phenobarbital has been researched along with Bone Fractures in 7 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After adjustment for prior fracture, use (ever) of corticosteroids, comorbidity, social variables, and diagnosis of epilepsy, carbamazepine [CBZ; odds ratio (OR), 1." | 3.72 | Fracture risk associated with use of antiepileptic drugs. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vestergaard, P | 1 |
| Rejnmark, L | 1 |
| Mosekilde, L | 1 |
| Chevrel, G | 1 |
| Limouzin, A | 1 |
| Garnero, P | 1 |
| de Montalivet, C | 1 |
| Loubier, D | 1 |
| Sotaniemi, EA | 1 |
| Hakkarainen, HK | 1 |
| Puranen, JA | 1 |
| Lahti, RO | 1 |
| Petersen, EA | 1 |
| Haase, J | 2 |
| Fitz, CR | 1 |
| Harwood-Nash, DC | 1 |
| Seitz, HJ | 1 |
| Faupel, RP | 1 |
| Kampf, SC | 1 |
| Tarnowski, W | 1 |
| Jepsen, BV | 1 |
| Bech, H | 1 |
| Langeback, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for phenobarbital and Bone Fractures
| Article | Year |
|---|---|
Fracture risk associated with use of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female | 2004 |
Fractures and handicap in an adult population: A clinical study.
Topics: Adult; Biomarkers; Calcium; Collagen Type I; Comorbidity; Disabled Persons; Epilepsy; Female; Fractu | 2007 |
Radiologic bone changes and hypocalcemia with anticonvulsant therapy in epilepsy.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Anticonvulsants; Back Pain; Calcium; Carbamazepine; D | 1972 |
Unstable fractures in children with acute, severe brain injury.
Topics: Accidents, Traffic; Arm Injuries; Brain Injuries; Chlorpromazine; Female; Femoral Fractures; Fractur | 1974 |
Radiology of the ear in children.
Topics: Child; Child, Preschool; Chlorpromazine; Cholesteatoma; Cochlea; Congenital Abnormalities; Ear; Ear | 1974 |
Influence of different types of narcosis and of neck fracture on the concentration of glycolytic intermediates and related compounds in rat liver.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Anesthetics; Animals; Citrates; Ethyl Ethers; Fract | 1973 |
Spinal fracture following radiculography using meglumine iothalamate (Conray).
Topics: Adipates; Adult; Contrast Media; Diazepam; Female; Fractures, Bone; Humans; Hypesthesia; Iothalamic | 1973 |