phenobarbital has been researched along with Body Weight in 479 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
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"Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
"The effect of dietary taurine on endogenous hypercholesterolemia induced by a phenobarbital-containing diet was investigated." | 7.70 | Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets. ( Mochizuki, H; Takido, J; Yokogoshi, H, 1999) |
"We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats." | 7.69 | Effect of pregnancy on plasma phenobarbital concentrations in rats. ( Domoto, H; Furuno, K; Gomita, Y; Kawasaki, H; Moriyama, M; Oishi, R; Yamashita, S, 1995) |
"This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 7.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
"This study was undertaken to investigate the influence of dietary vitamin A deficiency and type of diet on tetrachlorodibenzo-p-dioxin (TCDD)- and phenobarbital-induced liver tumor promotion in rats." | 7.68 | Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency. ( Ahlborg, UG; Busk, L; Flodström, S; Kronevi, T, 1991) |
" infusion of phenobarbital to onset of loss of righting reflex showed that the starved animals required a larger body weight normalized dose and that they had higher phenobarbital concentrations in serum, serum water, brain and cerebrospinal fluid at the pharmacologic endpoint." | 7.67 | Kinetics of drug action in disease states. XX. Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition. ( Levy, G; Wanwimolruk, S, 1987) |
" sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 7.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
"Phenobarbital treatment increased mRNA levels in both genders." | 5.28 | Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver. ( Callaerts, A; Coecke, S; Guillouzo, A; Morel, F; Rogiers, V; Van Bezooijen, CF; Vandenberghe, Y; Vercruysse, A; Verleye, G, 1991) |
"Pretreatment with phenobarbital (PB, 3 x 80 mg/kg i." | 5.28 | Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule. ( Charles, SJ; Connolly, AK; Powell, CJ, 1991) |
"Findings will provide timely information on the safety, efficacy, and optimal dosing of t-PA to treat moderate/severe COVID-19-induced ARDS, which can be rapidly adapted to a phase III trial (NCT04357730; FDA IND 149634)." | 4.21 | ( Abbasi, S; Abd El-Wahab, A; Abdallah, M; Abebe, G; Aca-Aca, G; Adama, S; Adefegha, SA; Adidigue-Ndiome, R; Adiseshaiah, P; Adrario, E; Aghajanian, C; Agnese, W; Ahmad, A; Ahmad, I; Ahmed, MFE; Akcay, OF; Akinmoladun, AC; Akutagawa, T; Alakavuklar, MA; Álava-Rabasa, S; Albaladejo-Florín, MJ; Alexandra, AJE; Alfawares, R; Alferiev, IS; Alghamdi, HS; Ali, I; Allard, B; Allen, JD; Almada, E; Alobaid, A; Alonso, GL; Alqahtani, YS; Alqarawi, W; Alsaleh, H; Alyami, BA; Amaral, BPD; Amaro, JT; Amin, SAW; Amodio, E; Amoo, ZA; Andia Biraro, I; Angiolella, L; Anheyer, D; Anlay, DZ; Annex, BH; Antonio-Aguirre, B; Apple, S; Arbuznikov, AV; Arinsoy, T; Armstrong, DK; Ash, S; Aslam, M; Asrie, F; Astur, DC; Atzrodt, J; Au, DW; Aucoin, M; Auerbach, EJ; Azarian, S; Ba, D; 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" The seizures were controlled by phenobarbital." | 3.88 | [Vomiting associated with weight stagnation and convulsions: urea cycle disorder should be suspected]. ( Abilkacem, R; Agadr, A; Boujrad, S; Hasbaoui, BE, 2018) |
"Phenobarbital is the first-line treatment for neonatal seizures." | 3.79 | Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia. ( Barks, JD; Bhatt-Mehta, V; Dillon, CH; Ng, CM; Shellhaas, RA, 2013) |
"Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
" Sodium phenobarbital was fed to groups of 20 rats of each sex at a dose of 100 mg/kg body weight/day by gavage as a positive control for hepatic microsomal enzyme induction." | 3.70 | Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog. ( Chappel, CI; Procter, BG, 1998) |
"Biliary cirrhosis was induced by bile duct ligation, and micronodular cirrhosis by chronic exposure to phenobarbital/CCl4 in male rats." | 3.70 | The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. ( Clozel, M; Gerbes, AL; Reichen, J; Sägesser, H; Steiner, MJ, 1998) |
"The induction of a hepatic pleiotropic response, including increase in liver/body weight ratio, induction of hepatic CYP2B and CYP3A protein and catalytic activity, and hepatic microsomal epoxide hydration activity, was investigated in male cotton rats (Sigmodon hispidus) administered graded dietary concentrations (0-1500 ppm) of phenobarbital (PB) for 14 days." | 3.70 | Dose-response relationships for cytochrome P450 induction by phenobarbital in the cotton rat (Sigmodon hispidus). ( Henneman, JR; Jones, CR; Lubet, RA; Nims, RW, 1998) |
"The effect of dietary taurine on endogenous hypercholesterolemia induced by a phenobarbital-containing diet was investigated." | 3.70 | Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets. ( Mochizuki, H; Takido, J; Yokogoshi, H, 1999) |
"We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats." | 3.69 | Effect of pregnancy on plasma phenobarbital concentrations in rats. ( Domoto, H; Furuno, K; Gomita, Y; Kawasaki, H; Moriyama, M; Oishi, R; Yamashita, S, 1995) |
"The present study determined the effect of genetic obesity and phenobarbital (PB) treatment on the expression and regulation of the hepatic cytochrome P450 enzyme (CYP2C11) in Fa/? and fa/fa Zucker rats." | 3.68 | Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment. ( Bandyopadhyay, AM; Blouin, RA; Chaudhary, I; Gemzik, B; Parkinson, A; Robertson, LW, 1993) |
" The induction characteristics of SK&F 86002 were compared to those of the classical inducer, phenobarbital, and morphological features of both SK&F 86002 and phenobarbital induced hepatocellular hypertrophy were quantitated." | 3.68 | Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat. ( Howard, MO; Newton, JF; Qualls, CW; Schwartz, LW; Ventre, JR; Yodis, LA, 1991) |
"Higher body and carcass (body - liver) weights in sodium phenobarbital (PB) treated mice correlate with formation of multiple hepatocellular adenomas in yellow Avy/A and agouti A/a (C3H x VY) F1 hybrid male mice." | 3.68 | Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice. ( Bazare, JJ; Harmon, JR; Law, MG; Leakey, JE; Webb, PJ; Wolff, GL, 1991) |
"This study was undertaken to determine the incidence of endotracheal intubation after the use of diazepam compared with phenobarbital or phenytoin in emergency treatment of seizures in children." | 3.68 | Diazepam and intubation in emergency treatment of seizures in children. ( Dimand, RJ; Karr, VA; Kennedy, KJ; Orr, RA; Venkataraman, ST, 1991) |
" Liver carcinogenesis was initiated by intraperitoneal injection of diethylnitrosamine (DEN) in male B6C3F1 mice at 100 or 200 mumol/kg body weight once a week for 10 weeks (total exposure 1000 or 2000 mumol/kg body weight)." | 3.68 | Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis. ( Iatropoulos, MJ; Tokumo, K; Williams, GM, 1991) |
"This study was undertaken to investigate the influence of dietary vitamin A deficiency and type of diet on tetrachlorodibenzo-p-dioxin (TCDD)- and phenobarbital-induced liver tumor promotion in rats." | 3.68 | Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency. ( Ahlborg, UG; Busk, L; Flodström, S; Kronevi, T, 1991) |
"Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine; subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg body weight for up to 49 weeks." | 3.68 | DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion. ( Barthel, G; Bursch, W; Schulte-Hermann, R; Timmermann-Trosiener, I, 1990) |
"05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
"Barbiturates, such as phenobarbital (PHB), are often used during pregnancy and early neonatal life to prevent epileptic seizures, hyperbilirubinemia and the stressful effects of labor." | 3.67 | The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus. ( Antolick, LL; Jacobson, CD; Scholey, R; Uemura, E, 1988) |
" infusion of phenobarbital to onset of loss of righting reflex showed that the starved animals required a larger body weight normalized dose and that they had higher phenobarbital concentrations in serum, serum water, brain and cerebrospinal fluid at the pharmacologic endpoint." | 3.67 | Kinetics of drug action in disease states. XX. Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition. ( Levy, G; Wanwimolruk, S, 1987) |
" sodium phenobarbital (PB) in the diet to yellow Avy/A and agouti A/a (C3H X VY) F1 hybrid male mice, two subgroups differing in responsiveness to PB with respect to promotion of hepatocellular adenomas and body weight gain were observed within each genotype." | 3.67 | Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital. ( Chen, JJ; Morrissey, RL; Wolff, GL, 1986) |
"Gravid Sprague-Dawley-derived rats were injected SC twice daily with either 20 or 40 mg/kg pentobarbital sodium (PT), sodium phenobarbital (PH), or the same volume of the saline vehicle on days 9-21 of pregnancy." | 3.67 | Maternal barbiturate administration and offspring response to shock. ( Chao, S; Grace, R; Mackler, B; Martin, DC; Martin, JC; Shores, P, 1985) |
" In contrast, the liver neoplasm promoter phenobarbital increased the multiplicity, although not the incidence, of liver neoplasms when given after FAA." | 3.67 | Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide. ( Furuya, K; Levine, WG; Mori, H; Numoto, S; Williams, GM, 1985) |
"Steady-state serum concentrations of phenytoin and phenobarbital were obtained in 70 epileptic patients in Taiwan and evaluated with respect to age, sex, and body weight." | 3.67 | Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan. ( Lai, ML, 1985) |
"Offspring of C57BL/6J mice injected daily with phenobarbital (20 or 40 mg/kg) for the last 6 or 7 days of pregnancy were compared with offspring of saline control mice on behavioral and neurochemical measures of brain function at 21 days of age." | 3.66 | Effects of prenatal maternal injections of phenobarbital on brain neurotransmitters and behavior of young C57 mice. ( Middaugh, LD; Simpson, LW; Thomas, TN; Zemp, JW, 1981) |
"0 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) for 140 days after a 70% partial hepatectomy and diethylnitrosamine administration (10 mg/kg body weight) to determine if 345-HBB had tumor-promoting ability in a two-stage hepatocarcinogenesis assay." | 3.66 | Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability. ( Aust, SD; Goodman, JI; Jensen, RK; Sleight, SD; Trosko, JE, 1983) |
"The effect of prenatal exposure to phenobarbital (40mg/Kg/day from day 12 to day 19 of pregnancy) on sexual development of male offspring was investigated." | 3.66 | Reproductive dysfunction in male rats following prenatal exposure to phenobarbital. ( Gupta, C; Shapiro, BH; Yaffe, SJ, 1980) |
"The effects of pretreatment for 4 days with the hepatic microsomal enzyme inducers phenobarbital (8 mg/100 g body weight), spironolactone (20 mg/100 g body weight) and pregnenolone-16alpha-carbonitrile (7 mg/100 g body weight) on bile flow and bile pipid secretion have been compared in rats." | 3.65 | Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat. ( Paumgartner, G; Schwarz, HP; von Bergmann, K, 1975) |
"Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use." | 2.68 | Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996) |
"Spontaneous recurrent seizures (SRS) in TLE can present after a latent period following a neurological insult (traumatic brain injury, SE event, viral infection, etc." | 1.62 | Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital. ( Barker-Haliski, M; Knox, K; Koneval, Z; Metcalf, C; White, HS; Wilcox, KS; Zierath, D, 2021) |
"In covariate (sub)models of population pharmacokinetic models, most covariates are normalized to the median value; however, for body weight, normalization to 70 kg or 1 kg is often applied." | 1.51 | The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models. ( Aarons, L; Calvier, EAM; Goulooze, SC; Knibbe, CAJ; Krekels, EHJ; Välitalo, PAJ; Völler, S, 2019) |
"Pretreatment with bicyclol showed a marked reduction in the above condition." | 1.38 | A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model. ( Liu, G; Sun, H; Wei, H; Yu, L, 2012) |
"Phenobarbital (PB) is an efficacious and well-studied hepatic tumor promoting agent." | 1.37 | Effect of vitamin E on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-κB after treatment with phenobarbital. ( Glauert, HP; Harp, C; Li, J; Spear, BT; Tharappel, JC, 2011) |
" However, because of sampling restrictions, it is often difficult to perform traditional pharmacokinetic studies in neonates and infants." | 1.37 | Population pharmacokinetics of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants: an update. ( Aki, H; Ikeda, H; Mimemoto, M; Suematsu, F; Takiguchi, T; Yukawa, E; Yukawa, M, 2011) |
"The aim of the present study was to build population pharmacokinetic models for the clearance of valproate (VPA) in 2 separate populations of Serbian patients with epilepsy, children and adults." | 1.36 | Factors influencing valproate pharmacokinetics in children and adults. ( Jankovic, S; Jankovic, SM; Milovanovic, JR, 2010) |
" In summary, PB at a dose level which produces liver hypertrophy, a transient stimulation of replicative DNA synthesis and on chronic administration altered hepatic foci, three key events in the established mode of action for PB-induced rodent liver tumour formation, results in a significant increase in liver tumours in male C57BL/10 J mice." | 1.35 | Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse. ( Jones, HB; Lake, BG; Orton, TC, 2009) |
" Well-known toxic effects of PB on the liver and thyroid were observed in a dose-dependent manner, along with altered lipid, glucose, and electrolyte metabolism." | 1.35 | Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats. ( Enomoto, A; Harada, T; Ishizuka, K; Kawakatsu, H; Kojima, S; Kosaka, T; Nakashima, N; Saka, M; Sasaki, J; Tomita, M; Yoshida, T, 2009) |
" A one-compartment open pharmacokinetic model with first-order elimination was used." | 1.33 | Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants. ( Minemoto, M; Suematsu, F; Yukawa, E; Yukawa, M, 2005) |
"25 mg/kg/day)-injected castrated male Crj:CD(SD) IGS rats (seven weeks of age) were dosed for 10 days by oral gavage with vehicle (corn oil) or the following chemicals: propylthiouracil (PTU; 2." | 1.32 | Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators. ( Kawamura, S; Kunimatsu, T; Mikami, N; Miyata, K; Okuno, Y; Seki, T; Sukata, T; Yabushita, S; Yamada, T, 2004) |
"To develop a population pharmacokinetic model to evaluate the effects of variety of covariates on clearance of carbamazepine (CBZ) and its main metabolite carbamazepine-10,11-epoxide (CBZE) in Chinese population." | 1.32 | Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data. ( Jiao, Z; Shi, XJ; Zhao, ZG; Zhong, MK, 2004) |
" For the current studies, male rats were dosed for 15 days via oral gavage and euthanized on the morning of test day 15." | 1.31 | Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators. ( Frame, SR; Ladics, GS; O'Connor, JC, 2002) |
"In PB- and BS-treated livers, hepatomegaly was attributable to hepatocyte proliferation and enzyme induction." | 1.31 | Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates. ( Fujieda, Y; Furukawa, S; Goryo, M; Hayashi, K; Ikeyama, S; Miyamoto, Y; Okada, K; Tamura, T; Usuda, K, 2000) |
" Pharmacokinetic interactions between antiepileptic drugs represent a major complication of epilepsy treatment with polytherapy." | 1.31 | Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview. ( Yukawa, E, 2000) |
" Weanling male CD rats (21 days old) were dosed for 30 d by gavage with vehicle (0." | 1.31 | Evaluation of the male pubertal assay's ability to detect thyroid inhibitors and dopaminergic agents. ( Carney, EW; Crissman, JW; Marty, MS, 2001) |
"The average numbers of liver neoplasms in groups 2 and 3 were significantly smaller than in group 1 (P < 0." | 1.31 | Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats. ( Mori, H; Okamoto, K; Rahman, KM; Sugie, S; Ushida, J; Watanabe, T, 2001) |
"Tamoxifen is a potent rat liver carcinogen, currently being used as a long-term chemopreventative for breast cancer in healthy women." | 1.31 | Cumulative exposure to tamoxifen: DNA adducts and liver cancer in the rat. ( Carthew, P; Edwards, RE; Heydon, RT; Lee, PN; Martin, EA; Nolan, BM, 2001) |
" Separate groups of mice were given phenobarbital (PB) parenterally by intraperitoneal injection at a dosage of 160 mg/kg/day for 3 days." | 1.30 | Opposite effects of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice. ( Birnbaum, LS; DeVito, MJ; Riddle, MM; Smialowicz, RJ; Williams, WC, 1997) |
"The total body weight was decreased under all experimental conditions." | 1.30 | Sublethal effects of hexavalent chromium on the body growth rate and liver function enzymes of phenobarbitone-pretreated and promethazine-pretreated rabbits. ( Anjum, F; Shakoori, AR, 1997) |
" Patients received phenobarbitone as monotherapy or in combination with either of the antiepileptic drugs carbamazepine or valproic acid." | 1.30 | Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1998) |
"As phenobarbital also has a hepatotrophic effect, its role in liver regeneration following partial hepatectomy (HTX) is not elucidated." | 1.30 | Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration. ( Hashimoto, M; Kothary, PC; Raper, SE, 1999) |
"Phenobarbital sodium (PB) was administered at dietary levels of 0 (control), 8, 30, 125 and 500 ppm to groups of 20 male F344/DuCrj rats for 104 weeks." | 1.30 | Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats. ( Fukushima, S; Funae, Y; Hagiwara, A; Ito, N; Masuda, C; Miyata, E; Sano, M; Shirai, T; Tamano, S, 1999) |
"Chloroform treatment did not affect the activity of N-nitrosodimethylamine N-demethylase in pretreated rats; the high dose increased the activity in control rats." | 1.29 | Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat. ( Aoyama, T; Elovaara, E; Gelboin, HV; Klockars, M; Nakajima, T; Okino, T; Riihimäki, V; Vainio, H, 1995) |
" However, there are no dose-response studies to address the relationship between induction of hepatic UDP-GT and alteration in thyroid homeostasis." | 1.29 | Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study. ( Barter, RA; Klaassen, CD; Liu, J; Liu, Y, 1995) |
"05), area under the curve and terminal half-life were significantly increased (p < 0." | 1.29 | Indocyanine green pharmacokinetics in rats with progressive carbon tetrachloride-induced hepatocellular insufficiency. ( Delrat, P; Dupin, S; Houin, G; Le Quellec, A; Voigt, JJ, 1994) |
" PB pretreatment also enhanced some monitored renal effects of a toxic dose (0." | 1.29 | Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat. ( Anestis, DK; Beers, KW; Brown, PI; Nicoll, DW; Rankin, GO, 1993) |
" These values are similar to those previously reported from both traditional and NONMEM pharmacokinetic studies." | 1.29 | Determination of phenobarbitone population clearance values for South African children. ( Botha, JH; Gray, AL; Miller, R, 1995) |
"Treatment with phenobarbital, which increased steady-state RcGshT mRNA by five- to sixfold, RcGshT polypeptide, and biliary GSH secretion by onefold in controls, had a smaller effect on steady-state RcGshT-mRNA level in EHBR (by 1." | 1.29 | Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats. ( Cai, J; Horie, T; Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Sun, WM; Takenaka, O; Takikawa, H; Yi, J, 1996) |
"Benzene is a known carcinogen and hematopoietic toxin in humans and experimental animals." | 1.29 | Repeated oral benzene exposure alters enzymes involved in benzene metabolism. ( Carr, JB; Daiker, DH; Moslen, MT; Ward, JB, 1996) |
"Routine clinical pharmacokinetic data collected from patients receiving phenobarbitone have been analysed to evaluate the role of patient characteristics for estimating dosing regimens." | 1.28 | Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens. ( Aoyama, T; Higuchi, S; Yukawa, E, 1992) |
"Phenobarbital treatment increased mRNA levels in both genders." | 1.28 | Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver. ( Callaerts, A; Coecke, S; Guillouzo, A; Morel, F; Rogiers, V; Van Bezooijen, CF; Vandenberghe, Y; Vercruysse, A; Verleye, G, 1991) |
"Pretreatment with phenobarbital (PB, 3 x 80 mg/kg i." | 1.28 | Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule. ( Charles, SJ; Connolly, AK; Powell, CJ, 1991) |
" Four-day-old female F344/N rats were dosed with diethylnitrosamine (10 mg/kg)." | 1.28 | Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis. ( Duitsman, P; Hendrich, S; Jackson, A; Krueger, SK; Myers, RK, 1991) |
"Phenobarbital treatment caused an increase in ovulation rate that was most pronounced in thin ewes and those on the low-protein diet." | 1.28 | Effects of phenobarbital, dietary protein intake, and ewe liveweight on ovulation rate and concentrations of plasma FSH and hepatic microsomal enzymes. ( Cope, B; McGowan, LT; McLaughlin, R; Payne, E; Peterson, AJ; Smith, JF, 1990) |
" These findings should therefore be considered when defining dosage regimens or interpreting serum drug concentrations." | 1.28 | Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid. ( Aoyama, T; Higuchi, S; Hirata, K; Ieiri, I; Yamada, H, 1990) |
" An antipyrine pharmacokinetic and impedance analysis of 15 healthy male subjects was performed before and on the 14th day of phenobarbital administration (i." | 1.28 | Bioimpedance assessment of antipyrine pharmacokinetics before and after enzyme induction. ( Peterson, EL; Pilla, AM; Popovich, J; Svensson, CK; Zarowitz, BJ, 1990) |
"The dose-response and plasma concentration-response relationships of cyclosporine after both inducing and inhibiting its metabolism were studied in a mouse heart transplant model." | 1.28 | In vivo evaluation of the effects of altered cyclosporine metabolism on its immunosuppressive potency. ( Babany, G; Babany, I; Kates, RE; Morris, RE; Shepherd, S, 1989) |
" The ip LD50 of PC in Swiss male mice was 22 mmol/kg." | 1.27 | Toxicity of 1-phenylcyclohexene and its interaction with phencyclidine. ( Berg, IE; Chaturvedi, AK; Choudhuri, MS; Hu, CY; Rao, NG, 1984) |
" Rats were treated orally with MPB (maintenance dosage = 800 mg/kg X 2/day), PHB (100 X 2) or COD (50 X 2) twice a day (10:00 a." | 1.27 | Physical dependence on meprobamate after repeated oral administration in rats. ( Nakamura, H; Shimizu, M, 1983) |
"Pretreatment with phenobarbital, piperonyl butoxide (2 h), SKF 525-A, or small multiple doses of OOS protected against the OOS-induced elevated level of bronchopulmonary lavage LDH, and the other signs of delayed toxicity including morphological alteration of Clara cells." | 1.27 | Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats. ( Fukuto, TR; Gandy, J; Hasegawa, L; Imamura, T, 1983) |
"Rats treated with clofibrate revealed foci of cellular alteration that were more often basophilic and occurred slightly sooner (wk 42) than those in untreated controls (wk 60)." | 1.27 | Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility. ( Greaves, P; Irisarri, E; Monro, AM, 1986) |
"When phenobarbital was present in the diet, feeding the high polyunsaturated fat diet slightly increased the number of GGT-positive foci and the incidence of tumors." | 1.27 | Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats. ( Glauert, HP; Pitot, HC, 1986) |
" Ethylmorphine N-demethylation was decreased after dosing with the imidazo[4,5-b]pyridine-containing drug." | 1.27 | The induction profile of three orally active imidazopyridine-containing cardiotonic agents in rat hepatic microsomes. ( Bernstein, JR; Franklin, RB, 1986) |
"The incidence of thyroid adenomas and cancers was 20% (4/20) and 10% (2/20) in rats treated with DHPN alone." | 1.27 | Effects of castration before and after treatment with N-bis (2-hydroxypropyl)-nitrosamine (DHPN) on the development of thyroid tumors in rats treated with DHPN followed by phenobarbital. ( Hashimoto, H; Hiasa, Y; Katoh, Y; Kitahori, Y; Konishi, N; Minami, S; Murata, Y; Ohshima, M; Sakaguchi, Y; Shimoyama, T, 1987) |
" Most of the adverse effects of this dose of phenobarbitone in the gerbil can thus be seen to be associated either with reproductive impairment or with exposure during sensitive periods of early development." | 1.27 | Phenobarbitone: adverse effects on reproductive performance and offspring development in the Mongolian gerbil, (Meriones unguiculatus). ( Chapman, JB; Cutler, MG, 1988) |
"Phenobarbital treatment increased liver weight and mean hepatocyte volume by 39 and 26%, respectively, while total DNA content did not change, thus indicating that the hepatomegaly results principally from hypertrophy rather than hyperplasia." | 1.27 | Bile acid secretion and pool size during phenobarbital induced hypercholeresis. ( Alpini, G; Berk, PD; Jones, MJ; Kiang, CL; Okuda, H; Sorrentino, D; Tavoloni, N, 1988) |
"In benzyl isothiocyanate-treated animals, an induction of subunit 3 was found as well as an increase in the relative amount of subunit 2." | 1.27 | Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene. ( Müller, F; Snoek, MC; van Berkel, WJ; van Bladeren, PJ; Vos, RM, 1988) |
"To study the effects of SKF-525A, an inhibitor of cytochrome P-450, and of sodium phenobarbital (PB), a drug-metabolizing enzyme inducer, on the teratogenicity of thiabendazole (TBZ), pregnant mice were given ip either a single dose of 40 mg SKF-525A/kg 1 hr before oral dosing with 250 or 500 mg TBZ/kg or a dose of 75 mg PB/kg/day on three consecutive days before oral administration of a dose of 500 or 1000 mg TBZ/kg." | 1.27 | Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice. ( Imamichi, T; Ogata, A; Sasaki, M; Suzuki, K; Yoneyama, M, 1987) |
"Clotrimazole treatment, in contrast to phenobarbital treatment, also caused a large induction of l-naphthol glucuronosyltransferase in females." | 1.27 | Induction of hepatic oxidative and conjugative drug metabolism in the hamster by N-substituted imidazoles. ( Franklin, MR; Ritter, JK, 1987) |
"Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil." | 1.27 | The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. ( Herren-Freund, SL; Khoury, MD; Olson, G; Pereira, MA, 1987) |
"Diazepam was more effective than oxazepam and its effect was proportionate to dose." | 1.27 | Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver. ( Diwan, BA; Rice, JM; Ward, JM, 1986) |
" The activities of NADPH-cytochrome P-450 reductase, AHH, and ECOD following treatment with HCB were similar to those found after dosing with PB." | 1.27 | A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail. ( Buhler, DR; Carpenter, HM; Williams, DE, 1985) |
"Phenobarbital pretreatment prevented the convulsions and pulmonary damage produced by a 50 mg/kg i." | 1.27 | The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat. ( Hanzlik, RP; Hogberg, K; Penney, DA; Traiger, GJ, 1985) |
"The LD50 of phencyclidine (PCP, 234 mumol/kg, i." | 1.26 | The role of hepatic microsomal enzymes in the modulation of phencyclidine-induced toxicity. ( Berg, IE; Chaturvedi, AK; Rao, NG, 1981) |
"In phenobarbital-treated rats disulfiram 100 mg/kg did not alter the induction response as indicated by the cytochrome P-450 content, but inhibited the p-nitroanisole activity to control levels." | 1.26 | Effect of long-term disulfiram administration on rat liver. ( Andreasen, PB; Milandri, M; Poulsen, HE; Ranek, L, 1980) |
" PhB level in the serum increased parallel to the graded increment in dosage from 0." | 1.26 | Experimental dependence on barbiturates. II. Relationship between drug levels in serum and brain and the development of dependence in rats. ( Izumi, T; Tagashira, E; Yanaura, S, 1979) |
" 3,4,3',4'-Tetrachlorobiphenyl was also toxic at a dose of 50 mg/kg, in keeping with its weak MC-type-inducing ability." | 1.26 | Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats. ( Miki, M; Ozawa, N; Yoshihara, S; Yoshimura, H, 1979) |
"Phenobarbital pretreatment provided little or no protection." | 1.26 | Iodipamide hepatotoxicity in the rat. ( Barnhart, JL; Burk, RF, 1979) |
" The plasma level/dosage ratio has been found to have a highly significant correlation with the age of the patient both for dosage in mg/kg and in mg/m2." | 1.26 | Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children. ( Nino, LM; Principi, N; Rossi, LN, 1979) |
" The acute LD50 for MIS was increased from 1." | 1.26 | Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice. ( Workman, P, 1979) |
" the first dosing period was 42 dyas (6 weeks) in which drugs were repeatedly administered orally once daily, followed by a withdrawal period (7 days), the second dosing period was continued from the 50th-78th day in which the form and schedule of drug administration was as in the first dosing period." | 1.26 | [Studies on the physical dependence liability of chlorphenesin carbamate (author's transl)]. ( Aihara, H; Saito, S; Sasajima, M; Tanaka, Y; Tarumoto, Y, 1977) |
"Phenobarbital treatment induced the activities of all drug enzymes and inhibited the lipid peroxidation in either sex during the period of thiamine deficiency." | 1.26 | Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats. ( Galdhar, NR; Pawar, SS, 1976) |
"Phenobarbital treatment antagonized THC-induced reduction of fetal body weight, but did not reduce resorption rate." | 1.26 | Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism. ( Harbison, RD; Lubin, DJ; Mantilla-Plata, B, 1977) |
"Phenobarbital was administered daily to rat pups during the period of their brain growth spurt." | 1.26 | Phenobarbital-induced brain growth retardation in artificially reared rat pups. ( Bailey, BG; Diaz, J; Schain, RJ, 1977) |
"In these tests latency to convulsions and lethality associated with electroshock were more sensitive to THC." | 1.26 | Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice. ( Barry, H; Sofia, RD, 1977) |
" Subtherapeutic levels appear to be due to inadequate dosage adjustment." | 1.26 | The necessity of drug level monitoring in anticonvulsant drug therapy. ( Bailey, DG; Davis, HL; Johnson, GE; Wilson, TW, 1976) |
" Evaluation of dose-response curves revealed saturation phenomena." | 1.26 | Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat. ( Bircher, J; Lauterburg, BH, 1976) |
" The rats (drug dependence-experimented rats) who survived the first stage of this experiment were continuously subjected to re-administration by the same dosage schedule as in Exp." | 1.25 | [Comparison of development of drug dependence in naive and drug dependence-experienced rats]. ( Tagashira, E; Yanaura, S, 1975) |
" Physical dependence on phenobarbital and diazepam was produced using the same dosage schedules as with morphine." | 1.25 | Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. ( Suzuki, T; Tagashira, E; Yanaura, S, 1975) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 332 (69.31) | 18.7374 |
1990's | 100 (20.88) | 18.2507 |
2000's | 32 (6.68) | 29.6817 |
2010's | 13 (2.71) | 24.3611 |
2020's | 2 (0.42) | 2.80 |
Authors | Studies |
---|---|
Flaherty, PT | 1 |
Greenwood, TD | 1 |
Manheim, AL | 1 |
Wolfe, JF | 1 |
Nese, M | 1 |
Riboli, G | 1 |
Brighetti, G | 1 |
Sassi, V | 1 |
Camela, E | 1 |
Caselli, G | 1 |
Sassaroli, S | 1 |
Borlimi, R | 1 |
Aucoin, M | 1 |
Cooley, K | 1 |
Saunders, PR | 1 |
Carè, J | 1 |
Anheyer, D | 1 |
Medina, DN | 1 |
Cardozo, V | 1 |
Remy, D | 1 |
Hannan, N | 1 |
Garber, A | 1 |
Velayos, M | 1 |
Muñoz-Serrano, AJ | 1 |
Estefanía-Fernández, K | 1 |
Sarmiento Caldas, MC | 1 |
Moratilla Lapeña, L | 1 |
López-Santamaría, M | 1 |
López-Gutiérrez, JC | 1 |
Li, J | 2 |
Zhang, J | 1 |
Shen, S | 1 |
Zhang, B | 2 |
Yu, WW | 1 |
Toyoda, H | 1 |
Huang, DQ | 1 |
Le, MH | 1 |
Nguyen, MH | 1 |
Huang, R | 1 |
Zhu, L | 1 |
Wang, J | 6 |
Xue, L | 1 |
Liu, L | 2 |
Yan, X | 2 |
Huang, S | 1 |
Li, Y | 6 |
Xu, T | 1 |
Li, C | 2 |
Ji, F | 1 |
Ming, F | 1 |
Zhao, Y | 2 |
Cheng, J | 1 |
Wang, Y | 3 |
Zhao, H | 1 |
Hong, S | 1 |
Chen, K | 2 |
Zhao, XA | 1 |
Zou, L | 1 |
Sang, D | 1 |
Shao, H | 1 |
Guan, X | 1 |
Chen, X | 2 |
Chen, Y | 4 |
Wei, J | 1 |
Zhu, C | 1 |
Wu, C | 1 |
Moore, HB | 1 |
Barrett, CD | 1 |
Moore, EE | 1 |
Jhunjhunwala, R | 1 |
McIntyre, RC | 1 |
Moore, PK | 1 |
Hajizadeh, N | 1 |
Talmor, DS | 1 |
Sauaia, A | 1 |
Yaffe, MB | 1 |
Liu, C | 3 |
Lin, Y | 1 |
Dong, Y | 1 |
Wu, Y | 1 |
Bao, Y | 1 |
Yan, H | 2 |
Ma, J | 1 |
Fernández-Cuadros, ME | 1 |
Albaladejo-Florín, MJ | 1 |
Álava-Rabasa, S | 1 |
Usandizaga-Elio, I | 1 |
Martinez-Quintanilla Jimenez, D | 1 |
Peña-Lora, D | 1 |
Neira-Borrajo, I | 1 |
López-Muñoz, MJ | 1 |
Rodríguez-de-Cía, J | 1 |
Pérez-Moro, OS | 1 |
Abdallah, M | 1 |
Alsaleh, H | 1 |
Baradwan, A | 1 |
Alfawares, R | 1 |
Alobaid, A | 1 |
Rasheed, A | 1 |
Soliman, I | 1 |
Wendel Garcia, PD | 1 |
Fumeaux, T | 1 |
Guerci, P | 1 |
Heuberger, DM | 1 |
Montomoli, J | 2 |
Roche-Campo, F | 1 |
Schuepbach, RA | 1 |
Hilty, MP | 1 |
Poloni, TE | 1 |
Carlos, AF | 1 |
Cairati, M | 1 |
Cutaia, C | 1 |
Medici, V | 1 |
Marelli, E | 1 |
Ferrari, D | 1 |
Galli, A | 1 |
Bognetti, P | 1 |
Davin, A | 1 |
Cirrincione, A | 1 |
Ceretti, A | 1 |
Cereda, C | 1 |
Ceroni, M | 1 |
Tronconi, L | 1 |
Vitali, S | 1 |
Guaita, A | 1 |
Leeds, JS | 1 |
Raviprakash, V | 1 |
Jacques, T | 1 |
Scanlon, N | 1 |
Cundall, J | 1 |
Leeds, CM | 1 |
Riva, A | 1 |
Gray, EH | 1 |
Azarian, S | 1 |
Zamalloa, A | 1 |
McPhail, MJW | 1 |
Vincent, RP | 1 |
Williams, R | 3 |
Chokshi, S | 1 |
Patel, VC | 1 |
Edwards, LA | 1 |
Alqarawi, W | 1 |
Birnie, DH | 1 |
Golian, M | 1 |
Nair, GM | 1 |
Nery, PB | 1 |
Klein, A | 1 |
Davis, DR | 1 |
Sadek, MM | 1 |
Neilipovitz, D | 1 |
Johnson, CB | 1 |
Green, MS | 1 |
Redpath, C | 1 |
Miller, DC | 1 |
Beamer, P | 1 |
Billheimer, D | 1 |
Subbian, V | 1 |
Sorooshian, A | 1 |
Campbell, BS | 1 |
Mosier, JM | 1 |
Novaretti, JV | 1 |
Astur, DC | 1 |
Cavalcante, ELB | 1 |
Kaleka, CC | 1 |
Amaro, JT | 1 |
Cohen, M | 1 |
Huang, W | 1 |
Li, T | 1 |
Ling, Y | 1 |
Qian, ZP | 1 |
Zhang, YY | 1 |
Huang, D | 1 |
Xu, SB | 1 |
Liu, XH | 1 |
Xia, L | 1 |
Yang, Y | 3 |
Lu, SH | 1 |
Lu, HZ | 1 |
Zhang, R | 2 |
Ma, JX | 1 |
Tang, S | 1 |
Li, CM | 1 |
Wan, J | 1 |
Wang, JF | 1 |
Ma, JQ | 1 |
Luo, JJ | 1 |
Chen, HY | 2 |
Mi, SL | 1 |
Chen, SY | 1 |
Su, YG | 1 |
Ge, JB | 1 |
Milheiro, SA | 1 |
Gonçalves, J | 1 |
Lopes, RMRM | 1 |
Madureira, M | 1 |
Lobo, L | 1 |
Lopes, A | 1 |
Nogueira, F | 1 |
Fontinha, D | 1 |
Prudêncio, M | 1 |
M Piedade, MF | 1 |
Pinto, SN | 1 |
Florindo, PR | 1 |
Moreira, R | 1 |
Castillo-Lora, J | 1 |
Delley, MF | 1 |
Laga, SM | 1 |
Mayer, JM | 1 |
Sutjarit, N | 1 |
Thongon, N | 1 |
Weerachayaphorn, J | 1 |
Piyachaturawat, P | 1 |
Suksamrarn, A | 1 |
Suksen, K | 1 |
Papachristou, DJ | 1 |
Blair, HC | 1 |
Hu, Y | 1 |
Shen, P | 1 |
Zeng, N | 1 |
Wang, L | 3 |
Yan, D | 1 |
Cui, L | 1 |
Yang, K | 2 |
Zhai, C | 1 |
Yang, M | 1 |
Lao, X | 1 |
Sun, J | 1 |
Ma, N | 1 |
Wang, S | 1 |
Ye, W | 1 |
Guo, P | 1 |
Rahimi, S | 1 |
Singh, MP | 1 |
Gupta, J | 1 |
Nakanishi, I | 1 |
Ohkubo, K | 1 |
Shoji, Y | 1 |
Fujitaka, Y | 1 |
Shimoda, K | 1 |
Matsumoto, KI | 1 |
Fukuhara, K | 1 |
Hamada, H | 1 |
van der Boom, T | 1 |
Gruppen, EG | 1 |
Lefrandt, JD | 1 |
Connelly, MA | 1 |
Links, TP | 1 |
Dullaart, RPF | 1 |
Berry, JD | 1 |
Bedlack, R | 1 |
Mathews, D | 1 |
Agnese, W | 1 |
Apple, S | 1 |
Meloncelli, S | 1 |
Divizia, M | 1 |
Germani, G | 1 |
Adefegha, SA | 1 |
Bottari, NB | 1 |
Leal, DB | 1 |
de Andrade, CM | 1 |
Schetinger, MR | 1 |
Martínez-Velasco, A | 1 |
Perez-Ortiz, AC | 1 |
Antonio-Aguirre, B | 1 |
Martínez-Villaseñor, L | 1 |
Lira-Romero, E | 1 |
Palacio-Pastrana, C | 1 |
Zenteno, JC | 1 |
Ramirez, I | 1 |
Zepeda-Palacio, C | 1 |
Mendoza-Velásquez, C | 1 |
Camacho-Ordóñez, A | 1 |
Ortiz Bibriesca, DM | 1 |
Estrada-Mena, FJ | 1 |
Martin, BL | 1 |
Thompson, LC | 1 |
Kim, YH | 2 |
Snow, SJ | 1 |
Schladweiler, MC | 1 |
Phillips, P | 1 |
Harmon, M | 1 |
King, C | 1 |
Richards, J | 1 |
George, I | 1 |
Haykal-Coates, N | 1 |
Gilmour, MI | 1 |
Kodavanti, UP | 1 |
Hazari, MS | 1 |
Farraj, AK | 1 |
Shen, Z | 1 |
Zou, Y | 1 |
Gao, K | 1 |
Lazar, S | 1 |
Wurtzel, JGT | 1 |
Ma, P | 1 |
Goldfinger, LE | 1 |
Vukelic, M | 1 |
Laloo, A | 1 |
Kyttaris, VC | 1 |
Chen, R | 1 |
Chen, J | 2 |
Xun, J | 1 |
Hu, Z | 1 |
Huang, Q | 2 |
Steinhart, C | 1 |
Shen, Y | 1 |
Lu, H | 1 |
Mansuri, A | 1 |
Lokhande, K | 1 |
Kore, S | 1 |
Gaikwad, S | 1 |
Nawani, N | 1 |
Swamy, KV | 1 |
Junnarkar, M | 1 |
Pawar, S | 1 |
Shaheen, MY | 1 |
Basudan, AM | 1 |
Niazy, AA | 1 |
van den Beucken, JJJP | 1 |
Jansen, JA | 1 |
Alghamdi, HS | 1 |
Gao, Q | 2 |
Guo, X | 1 |
Cao, Y | 1 |
Jia, X | 1 |
Xu, S | 1 |
Lu, C | 2 |
Zhu, H | 2 |
Melku, M | 1 |
Abebe, G | 1 |
Teketel, A | 1 |
Asrie, F | 1 |
Yalew, A | 1 |
Biadgo, B | 1 |
Kassa, E | 1 |
Damtie, D | 1 |
Anlay, DZ | 1 |
Ahmed, MFE | 1 |
Ramadan, H | 1 |
Seinige, D | 1 |
Kehrenberg, C | 1 |
Abd El-Wahab, A | 1 |
Volkmann, N | 1 |
Kemper, N | 1 |
Schulz, J | 1 |
Hu, MY | 1 |
Wu, YN | 1 |
McEvoy, MP | 1 |
Wang, YF | 1 |
Cong, WL | 1 |
Liu, LP | 1 |
Li, XX | 1 |
Zhou, CL | 1 |
Chen, WM | 1 |
Wei, KL | 1 |
Tung, SY | 1 |
Shen, CH | 1 |
Chang, TS | 1 |
Yen, CW | 1 |
Hsieh, YY | 1 |
Chiu, WN | 1 |
Hu, JH | 1 |
Lu, SN | 1 |
Hung, CH | 1 |
Alakavuklar, MA | 1 |
Fuqua, C | 1 |
Luo, KL | 1 |
Underwood, RS | 1 |
Greenwald, I | 1 |
Elashiry, MM | 1 |
Elashiry, M | 1 |
Zeitoun, R | 1 |
Elsayed, R | 1 |
Tian, F | 1 |
Saber, SE | 1 |
Elashry, SH | 1 |
Tay, FR | 1 |
Cutler, CW | 1 |
O'Dowd, A | 1 |
Maciel, M | 1 |
Poole, ST | 1 |
Jobling, MG | 1 |
Rollenhagen, JE | 1 |
Woods, CM | 1 |
Sincock, SA | 1 |
McVeigh, AL | 1 |
Gregory, MJ | 1 |
Maves, RC | 1 |
Prouty, MG | 1 |
Holmes, RK | 1 |
Savarino, SJ | 1 |
Mor, MK | 1 |
Palevsky, PM | 1 |
Kaufman, JS | 1 |
Thiessen Philbrook, H | 1 |
Weisbord, SD | 1 |
Parikh, CR | 1 |
John, CM | 1 |
Phillips, NJ | 1 |
Jarvis, GA | 1 |
Zhu, Y | 1 |
Kilburn, S | 1 |
Kapoor, M | 1 |
Chaturvedi, S | 1 |
Shaw, KJ | 1 |
Chaturvedi, V | 1 |
Kong, X | 1 |
Zhang, T | 1 |
Xiao, H | 1 |
Feng, X | 1 |
Tu, H | 1 |
Feng, J | 1 |
Sabet, M | 1 |
Tarazi, Z | 1 |
Griffith, DC | 1 |
Nguyen, F | 1 |
Guan, P | 1 |
Guerrero, DT | 1 |
Kolla, V | 1 |
Naraparaju, K | 1 |
Perry, LM | 1 |
Soberman, D | 1 |
Pressly, BB | 1 |
Alferiev, IS | 1 |
Chorny, M | 1 |
Brodeur, GM | 1 |
Gao, X | 2 |
Cheng, YH | 1 |
Enten, GA | 1 |
DeSantis, AJ | 1 |
Gaponenko, V | 1 |
Majetschak, M | 1 |
Kim, DY | 1 |
Choi, MJ | 1 |
Ko, TK | 1 |
Lee, NH | 2 |
Kim, OH | 1 |
Cheon, HG | 1 |
Cai, H | 1 |
Yip, V | 1 |
Lee, MV | 1 |
Wong, S | 1 |
Saad, O | 1 |
Ma, S | 1 |
Ljumanovic, N | 1 |
Khojasteh, SC | 1 |
Kamath, AV | 1 |
Shen, BQ | 1 |
Cuypers, ML | 1 |
Chanteux, H | 1 |
Gillent, E | 1 |
Bonnaillie, P | 1 |
Saunders, K | 1 |
Beckers, C | 1 |
Delatour, C | 1 |
Dell'Aiera, S | 1 |
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Gray, JE | 1 |
Hoffman, AM | 1 |
Li, X | 4 |
Post, AK | 1 |
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Collins, SL | 1 |
Luo, Y | 1 |
Smith, MD | 1 |
Temitayo, GI | 1 |
Olawande, B | 1 |
Emmanuel, YO | 1 |
Timothy, AT | 1 |
Kehinde, O | 1 |
Susan, LF | 1 |
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Joseph, OO | 1 |
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Desmarini, D | 1 |
Liuwantara, D | 1 |
Sorrell, TC | 1 |
Hawthorne, WJ | 1 |
Djordjevic, JT | 1 |
Verso, MG | 1 |
Costantino, C | 1 |
Marrella, A | 1 |
Immordino, P | 1 |
Vitale, F | 1 |
Amodio, E | 1 |
Wang, YD | 1 |
Yao, WL | 1 |
Xin, ZM | 1 |
Han, TT | 1 |
Wang, ZG | 1 |
Chen, L | 1 |
Cai, C | 1 |
Zhang, Y | 4 |
Ba, D | 1 |
Wen, S | 1 |
Tian, Q | 1 |
Lv, W | 1 |
Cheng, G | 1 |
Li, N | 1 |
Yue, XY | 1 |
Chu, WJ | 1 |
Chen, Q | 1 |
Choi, ES | 1 |
Zhao, X | 3 |
Zhou, HD | 1 |
Sun, XF | 1 |
Sharma, S | 2 |
Chhoker, S | 1 |
Xie, C | 1 |
Ong, EWY | 1 |
Tan, ZK | 1 |
Evans, S | 1 |
Weinheimer, CJ | 1 |
Kovacs, A | 1 |
Williams, JW | 1 |
Randolph, GJ | 1 |
Jiang, W | 1 |
Barger, PM | 1 |
Mann, DL | 1 |
Liu, J | 3 |
Huang, Y | 1 |
Kong, L | 1 |
Yu, X | 1 |
Feng, B | 1 |
Liu, D | 1 |
Zhao, B | 1 |
Mendes, GC | 1 |
Yuan, P | 1 |
Ge, D | 1 |
Wang, WM | 1 |
Fontes, EPB | 1 |
Li, P | 1 |
Shan, L | 1 |
He, P | 1 |
Katoh, T | 1 |
Sengoku, T | 1 |
Hirata, K | 3 |
Ogata, K | 1 |
Suga, H | 1 |
Shun, C | 1 |
Yong-Yi, J | 1 |
Mei-Li, C | 1 |
Shi-Li, L | 1 |
Jian-Bo, Z | 1 |
Dan-Li, W | 1 |
Zhi-Min, G | 1 |
Ibrahim, AM | 1 |
Zakhary, SY | 1 |
Amin, SAW | 1 |
Ugurlu, M | 1 |
Fornari, VJ | 1 |
Hartmann, MSM | 1 |
Vanni, JR | 1 |
Rodriguez, R | 1 |
Langaro, MC | 1 |
Pelepenko, LE | 1 |
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Nakanjako, D | 1 |
Zalwango, F | 1 |
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Andia Biraro, I | 1 |
Bukirwa, VD | 1 |
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Elliott, A | 1 |
Zhao, G | 1 |
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Hao, S | 1 |
Wang, X | 1 |
Qu, G | 1 |
Xing, Y | 1 |
Xu, X | 1 |
Maierhofer, M | 1 |
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Mayr, T | 1 |
Liu, Y | 3 |
Zhang, Q | 1 |
Bigliardi, AP | 1 |
Fernandes, CLF | 1 |
Pinto, EA | 1 |
Dos Santos, M | 1 |
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Baisch, PRM | 1 |
Soares, MCF | 1 |
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da Silva Júnior, FMR | 1 |
Yu, W | 1 |
Ju, C | 1 |
Wang, K | 1 |
Zheng, Z | 1 |
Liu, H | 1 |
Gao, Y | 1 |
Martínez-Navarro, EM | 1 |
Cebrián-Tarancón, C | 1 |
Moratalla-López, N | 1 |
Lorenzo, C | 1 |
Alonso, GL | 1 |
Salinas, RM | 1 |
Bermúdez de Castro, JM | 1 |
Modesto-Mata, M | 1 |
Martín-Francés, L | 1 |
García-Campos, C | 1 |
Martínez de Pinillos, M | 1 |
Martinón-Torres, M | 1 |
Hasani, M | 1 |
Wu, F | 2 |
Warriner, K | 1 |
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Gretzke, D | 1 |
Hörlein, R | 1 |
Turpault, S | 1 |
Atzrodt, J | 1 |
Derdau, V | 1 |
Yao, Y | 1 |
Ou, X | 1 |
Zhao, S | 1 |
Tian, B | 1 |
Jin, S | 1 |
Jiang, Z | 1 |
Zhou, Z | 1 |
Liu, M | 2 |
Jiang, GD | 1 |
Mou, LH | 1 |
Chen, JJ | 3 |
Li, ZY | 1 |
He, SG | 1 |
Reale, E | 1 |
Fustinoni, S | 1 |
Mercadante, R | 1 |
Polledri, E | 1 |
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Grant, PC | 1 |
Levy, K | 1 |
Lattimer, TA | 1 |
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Kerr, CW | 1 |
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Uemoto, AT | 1 |
Dos Santos, MP | 1 |
Barion, MRL | 1 |
Carciofi, AC | 1 |
de Paula Dorigam, JC | 1 |
Ribeiro, LB | 1 |
Vasconcellos, RS | 1 |
Waller, SB | 1 |
Peter, CM | 1 |
Hoffmann, JF | 1 |
Cleff, MB | 1 |
Faria de, RO | 1 |
Zani, JL | 1 |
Martins, BA | 1 |
Sande, D | 1 |
Solares, MD | 1 |
Takahashi, JA | 1 |
Yang, S | 2 |
Jia, Y | 1 |
Yin, C | 1 |
Zhao, R | 1 |
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Wu, B | 2 |
Deepa, M | 1 |
Mo, J | 1 |
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Wan, MT | 1 |
Shi, J | 1 |
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Winkler, C | 1 |
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Saejio, A | 1 |
Shanmugam, S | 1 |
Liu, X | 1 |
Sun, M | 1 |
Bai, Z | 1 |
Jaque-Fernandez, F | 1 |
Beaulant, A | 1 |
Berthier, C | 1 |
Monteiro, L | 1 |
Allard, B | 1 |
Casas, M | 1 |
Rieusset, J | 1 |
Jacquemond, V | 1 |
Góngora-García, OR | 1 |
Aca-Aca, G | 1 |
Baz-Rodríguez, SA | 1 |
Monte, A | 1 |
Maganaris, C | 1 |
Baltzopoulos, V | 1 |
Zamparo, P | 1 |
Wang, Z | 2 |
Hou, Y | 1 |
Cai, L | 1 |
Tu, YJ | 1 |
Tan, B | 1 |
Jiang, L | 1 |
Wu, ZH | 1 |
Yu, HJ | 1 |
Li, XQ | 1 |
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Thompson, RP | 1 |
Weibel, ER | 1 |
van den Brenk, HA | 1 |
Sharpington, C | 1 |
Hatfield, GK | 1 |
Miya, TS | 1 |
Bousquet, WF | 1 |
Marshall, A | 1 |
Yeung, CY | 1 |
Yu, VY | 1 |
Vapaatalo, H | 1 |
Lehtinen, L | 1 |
Vorne, M | 1 |
Kaltiala, EH | 1 |
Hänninen, O | 1 |
Kivisaari, E | 1 |
Antila, K | 1 |
Furner, RL | 1 |
Gram, TE | 1 |
Stitzel, RE | 1 |
Bond, EJ | 1 |
De Matteis, F | 1 |
Kaschnitz, R | 1 |
Ariyoshi, T | 1 |
Takabatake, E | 1 |
Remmer, H | 1 |
Fahim, MS | 1 |
Hall, DG | 1 |
Jones, TM | 1 |
Fahim, Z | 1 |
Whitt, FD | 1 |
Becker, BA | 2 |
Moore, MR | 1 |
Battistini, V | 1 |
Beattie, AD | 1 |
Goldberg, A | 1 |
Whittaker, JA | 1 |
Evans, DA | 1 |
Paulini, K | 1 |
Kulka, R | 1 |
Owen, NV | 1 |
Griffing, WJ | 1 |
Hoffman, DG | 1 |
Gibson, WR | 1 |
Anderson, RC | 1 |
Short, CR | 1 |
Yamamoto, RS | 1 |
Arai, Y | 2 |
Gorski, RA | 2 |
Huidobro, F | 1 |
Huidobro, JP | 1 |
Larraín, G | 1 |
Schwartz, HL | 1 |
Bernstein, G | 1 |
Oppenheimer, JH | 1 |
Sladek, NE | 1 |
Mannering, GJ | 1 |
Paalzow, L | 1 |
Loeb, L | 1 |
Leung, KC | 1 |
Stone, GS | 1 |
Hine, CH | 1 |
Juchau, MR | 1 |
4 reviews available for phenobarbital and Body Weight
Article | Year |
---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Protection by catatoxic steroids against cyclophosphamide-induced organ lesions.
Topics: Adrenal Glands; Animals; Body Weight; Bone Marrow; Cyclophosphamide; Desoxycorticosterone; Enzyme In | 1970 |
[On the problem of foreign substances detoxification through the liver].
Topics: Benzopyrenes; Body Weight; Carbon Monoxide Poisoning; Coumarins; Endoplasmic Reticulum; Freeze Dryin | 1968 |
5 trials available for phenobarbital and Body Weight
Article | Year |
---|---|
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; | 2022 |
[Elsinore banting tablets. A controlled clinical trial in general practice].
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Drug Combinations; Ephedrine; Female; Foll | 1980 |
Antenatal phenobarbital therapy and neonatal outcome. II: Neurodevelopmental outcome at 36 months.
Topics: Anticonvulsants; Body Height; Body Weight; Cerebral Hemorrhage; Child Development; Child, Preschool; | 1996 |
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D | 1996 |
Operative blood loss in guillotine tonsillectomy and adenoidectomy in children: a comparison of three premedicant drugs.
Topics: Adenoidectomy; Blood Volume; Body Weight; Child; Child, Preschool; Colorimetry; Diazepam; Female; He | 1973 |
471 other studies available for phenobarbital and Body Weight
Article | Year |
---|---|
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA | 1996 |
Development of an antiepileptogenesis drug screening platform: Effects of everolimus and phenobarbital.
Topics: Animals; Anticonvulsants; Body Weight; Convulsants; Cost of Illness; Disease Models, Animal; Drug Co | 2021 |
The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.
Topics: Adult; Body Weight; Humans; Infant, Newborn; Models, Biological; Obesity; Pharmacokinetics; Phenobar | 2019 |
[Vomiting associated with weight stagnation and convulsions: urea cycle disorder should be suspected].
Topics: Adolescent; Anticonvulsants; Body Weight; Failure to Thrive; Female; Headache; Humans; Hyperammonemi | 2018 |
Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice.
Topics: Alkylating Agents; Animals; beta Catenin; Blotting, Western; Body Weight; Cell Line, Tumor; Cell Pro | 2013 |
Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.
Topics: Animals; Body Weight; Cell Proliferation; Cyclin D1; Cytochrome P-450 CYP1A2; Drug Synergism; Fluoro | 2013 |
Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.
Topics: Animals; Base Sequence; Body Weight; Carcinogens; Constitutive Androstane Receptor; DNA Adducts; DNA | 2014 |
Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Diet; Enzyme Induction; Fumonisins; Glutat | 2008 |
Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response.
Topics: Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Analgesics, Non-Narcotic; Animals; Aspart | 2009 |
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: inhibition of cell proliferation and induction of apoptosis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Proliferation; Diethylnitrosamine; Di | 2009 |
Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse.
Topics: Animals; Body Weight; DNA Replication; Dose-Response Relationship, Drug; Female; Hepatocytes; Hypnot | 2009 |
Multiple organ toxicity, including hypochromic anemia, following repeated dose oral administration of phenobarbital (PB) in rats.
Topics: Administration, Oral; Anemia, Hypochromic; Animals; Body Weight; Eating; Female; Gait; Iron; Liver; | 2009 |
Factors influencing valproate pharmacokinetics in children and adults.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Pre | 2010 |
Assessment of subclinical, toxicant-induced hepatic gene expression profiles after low-dose, short-term exposures in mice.
Topics: Animals; Body Weight; Clinical Chemistry Tests; Cytochrome P-450 Enzyme System; Dose-Response Relati | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
Effect of vitamin E on hepatic cell proliferation and apoptosis in mice deficient in the p50 subunit of NF-κB after treatment with phenobarbital.
Topics: Animals; Antioxidants; Apoptosis; Body Weight; Cell Proliferation; Hepatocytes; Liver; Mice; Mice, I | 2011 |
Population pharmacokinetics of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants: an update.
Topics: Age Factors; Anticonvulsants; Asian People; Body Weight; Dose-Response Relationship, Drug; Drug Moni | 2011 |
A novel antihepatitis drug, bicyclol, prevents liver carcinogenesis in diethylnitrosamine-initiated and phenobarbital-promoted mice tumor model.
Topics: Analysis of Variance; Animals; Antineoplastic Agents; Biphenyl Compounds; Body Weight; Cell Line; Di | 2012 |
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dioxolanes; Dose-Response | 2012 |
Population pharmacokinetics of phenobarbital in infants with neonatal encephalopathy treated with therapeutic hypothermia.
Topics: Age Factors; Anticonvulsants; Body Temperature; Body Weight; Female; Humans; Hypothermia, Induced; H | 2013 |
Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators.
Topics: Androgens; Animals; Antibody Formation; Antithyroid Agents; Aromatase Inhibitors; Body Weight; Drug | 2002 |
Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat.
Topics: Animals; Body Weight; Clinical Enzyme Tests; Drug Synergism; Ethanol; Fatty Liver, Alcoholic; Hepato | 2002 |
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Beta vulgaris; Betacyanins; Body | 2003 |
Influence of recipient gender on cytochrome P450 isoforms expression in intrasplenic fetal liver tissue transplants in rats.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cell Transplantation; Cytochrome P-450 Enzyme System; Dex | 2003 |
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity.
Topics: Animal Feed; Animals; Aryl Hydrocarbon Hydroxylases; Bile Acids and Salts; Bilirubin; Biological Tra | 2003 |
Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Carotenoids; Disease Models, Animal; Food | 2003 |
[ON THE DURATION OF SLEEP INDUCED BY PHENOBARBITAL, MORPHINE, MEPROBAMATE, METAMINODIAZEPOXIDE AND CHLORPROMAZINE ACCORDING TO WEIGHT (AGE) IN THE GUINEA PIG].
Topics: Aging; Body Weight; Chlorpromazine; Guinea Pigs; Meprobamate; Morphine; Pharmacology; Phenobarbital; | 1963 |
Enhanced rat Hershberger assay appears reliable for detection of not only (anti-)androgenic chemicals but also thyroid hormone modulators.
Topics: Administration, Oral; Androgen Antagonists; Animals; Antithyroid Agents; Body Weight; Castration; Di | 2004 |
Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Asian People; Body Weight; Carbamazepine; | 2004 |
Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants.
Topics: Administration, Rectal; Aging; Biological Availability; Body Weight; Clinical Trials as Topic; Femal | 2005 |
The inhibitory effect of sodium selenite on N-nitrosodiethylamine-induced and phenobarbital promoted liver tumourigenesis in rats based on the modulation of polyamine levels.
Topics: alpha-Fetoproteins; Animals; Body Weight; Diethylnitrosamine; Liver; Liver Neoplasms, Experimental; | 2005 |
The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Cell Enlargement; Cell Proli | 2006 |
On the mechanism of hepatocarcinogenesis of benzodiazepines: evidence that diazepam and oxazepam are CYP2B inducers in rats, and both CYP2B and CYP4A inducers in mice.
Topics: Animals; Benzodiazepines; Blotting, Western; Body Weight; Carcinogens; Cytochrome P-450 CYP1A1; Cyto | 2006 |
Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats.
Topics: Anesthetics, General; Animals; Body Temperature; Body Weight; Diastole; Echocardiography, Doppler; H | 2007 |
Chemo-preventive effect of Star anise in N-nitrosodiethylamine initiated and phenobarbital promoted hepato-carcinogenesis.
Topics: Animals; Antioxidants; Body Weight; Cell Transformation, Neoplastic; Diethylnitrosamine; Erythrocyte | 2007 |
Sodium selenite enhances glutathione peroxidase activity and DNA strand breaks in hepatoma induced by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Alanine Transaminase; Animals; Body Weight; Carcinoma, Hepatocellular; Comet Assay; Diethylnitrosami | 2008 |
Response to neonatal anesthesia: effect of sex on anatomical and behavioral outcome.
Topics: Anesthesia; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Temperature; Body | 2008 |
Phenobarbital withdrawal weight loss is in part independent of ingestion.
Topics: Animals; Body Weight; Humans; Phenobarbital; Potassium; Rats; Sodium; Substance Withdrawal Syndrome; | 1966 |
Synergistic effect of a choline-devoid diet and phenobarbital in promoting the emergence of foci of gamma-glutamyltranspeptidase-positive hepatocytes in the liver of carcinogen-treated rats.
Topics: Animals; Body Weight; Choline; Cocarcinogenesis; Diet; Diethylnitrosamine; gamma-Glutamyltransferase | 1980 |
Effects of dietary vitamin E and selenium on the mixed-function oxygenase system of male and female chicks.
Topics: Animals; Body Weight; Chickens; Diet; Enzyme Induction; Female; Glutathione Peroxidase; Male; Mixed | 1981 |
Effects of prenatal maternal injections of phenobarbital on brain neurotransmitters and behavior of young C57 mice.
Topics: Animals; Behavior, Animal; Body Weight; Brain Chemistry; Female; Mice; Mice, Inbred C57BL; Neurotran | 1981 |
Effect of acute and chronic phenobarbital treatment on GABA and other amino acids contents in seven regions of the rat brain.
Topics: Amino Acids; Animals; Body Weight; Brain; gamma-Aminobutyric Acid; Humans; Liver; Male; Neurotransmi | 1982 |
Plasma alpha-fetoprotein elevation and mutagenicity of urine as early predictors of carcinogenecity in benzo(alpha)pyrene fed rats.
Topics: alpha-Fetoproteins; Animals; Benzo(a)pyrene; Benzopyrenes; Body Weight; Carcinogens; gamma-Glutamylt | 1981 |
Enhancement of carrageenan and dextran-induced edemas by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds.
Topics: Animals; Body Weight; Carrageenan; Cytochrome P-450 Enzyme System; Dextrans; Dioxins; Dose-Response | 1983 |
Kinetic alterations in rat liver microsomal cholecalciferol 25-hydroxylase associated with phenobarbital administration.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cholecalciferol; Cholestanetriol 26-Monooxygenase; | 1980 |
Biochemical studies on the toxicity of n-octane and n-nonane.
Topics: Alkanes; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Female; Glucose-6-Pho | 1980 |
Influence of vitamin D3 status, phenobarbital, and diphenylhydantoin treatment on the plasma 25-hydroxyvitamin D3 concentrations in the rat.
Topics: Alanine Transaminase; Aniline Hydroxylase; Animals; Body Weight; Calcifediol; Cholecalciferol; Cytoc | 1981 |
Dose-related effects of phenobarbital on hepatic microsomal enzymes.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induc | 1983 |
Hepatic tumor-promoting ability of 3,3',4,4',5,5'-hexabromobiphenyl: the interrelationship between toxicity, induction of hepatic microsomal drug metabolizing enzymes, and tumor-promoting ability.
Topics: Animals; Body Weight; Female; Liver Neoplasms; Organ Size; Phenobarbital; Polybrominated Biphenyls; | 1983 |
Long-term effects of neonatal phenobarbital exposure on aflatoxin b1 disposition in adult rats.
Topics: Aflatoxin B1; Aflatoxins; Age Factors; Animals; Animals, Newborn; Body Weight; DNA; Female; Liver; M | 1983 |
Experimental induction of chronic aflatoxicosis in chickens by purified aflatoxin B1 and its reversal by activated charcoal, phenobarbital, and reduced glutathione.
Topics: Aflatoxin B1; Aflatoxins; Animals; Aspartate Aminotransferases; Body Weight; Charcoal; Chickens; Chr | 1984 |
Toxicity of 1-phenylcyclohexene and its interaction with phencyclidine.
Topics: Animals; Body Temperature; Body Weight; Cyclohexanes; Glutathione; Lethal Dose 50; Liver; Male; Mice | 1984 |
In vitro hepatic enzyme activity in rats exposed nose-only to cigarette smoke.
Topics: Animals; Body Weight; Carboxyhemoglobin; Glutathione; In Vitro Techniques; Liver; Male; Methylcholan | 1984 |
Rat liver sulfotransferases: effects of gonadal hormones and other factors on enzyme activities.
Topics: Aging; Androsterone; Animals; Body Weight; Corticosterone; Cytosol; Estradiol; Gonadal Steroid Hormo | 1984 |
Carcinogenic effects induced in Wistar rats by combined treatment with technical-grade dichlorodiphenyltrichloroethane and sodium phenobarbital.
Topics: Animals; Body Weight; Cocarcinogenesis; DDT; Diet; Female; Liver Neoplasms, Experimental; Male; Phen | 1983 |
[Estimation of drug-metabolizing enzyme activities by measuring urinary metabolites of aspirin].
Topics: Animals; Aspirin; Biotransformation; Body Weight; Cytochrome P-450 Enzyme System; Gentisates; Male; | 1983 |
Cross-physical dependence liability of psychotropic drugs in rats dependent on barbiturates.
Topics: Animals; Body Weight; Humans; Phenobarbital; Psychotropic Drugs; Rats; Rats, Inbred Strains; Substan | 1983 |
Persistence of drug experience in rats formerly dependent on phenobarbital or meprobamate.
Topics: Animals; Body Temperature; Body Weight; Codeine; Humans; Male; Meprobamate; Phenobarbital; Rats; Rat | 1983 |
Physical dependence on meprobamate after repeated oral administration in rats.
Topics: Administration, Oral; Animals; Body Temperature; Body Weight; Codeine; Humans; Male; Meprobamate; Ph | 1983 |
Tumorigenic effect of sodium arsenite in rat kidney.
Topics: Animals; Arsenic; Arsenites; Body Weight; Carcinogens; Diethylnitrosamine; Hepatectomy; Kidney Neopl | 1983 |
Inhibition by phenobarbital and lack of effect of amobarbital on the development of liver tumors induced by N-nitrosodiethylamine in juvenile B6C3F1 mice.
Topics: Adenocarcinoma; Adenoma; Amobarbital; Animals; Body Weight; Diethylnitrosamine; Liver Neoplasms, Exp | 1984 |
Induction of liver microsomal NADPH cytochrome C reductase and cytochrome P-450 by some new synthetic pyrethroids.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Insecticides; Male; Methylch | 1980 |
The effects of phenobarbitone on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the guinea-pig.
Topics: Adrenal Cortex Hormones; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochrome Reductases | 1983 |
Portal vein ligation selectively lowers hepatic cytochrome P450 levels in rats.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Energy Intake; Liver; Male; Microsomes, Liver; | 1983 |
Dietary quinine has a nongustatory effect on food intake in rats.
Topics: Animals; Body Weight; Diet; Environment; Feeding Behavior; Female; Phenobarbital; Quinine; Rats; Tas | 1983 |
Effect of drug metabolism inducer and inhibitor on O,O,S-trimethyl phosphorothioate-induced delayed toxicity in rats.
Topics: Animals; Body Weight; L-Lactate Dehydrogenase; Lethal Dose 50; Lung; Male; Organothiophosphates; Org | 1983 |
Effect of prenatal exposure to phenobarbital on the development of monoamine oxidase and glucocorticoids.
Topics: Adrenal Cortex; Aging; Animals; Body Weight; Corticosterone; Female; Glucocorticoids; Growth; Liver; | 1983 |
Dietary cholesterol-induced changes of xenobiotic metabolism in liver. I. Influence of xenobiotic administration on hepatic membrane structure.
Topics: 1-Naphthylamine; Anilino Naphthalenesulfonates; Animals; Body Weight; Carbon Tetrachloride; Choleste | 1982 |
Anticonvulsant therapy and vitamin D metabolism: evidence for different mechanisms for phenytoin and phenobarbital.
Topics: 25-Hydroxyvitamin D 2; Animals; Body Weight; Diet; Ergocalciferols; Male; Parathyroid Hormone; Pheno | 1980 |
The fate of phenobarbitone in children in hypothermia and at normal body temperature.
Topics: Adolescent; Age Factors; Body Temperature; Body Weight; Child; Child, Preschool; Furosemide; Glucuro | 1982 |
Decreased levels of S-adenosylmethionine in the livers of rats fed phenobarbital and DDT.
Topics: Animals; Body Weight; Choline; DDT; Diet; Eating; Liver; Male; Methionine; Organ Size; Phenobarbital | 1982 |
High yield micronodular cirrhosis in the rat.
Topics: Animals; Ascites; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Liver; Liver | 1982 |
Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Animals; Barbital; Barbiturates; Body Weight; Carcinogens; Kidney; Liver; Male; Neoplasms, Experimen | 1982 |
Neuronal losses in mice following both prenatal and neonatal exposure to phenobarbital.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Cerebellum; Hippocampus; Mice; Mice, Inbred Strains; | 1982 |
Effects of disulfiram on mixed function oxidase system and trace element concentration in the liver of rats.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Disulfiram; Kinetics; Liver; Male; Microsomes, | 1982 |
Effects of partial hepatectomy and dietary phenobarbital on liver and mammary tumorigenesis by two N-hydroxy-N-acylaminobiphenyls in female CD rats.
Topics: Aminobiphenyl Compounds; Animals; Body Weight; Female; Hepatectomy; Hydroxamic Acids; Liver Neoplasm | 1981 |
Phenobarbitone-induced enlargement of the liver in the rat: its relationship to carbon tetrachloride-induced cirrhosis.
Topics: Animals; Body Weight; Carbon Tetrachloride; Dose-Response Relationship, Drug; Hepatomegaly; Liver; L | 1981 |
Role of drug metabolism in protection against chlorphentermine-induced pulmonary phospholipidosis in adult rat.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Body Weight; Chlorphentermine; Cytochrome P | 1981 |
Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice.
Topics: Acrylamides; Animals; Body Weight; Lethal Dose 50; Male; Mice; Nervous System Diseases; Organ Size; | 1981 |
Enhancing effect of barbital on N-2-fluorenylacetamide-induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Barbital; Barbiturates; Body Weight; Kinetics; Liver; Male; Organ Si | 1981 |
Weight gain in young Mongolian gerbils (Meriones unguiculatus) of mothers treated with neurotropic substances, hypoxia or electroconvulsive shock.
Topics: Animals; Animals, Newborn; Body Weight; Central Nervous System Agents; Electroshock; Ethanol; Female | 1981 |
The role of hepatic microsomal enzymes in the modulation of phencyclidine-induced toxicity.
Topics: Animals; Body Weight; Cysteine; Eating; Lethal Dose 50; Liver; Male; Maleates; Methylcholanthrene; M | 1981 |
Initiation and promotion of liver tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Carcinogens; Kinetics; Liver Neoplasms; Neoplasms, Expe | 1981 |
Reproductive dysfunction in male rats following prenatal exposure to phenobarbital.
Topics: Animals; Body Weight; Estrus; Female; Luteinizing Hormone; Male; Phenobarbital; Pregnancy; Prenatal | 1980 |
The induction of rat hepatic microsomal xenobiotic metabolism by n-octadecyl beta-(3',5'-di-tert-butyl-4'-hydroxyphenyl)-propionate.
Topics: Animals; Antioxidants; Body Weight; Butylated Hydroxytoluene; Enzyme Induction; Female; Inactivation | 1980 |
Effect of diet and drugs on the qualitative and quantitative distribution of cytochromes P-450 in rat liver.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 Enzyme System; Diet; Ethanol; Flavonoids | 1980 |
Effect of long-term disulfiram administration on rat liver.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Disulfiram; Female; Glutathione; Liver; Micros | 1980 |
Modification of hepatic drug metabolizing enzyme activities and their induction by dietary protein.
Topics: Animals; Body Weight; Dietary Proteins; Enzyme Induction; Liver; Male; Methylcholanthrene; Organ Siz | 1980 |
Subcellular distribution and covalent binding of aflatoxins as functions of dietary manipulation.
Topics: Aflatoxins; Animals; Body Weight; Caseins; Liver; Male; Phenobarbital; Rats | 1980 |
Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Drug Synergism; | 1980 |
Phenobarbital effects on weight gain and circadian cycling of food intake and body temperature.
Topics: Animals; Body Temperature; Body Weight; Circadian Rhythm; Diet; Eating; Liver; Male; Phenobarbital; | 1980 |
Dose-dependent induction of the microsomal monooxygenase system by phenobarbital and 3-methylcholanthrene in the ad libitum and calorie-restricted female rat.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Cytochrome P-450 Enzyme System; Diet; Dose-Response Re | 1995 |
Experimental model of cirrhosis in rabbits exposed to carbon tetrachloride by inhalation.
Topics: Administration, Inhalation; Animals; Body Weight; Carbon Tetrachloride Poisoning; Hexobarbital; Live | 1995 |
Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat.
Topics: Alanine Transaminase; Animals; Antibodies, Monoclonal; Antibody Formation; Aryl Hydrocarbon Hydroxyl | 1995 |
In vitro glucuronidation of peroxisomal proliferators: 2-ethylhexanoic acid enantiomers and their structural analogs.
Topics: Animals; Body Weight; Caproates; Chromatography, High Pressure Liquid; Clofibrate; Glucuronates; Glu | 1995 |
Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Enzyme Induction; Glucuronosyltransf | 1995 |
Inhibitory effect of vanadium on rat liver carcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Body Weight; Carcinogens; Diethylnitrosamine; F | 1995 |
Development of altered hepatocyte foci by separate and combined treatments with radiation and diethylnitrosamine in neonatal rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Female; Gamma Rays; Glutathione Transferase; Liver; Liver | 1994 |
Rapid development of hepatic tumors in transforming growth factor alpha transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital.
Topics: Animals; Body Weight; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Gene Expression; Immunohi | 1994 |
Teratogenicity of 13-cis retinoic acid and phenobarbital sodium in CF-1 mice.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Animals, Newborn; Body Weight; Bone and | 1993 |
Gomisin A, a lignan component of Schizandora fruits, inhibits development of preneoplastic lesions in rat liver by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cell Nucleus; Cyclooctanes; Dioxoles; Drugs, Chinese | 1994 |
Liver microsomal mixed-function oxidases in response to polyunsaturated/saturated and n-6/n-3 fatty acid ratios of dietary lipids in rats.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Diet; Dietary Fats, Unsaturated; Eicosapentaen | 1994 |
Indocyanine green pharmacokinetics in rats with progressive carbon tetrachloride-induced hepatocellular insufficiency.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Half-Life; Indocyanine Green; Liver; Liver Cir | 1994 |
UDP glucuronosyltransferase gene expression is involved in the stimulation of ascorbic acid biosynthesis by xenobiotics in rats.
Topics: Analysis of Variance; Animals; Ascorbic Acid; Base Sequence; Blotting, Northern; Body Weight; Chlora | 1993 |
Effect of microsomal enzyme modulators on N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS)-induced nephrotoxicity in the Fischer 344 rat.
Topics: Animals; Body Weight; Cobalt; Drug Synergism; Fungicides, Industrial; Injections, Intraperitoneal; K | 1993 |
Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to carcinogenesis and nuclear localization.
Topics: Animals; Body Weight; Carcinogens; Cell Nucleus; Clofibric Acid; Diethylhexyl Phthalate; DNA; Guanos | 1993 |
Expression of a male-specific cytochrome P450 isozyme (CYP2C11) in fa/fa Zucker rats: effect of phenobarbital treatment.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Body Weight; Cytochrome P-450 Enzyme System; | 1993 |
Alterations in populations of GST-p-immunoreactive single hepatocytes and hepatocellular foci after a single injection of N-nitrosodiethylamine with or without phenobarbital promotion in male F344/NCr rats.
Topics: Animals; Body Weight; Cells, Cultured; Diethylnitrosamine; Glutathione Transferase; Liver; Male; Org | 1993 |
Effects of hepatic enzyme inducers and mitogens on experimental Tyzzer's disease in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bacillaceae Infections; Bacillus; Body W | 1993 |
Comparative pharmacodynamics of CYP2B induction by phenobarbital in the male and female F344/NCr rat.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induc | 1993 |
Effect of pregnancy on plasma phenobarbital concentrations in rats.
Topics: Animals; Anticonvulsants; Body Weight; Female; Phenobarbital; Pregnancy; Pregnancy, Animal; Rats; Ra | 1995 |
Effects of gomisin A on the promotor action and serum bile acid concentration in hepatocarcinogenesis induced by 3'-methyl-4-dimethylamino-azobenzene.
Topics: Animals; Anticarcinogenic Agents; Bile Acids and Salts; Body Weight; Carcinogens; Cyclooctanes; Deox | 1995 |
Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver.
Topics: Animals; Body Weight; Chromatography, High Pressure Liquid; Diethylnitrosamine; Female; gamma-Glutam | 1995 |
Determination of phenobarbitone population clearance values for South African children.
Topics: Anticonvulsants; Body Weight; Child; Child, Preschool; Female; Humans; Individuality; Male; Phenobar | 1995 |
Neonatal phenobarbital-induced persistent alterations in plasma testosterone profiles and testicular function.
Topics: Aging; Androgens; Animals; Animals, Newborn; Body Weight; Dose-Response Relationship, Drug; Female; | 1996 |
Reversibility of promoter induced hepatic focal lesion growth in mice.
Topics: Animals; Apoptosis; Body Weight; Carcinogens; Cell Division; Dieldrin; Diet; Diethylnitrosamine; Eos | 1996 |
Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats.
Topics: Analysis of Variance; Animals; Bile; Body Weight; Cysteine; Female; Glutamate-Cysteine Ligase; Gluta | 1996 |
Repeated oral benzene exposure alters enzymes involved in benzene metabolism.
Topics: Administration, Oral; Aldehyde Dehydrogenase; Animals; Benzene; Body Weight; Cytochrome P-450 Enzyme | 1996 |
The effect of two periods of short-term fasting during the promotion stage of hepatocarcinogenesis in rats: the role of apoptosis and cell proliferation.
Topics: Animals; Biomarkers, Tumor; Body Weight; Carcinogens; Fasting; Female; Glutathione Transferase; Live | 1997 |
Enhancing effects of phenobarbital and 3-methylcholanthrene on GST-P-positive liver cell foci development in a new medium-term rat liver bioassay using D-galactosamine.
Topics: Animals; Biological Assay; Blood Chemical Analysis; Body Weight; Carcinogens; Diet; Diethylnitrosami | 1997 |
Suppression by phenobarbital of ethionine-induced hepatocellular carcinoma formation and hepatic S-adenosylethionine levels.
Topics: Adenosine; Animals; Body Weight; Ethionine; Liver; Liver Neoplasms; Male; Methylation; Organ Size; P | 1997 |
Sodium phenobarbital-enhanced mutation frequency in the liver DNA of lacZ transgenic mice treated with diethylnitrosamine.
Topics: Animals; Body Weight; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; DNA; Drug Synergism; Lac Op | 1997 |
Changes in protein and mRNA levels of growth factor/growth factor receptors in rat livers after administration of phenobarbitone or methylclofenapate.
Topics: Animals; Body Weight; Clofenapate; ErbB Receptors; Growth Substances; Liver; Male; Organ Size; Pheno | 1997 |
Opposite effects of 2,2',4,4',5,5'-hexachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the antibody response to sheep erythrocytes in mice.
Topics: Animals; Antibody Formation; Body Weight; Cytochrome P-450 CYP2B1; Drug Interactions; Erythrocytes; | 1997 |
Sublethal effects of hexavalent chromium on the body growth rate and liver function enzymes of phenobarbitone-pretreated and promethazine-pretreated rabbits.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Carci | 1997 |
Phenobarbital sensitivity in HAS and LAS rats before and after chronic administration of ethanol.
Topics: Animals; Body Weight; Diet; Drug Interactions; Drug Tolerance; Ethanol; GABA Modulators; Hypnotics a | 1997 |
Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats.
Topics: Administration, Oral; Animals; Antimetabolites; Body Weight; Bromodeoxyuridine; Cell Division; Cytoc | 1997 |
Characterization of the induction of rat microsomal cytochrome P450 by tacrine.
Topics: Animals; Benzoflavones; Body Weight; Cholinesterase Inhibitors; Cytochrome P-450 Enzyme System; Enzy | 1997 |
The effect of hepatocyte enlargement on the hemodynamic characteristics of the isolated perfused rat liver preparation.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Hypertrophy; Hypotonic Solutions; In Vitro T | 1998 |
Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog.
Topics: Alkaline Phosphatase; Animal Feed; Animals; Ascorbic Acid; Biomarkers; Body Weight; Carboxylesterase | 1998 |
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool | 1998 |
The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Bilirubin; Blood Pressure; Body Weight; Bosentan; Carbon | 1998 |
Differential effects of nongenotoxic and genotoxic carcinogens on the preneoplastic lesions in the rat liver.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cell Count; Clofibrate; Diethylnitrosamine; | 1998 |
Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Connexins; Cytochrome P-450 CYP2B1; Eating; Gap Ju | 1998 |
Phenobarbital in comparison with carbon tetrachloride and phenobarbital-induced cirrhosis in rat liver regeneration.
Topics: Animals; Body Weight; Carbon Tetrachloride; Cell Division; DNA; Hepatectomy; Kinetics; Liver; Liver | 1999 |
Dose-response relationships for cytochrome P450 induction by phenobarbital in the cotton rat (Sigmodon hispidus).
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Body Weight; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P | 1998 |
Transplantation of fetal liver tissue suspension into the spleens of adult syngenic rats: inducibility of cytochrome P450 dependent monooxygenase functions by beta-naphthoflavone, phenobarbital and dexamethasone.
Topics: Animals; beta-Naphthoflavone; Body Weight; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Ind | 1999 |
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
Topics: Animals; Body Temperature; Body Weight; Carcinogens; Circadian Rhythm; Diethylnitrosamine; Laparotom | 1999 |
Expression of myc, fos and Ha-ras associated with chemically induced cell proliferation in the rat liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Carcinogens; Cell Division; | 1994 |
Inhibitory effect of Trianthema portulacastrum L. diethylnitroso-amine-induced phenobarbital promoted hepatocarcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Diethylnitrosamine; Drinking Behavior; E | 1999 |
Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets.
Topics: Animals; Bile Acids and Salts; Body Weight; Cholesterol; Diet; Drug Interactions; Eating; Feces; Hyp | 1999 |
Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure.
Topics: Animals; Antithyroid Agents; Body Fluids; Body Weight; Cell Division; Epithelial Cells; Estrus; Fema | 1999 |
Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Diet; Dose-Respo | 1999 |
Severe symptoms following a massive intentional L-thyroxine ingestion.
Topics: Adult; Antidotes; Body Weight; Charcoal; Diazepam; Haloperidol; Humans; Intubation, Intratracheal; M | 1999 |
Some studies on the rodenticidal action of indomethacin.
Topics: Administration, Oral; Animals; Bile Ducts; Body Weight; Cholestyramine Resin; Diazepam; Drug Interac | 1999 |
Apoptosis and cell proliferation in rat hepatocytes induced by barbiturates.
Topics: Animals; Apoptosis; Barbital; Barbiturates; Body Weight; Bromodeoxyuridine; Cell Division; Hepatomeg | 2000 |
Xenobiotics modulate the p53 response to DNA damage in preneoplastic enzyme-altered foci in rat liver; effects of diethylnitrosamine and phenobarbital.
Topics: Animals; Blotting, Western; Body Weight; Carcinogens; Cell Count; Diethylnitrosamine; DNA Damage; Fe | 2000 |
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats.
Topics: 1,2-Dimethylhydrazine; 2-Acetylaminofluorene; Alkylating Agents; Animals; Body Weight; Butylhydroxyb | 2000 |
Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Body Weight; Carbamazepine; Child; Child, Preschool; | 2000 |
Failure to demonstrate chemoprevention by the monoterpene perillyl alcohol during early rat hepatocarcinogenesis: a cautionary note.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Carcinogens; Cell Division; DNA; Eating; G | 2000 |
Downregulation of hepatic cytochrome P450 in chronic renal failure.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Dexamethasone; Down-Regulation; Erythromycin; | 2001 |
Combined supplementation of vanadium and 1alpha,25-dihydroxyvitamin D3 inhibit placental glutathione S-transferase positive foci in rat liver carcinogenesis.
Topics: Administration, Oral; Animals; Body Weight; Calcitriol; Carcinogens; Diethylnitrosamine; Drug Intera | 2000 |
Evaluation of the male pubertal assay's ability to detect thyroid inhibitors and dopaminergic agents.
Topics: Animals; Antithyroid Agents; Body Weight; Bromocriptine; Dopamine Agonists; Dopamine Antagonists; Ge | 2001 |
Chemopreventive effects of scordinin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats.
Topics: Adenoma, Liver Cell; Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Hepatoce | 2001 |
Cumulative exposure to tamoxifen: DNA adducts and liver cancer in the rat.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; DNA; DNA Adducts; DNA Damage; Dose-Response | 2001 |
Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents.
Topics: Animals; Body Weight; Cell Communication; Cell Transformation, Neoplastic; Diet; Diethylhexyl Phthal | 2001 |
Phenobarbitone-induced stimulation of protein synthesis in liver of diabetic rat.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Insulin; Liver; Male; NADPH-Ferrihemoprotein | 1978 |
Barbiturate withdrawal and magnesium deficiency in mice.
Topics: Animals; Barbiturates; Body Weight; Brain; Humans; Magnesium; Magnesium Deficiency; Male; Mice; Mice | 1978 |
Effect of age and sex on liver response to phenoclor DP6, a polychlorinated biphenyl, in the rat.
Topics: Aging; Animals; Body Weight; Diet; Female; Liver; Male; Organ Size; Phenobarbital; Polychlorinated B | 1978 |
Experimental dependence on barbiturates. II. Relationship between drug levels in serum and brain and the development of dependence in rats.
Topics: Animals; Barbiturates; Body Weight; Circadian Rhythm; Feeding Behavior; Humans; Male; Motor Skills; | 1979 |
Effect of fasting and phenobarbital on hepatic UDP-glucuronic acid formation in the rat.
Topics: Animals; Bilirubin; Body Weight; Fasting; Glucuronates; Glucuronosyltransferase; Liver; Male; Organ | 1979 |
Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats.
Topics: Animals; Body Weight; Cell Fractionation; Cytochrome P-450 Enzyme System; Enzyme Induction; Lipid Me | 1979 |
Relationship between bile flow and Na+, K+-adenosinetriphosphatase in liver plasma membranes enriched in bile canaliculi.
Topics: Adenosine Triphosphatases; Animals; Bile; Body Weight; Cell Membrane; Enzyme Activation; Ethinyl Est | 1977 |
The properties of hydrogen peroxide production under hyperoxic and hypoxic conditions of perfused rat liver.
Topics: Aminopyrine; Animals; Body Weight; Catalase; Cytochrome c Group; Ethanol; Glycolates; Hydrogen Perox | 1975 |
Effect of cyclic AMP on the phenobarbital induced increase in cytochrome P-450 and hypertrophy of the endoplasmic reticulum of the rat liver.
Topics: Animals; Biotransformation; Body Weight; Bucladesine; Cyclic AMP; Cytochrome P-450 Enzyme System; Cy | 1975 |
The induction of hepatic microsomal metabolism in rats following acute administration of a mixture of polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Body Weight; Enzyme Induction; Female; In Vitro Techniques; Liver; Meth | 1976 |
Enhanced disappearance of drugs from plasma following polybrominated biphenyls.
Topics: Animals; Biphenyl Compounds; Body Weight; Female; Indocyanine Green; Liver; Methylcholanthrene; Mice | 1977 |
Effects of phenobarbital and diphenylhydantoin on acute vitamin D3 toxicity in the rat.
Topics: Animals; Body Weight; Cholecalciferol; Lethal Dose 50; Liver; Male; Phenobarbital; Phenytoin; Rats | 1978 |
Effect of diphenylhydantoin on the apposition of dentin. An experimental study in the rat.
Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Cholecalciferol; Connective Tissue; Dentinogene | 1977 |
Effects of hepatic microsomal enzyme inducers of the endogenous substrates vitamin D3 and folate in rat.
Topics: Animals; Anticonvulsants; Body Weight; Cholecalciferol; Enzyme Induction; Folic Acid; Formiminogluta | 1979 |
[Calcium metabolism and anticonvulsants drugs. Experimental study].
Topics: Alkaline Phosphatase; Animals; Body Weight; Calcium; Hydroxyproline; Liver; Male; Phenobarbital; Phe | 1979 |
The hepatic cytochrome level in the cat (Felis catus): normal value and variations in relation to some biological parameters.
Topics: Aging; Animals; Body Weight; Cats; Cytochrome P-450 Enzyme System; Enzyme Induction; Liver; Phenobar | 1979 |
[Antagonism of barbituric coma by stimulating products. Experimental study].
Topics: Animals; Body Weight; Choline; Coma; Cytidine Diphosphate Choline; Female; Glycolates; Injections, I | 1978 |
Hepatic drug metabolism in normal and vitamin E-deficient female Merino sheep.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Body Weight; Cytochrome P-450 Enzyme System; Cyto | 1977 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dos | 1979 |
Drug induced activity in lead-exposed mice.
Topics: Age Factors; Animals; Apomorphine; Body Weight; Brain Chemistry; Dextroamphetamine; Drinking Behavio | 1979 |
Correlation between age and plasma level/dosage ratio for phenobarbital in infants and children.
Topics: Age Factors; Body Weight; Child; Child, Preschool; Epilepsy; Humans; Infant; Phenobarbital; Seizures | 1979 |
Bile flow in response to pharmacologic agents. Hepatic DNA as a reference standard.
Topics: Animals; Bile; Body Weight; DNA; Ethinyl Estradiol; Liver; Male; Methylcholanthrene; Methylprednisol | 1979 |
Heterogeneous response of hepatic mixed function oxidases to chronic phenobarbital administration.
Topics: Animals; Body Weight; Carbon Dioxide; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxyge | 1979 |
The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.
Topics: Age Factors; Animals; Azo Compounds; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Hep | 1979 |
Bile formation and biliary lipid composition under the influence of clofibrate and phenobarbital pretreatment in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Clofibrate; Lipid Metabolism; Liver; | 1979 |
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice.
Topics: Animals; Body Temperature; Body Weight; Brain; Drug Interactions; Half-Life; Lethal Dose 50; Liver; | 1979 |
Circadian rhythm of hepatocellular structures in rats dosed phenobarbital.
Topics: Animals; Body Weight; Circadian Rhythm; Female; Liver; Male; Mitotic Index; Organ Size; Phenobarbita | 1979 |
[Studies on the physical dependence liability of chlorphenesin carbamate (author's transl)].
Topics: Animals; Behavior, Animal; Body Weight; Chlorphenesin; Dogs; Eating; Humans; Male; Phenobarbital; Su | 1977 |
Cross-dependence between phenobarbital and alcohol in rats.
Topics: Alcoholism; Animals; Body Weight; Humans; Male; Phenobarbital; Rats; Substance Withdrawal Syndrome; | 1977 |
[Neuropharmacological studies on drug dependence (I). Effects due to the difference in strain, sex and drug administration time on physical dependence development and characteristics of withdrawal signs in CNS-affecting drug dependent rats (author's trans
Topics: Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Body Weight; Conditioning, Classica | 1979 |
Effect of drugs affecting microsomal enzymes on serum protein pattern and fat content of the liver.
Topics: Animals; Blood Proteins; Body Weight; Carbon Tetrachloride Poisoning; Lipids; Liver; Male; Phenobarb | 1978 |
Alteration of hepatic detoxication enzyme activity by dietary arsenic trioxide.
Topics: Animals; Arsenic; Biotransformation; Body Weight; Diet; Drug Interactions; Eating; Female; Inactivat | 1978 |
Effect of phenobarbital on activity and learning in 6-hydroxydopamine treated rat pups.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain Chemistry; Catecholamines; Cognition; Habituati | 1978 |
Qualitative alterations of cytochrome P-450 in mouse liver microsomes after administration of acrylamide and methylmethacrylate.
Topics: Acrylamides; Animals; Body Weight; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide G | 1978 |
Pathological and toxicological data on chlorinated pesticides and phenobarbital.
Topics: Animals; Body Weight; Carcinogens; DDT; Drug Interactions; Female; Insecticides; Liver Neoplasms; Ma | 1978 |
Pharmacokinetics of di-n-propylacetate in epileptic patients.
Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; | 1975 |
Immunosuppression of rosette-forming cells.
Topics: Amphetamine; Animals; Body Weight; Caffeine; Erythrocytes; Humans; Immunity; Immunologic Techniques; | 1976 |
Comparative effect of phenobarbital and 3-methyl-cholanthrene on azodye metabolism in rat liver. I. In vitro studies on detoxication and activation processes.
Topics: Animals; Body Weight; Cytochromes; DNA; Methylcholanthrene; Microsomes, Liver; Organ Size; Oxidoredu | 1975 |
Effects of low and high protein diets on the induction of microsomal drug-metabolizing enzymes in rat liver.
Topics: Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Diet; Dietary Proteins; DNA; Enzyme I | 1975 |
Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats.
Topics: Acetanilides; Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochromes; | 1976 |
Effect of phenobarbital on lipid peroxidation in the liver.
Topics: Animals; Body Weight; Fatty Liver; Lipid Metabolism; Liver; Male; NADPH-Ferrihemoprotein Reductase; | 1976 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Long-term administration of DDT or phenobarbital-Na in Wistar rats.
Topics: Age Factors; Animals; Body Weight; DDT; Drug Administration Schedule; Female; Liver Neoplasms; Male; | 1977 |
[Phenobarbital treatment in premature infants with continuous blood level control].
Topics: Age Factors; Body Weight; Half-Life; Humans; Infant, Newborn; Infant, Premature, Diseases; Monitorin | 1977 |
Alteration of delta 9-tetrahydrocannabinol-induced teratogenicity by stimulation and inhibition of its metabolism.
Topics: Amniotic Fluid; Animals; Body Weight; Cleft Palate; Dronabinol; Drug Interactions; Female; Fetal Dea | 1977 |
Chronic phenobarbital administration: effects upon brain growth and behavior of artificially reared rats.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Cerebellum; Male; Motor Activity; Or | 1977 |
Differential increase of hepatic peroxisomal, mitochondrial and microsomal carnitine acyltransferases in clofibrate-fed rats.
Topics: Acyltransferases; Animals; Body Weight; Carnitine Acyltransferases; Centrifugation, Density Gradient | 1977 |
Phenobarbital-induced brain growth retardation in artificially reared rat pups.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Male; Organ Size; Phenobarbital; Rats | 1977 |
Comparative activity of delta9-tetrahydrocannabinol, diphenylhydantoin, phenobarbital and chlordiazepoxide on electroshcok seizure threshold in mice.
Topics: Animals; Body Weight; Chlordiazepoxide; Dronabinol; Electroshock; Glucose; Male; Mice; Phenobarbital | 1977 |
Hepatic steroid hydroxylase and aminopyrine N-demethylase activities in pregnant rats and rabbits, and the effect of phenobarbital.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cytochrome P-450 Enzyme System; Female; Hemeprotein | 1976 |
Effect of fasting on hepatic ligandin, Z protein, and organic anion transfer from plasma in rats.
Topics: Animals; Body Weight; Carrier Proteins; Cytoplasm; Fasting; Glutathione Transferase; Liver; Male; Or | 1976 |
The necessity of drug level monitoring in anticonvulsant drug therapy.
Topics: Body Weight; Dose-Response Relationship, Drug; Epilepsy; Humans; Patient Compliance; Phenobarbital; | 1976 |
Effect of 1-(m-chlorophenyl)-3-N,N-dimethyl-carbamoyl-5-methoxypyrazole (PZ-177) on drug-metabolizing enzyme on rat liver.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Body Weight; Enzyme Induction; Kin | 1976 |
Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Bile Ducts; Body Weight; Cell Nucleus; DNA; Drug Synergism; Injections, Intraperitoneal; Li | 1975 |
Effect of phenobarbital, spironolactone and pregnenolone-16 alpha-carbonitrile on bile formation in the rat.
Topics: Animals; Bile; Bile Acids and Salts; Body Weight; Cholesterol; Liver; Male; Organ Size; Phenobarbita | 1975 |
The effect of diet on the toxicity of paracetamol and the safety of paracetamol-methionine mixtures.
Topics: Acetaminophen; Animals; Body Weight; Caseins; Chemical and Drug Induced Liver Injury; Cysteine; Cyto | 1975 |
Effect of chronic phenobarbital administration upon brain growth of the infant rat.
Topics: Animals; Animals, Newborn; Body Weight; Brain; Injections, Subcutaneous; Male; Organ Size; Phenobarb | 1975 |
Aspartate aminotransferase and alanine aminotransferase activities in plasma: statistical distributions, individual variations, and reference values.
Topics: Adolescent; Adult; Age Factors; Aged; Alanine Transaminase; Analysis of Variance; Aspartate Aminotra | 1975 |
Treatment of hypernatraemic dehydration in infancy.
Topics: Bicarbonates; Body Weight; Dehydration; Gastroenteritis; Humans; Hyperglycemia; Hypernatremia; Hypoc | 1975 |
Phenobarbital-enhanced biliary excretion of administered unconjugated and conjugated sulfobromophthalein (BSP) in the rat.
Topics: Animals; Bile; Body Weight; Female; Glutathione; Injections, Intravenous; Injections, Subcutaneous; | 1975 |
Drug-induced alterations in hepatic fatty acid desaturase activity.
Topics: Animals; Appetite; Body Weight; Drinking; Fatty Acid Desaturases; Fatty Acids, Nonesterified; Fenflu | 1975 |
Effects of methotrexate and phenobarbital on the hepatic microsomal drug-metabolizing enzymes in normal rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biphenyl Compounds; Body Weight; Cytochrome P-450 Enzyme Sys | 1975 |
Liver blood flow and blood volume following chronic phenobarbitone administration.
Topics: Animals; Blood Volume; Blood Volume Determination; Body Weight; Gold Radioisotopes; Liver Circulatio | 1975 |
Effects and complications of high efficiency dialysis.
Topics: Barbiturates; Blood Urea Nitrogen; Body Weight; Calcium; Creatinine; Edema; Headache; Humans; Hypote | 1975 |
Parathion-induced toxicity and phenobarbital-induced protection against parathion during prenatal development.
Topics: Animals; Body Weight; Cholinesterases; Female; Fetal Death; Fetus; Maternal-Fetal Exchange; Mice; Pa | 1975 |
Comparison of the induction course, biophysical chemical interactions and photochemical action spectra of phenobarbital and 3-methylcholanthrene induce hepatic microsomal P-450.
Topics: Aniline Compounds; Animals; Biotransformation; Body Weight; Carbon Monoxide; Codeine; Cytochrome P-4 | 1975 |
Some effects of prenatal exposure to d-amphetamine sulfate and phenobarbital on developmental neurochemistry and on behavior.
Topics: Animals; Avoidance Learning; Behavior, Animal; Birth Weight; Body Weight; Brain; Brain Chemistry; Co | 1975 |
[Comparison of development of drug dependence in naive and drug dependence-experienced rats].
Topics: Administration, Oral; Animals; Body Weight; Chlordiazepoxide; Diazepam; Eating; Female; Humans; Male | 1975 |
[Dependence on and preference for morphine (II). Comparison among morphine, phenobarbital and diazepam].
Topics: Animals; Body Weight; Choice Behavior; Decision Making; Diazepam; Female; Humans; Male; Methods; Mor | 1975 |
Conditioned learning in young rats born of drug-addicted parents and raised on addictive drugs.
Topics: Animals; Animals, Newborn; Avoidance Learning; Birth Weight; Body Weight; Conditioning, Psychologica | 1975 |
Effects of vinyl chloride exposures to rats pretreated with phenobarbital.
Topics: Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme | 1975 |
Bone mineral in mentally retarded patients receiving long-term anticonvulsive therapy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Bone and Bones; Child; Female; Humans; | 1975 |
Effect of food deprivation, phenobarbital, and SKF-525A on teratogenicity induced by 2-sec-butyl-4,6-dinitrophenol (dinoseb) and on disposition of [14C]dinoseb in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Water; Body Weight; Bone and Bones; Dinitrophenols; Femal | 1975 |
Energy wastage in rats given drugs that induce microsomal enzymes.
Topics: Aminopyrine; Animals; Barbiturates; Body Weight; Energy Metabolism; Enzyme Induction; Ethanol; Femal | 1975 |
The effects of tranquillizing drugs on timing behaviour in rats.
Topics: Animals; Body Weight; Chlordiazepoxide; Chlorpromazine; Conditioning, Operant; Male; Phenobarbital; | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; C | 1975 |
[Premedication in childhood].
Topics: Adolescent; Age Factors; Atropine; Benperidol; Body Weight; Child; Child, Preschool; Diazepam; Drug | 1975 |
Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion.
Topics: Animals; Body Weight; Diazepam; Diet; Feeding Behavior; Female; Humans; Levallorphan; Male; Morphine | 1975 |
Conditioned avoidance behavior in pretrained rats intermittently treated with addictive drugs.
Topics: Amphetamine; Animals; Avoidance Learning; Body Weight; Conditioning, Operant; Dose-Response Relation | 1975 |
Effect of daily injection of phenobarbital on ovulation in hamsters.
Topics: Animals; Body Weight; Cricetinae; Estrus; Female; Ovulation; Phenobarbital; Pregnancy; Prostaglandin | 1975 |
Origin of brain growth retardation in young rats treated with phenobarbital.
Topics: Animals; Animals, Newborn; Barbiturates; Body Weight; Brain; Cerebellum; Depression, Chemical; Male; | 1976 |
Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat.
Topics: Aminopyrine; Animals; Bile Ducts; Body Weight; Carbon Dioxide; Hepatectomy; Kinetics; Liver; Male; O | 1976 |
Ethanol-a direct inducer of drug metabolism.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Diet; Dietary Fats; Ethanol; Male; Microsomes, | 1976 |
Measurement and alteration of the capacity of the distended biliary tree in the rat.
Topics: Animals; Biliary Tract; Body Weight; Cricetinae; Guinea Pigs; Lithocholic Acid; Liver; Male; Mannito | 1976 |
Influence of agents affecting monooxygenase activity on taurolithocholic acid-induced cholestasis.
Topics: Animals; Bile; Body Weight; Chlordecone; Cholestasis; Cobalt; Cytochrome P-450 Enzyme Inhibitors; Cy | 1992 |
Hepatic glycogen depletion in fed female rats induced by piroxicam.
Topics: Animals; Body Weight; Female; Glucose-6-Phosphatase; Glycogen Synthase; Liver Glycogen; Nadolol; Phe | 1992 |
Chloroform inhibits the development of diethylnitrosamine-initiated, phenobarbital-promoted gamma-glutamyltranspeptidase and placental form glutathione S-transferase-positive foci in rat liver.
Topics: Analysis of Variance; Animals; Body Weight; Chloroform; Cytochrome P-450 CYP1A1; Cytochrome P-450 CY | 1992 |
Phenobarbitone population pharmacokinetics from routine clinical data: role of patient characteristics for estimating dosing regimens.
Topics: Adolescent; Aging; Anticonvulsants; Body Weight; Child; Drug Interactions; Female; Humans; Male; Mod | 1992 |
Ovariectomy promotes the growth of altered hepatic foci after withdrawal and reintroduction of phenobarbital during hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; gamma-Glutamyltransferase; | 1992 |
Benzoyl-CoA ligase activity in the liver and kidney cortex of weanling guinea pigs treated with various inducers: relationship with hippurate synthesis and carnitine levels.
Topics: Animals; Benzoates; Benzoic Acid; Body Weight; Carnitine; Coenzyme A Ligases; Guinea Pigs; Hippurate | 1992 |
Lack of modifying effects of 6-mercaptopurine in a medium term bioassay system for liver carcinogenesis using male F344 rats.
Topics: Animals; Body Weight; Diethylnitrosamine; Leukocyte Count; Liver Neoplasms, Experimental; Male; Merc | 1992 |
Microsomal lauric acid hydroxylase activities after treatment of rats with three classical cytochrome P450 inducers and peroxisome proliferating compounds.
Topics: Adipates; Animals; Aroclors; Body Weight; Chlorodiphenyl (54% Chlorine); Cytochrome P-450 CYP4A; Cyt | 1992 |
Comparative biochemical and morphometric changes associated with induction of the hepatic mixed function oxidase system in the rat.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cytoch | 1991 |
Susceptibility to phenobarbital promotion of hepatotumorigenesis: correlation with differential expression and induction of hepatic drug metabolizing enzymes in heavy and light male (C3H x VY) F1 hybrid mice.
Topics: Adenoma; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Body Weight; Carcinogens; Cytoch | 1991 |
Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by phenobarbital.
Topics: Anemia, Hypochromic; Animals; Body Weight; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltrans | 1991 |
Dose response study of N-nitrosodiethanolamine initiation of rat hepatocarcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cocarcinogenesi | 1991 |
Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.
Topics: Animals; Body Weight; Carcinogens; Cell Survival; Clofibrate; Cyproterone; Cyproterone Acetate; Fema | 1990 |
Tumor promoting effect of goitrogens on the rat thyroid.
Topics: Animals; Antithyroid Agents; Body Weight; Carcinogens; Male; Nitrosamines; Organ Size; Phenobarbital | 1990 |
Induction of 8-hydroxydeoxyguanosine but not initiation of carcinogenesis by redox enzyme modulations with or without menadione in rat liver.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Body Weight; Cytochrome Reductases; Deoxyguanosine; Dicumarol; | 1991 |
In vivo effects of macrolides on thyroid hormone serum levels and on hepatic type 1 5'-deiodinase in rat. A comparative study with amiodarone, phenobarbital and propranolol.
Topics: Amiodarone; Animals; Anti-Bacterial Agents; Body Weight; Iodide Peroxidase; Liver; Macrolides; Male; | 1991 |
Effects of gomisin A on hepatocarcinogenesis by 3'-methyl-4-dimethylaminoazobenzene in rats.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Cyclooctanes; Dioxoles; Lignans; Liver Neoplasms, Exp | 1991 |
Effect of varying the concentration of phenobarbital and its duration of treatment on the evolution of carcinogen induced enzyme-altered foci in rat liver.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Carcinogens; Diethylnitrosamine; Dose-Response Rela | 1991 |
Effect of the aging process on the gender and phenobarbital dependent expression of glutathione S-transferase subunits in brown Norway rat liver.
Topics: Aging; Animals; Body Weight; Cytosol; Female; Glutathione Transferase; Isoenzymes; Liver; Male; Orga | 1991 |
Diazepam and intubation in emergency treatment of seizures in children.
Topics: Adolescent; Body Weight; Case-Control Studies; Child; Child, Preschool; Diazepam; Drug Therapy, Comb | 1991 |
Functional tolerance to the hypothermic effect of phenobarbital in rats.
Topics: Animals; Body Temperature; Body Weight; Brain; Drug Tolerance; Eating; Male; Phenobarbital; Rats; Ra | 1991 |
Age-dependent induction of preneoplastic liver cell foci by 2-acetylaminofluorene, phenobarbital and acetaminophen in F344 rats initially treated with diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Acetaminophen; Aging; Animals; Biomarkers, Tumor; Body Weight; Carcinogens; D | 1991 |
Butylated hydroxytoluene lacks the activity of phenobarbital in enhancing diethylnitrosamine-induced mouse liver carcinogenesis.
Topics: Animals; Body Weight; Butylated Hydroxytoluene; Carcinogens; Diethylnitrosamine; Drug Synergism; Liv | 1991 |
Comparison of the effects of propylthiouracil, amiodarone, diphenylhydantoin, phenobarbital, and 3-methylcholanthrene on hepatic and renal T4 metabolism and thyroid gland function in rats.
Topics: Amiodarone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Glucuronosyltransf | 1991 |
Quantitative stereologic study of the effects of varying the time between initiation and promotion on four histochemical markers in rat liver during hepatocarcinogenesis.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Female; gamma-Glutamyltransferase; Gluta | 1990 |
Tumor promotion by the peroxisome proliferator nafenopin involving a specific subtype of altered foci in rat liver.
Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Carcinoma; Female; gamma-Glutamyltransferase; Liver; | 1990 |
Enhanced preneoplastic liver lesion development under 'selection pressure' conditions after administration of deoxycholic or lithocholic acid in the initiation phase in rats.
Topics: Animals; Body Weight; Deoxycholic Acid; gamma-Glutamyltransferase; Glutathione Transferase; Lithocho | 1990 |
Shifting necrosis: butylated hydroxytoluene (BHT) and phenobarbital move cocaine-induced hepatic necrosis across the lobule.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Butylated Hydroxytoluene; C | 1991 |
Effects of alpha-tocopherol, phenobarbital, and butylated hydroxyanisole during promotion of diethylnitrosamine-initiated rat hepatocarcinogenesis.
Topics: Analysis of Variance; Animals; Body Weight; Butylated Hydroxyanisole; Diethylnitrosamine; Eating; Li | 1991 |
Modulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin and phenobarbital-induced promotion of hepatocarcinogenesis in rats by the type of diet and vitamin A deficiency.
Topics: Animals; Body Weight; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diet; Female; Liver; | 1991 |
Neonatal diethylstilbestrol treatment alters aflatoxin B1-DNA adduct concentrations in adult rats.
Topics: Aflatoxin B1; Aflatoxins; Animals; Animals, Newborn; Body Weight; Carcinogens; Chromatography, High | 1990 |
Substitution of psychoactive drugs in pentobarbital-dependent rats.
Topics: Animals; Antidepressive Agents; Arousal; Body Weight; Brain; Bromazepam; Bupropion; Diazepam; Dose-R | 1990 |
Effects of phenobarbital, dietary protein intake, and ewe liveweight on ovulation rate and concentrations of plasma FSH and hepatic microsomal enzymes.
Topics: Analysis of Variance; Animals; Body Weight; Cytochrome P-450 Enzyme System; Cytochromes b5; Dietary | 1990 |
Genetic differences in maternal behaviour patterns in mice administered phenobarbital during pregnancy.
Topics: Animals; Body Weight; Female; Injections, Intraperitoneal; Lactation; Maternal Behavior; Mice; Mice, | 1990 |
Roles of dietary corn oil in the regulation of cytochromes P450 and glutathione S-transferases in rat liver.
Topics: Acetone; Animals; Blotting, Western; Body Weight; Corn Oil; Cytochrome P-450 Enzyme System; Dietary | 1990 |
Hypolipidemic activity in rodents of phenobarbital and related derivatives.
Topics: Animals; Barbiturates; Body Weight; Enzymes; Hypolipidemic Agents; Lipids; Male; Phenobarbital; Rats | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--carbamazepine.
Topics: Aging; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Female; Huma | 1990 |
Analysis of the factors influencing anti-epileptic drug concentrations--valproic acid.
Topics: Adolescent; Adult; Aging; Aspartate Aminotransferases; Body Weight; Carbamazepine; Dose-Response Rel | 1990 |
Comparison of initiation potential of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in an in vivo carcinogen bioassay system.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Enzyme Induction; Galactosamine; Glutathio | 1990 |
Bioimpedance assessment of antipyrine pharmacokinetics before and after enzyme induction.
Topics: Adult; Antipyrine; Body Composition; Body Weight; Electric Conductivity; Enzyme Induction; Humans; M | 1990 |
DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion.
Topics: Animals; Body Weight; Carcinogens; Cell Division; DNA Replication; Female; Liver; Liver Neoplasms; N | 1990 |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat.
Topics: Animals; Body Weight; Choline Deficiency; Cocarcinogenesis; Diet; Liver; Liver Neoplasms, Experiment | 1990 |
Pulmonary toxicity of inhaled styrene in acetone-, phenobarbital- and 3-methylcholanthrene-treated rats.
Topics: Acetone; Animals; Body Weight; Cytochrome P-450 Enzyme System; Glutathione; Lung; Lung Diseases; Mal | 1990 |
Amplification of chloroform hepatotoxicity and lethality by dietary chlordecone (kepone) in mice.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Body Weight; Chlordecone; Chloroform; Dr | 1988 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Additive effect of combined spironolactone and phenobarbital treatment on hepatic bilirubin UDP-glucuronyltransferase.
Topics: Animals; Body Weight; Drug Synergism; Enzyme Induction; Glucuronosyltransferase; Male; Microsomes, L | 1989 |
Possible involvement of arachidonic acid metabolism in phenobarbital promotion of hepatocarcinogenesis.
Topics: Acetophenones; Animals; Arachidonic Acid; Arachidonic Acids; Biomarkers, Tumor; Body Weight; Diethyl | 1989 |
Brief maternal deprivation of rats reduces hepatic mixed function oxidase activities.
Topics: Aminopyrine; Animals; Benzphetamine; Biotransformation; Body Weight; Coumarins; Enzyme Induction; Fe | 1989 |
Carcinogenic potential of cooked food mutagens (IQ and MeIQ) in Wistar rats after short-term exposure.
Topics: Animals; Body Weight; Carcinogenicity Tests; Carcinogens; Cell Division; Food Analysis; Liver; Male; | 1989 |
In vivo evaluation of the effects of altered cyclosporine metabolism on its immunosuppressive potency.
Topics: Animals; Body Weight; Cimetidine; Cyclosporins; Cytochrome P-450 Enzyme System; Dose-Response Relati | 1989 |
A semipurified diet that suppresses phenobarbital promotion of hepatocarcinogenesis in the rat.
Topics: Animals; Body Weight; Cocarcinogenesis; Diet; Diethylnitrosamine; Female; Food, Formulated; Liver; L | 1989 |
The effect of phenobarbital on human plasma lipids.
Topics: Adult; Aged; Aging; Apolipoproteins; Body Weight; Cholesterol; Epilepsy; Female; Humans; Lipids; Mid | 1989 |
Effects of delta 9-tetrahydrocannabinol, phenobarbital, and their combination on pregnancy and offspring in rats.
Topics: Animals; Body Weight; Dronabinol; Drug Combinations; Female; Litter Size; Phenobarbital; Pregnancy; | 1987 |
Effects of a high-sucrose diet on the development of enzyme-altered foci in chemical hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Dietary Carbohydrates; DNA; Female; gamma-Glutamyltransferas | 1985 |
Antidepressant properties of the triazolobenzodiazepines alprazolam and adinazolam: studies on the olfactory bulbectomized rat model of depression.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Biogenic Amines; B | 1985 |
Effect of repeated administration of monomethyl-aminoantipyrine on the activities of gamma-glutamyltranspeptidase and microsomal drug metabolizing enzymes in rat liver.
Topics: Aminopyrine; Animals; Body Weight; Cytochrome P-450 Enzyme System; Dipyrone; gamma-Glutamyltransfera | 1985 |
Effects of the hepatocarcinogen nafenopin, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital.
Topics: Animals; Body Weight; Catalase; gamma-Glutamyltransferase; Glutathione Peroxidase; Glutathione Trans | 1985 |
Characterization of dimethylnitrosamine-induced focal and nodular lesions in the livers of newborn mice.
Topics: Animals; Animals, Newborn; Body Weight; Dimethylnitrosamine; Female; gamma-Glutamyltransferase; Hype | 1985 |
Effects of dietary selenium concentration on the development of enzyme-altered liver foci and hepatocellular carcinoma induced by diethylnitrosamine or N-acetylaminofluorene in rats.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Diet; Diethylnitrosamine; Dose-Response Relationship, D | 1985 |
Comparative study on pyruvate kinase activity-reducing action of various promoters of hepatocarcinogenesis.
Topics: Animals; Body Weight; Carcinogens; Dexamethasone; Diet; Ethinyl Estradiol; gamma-Glutamyltransferase | 1986 |
Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
Topics: Animals; Body Weight; Clofibrate; Diethylnitrosamine; gamma-Glutamyltransferase; Glucosephosphate De | 1986 |
Influence of dietary fat on the promotion of diethylnitrosamine-induced hepatocarcinogenesis in female rats.
Topics: Analysis of Variance; Animals; Body Weight; Cocarcinogenesis; Dietary Fats; Diethylnitrosamine; Fatt | 1986 |
Dietary effects on initiation and promotion of hepatocarcinogenesis in rat.
Topics: Animals; Body Weight; Diet; Female; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; | 1988 |
Tumor promoting activities of ethylphenylacetylurea and diethylacetylurea, the ring hydrolysis products of barbiturate tumor promoters phenobarbital and barbital, in rat liver and kidney initiated by N-nitrosodiethylamine.
Topics: Animals; Barbital; Body Weight; Carcinogens; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Enz | 1989 |
Postnatal changes in hepatic microsomal enzyme activities in the puppy.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Cytochrome P-450 Enzyme System; Dogs; Female; Glucose | 1985 |
Phenobarbital-induced alterations in the activities of the transport and hydrolytic components of the glucose-6-phosphatase system in smooth and rough subfractions of the rat hepatic endoplasmic reticulum.
Topics: Animals; Biological Transport; Body Weight; Cell Compartmentation; Endoplasmic Reticulum; Glucose-6- | 1987 |
Temporal relationship between the onset of daily gonadotrophin surges and of puberty in female golden hamsters.
Topics: Animals; Body Weight; Cricetinae; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormo | 1986 |
The induction profile of three orally active imidazopyridine-containing cardiotonic agents in rat hepatic microsomes.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Body Weight; Cardiotonic Agents; Cytochrome P-450 CYP1A1; En | 1986 |
Promotion of hepatocarcinogenesis by suxibuzone in rats initiated with 3'-methyl-4-dimethylaminoazobenzene.
Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Drug Interactions; Liver; Liver Neoplasms; | 1987 |
Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study.
Topics: Aminocaproic Acid; Animals; Body Weight; Butylated Hydroxyanisole; Dexamethasone; Diet; Diterpenes; | 1987 |
Effects of castration before and after treatment with N-bis (2-hydroxypropyl)-nitrosamine (DHPN) on the development of thyroid tumors in rats treated with DHPN followed by phenobarbital.
Topics: Animals; Body Weight; Gonadal Steroid Hormones; Hyperplasia; Male; Nitrosamines; Orchiectomy; Organ | 1987 |
Phenobarbitone: adverse effects on reproductive performance and offspring development in the Mongolian gerbil, (Meriones unguiculatus).
Topics: Animals; Body Weight; Drinking; Female; Gerbillinae; Growth; Half-Life; Male; Phenobarbital; Pregnan | 1988 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Inductive effects of fenofibrate and metabolism of phenobarbital.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Fenofibrate; In Vitro Techniques; Liver; Male; | 1988 |
The influence of prenatal phenobarbital exposure on the growth of dendrites in the rat hippocampus.
Topics: Aging; Animals; Body Weight; Dendrites; Female; Hippocampus; Phenobarbital; Pregnancy; Prenatal Expo | 1988 |
Bile acid secretion and pool size during phenobarbital induced hypercholeresis.
Topics: Animals; Bile Acids and Salts; Body Weight; DNA; Hypercholesterolemia; Kinetics; Liver; Male; Organ | 1988 |
Effects of treatment with phenobarbitone or isoniazid on hepatotoxicity due to prolonged subanaesthetic halothane inhalation.
Topics: Animals; Body Weight; Chemical and Drug Induced Liver Injury; Halothane; Isoniazid; Liver; Male; Org | 1988 |
Differential induction of rat hepatic glutathione S-transferase isoenzymes by hexachlorobenzene and benzyl isothiocyanate. Comparison with induction by phenobarbital and 3-methylcholanthrene.
Topics: Animals; Body Weight; Chlorobenzenes; Enzyme Induction; Glutathione Transferase; Hexachlorobenzene; | 1988 |
P-450 enzyme induction by 5-ethyl-5-phenylhydantoin and 5,5-diethylhydantoin, analogues of barbiturate tumor promoters phenobarbital and barbital, and promotion of liver and thyroid carcinogenesis initiated by N-nitrosodiethylamine in rats.
Topics: Animals; Barbital; Barbiturates; Body Weight; Cytochrome P-450 Enzyme System; Diethylnitrosamine; En | 1988 |
Failure of phenobarbitone to potentiate the adverse effects of two ethylene-bis-dithiocarbamate (EBDC) fungicides.
Topics: Animals; Body Weight; Drug Synergism; Female; Liver; Male; Maneb; Phenobarbital; Rats; Rats, Inbred | 1988 |
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Topics: Acetaminophen; Animals; Body Weight; Cocarcinogenesis; DNA; Glutathione Transferase; Liver; Liver Ne | 1988 |
Alteration of hepatic drug metabolizing activities and contents of cytochrome P-450 isozymes by neonatal monosodium glutamate treatment.
Topics: Animals; Animals, Newborn; Biotransformation; Body Weight; Cytochrome b Group; Cytochrome P-450 Enzy | 1988 |
Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital.
Topics: Animals; Body Weight; Cell Transformation, Neoplastic; Eating; Female; Male; Nitrosamines; Organ Siz | 1988 |
Dinitrotoluene isomer-specific hepatocarcinogenesis in F344 rats.
Topics: Animals; Body Weight; Carcinogens; Dinitrobenzenes; Epoxide Hydrolases; Isomerism; Liver; Liver Neop | 1987 |
In vitro activation and resultant binding of benzo[a]pyrene to DNA by microsomes from rats fed corn and menhaden oils.
Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Aryl Hydrocarbon Hydroxylases; Benzopyrene Hydroxylase; Benz | 1986 |
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Female; Fetal Resorption; Male; M | 1987 |
Induction of hepatic oxidative and conjugative drug metabolism in the hamster by N-substituted imidazoles.
Topics: Animals; Body Weight; Clotrimazole; Cricetinae; Cytochrome P-450 Enzyme System; Female; Glucuronates | 1987 |
[Liver cytochrome P-450 induction in rats by drug preparations and the body vitamin A allowance].
Topics: Aminopyrine; Animals; Body Weight; Cytochrome P-450 Enzyme System; Drug Combinations; Enzyme Inducti | 1987 |
Interaction of induction, ontogenetic development and liver regeneration on the monooxygenase level.
Topics: Age Factors; Aging; Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Coumarins; Cytochrome | 1987 |
Kinetics of drug action in disease states. XX. Effects of acute starvation on the pharmacodynamics of phenobarbital, ethanol and pentylenetetrazol in rats and effects of refeeding and diet composition.
Topics: Animals; Blood Proteins; Body Weight; Central Nervous System; Diet; Dietary Carbohydrates; Dietary P | 1987 |
The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver.
Topics: Acetates; Adenoma; Animals; Body Weight; Dichloroacetic Acid; Drug Synergism; Ethylnitrosourea; Live | 1987 |
Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liver.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cocarcinogenesis; Cytochrome P-450 Enzyme System; D | 1986 |
Early weight-change patterns in neonatal abstinence.
Topics: Birth Weight; Body Weight; Energy Intake; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exch | 1986 |
Accuracy of five methods for predicting phenobarbital concentrations in pediatric patients.
Topics: Adolescent; Biological Availability; Body Weight; Child; Child, Preschool; Humans; Infant; Kinetics; | 1986 |
Amplified response to phenobarbital promotion of hepatotumorigenesis in obese yellow Avy/A (C3H x VY) F-1 hybrid mice.
Topics: Adenoma; Animals; Body Weight; Hybridization, Genetic; Liver; Liver Neoplasms, Experimental; Male; M | 1986 |
Susceptible and resistant subgroups in genetically identical populations: response of mouse liver neoplasia and body weight to phenobarbital.
Topics: Adenoma; Animals; Body Weight; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred C3H; Mice, Mu | 1986 |
Modulation of rat hepatic microsomal testosterone hydroxylases by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related toxic isostereomers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Body Weight; Cytochrome P-450 CYP1A1; Dioxins; In Vitro Tech | 1985 |
Comparative tumor-promoting activities of phenobarbital, amobarbital, barbital sodium, and barbituric acid on livers and other organs of male F344/NCr rats following initiation with N-nitrosodiethylamine.
Topics: Amobarbital; Animals; Barbital; Barbiturates; Body Weight; Diethylnitrosamine; Liver Neoplasms, Expe | 1985 |
Enhancement of hepatocarcinogenesis by sorbitan fatty acid ester, a liver pyruvate kinase activity-reducing substance.
Topics: Animals; Bile Ducts; Body Weight; Hemangioma; Liver; Liver Neoplasms; Liver Neoplasms, Experimental; | 1985 |
N-Nitroso-N-methylurea initiation in multiple tissues for organ-specific tumor promotion in rats by phenobarbital.
Topics: Animals; Body Weight; Carcinogens; Female; Liver; Liver Neoplasms, Experimental; Male; Methylnitroso | 1985 |
Neonatal phenobarbital imprinting of hepatic microsomal enzymes in adult rats: modulation by neonatal testosterone presence.
Topics: Animals; Animals, Newborn; Body Weight; Castration; Cytochrome P-450 Enzyme System; Female; Glucuron | 1985 |
Maternal barbiturate administration and offspring response to shock.
Topics: Animals; Avoidance Learning; Body Weight; Brain; Conditioning, Operant; Electroshock; Female; Humans | 1985 |
Serum concentrations of valproic acid: influence of dose and comedication.
Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps | 1985 |
Interstrain differences in susceptibility to liver carcinogenesis initiated by N-nitrosodiethylamine and its promotion by phenobarbital in C57BL/6NCr, C3H/HeNCrMTV- and DBA/2NCr mice.
Topics: Animals; Body Weight; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms, Experimental; Male; Mic | 1986 |
Absence of a promoting or sequential syncarcinogenic effect in rat liver by the carcinogenic hypolipidemic drug nafenopin given after N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Administration, Oral; Animals; Body Weight; Carcinogens; Drug Synergism; Live | 1985 |
A comparison of the effects of hexachlorobenzene, beta-naphthoflavone, and phenobarbital on cytochrome P-450 and mixed-function oxidases in Japanese quail.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Chemical and Drug Induced Liver Injury; Ch | 1985 |
The acute toxicity of cyclopentadienyl manganese tricarbonyl in the rat.
Topics: Animals; Body Weight; Drug Tolerance; Lethal Dose 50; Male; Manganese; Manganese Poisoning; Organ Si | 1985 |
Steady-state serum levels of anticonvulsant drugs in Chinese epileptic patients living in Taiwan.
Topics: Adolescent; Adult; Age Factors; Asian People; Body Weight; Child; Epilepsy; Female; Humans; Male; Mi | 1985 |
Long-term behavioral effects of phenobarbital in suckling rats.
Topics: Animal Population Groups; Animals; Animals, Suckling; Behavior, Animal; Body Weight; Brain; Dose-Res | 1985 |
[Nomogram for phenobarbital dosage in children].
Topics: Body Weight; Child; Humans; Mathematics; Phenobarbital | 1985 |
Xenobiotic imprinting of hepatic metabolic enzyme systems: effect of neonatal 3-methylcholanthrene administration.
Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Inductio | 1985 |
Comparison of the impact of continuous and intermittent exposure to vinyl chloride, including phenobarbital effect.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Body Weight; Envir | 1985 |
Hepato- and neuro-toxicity by ethylenthiourea.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Ethylenethiourea; Female; Imidazoles; Lethal D | 1985 |
Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Body Weight; Dioxoles; Enzyme Induction; Flavonoids; Ma | 1985 |
Effects of selenium supplementation on hepatocarcinogenesis in rats.
Topics: Animals; Body Weight; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Org | 1985 |
[Studies on liver enlargement through phenobarbital].
Topics: Animals; Body Weight; Cell Nucleus; DNA; Hepatomegaly; Injections, Intraperitoneal; Liver; Male; Nuc | 1970 |
Long-term effects of carbon tetrachloride and sodium phenobarbitone administration on rat serum proteins.
Topics: Alpha-Globulins; Animals; Blood Proteins; Body Weight; Carbon Tetrachloride; gamma-Globulins; Immuno | 1973 |
The influence of antiepileptic drugs on the morphologic picutre of the rhinencephalon in rats.
Topics: Administration, Oral; Animals; Body Weight; Drug Tolerance; Female; Limbic System; Male; Olfactory B | 1973 |
Massive lethal hepatic necrosis in rats anesthetized with fluroxene, after microsomal enzyme induction.
Topics: Anesthesia, Inhalation; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Cytochrome P-4 | 1973 |
Induction of UDP glucuronyltransferase in the liver and extrahepatic organs of the rat.
Topics: Animals; Body Weight; Chlorpromazine; Digitonin; Enzyme Induction; Glucuronosyltransferase; Hexosylt | 1973 |
Effect of phenobarbital administration on liver and plasma gamma-glutamyl-transpeptidase: clinical and experimental investigations.
Topics: Animals; Body Weight; Chronic Disease; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Induction; ga | 1973 |
Riboflavin and drug metabolism in adult male and female rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Body Weight; Cytochrome c Group; Cytochr | 1974 |
Effect of phenobarbitone on bile flow and bilirubin metabolism in man and the rat.
Topics: Adipates; Animals; Bile; Bilirubin; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; G | 1973 |
Drug hydroxylation and glucuronidation in liver microsomes of phenobarbital-treated rats.
Topics: Animals; Anisoles; Body Weight; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Digitonin; Gl | 1973 |
The effect of phenobarbital on cholesterol gallstones in hamsters.
Topics: Animals; Bile; Bilirubin; Body Weight; Cholelithiasis; Cholesterol; Cricetinae; Diet; Glucuronosyltr | 1973 |
Time-course of induction of microsomal enzymes following treatment with polychlorinated biphenyl.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Diet; Enzyme Induction; Feeding Behavior; Kine | 1974 |
Effect of silybin on the hepatic microsomal drug-metabolising enzyme system in the rat.
Topics: Alcohols; Aniline Compounds; Animals; Anisoles; Antipyrine; Binding Sites; Body Weight; Cytochrome P | 1974 |
[Effect of DDT pretreatment of young ducks on eventual reaction towards a peanut oil-cake by aspergillus flavus].
Topics: Aflatoxins; Animals; Aspergillus flavus; Body Weight; DDT; Ducks; Liver; Male; Phenobarbital | 1974 |
Decreased effect of phenobarbital treatment on microsomal drug metabolizing enzyme activity during gestation.
Topics: Animals; Benzopyrenes; Body Weight; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemic | 1974 |
Liver enlargement and hepatoxicity: an investigation into the effects of several agents on rat liver enzyme activities.
Topics: Alanine Transaminase; Amides; Animals; Anticholesteremic Agents; Barbiturates; Body Weight; Butyrate | 1967 |
Effect of starvation on the in vivo metabolism and effect of drugs in female and male rats.
Topics: Amides; Anesthesia; Animals; Barbiturates; Body Weight; Carisoprodol; Diphosphates; Female; Hexobarb | 1967 |
Biochemical changes in rat liver in response to treatment with drugs and other agents. I. Effects of anticonvulsant, anti-inflammatory, hypocholesterolaemic and adrenergic beta-blocking agents.
Topics: Acetanilides; Aminopyrine; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Anticonvulsa | 1969 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7535.
Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Cell Division; Fluorenes; Glucosephosp | 1968 |
Effect of phenobarbital treatment on lysosomal enzyme activity in rat liver.
Topics: Acid Phosphatase; Animals; Body Weight; Cathepsins; Glucose-6-Phosphatase; Glucuronates; Glucuronida | 1971 |
The effects of various drugs and toxic agents on bile flow rate and composition in the rat.
Topics: Adenosine Triphosphate; Animals; Bile; Bile Acids and Salts; Bilirubin; Body Temperature; Body Weigh | 1971 |
Infantile diarrhoea in a population of low socio-economic group.
Topics: Ascaris; Aspirin; Body Weight; Diarrhea, Infantile; Diet; Entamoeba histolytica; Escherichia coli; F | 1971 |
Increase of microsomal glucose-6-phosphatase activity after chronic ethanol administration.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Dietary Carbohydrates; Dietary Fats; Dietary P | 1973 |
Activity of microsomal enzymes in the livers of rats fed rapeseed oil.
Topics: Aminopyrine N-Demethylase; Animals; Azo Compounds; Body Weight; Cytochrome P-450 Enzyme System; Diet | 1974 |
[Anticonvulsants and vitamin D metabolism (author's transl)].
Topics: Animals; Anticonvulsants; Avitaminosis; Body Weight; Calcium; Calcium Radioisotopes; Cholecalciferol | 1974 |
Changes in pressor activity of angiotensin II induced by pentolinium and phenobarbital in rats.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Drug Synergism; Injections, Intravenous; Pento | 1974 |
Comparison of drug-metabolizing and olefin-forming systems in rat liver.
Topics: Animals; Body Weight; Dietary Fats; Fatty Acids; In Vitro Techniques; Liver; Male; Microsomes; NADP; | 1967 |
[On the influencing of food intake by psychotropic drugs].
Topics: Amitriptyline; Animals; Behavior, Animal; Body Weight; Central Nervous System; Central Nervous Syste | 1966 |
Drug metabolism in tumor-bearing rats. I. Activities of NADPH-linked electron transport and drug-metabolizing enzyme systems in liver microsomes of tumor-bearing rats.
Topics: Aminopyrine; Aniline Compounds; Animals; Barbiturates; Body Weight; Carcinoma 256, Walker; Carisopro | 1968 |
The inhibitory effect of aureomycin (chlortetracycline) pretreatment on some rat liver microsomal enzyme activities.
Topics: Albumins; Aminopyrine; Animals; Body Weight; Chlortetracycline; Cytochromes; Depression, Chemical; H | 1969 |
Changes in the serum concentration of cholesterol, triglycerides and phospholipids in the mouse and rat after administration of either chlorcyclizine or phenobarbital.
Topics: Animals; Benzophenones; Body Weight; Cholesterol; Female; Fluorenes; Histamine H1 Antagonists; Liver | 1970 |
Effect of inhibitors and inducers of drug metabolism on ethanol metabolism in vivo.
Topics: Animals; Body Weight; Ethanol; Female; Histamine H1 Antagonists; Male; Mathematics; Metabolism; Mice | 1970 |
Effect of phenobarbital and chlorcyclizine on the development of atheromatosis in the cholesterol-fed rabbit.
Topics: Animals; Anisoles; Aorta; Arteriosclerosis; Body Weight; Carbon Isotopes; Cholesterol; Dealkylation; | 1970 |
Toxicologic studies of glycopyrrolate in combination with other drugs.
Topics: Animals; Ataxia; Body Weight; Carbamates; Catechols; Dogs; Feeding Behavior; Female; Glycopyrrolate; | 1971 |
Renal salt and water excretion in the budgerygah (Melopsittacus undulatus).
Topics: Anesthesia, General; Animals; Body Weight; Chlorides; Female; Glomerular Filtration Rate; Inulin; Ki | 1972 |
Influence of dietary iron levels on hepatic drug metabolism in vivo and in vitro in the rat.
Topics: Aminopyrine; Anemia, Hypochromic; Aniline Compounds; Animals; Body Weight; Cytochrome c Group; Cytoc | 1972 |
Study of the increased glyceryl trinitrate metabolism after pretreatment with phenobarbital in rat liver.
Topics: Animals; Body Weight; Dactinomycin; Ethionine; Glucose-6-Phosphatase; Glucosephosphate Dehydrogenase | 1972 |
Effect of various factors on iron absorption in mice with X-linked anaemia.
Topics: Administration, Oral; Anemia, Hypochromic; Animals; Ascorbic Acid; Biological Transport; Body Weight | 1974 |
Effect of n-hexane inhalation on the monooxygenase system in mice liver microsomes.
Topics: Alkanes; Animals; Body Weight; Cyclohexanes; Cyclohexanols; Cytochrome P-450 Enzyme System; Cytochro | 1974 |
Induction by phenobarbital of hepatic microsomal drug-metabolizing enzyme system in partially hepatectomized rats.
Topics: Aminopyrine N-Demethylase; Animals; Body Weight; Cyanides; Cytochrome P-450 Enzyme System; Cytochrom | 1974 |
A comparison of the effect of barbitone, phenobarbitone, pentobarbitone and barbituric acid on the growth rate of rats and mice.
Topics: Animals; Barbiturates; Body Weight; Female; Growth; Kidney; Liver; Male; Mice; Organ Size; Pentobarb | 1974 |
Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines.
Topics: Animals; Apomorphine; Behavior, Animal; Body Weight; Catecholamines; Chlorpromazine; Diazepam; Dose- | 1974 |
Normal shuttle box avoidance learning after chronic phenobarbital intoxication in mice.
Topics: Animals; Ataxia; Avoidance Learning; Behavior, Animal; Body Weight; Depression, Chemical; Dose-Respo | 1974 |
[Drug dependence in rats: substitution test and sequential changes in body weight].
Topics: Animals; Body Weight; Codeine; Drug Therapy, Combination; Humans; Male; Meprobamate; Morphine; Morph | 1974 |
Alcohol, barbiturate, and bromide withdrawal syndromes in mice.
Topics: Alcohol Drinking; Alcoholism; Animals; Barbiturates; Body Weight; Bromides; Diet; Disease Models, An | 1973 |
Newborn infants of mothers on methadone maintenance.
Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, D | 1974 |
Prevention by catatoxic steroids of lithocholic acid-induced biliary concrements in the rat.
Topics: Animals; Bile Acids and Salts; Body Weight; Common Bile Duct; Female; Gallstones; Jaundice; Lithocho | 1972 |
Phenobarbital-mediated increase in ring- and N-hydroxylation of the carcinogen N-2-fluorenylacetamide, and decrease in amounts bound to liver deoxyribonucleic acid.
Topics: Acetamides; Animals; Body Weight; Carbon Isotopes; Carbon Monoxide; Carcinogens; Chromatography, Pap | 1972 |
Effect in rats of subacute administration of ethosuximide, methsuximide and phensuximide on hepatic microsomal enzymes and porphyrin turnover.
Topics: 5-Aminolevulinate Synthetase; Animals; Anticonvulsants; Body Weight; Ethosuximide; Liver; Male; Micr | 1972 |
[Tolerance and physical dependence producing liability of doxepin].
Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; M | 1972 |
Effects of chlorpromazine and phenobarbital on rat liver and brain oxidative N-oxidase and N-demethylase activities.
Topics: Animals; Body Weight; Brain; Chlorpromazine; Liver; Male; Organ Size; Oxidoreductases, N-Demethylati | 1972 |
The absence of effect of phenobarbital on halothane toxicity.
Topics: Aerosols; Animals; Aspartate Aminotransferases; Body Weight; Halothane; Kidney; L-Lactate Dehydrogen | 1973 |
Effect of phenobarbital and SKF 525A on the toxicity, elimination and metabolism of cyclophosphamide in newborn mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Carbon Isotopes; Cyclophosphamide; Drug Synergism | 1973 |
Effect of protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system. I. Effect on substrate interaction with cytochrome P-450.
Topics: Appetite; Body Weight; Cytochrome P-450 Enzyme System; Dietary Proteins; Enzyme Induction; Kinetics; | 1973 |
Changes of fluoride content in bone: an index of drug defluorination in vivo.
Topics: Anesthetics; Animals; Biotransformation; Body Weight; Bone and Bones; Chlorine; Drug Interactions; E | 1973 |
Stimulation of hepatic microsomal drug-metabolizing enzymes in mice by 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 3,4-benzpyrene.
Topics: Aminopyrine N-Demethylase; Aniline Compounds; Animals; Benzopyrenes; Body Weight; Cytochrome P-450 E | 1973 |
Effect of phenobarbital induction on galactose elimination capacity in the rat.
Topics: Animals; Body Weight; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Galactose; Kinetics; | 1973 |
Ovulatory and body weight response of the hamster to constant light or pinealectomy.
Topics: Animals; Body Weight; Cricetinae; Estrus; Female; Light; Ovulation; Phenobarbital; Pineal Gland; Pre | 1973 |
Neonatal hyperthyroidism.
Topics: Adult; Body Weight; Breast Diseases; Diarrhea; Digitalis Glycosides; Female; Graves Disease; Humans; | 1973 |
Effects of dietary protein quality on drug metabolism in the rat.
Topics: Anesthesia; Aniline Compounds; Animals; Body Weight; Caseins; Cytochrome P-450 Enzyme System; Dealky | 1973 |
Effect of various steroids on the hepatic glucuronidation and biliary excretion of bilirubin.
Topics: Animals; Bile; Bile Pigments; Bilirubin; Body Weight; Female; Glucuronates; Hexosyltransferases; Hyd | 1973 |
The effect of thiamine deficiency on the actions of drugs effecting the central nervous system.
Topics: Analgesia; Animals; Appetite; Body Weight; Brain; Chlordiazepoxide; Dextroamphetamine; Lethal Dose 5 | 1973 |
Effect of benzene on hepatic drug metabolism and ultrastructure.
Topics: Animals; Azo Compounds; Benzene; Benzene Derivatives; Benzoates; Body Weight; Carbon Radioisotopes; | 1973 |
Comparison of phenobarbital with orphenadrine hydrochloride and tofenacine hydrochloride for enzyme-inducing activity in young and adult rats.
Topics: Aging; Animals; Benzene Derivatives; Body Weight; Drug Tolerance; Enzyme Induction; Ethers; Ethylami | 1973 |
Effect of underfeeding suckling rats on the activity of hepatic drug metabolizing enzymes.
Topics: Animals; Animals, Newborn; Benzoates; Biphenyl Compounds; Body Weight; Coumarins; Cytochrome P-450 E | 1973 |
Enhancement of hepatic detoxification enzyme activity by dietary mercuric acetate.
Topics: Acetates; Animals; Anisoles; Body Weight; Diet; Dose-Response Relationship, Drug; Drug Synergism; Fe | 1973 |
Effects of inositol, diphenylhydantoin and phenobarbital on HEOD storage in rat adipose tissue.
Topics: Adipose Tissue; Aminopyrine N-Demethylase; Animals; Body Weight; Dieldrin; Inositol; Male; Microsome | 1973 |
[Studies in mice on the effectiveness of various methods of enzyme induction with phenobarbital].
Topics: Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Enzyme Induction; Fema | 1973 |
Differential effects of benzodioxane, chroman, and dihydrobenzofuran analogs of clofibrate on various parameters of hepatic drug metabolism.
Topics: Aniline Compounds; Animals; Benzofurans; Benzopyrans; Body Weight; Clofibrate; Cytochrome P-450 Enzy | 1974 |
Increased liver microsomal androgen metabolism by phenobarbital: correlation with decreased androgen action on the seminal vesicles of the rat.
Topics: Androgens; Animals; Body Weight; Diet; Dose-Response Relationship, Drug; Fluoxymesterone; Hydroxylat | 1974 |
Hepatic microsomal enzyme induction by inhalation anesthetics: mechanism in the rat.
Topics: Anesthesia, Inhalation; Animals; Biotransformation; Body Weight; Cytochrome P-450 Enzyme System; Cyt | 1974 |
Effects of benzoquinolizine homologues on proliferative and exudative inflammation.
Topics: Adrenal Glands; Animals; Anti-Inflammatory Agents; Body Weight; Carrageenan; Catecholamines; Chlorpr | 1974 |
In vivo enrichment of hepatic microsomes with isotopic iron.
Topics: Anemia, Hypochromic; Animals; Body Weight; Cytochromes; Deficiency Diseases; Dose-Response Relations | 1974 |
Effect of chronic treatment with phenobarbital or 3-methylcholanthrene on the male reproductive system in rats.
Topics: Animals; Body Weight; Carbon Radioisotopes; Chromatography, Thin Layer; Cytochrome P-450 Enzyme Syst | 1974 |
The lack of effects of pretreatment with phenobarbital and chlorpromazine on the acute toxicity of benzene in rats.
Topics: Aerosols; Animals; Benzene; Body Weight; Carbon Radioisotopes; Chlorpromazine; Chromatography, Gas; | 1974 |
An experimental investigation of dependence liability of methaqualone in rats.
Topics: Acoustic Stimulation; Animals; Body Temperature; Body Weight; Dose-Response Relationship, Drug; Drug | 1974 |
The effect of phenobarbitone treatment of rats and of protein deprivation on the capacity of liver slices to conjugate bilirubin.
Topics: Animals; Bile Acids and Salts; Bilirubin; Body Weight; Depression, Chemical; Edetic Acid; In Vitro T | 1969 |
Enhancement of progressive-ratio performance by chlordiazepoxide and phenobarbital.
Topics: Animals; Body Weight; Chlordiazepoxide; Columbidae; Conditioning, Operant; Feeding Behavior; Food De | 1972 |
A possible role for the mixed function oxidase enzyme system in the requirement for selenium in the rat.
Topics: Aminopyrine; Animals; Body Weight; Castration; Deficiency Diseases; Estradiol; Female; Feminization; | 1972 |
The effect of phenobarbital on intestinal calcium transport.
Topics: Animals; Body Weight; Calcium; Calcium Isotopes; Duodenum; Ileum; Intestinal Absorption; Intestine, | 1972 |
Effects of microsomal enzyme inducers on animals poisoned with hepatotoxins.
Topics: Alanine Transaminase; Animals; Barbiturates; Blood Proteins; Body Weight; Carbon Tetrachloride; Carb | 1972 |
Effects of ascorbic acid deficiency on kinetics of drug hydroxylation in male guinea pigs.
Topics: Aniline Compounds; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cytochromes; Guine | 1972 |
Microsomal drug-metabolizing enzymes activity and induction in the rat liver after portacaval shunt.
Topics: Animals; Body Weight; Enzyme Induction; Hexobarbital; Male; Microsomes, Liver; Organ Size; Phenobarb | 1972 |
Effect of phenobarbitone on hepatic microsomal enymes of the mmale rat.
Topics: Animals; Body Weight; Glucuronates; Hexosyltransferases; Liver; Male; Microsomes, Liver; Organ Size; | 1972 |
The value of stereology in analysing structure and function of cells and organs.
Topics: Animals; Body Weight; Capillaries; Cell Biology; Cells; Diffusion; Dogs; Endoplasmic Reticulum; Gase | 1972 |
Effect of phenobarbital on growth of a metastasising, allogeneic sarcoma in the rat.
Topics: Animals; Body Weight; Cobalt Isotopes; Female; Immunosuppression Therapy; Lung Neoplasms; Lymphatic | 1972 |
Ethanol tolerance and ethanol-drug interactions in the rat.
Topics: Animals; Barbiturates; Behavior, Animal; Body Weight; Depression, Chemical; Drug Interactions; Drug | 1972 |
Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.
Topics: Aflatoxins; Animals; Biotransformation; Body Weight; Carcinogens; Enzyme Induction; Liver; Liver Neo | 1971 |
Phenobarbitone enhancement of bromsulphalein clearance in neonatal hyperbilirubinemia.
Topics: Bilirubin; Body Weight; Female; Humans; Infant, Newborn; Jaundice, Neonatal; Liver; Liver Function T | 1971 |
Variations of serum diphenylhydantoin concentrations in epileptic out-patients.
Topics: Adolescent; Adult; Aged; Blood Proteins; Body Weight; Drug Synergism; Epilepsy; Female; Humans; Male | 1971 |
Effect of phenobarbital on the restoration of impaired drug metabolism in carbon tetrachloride-induced liver damage.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Clinical Enzyme Tests; Cytochromes; Enzyme Act | 1971 |
The effect of intestinal obstruction on liver microsomal enzymes in rats.
Topics: Anesthesia; Animals; Body Temperature; Body Weight; Chlorpromazine; Hematocrit; Intestinal Obstructi | 1968 |
Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7409.
Topics: Animals; Body Weight; Carcinogens; Fluorenes; Liver Neoplasms; Male; Neoplasms, Experimental; Organ | 1967 |
Repeated derepression cycles of the glucuronolactone dehydrogenase and cytochrome P-450 in the rat liver induced by phenobarbitone administration.
Topics: Alcohol Oxidoreductases; Body Weight; Cytochromes; Liver; Organ Size; Phenobarbital | 1969 |
Factors affecting the metabolism and response to hexobarbital.
Topics: Age Factors; Animals; Body Weight; Breeding; Female; Hexobarbital; Liver; Male; Methylcholanthrene; | 1969 |
Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes.
Topics: Adjuvants, Anesthesia; Aniline Compounds; Animals; Anisoles; Blood Proteins; Body Weight; Carbon Dis | 1969 |
Aryl 4-hydroxylase, cytochrome P-450 and microsomal lipids in essential fatty acid deficiency.
Topics: Aniline Compounds; Animals; Body Weight; Cytochromes; Deficiency Diseases; Fatty Acids, Essential; H | 1970 |
Drug metabolism in ethanol-induced fatty liver.
Topics: Animals; Body Weight; Choline Deficiency; Cytochromes; Endoplasmic Reticulum; Ethanol; Fatty Liver; | 1970 |
Drug-steroid interaction in the pregnant rat, fetus, and neonate.
Topics: Abnormalities, Drug-Induced; Aniline Compounds; Animals; Animals, Newborn; Ascorbic Acid; Body Weigh | 1970 |
Effect of phenobarbital and SKF 525A pretreatment on diphenylhydantoin teratogenicity in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Depression, Chemical; Drug Synergism; Female; Fet | 1970 |
The effects of certain barbiturates on the hepatic porphyrin metabolism of rats.
Topics: Administration, Oral; Amino Acid Oxidoreductases; Amobarbital; Animals; Barbiturates; Body Weight; I | 1970 |
Genetic control of phenylbutazone metabolism in man.
Topics: Body Height; Body Weight; Female; Genetics, Medical; Humans; Liver; Male; Phenobarbital; Phenylbutaz | 1970 |
[The mechanism of liver enlargement after treatment with different doses of phenobarbital].
Topics: Age Factors; Animals; Body Weight; DNA; Hepatomegaly; Liver; Male; Organ Size; Phenobarbital; Protei | 1971 |
Effects of dietary administration of 5-(3,4-dichloro-phenyl)-5-ethylbarbituric acid (dichlorophenobarbital) to rats: emphasis on hepatic drug-metabolizing enzymes and morphology.
Topics: Animals; Anisoles; Barbiturates; Body Weight; Chlorine; Dealkylation; Enzyme Induction; Female; Hepa | 1971 |
Induction of hepatic microsomal hydroxylating enzymes by technical piperonyl butoxide and some of its analogs.
Topics: Animals; Anisoles; Biotransformation; Body Weight; Cytochromes; Dioxoles; Enzyme Induction; Ethers, | 1971 |
Controlling factors in urethan carcinogenesis in mice: effect of enzyme inducers and metabolic inhibitors.
Topics: Animals; Body Weight; Chlordan; Cycloheximide; Dactinomycin; Flavonoids; Hematocrit; Lung Neoplasms; | 1971 |
Protection against the neural organizing effect of exogenous androgen in the neonatal female rat.
Topics: Animals; Animals, Newborn; Body Weight; Chlorpromazine; Desoxycorticosterone; Female; Hypothalamus; | 1968 |
Critical exposure time for androgenization of the developing hypothalamus in the female rat.
Topics: Animals; Body Weight; Female; Hypothalamus; Infertility, Female; Organ Size; Ovary; Pentobarbital; P | 1968 |
Tolerance to morphine in the white mice.
Topics: Aminopyrine; Animals; Behavior, Animal; Body Temperature; Body Weight; Drug Tolerance; Mice; Morphin | 1968 |
Liver growth associated with the induction of aminopyrine demethylase activity after phenobarbital treatment in adult male rats.
Topics: Aminopyrine; Animals; Body Weight; Injections, Intraperitoneal; Liver; Male; Mitosis; Organ Size; Ph | 1968 |
Effect of phenobarbital administration on the subcellular distribution of 125-I-thyroxine in rat liver: mportance of microsomal binding.
Topics: Animals; Binding Sites; Body Weight; Cell Nucleus; Endoplasmic Reticulum; Iodine Isotopes; Liver; Ma | 1969 |
Barbiturate mortality in hypothyroid and hyperthyroid rats.
Topics: Amobarbital; Animals; Barbiturates; Basal Metabolism; Body Temperature; Body Weight; Hexobarbital; H | 1969 |
Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.
Topics: Acetates; Animals; Benzene Derivatives; Benzopyrenes; Body Weight; Cytochromes; Glycogen; Liver; Mal | 1969 |
Studies of analgesic and anticonvulsant activity in mice by high-frequency electrical stimulation.
Topics: Age Factors; Analgesics; Animals; Anticonvulsants; Aspirin; Body Weight; Electric Stimulation; Elect | 1969 |
Microsome-specific stimulation by phenobarbital of amino acid incorporation in vivo.
Topics: Animals; Body Weight; In Vitro Techniques; Leucine; Liver; Microsomes; Organ Size; Phenobarbital; Pr | 1965 |
Some effects of alcohol and reduced temperature on the performance of rats.
Topics: Animals; Behavior, Animal; Body Temperature; Body Weight; Cold Temperature; Drug Tolerance; Ethanol; | 1966 |
Effects of 3,4-benzpyrene, phenobarbital, and chlordane on the nucleic acid and protein content of subfractions of rat liver homogenates.
Topics: Animals; Benzopyrenes; Body Weight; Cell Nucleus; Chlordan; DNA; Endoplasmic Reticulum; Liver; Male; | 1966 |