phenobarbital has been researched along with Brain Edema in 19 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "22 patients with severe preeclampsia-eclampsia were treated in our Intensive Care Unit from 1972 to 1978." | 1.26 | [Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)]. ( Larsen, R; Radke, J; Turner, E, 1980) |
| "Recurrent acute respiratory failure in an epileptic subject is described." | 1.25 | Respiratory failure as a seizure phenomenon. A case report. ( Malatinský, J; Procházka, M; Sámel, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 1 (5.26) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Zombori, L | 1 |
| Bacon, M | 1 |
| Wood, H | 1 |
| Chatterjee, F | 1 |
| Venkateswaran, R | 1 |
| Lampariello, S | 1 |
| Yoong, M | 1 |
| Matsusue, A | 1 |
| Hara, K | 1 |
| Kageura, M | 1 |
| Kashiwagi, M | 1 |
| Lu, W | 1 |
| Ishigami, A | 1 |
| Gotohda, T | 1 |
| Tokunaga, I | 1 |
| Nisimura, A | 1 |
| Sugimura, T | 1 |
| Kubo, S | 1 |
| Piatt, JH | 1 |
| Schiff, SJ | 1 |
| Sagraves, R | 1 |
| Bradberry, JC | 1 |
| Stopfkuchen, H | 1 |
| Schranz, D | 1 |
| Schwarz, M | 1 |
| Tegtmeyer, F | 1 |
| Wirth, S | 1 |
| Deering, WM | 1 |
| Steer, CR | 1 |
| Svenningsen, NW | 1 |
| Blennow, G | 1 |
| Lindroth, M | 1 |
| Gäddlin, PO | 1 |
| Ahlström, H | 1 |
| Larsen, R | 1 |
| Turner, E | 1 |
| Radke, J | 1 |
| Lin, SZ | 1 |
| Chiou, TL | 1 |
| Chiang, YH | 1 |
| Song, WS | 1 |
| Venes, JL | 1 |
| Shaywitz, BA | 1 |
| Spencer, DD | 1 |
| Gaab, M | 1 |
| Herrmann, F | 1 |
| Kerscher, J | 1 |
| Rausch, K | 1 |
| Lochner, J | 1 |
| Pflughaupt, KW | 1 |
| Khalid, MS | 1 |
| Schulz, H | 1 |
| Malatinský, J | 1 |
| Procházka, M | 1 |
| Sámel, M | 1 |
| Hill, A | 1 |
| Tchertkoff, V | 1 |
| Nayak, SV | 1 |
| Kamath, C | 1 |
| Salomon, MI | 1 |
| Lombroso, CT | 1 |
| Rish, BL | 1 |
| Caveness, WF | 1 |
| Bruncsák, A | 1 |
| Timár, S | 1 |
3 reviews available for phenobarbital and Brain Edema
| Article | Year |
|---|---|
Barbiturate therapy in the management of cerebral ischaemia.
Topics: Animals; Barbiturates; Brain; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Dogs; Humans | 1982 |
Pharmacologic considerations in the management of the asphyxiated newborn.
Topics: Asphyxia Neonatorum; Barbiturates; Brain; Brain Edema; Brain Ischemia; Free Radicals; Humans; Hypoxi | 1985 |
The treatment of status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases; | 1974 |
16 other studies available for phenobarbital and Brain Edema
| Article | Year |
|---|---|
Severe cortical damage associated with COVID-19 case report.
Topics: Acute Kidney Injury; Adolescent; Airway Extubation; Anticonvulsants; Blood Coagulation Disorders; Bo | 2021 |
Genetic analysis of ryanodine receptor 1 gene and carnitine palmitoyltransferase II gene: an autopsy case of neuroleptic malignant syndrome related to vegetamin.
Topics: Adult; Amino Acid Substitution; Antipsychotic Agents; Brain; Brain Edema; Carnitine O-Palmitoyltrans | 2009 |
High dose barbiturate therapy in neurosurgery and intensive care.
Topics: Barbiturates; Brain; Brain Diseases; Brain Edema; Brain Ischemia; Cerebrovascular Circulation; Criti | 1984 |
The effects of exchange transfusion on the pharmacokinetics of phenobarbital.
Topics: Brain Edema; Child, Preschool; Exchange Transfusion, Whole Blood; Hepatic Encephalopathy; Humans; Ki | 1983 |
[Therapy regimen in children with severe brain injury after the introduction of intracranial manometry].
Topics: Brain Edema; Brain Injuries; Child; Dexamethasone; Humans; Intracranial Pressure; Phenobarbital; Res | 1984 |
Neurologic aspects and treatment of La Crosse encephalitis.
Topics: Brain Edema; Child; Encephalitis, Arbovirus; Encephalitis, California; Humans; Phenobarbital; Phenyt | 1983 |
Brain-orientated intensive care treatment in severe neonatal asphyxia. Effects of phenobarbitone protection.
Topics: Asphyxia Neonatorum; Blood Transfusion; Brain Damage, Chronic; Brain Edema; Critical Care; Humans; I | 1982 |
[Intensive care of severe preeclampsia-eclampsia. A report on 22 cases (author's transl)].
Topics: Acute Kidney Injury; Adolescent; Adult; Brain Edema; Critical Care; Diazepam; Dihydralazine; Eclamps | 1980 |
Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema.
Topics: Animals; Blood Proteins; Blood-Brain Barrier; Brain Edema; Brain Injuries; Drug Therapy, Combination | 1994 |
Management of severe cerebral edema in the metabolic encephalopathy of Reye-Johnson syndrome.
Topics: Adolescent; Ammonia; Brain Edema; Cerebrospinal Fluid; Child; Child, Preschool; Female; Humans; Infa | 1978 |
Comparison of the effects of dexamethasone, barbiturate, and THAM on experimental brain oedema.
Topics: Animals; Brain; Brain Edema; Brain Injuries; Carbon Dioxide; Dexamethasone; Oxygen; Phenobarbital; R | 1979 |
The treatment and management of emergency status epilepticus.
Topics: Age Factors; Brain Edema; Child; Chlormethiazole; Diazepam; Emergencies; Epilepsy, Absence; Epilepsy | 1976 |
Respiratory failure as a seizure phenomenon. A case report.
Topics: Brain Edema; Diazepam; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Respiratory Insufficiency | 1975 |
Hyperosmolar nonketotic diabetic coma: vascular complications.
Topics: Adult; Aged; Brain Edema; Diabetic Coma; Diabetic Nephropathies; Esophageal and Gastric Varices; Fem | 1974 |
Relation of prophylactic medication to the occurrence of early seizures following craniocerebral trauma.
Topics: Brain Edema; Brain Injuries; Dexamethasone; Epilepsy, Post-Traumatic; Humans; Military Medicine; Phe | 1973 |
[On acute isoniazid poisoning on the basis of 2 successfully treated cases].
Topics: Adult; Alcoholism; Blood Transfusion; Brain; Brain Edema; Gastric Lavage; Glucose; Glutamates; Human | 1967 |