phenobarbital has been researched along with Bladder Cancer in 18 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two epidemiologic studies have reported an inverse association between use of phenobarbital (PB) and bladder cancer development." | 7.72 | Phenobarbital use and bladder cancer risk. ( Castelao, JE; Gago-Dominguez, M; Ross, RK; Yu, MC; Yuan, JM, 2003) |
| "Two epidemiologic studies have reported an inverse association between use of phenobarbital (PB) and bladder cancer development." | 3.72 | Phenobarbital use and bladder cancer risk. ( Castelao, JE; Gago-Dominguez, M; Ross, RK; Yu, MC; Yuan, JM, 2003) |
| "Phenobarbital treatment has been observed to be negatively associated with bladder cancer risk in a few studies." | 3.70 | Barbiturates, smoking, and bladder cancer risk. ( Bull, SA; Friedman, GD; Habel, LA, 1998) |
| "05% phenobarbital (PB), or weekly intraperitoneal injections of 2 mg of pepleomycin per kg body weight until week 36." | 3.67 | Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. ( Asamoto, M; Fukushima, S; Ito, N; Kurata, Y; Thamavit, W, 1989) |
| "Phenobarbital was continued for approximately 15 hours before patient peacefully died." | 1.62 | A Case Report of Phenobarbital for Proportionate Sedation to Control Refractory Symptoms at the End of Life in an Opioid Tolerant Patient. ( Atayee, RS; Edmonds, KP; Hirst, JM; Jones, JF, 2021) |
| " The public health implication of this lack of linearity in the low-dose area of the dose-response curve raises the question of whether low doses of carcinogens will reduce cancer risk." | 1.30 | Can the concept of hormesis Be generalized to carcinogenesis? ( Baldwin, LA; Calabrese, EJ, 1998) |
| " The dose-response of the promoters were examined in both sexes of rats by administration of saccharin at doses of 0." | 1.27 | Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat. ( Fukushima, S; Ito, N; Nakanishi, K; Shirai, T, 1983) |
| "National Cancer Institute and two Federal Agencies, seven drugs were listed." | 1.26 | Epidemiological studies of medically used drugs. ( Clemmesen, J; Hjalgrim-Jensen, S, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (66.67) | 18.7374 |
| 1990's | 4 (22.22) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, JF | 1 |
| Hirst, JM | 1 |
| Edmonds, KP | 1 |
| Atayee, RS | 1 |
| Castelao, JE | 1 |
| Gago-Dominguez, M | 1 |
| Yuan, JM | 1 |
| Ross, RK | 1 |
| Yu, MC | 1 |
| Tsuda, H | 2 |
| Fukushima, S | 4 |
| Imaida, K | 3 |
| Kurata, Y | 2 |
| Ito, N | 8 |
| Shirai, T | 3 |
| Nakanishi, K | 3 |
| Wang, CY | 2 |
| Garner, CD | 1 |
| Hirose, M | 1 |
| Clemmesen, J | 1 |
| Hjalgrim-Jensen, S | 1 |
| Hagiwara, A | 2 |
| Tamano, S | 1 |
| Tatematsu, M | 1 |
| Morimoto, S | 1 |
| Hasegawa, R | 1 |
| Futakuchi, M | 1 |
| Mizoguchi, Y | 1 |
| Yamaguchi, T | 1 |
| Lijinsky, W | 1 |
| Habel, LA | 1 |
| Bull, SA | 1 |
| Friedman, GD | 1 |
| Calabrese, EJ | 1 |
| Baldwin, LA | 1 |
| Thamavit, W | 1 |
| Asamoto, M | 1 |
| Diwan, BA | 1 |
| Ward, JM | 1 |
| Rice, JM | 1 |
| Masuda, A | 1 |
| Ogiso, T | 1 |
| Bertram, JS | 1 |
| Craig, AW | 1 |
1 review available for phenobarbital and Bladder Cancer
| Article | Year |
|---|---|
Organ-specific modifying effects of phenobarbital, saccharin and antioxidants on 2-stage chemical carcinogenesis.
Topics: Animals; Antioxidants; Ascorbic Acid; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogen | 1986 |
17 other studies available for phenobarbital and Bladder Cancer
| Article | Year |
|---|---|
A Case Report of Phenobarbital for Proportionate Sedation to Control Refractory Symptoms at the End of Life in an Opioid Tolerant Patient.
Topics: Analgesics, Opioid; Carcinoma, Transitional Cell; Death; Humans; Male; Middle Aged; Pain, Intractabl | 2021 |
Phenobarbital use and bladder cancer risk.
Topics: Age Distribution; Bias; Case-Control Studies; Drug Utilization; Epidemiologic Research Design; Femal | 2003 |
Organ-specific promoting effect of phenobarbital and saccharin in induction of thyroid, liver, and urinary bladder tumors in rats after initiation with N-nitrosomethylurea.
Topics: Adenocarcinoma, Papillary; Animals; Cocarcinogenesis; Liver Neoplasms; Male; Methylnitrosourea; Nitr | 1983 |
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Carcinogens; Dose-Response Relationshi | 1983 |
Effect of phenobarbital on the carcinogenesis of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide in rats.
Topics: Animals; Carcinogens; Drug Interactions; Drug Synergism; FANFT; Liver Neoplasms, Experimental; Male; | 1983 |
Epidemiological studies of medically used drugs.
Topics: 2-Naphthylamine; Brain Neoplasms; Epidemiologic Methods; Female; Humans; Isoniazid; Liver Neoplasms; | 1980 |
Organ-specific promoting effects of phenobarbital sodium and sodium saccharin in the induction of liver and urinary bladder tumors in male F344 rats.
Topics: 2-Acetylaminofluorene; Animals; Butylhydroxybutylnitrosamine; Cocarcinogenesis; Hyperplasia; Liver N | 1982 |
Analysis of the effects of promoting agents on liver and urinary bladder carcinogenesis in rats.
Topics: Animals; Carcinogens; Cocarcinogenesis; Dose-Response Relationship, Drug; Hyperplasia; Liver Neoplas | 1982 |
Alteration of intercellular communication in a human urothelial carcinoma cell-line by tumor-promoting agents.
Topics: Adult; Anticonvulsants; Antioxidants; Butylated Hydroxyanisole; Carcinogens; Carcinoma, Transitional | 1996 |
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Diethylnitrosamine; Ethylnitrosourea; Male; Meth | 1998 |
Barbiturates, smoking, and bladder cancer risk.
Topics: California; Cohort Studies; Humans; Hypnotics and Sedatives; Incidence; Phenobarbital; Risk Factors; | 1998 |
Can the concept of hormesis Be generalized to carcinogenesis?
Topics: Animals; Caffeic Acids; Carcinogenicity Tests; Carcinogens; Cell Division; Dioxins; DNA Ligases; Dos | 1998 |
Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.
Topics: Animals; Ascorbic Acid; Bleomycin; Body Weight; Butylated Hydroxytoluene; Cocarcinogenesis; Kidney N | 1989 |
Effects of sodium salts of phenobarbital and barbital on development of bladder tumors in male F344/NCr rats pretreated with either N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or N-nitrosobutyl-4-hydroxybutylamine.
Topics: Animals; Barbital; Barbiturates; Butylhydroxybutylnitrosamine; Carcinoma; Cocarcinogenesis; FANFT; M | 1989 |
Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.
Topics: Adenoma; Animals; Body Weight; Carbazoles; Carcinoma; Cocarcinogenesis; Kidney Neoplasms; Liver Neop | 1988 |
Effect of sodium phenobarbital and sodium saccharin in AIN-76A diet on carcinogenesis initiated with N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and N,N-dibutylnitrosamine in male F344 rats.
Topics: Animals; Esophageal Neoplasms; FANFT; Hydrogen-Ion Concentration; Liver Neoplasms, Experimental; Mal | 1986 |
Specific induction of bladder cancer in mice by butyl-(4-hydroxybutyl)-nitrosamine and the effects of hormonal modifications on the sex difference in response.
Topics: Animals; Castration; Female; Male; Mice; Neoplasm Metastasis; Neoplasms, Experimental; Nitrosamines; | 1972 |