head injury in children. ( Pfenninger, J, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (69.77) | 18.7374 |
| 1990's | 6 (13.95) | 18.2507 |
| 2000's | 2 (4.65) | 29.6817 |
| 2010's | 4 (9.30) | 24.3611 |
| 2020's | 1 (2.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ikonomidou, C | 1 |
| Wang, SH | 1 |
| Fuhler, NA | 1 |
| Larson, S | 1 |
| Capuano, S | 1 |
| Brunner, KR | 1 |
| Crosno, K | 1 |
| Simmons, HA | 1 |
| Mejia, AF | 1 |
| Noguchi, KK | 1 |
| Krishna, S | 1 |
| Hutton, A | 1 |
| Aronowitz, E | 1 |
| Moore, H | 1 |
| Vannucci, SJ | 1 |
| Ghosh, S | 1 |
| Cabassa Miskimen, AC | 1 |
| Brady, J | 1 |
| Robinson, MA | 1 |
| Zou, B | 1 |
| Weiss, M | 1 |
| Kang, PB | 1 |
| Wang, Q | 1 |
| Ishikawa, T | 1 |
| Michiue, T | 1 |
| Zhu, BL | 1 |
| Guan, DW | 1 |
| Maeda, H | 1 |
| Song, RB | 1 |
| Glass, EN | 1 |
| Kent, M | 1 |
| Castro, FA | 1 |
| deLahunta, A | 1 |
| Temkin, NR | 2 |
| JANZ, D | 1 |
| KAUTZ, G | 1 |
| CHAROKOPOS, S | 1 |
| SAKELLARIDES, N | 1 |
| ALLAMANES, I | 1 |
| STAURIANOS, N | 1 |
| POPEK, K | 4 |
| Staudt, F | 1 |
| Pfenninger, J | 1 |
| Pourtales, MC | 1 |
| Bourguignat, A | 2 |
| Ferard, G | 2 |
| Tulasne, PA | 1 |
| Metais, P | 2 |
| Jung, G | 1 |
| Klumpp, T | 1 |
| Yatsu, FM | 1 |
| Stopfkuchen, H | 1 |
| Schranz, D | 1 |
| Schwarz, M | 1 |
| Tegtmeyer, F | 1 |
| Wirth, S | 1 |
| Baratz, R | 1 |
| Mesulam, MM | 1 |
| Karbowski, K | 1 |
| Hoppe, E | 1 |
| Christensen, L | 1 |
| Christensen, KN | 1 |
| Hume, AL | 1 |
| Cant, BR | 1 |
| Promyslov, MS | 1 |
| Demchuk, ML | 1 |
| Hans, P | 1 |
| Triffaux, M | 1 |
| Bonhomme, V | 1 |
| Born, JD | 1 |
| Damas, F | 1 |
| Maertens de Noordhout, A | 1 |
| Lin, SZ | 1 |
| Chiou, TL | 1 |
| Chiang, YH | 1 |
| Song, WS | 1 |
| Gabriel Botella, F | 1 |
| Labios Gómez, M | 1 |
| Galindo Puerto, MJ | 1 |
| Chapa Villalba, MA | 1 |
| Gómez Aldaravi Gutiérrez, R | 1 |
| Escuret, E | 1 |
| Roquefeuil, B | 1 |
| Frerebeau, P | 1 |
| Baldy-Moulinier, M | 1 |
| Gaab, M | 1 |
| Herrmann, F | 1 |
| Kerscher, J | 1 |
| Rausch, K | 1 |
| Lochner, J | 1 |
| Pflughaupt, KW | 1 |
| Ibrahim, MZ | 1 |
| Jacobi, G | 1 |
| Dupuis, RE | 1 |
| Miranda-Massari, J | 1 |
| Hassett, JM | 1 |
| Doolittle, T | 1 |
| Molloy, M | 1 |
| Lalka, D | 1 |
| Borromei, A | 1 |
| Caramelli, R | 1 |
| Cipriani, G | 1 |
| Giancola, LC | 1 |
| Guerra, L | 1 |
| Lozito, A | 1 |
| Prandota, J | 1 |
| Wroblewski, BA | 1 |
| Garvin, WH | 1 |
| Ouellette, EM | 1 |
| Petersen, EA | 1 |
| Haase, J | 2 |
| Rish, BL | 1 |
| Caveness, WF | 1 |
| Swinyard, EA | 1 |
| Grohme, S | 1 |
| Schneider, H | 1 |
| Masshoff, W | 1 |
| Musil, F | 1 |
| Overgaard, J | 1 |
| Hein, O | 1 |
| Laursen, B | 1 |
| Ronde, F | 1 |
| Barnkob, F | 1 |
| Hinke, H | 1 |
10 reviews available for phenobarbital and Brain Injuries
| Article | Year |
|---|---|
Preventing and treating posttraumatic seizures: the human experience.
Topics: Animals; Anticonvulsants; Brain Injuries; Drug Evaluation, Preclinical; Drug Therapy, Combination; E | 2009 |
[Phenobarbital in newborn infants. Overview].
Topics: Asphyxia Neonatorum; Brain Injuries; Cerebral Hemorrhage; Electroencephalography; Half-Life; Humans; | 1984 |
[The post-traumatic epilepsy (author's transl)].
Topics: Brain Concussion; Brain Injuries; Brain Neoplasms; Carbamazepine; Diagnostic Errors; Electroencephal | 1981 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
[Post-traumatic epilepsy].
Topics: Brain Injuries; Carbamazepine; Child; Dose-Response Relationship, Drug; Electroencephalography; Epil | 1992 |
Anticonvulsants: pharmacotherapeutic issues in the critically ill patient.
Topics: Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Central Nervous System Diseases; Ep | 1991 |
[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].
Topics: Adolescent; Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Child; Child, Preschool; Drug The | 1987 |
Clinical pharmacokinetics of changes in drug elimination in children.
Topics: Adult; Anti-Bacterial Agents; Brain Injuries; Child; Child, Preschool; Colistin; Cystic Fibrosis; Di | 1985 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
Laboratory evaluation of antiepileptic drugs. Review of laboratory methods.
Topics: Animals; Anticonvulsants; Biological Assay; Brain Injuries; Diagnosis; Electroconvulsive Therapy; El | 1969 |
33 other studies available for phenobarbital and Brain Injuries
| Article | Year |
|---|---|
Mild hypothermia fails to protect infant macaques from brain injury caused by prolonged exposure to Antiseizure drugs.
Topics: Animals; Brain; Brain Injuries; Humans; Hypothermia; Hypothermia, Induced; Infant; Infant, Newborn; | 2022 |
The effects of adding prophylactic phenobarbital to therapeutic hypothermia in the term-equivalent hypoxic-ischemic rat.
Topics: Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Brain Injuries; Disease Models, Animal | 2018 |
Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury.
Topics: Anticonvulsants; Brain Injuries; Case-Control Studies; Developmental Disabilities; Female; Gestation | 2019 |
Molecular pathology of brain matrix metalloproteases, claudin5, and aquaporins in forensic autopsy cases with special regard to methamphetamine intoxication.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aquaporin 1; Aquaporin 4; Asphyxia; Brain; Brain Injurie | 2014 |
Magnetic resonance imaging and computed tomography findings of Dyke-Davidoff-Masson-like syndrome in a cat.
Topics: Animals; Anticonvulsants; Brain; Brain Diseases; Brain Injuries; Cat Diseases; Cats; Female; Magneti | 2015 |
[ETIOLOGY AND THERAPY OF STATUS EPILEPTICUS].
Topics: Abortion, Septic; Anticonvulsants; Birth Injuries; Brain Injuries; Brain Neoplasms; Chloral Hydrate; | 1963 |
[EPILEPSY IN INFANCY AND CHILDHOOD. REMARKS ON 360 PERSONAL CASES].
Topics: Adolescent; Adrenocorticotropic Hormone; Birth Injuries; Brain; Brain Damage, Chronic; Brain Disease | 1963 |
THE STUDY OF CHANGES IN THE SO-CALLED SUCCESSIVE CONTRAST IN NEUROLOGY.
Topics: Afterimage; Amphetamine; Arteriosclerosis; Brain Concussion; Brain Injuries; Brain Neoplasms; Bromid | 1964 |
Early prediction of outcome after severe head injury in children.
Topics: Adolescent; Blood Coagulation Tests; Brain Death; Brain Injuries; Child; Child, Preschool; Coma; Dex | 1984 |
[Changes in plasma enzyme activities and proteins in patients with severe head injuries. Effect of 2 sedative drugs: Gardenal and Gamma OH].
Topics: Adolescent; Adult; Aged; Blood Proteins; Brain Injuries; Female; Humans; Hydroxybutyrates; Male; Mid | 1984 |
[Plasma variations in severe head injuries: prognosis and post-traumatic surveillance. I. Enzymes].
Topics: Adolescent; Adult; Aged; Analysis of Variance; Aspartate Aminotransferases; Brain Injuries; Child; C | 1983 |
Pharmacologic protection against ischemic brain damage.
Topics: Adult; Animals; Arterial Occlusive Diseases; Barbiturates; Brain Injuries; Brain Ischemia; Cats; Cer | 1983 |
[Therapy regimen in children with severe brain injury after the introduction of intracranial manometry].
Topics: Brain Edema; Brain Injuries; Child; Dexamethasone; Humans; Intracranial Pressure; Phenobarbital; Res | 1984 |
Adult-onset stuttering treated with anticonvulsants.
Topics: Adult; Brain Injuries; Carbamazepine; Drug Therapy, Combination; Epilepsy, Post-Traumatic; Female; H | 1981 |
The clinical outcome of patients with severe head injuries, treated with highdose dexamethasone, hyperventilation and barbiturates.
Topics: Adolescent; Adult; Age Factors; Aged; Brain Injuries; Child; Child, Preschool; Chlorpromazine; Dexam | 1981 |
Central somatosensory conduction after head injury.
Topics: Adolescent; Adult; Body Temperature Regulation; Brain Injuries; Brain Stem; Child; Coma; Dominance, | 1981 |
Interrelationship between the functional state of the central nervous system and lipid peroxidation level in brain following craniocerebral trauma.
Topics: Amphetamine; Animals; Antioxidants; Behavior, Animal; Brain Chemistry; Brain Injuries; Central Nervo | 1995 |
Control of drug-resistant epilepsy after head injury with intravenous nimodipine.
Topics: Brain Injuries; Drug Therapy, Combination; Electroencephalography; Epilepsy, Generalized; Female; Hu | 1994 |
Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema.
Topics: Animals; Blood Proteins; Blood-Brain Barrier; Brain Edema; Brain Injuries; Drug Therapy, Combination | 1994 |
[Reflex sympathetic dystrophy syndrome associated with phenobarbital].
Topics: Aged; Anticonvulsants; Bone Resorption; Brain Injuries; Diphosphonates; Epilepsy, Generalized; Human | 1996 |
Effect of hyperventilation associated with administration of central nervous depressants in brain injuries.
Topics: Brain; Brain Injuries; Cerebrovascular Circulation; Diazepam; Humans; Hyperventilation; Phenobarbita | 1977 |
Comparison of the effects of dexamethasone, barbiturate, and THAM on experimental brain oedema.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Dexamethasone; Oxygen; Phenobarbital; R | 1979 |
Glycogen and its related enzymes of metabolism in the central nervous system.
Topics: 1,4-alpha-Glucan Branching Enzyme; Adenine Nucleotides; Adrenal Cortex Hormones; Animals; Blood Gluc | 1975 |
Hypersensitivity reaction to anticonvulsants following head injury.
Topics: Adolescent; Brain Injuries; Drug Eruptions; Humans; Male; Phenobarbital; Phenytoin | 1987 |
Once-daily administration of phenobarbital in adults. Clinical efficacy and benefit.
Topics: Adult; Brain Injuries; Coma; Female; Humans; Male; Middle Aged; Phenobarbital; Seizures | 1985 |
[Prevention of post-traumatic epilepsy following serious brain injuries. Closing report summarizing results of the research done within the framework of the state plan of research in the years 1965-1969; edited by Z. Servít].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Brain Injuries; Epilepsy, Post-Traumatic; Female; Humans; | 1972 |
Unstable fractures in children with acute, severe brain injury.
Topics: Accidents, Traffic; Arm Injuries; Brain Injuries; Chlorpromazine; Female; Femoral Fractures; Fractur | 1974 |
Relation of prophylactic medication to the occurrence of early seizures following craniocerebral trauma.
Topics: Brain Edema; Brain Injuries; Dexamethasone; Epilepsy, Post-Traumatic; Humans; Military Medicine; Phe | 1973 |
[Encephalopathies in vita reducta].
Topics: Adult; Aged; Brain; Brain Death; Brain Injuries; Carbon Monoxide Poisoning; Cerebellum; Cerebral Cor | 1969 |
[Clinical attempt to prevent post-traumatic epilepsy following severe brain injuries in adults].
Topics: Adolescent; Adult; Aged; Brain Injuries; Dibenzazepines; Electroencephalography; Epilepsy; Epilepsy, | 1969 |
Draft instructions for preventive treatment of posttraumatic epilepsy.
Topics: Brain Injuries; Czechoslovakia; Electroencephalography; Epilepsy, Post-Traumatic; Humans; Hydantoins | 1969 |
[Preventive treatment of post-traumatic epilepsy following brain injury. Closing report summarizing results of the research done in the framework of the state research plan for the years 1965-1969; edited by Z. Servit].
Topics: Atropa belladonna; Brain Concussion; Brain Injuries; Epilepsy; Ergotamine; Humans; Hydantoins; Pheno | 1972 |
[Brain lesions resulting from traffic accidents. Neurosurgical patients].
Topics: Accidents, Traffic; Adolescent; Adult; Age Factors; Aged; Brain Injuries; Child; Child, Preschool; F | 1970 |