phenobarbital has been researched along with Biliary Cirrhosis in 16 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Biliary cirrhosis was induced by bile duct ligation, and micronodular cirrhosis by chronic exposure to phenobarbital/CCl4 in male rats." | 3.70 | The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver. ( Clozel, M; Gerbes, AL; Reichen, J; Sägesser, H; Steiner, MJ, 1998) |
| " We investigated to what extent antipyrine clearance and metabolite formation are impaired in two models of liver cirrhosis in the rat, namely micronodular cirrhosis induced by chronic exposure to phenobarbital/CCl4 and biliary cirrhosis induced by bile duct ligation." | 3.68 | Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition. ( Buters, JT; Reichen, J; Zysset, T, 1993) |
| "Serum squalene levels did not change in patients with acute hepatitis, chronic active hepatitis and liver cirrhosis, but were significantly reduced in patients with intra- and extrahepatic cholestasis." | 3.66 | Serum squalene levels in hepatobiliary diseases. ( Hirayama, C; Ikawa, S; Yamanishi, Y, 1978) |
| " Except for the patients with cholestatic hepatitis, in whom marked cholestasis was virtually the only abnormality in liver biopsy specimens, serum bilirubin and bile acid concentrations were diminished during therapy, the hepatic clearance of sulfobromophthalein and 131-I-rose bengal was variably enhanced, and there was relief from pruritus." | 3.65 | Phenobarbital effects in cholestatic liver diseases. ( Bloomer, JR; Boyer, JL, 1975) |
| "Nuclear localization was found in biliary cirrhosis only." | 1.29 | Differential effect of micronodular and biliary cirrhosis on epidermal growth factor receptor expression in the rat. ( Marti, U; Oguey, D; Reichen, J, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (81.25) | 18.7374 |
| 1990's | 3 (18.75) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Müting, D | 1 |
| Fischer, R | 1 |
| Kalk, JF | 1 |
| Kruck, P | 1 |
| Rull, S | 1 |
| Rodríguez-San Román, JL | 1 |
| Velilla, JP | 1 |
| Bloomer, JR | 2 |
| Ghent, CN | 1 |
| Oguey, D | 1 |
| Reichen, J | 3 |
| Marti, U | 1 |
| Buters, JT | 1 |
| Zysset, T | 1 |
| Gerbes, AL | 1 |
| Steiner, MJ | 1 |
| Sägesser, H | 1 |
| Clozel, M | 1 |
| Stellaard, F | 1 |
| Bolt, MG | 1 |
| Boyer, JL | 2 |
| Klein, PD | 1 |
| Yamanishi, Y | 1 |
| Ikawa, S | 1 |
| Hirayama, C | 1 |
| Stiehl, A | 1 |
| Brunner, G | 1 |
| Bachs, L | 1 |
| Parés, A | 1 |
| Elena, M | 1 |
| Piera, C | 1 |
| Rodés, J | 1 |
| Mörl, M | 1 |
| Solymoss, B | 1 |
| Zsigmond, G | 1 |
| August, PJ | 1 |
| Kühn, HA | 1 |
| Richter, E | 1 |
3 reviews available for phenobarbital and Biliary Cirrhosis
| Article | Year |
|---|---|
[Current aspects of primary biliary cirrhosis (2)].
Topics: Azathioprine; Biliary Tract Diseases; Cholestyramine Resin; Cyclosporins; Diagnosis, Differential; H | 1983 |
Management of the intractable cholestasis of primary biliary cirrhosis.
Topics: Bile Acids and Salts; Calcium; Cholestasis; Cholestyramine Resin; Copper; Food, Formulated; Humans; | 1981 |
[Pathophysiology and clinical aspects of intrahepatic cholestasis].
Topics: Alkaline Phosphatase; Animals; Arsphenamine; Bile Acids and Salts; Bilirubin; Chlorpromazine; Cholan | 1970 |
1 trial available for phenobarbital and Biliary Cirrhosis
| Article | Year |
|---|---|
Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.
Topics: Adult; Cholestasis; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Liver Ci | 1989 |
12 other studies available for phenobarbital and Biliary Cirrhosis
| Article | Year |
|---|---|
[Chronic destructive non-suppurating cholangitis].
Topics: Aged; Alkaline Phosphatase; Antibodies, Antinuclear; Autoantibodies; Cholestyramine Resin; Female; g | 1982 |
Differential effect of micronodular and biliary cirrhosis on epidermal growth factor receptor expression in the rat.
Topics: Animals; Blotting, Northern; Blotting, Western; Carbon Tetrachloride; ErbB Receptors; Liver; Liver C | 1994 |
Metabolism of antipyrine in vivo in two rat models of liver cirrhosis. Its relationship to intrinsic clearance in vitro and microsomal membrane lipid composition.
Topics: Animals; Antipyrine; Bile Acids and Salts; Breath Tests; Carbon Tetrachloride; Lipids; Liver Cirrhos | 1993 |
The effect of endothelin and its antagonist Bosentan on hemodynamics and microvascular exchange in cirrhotic rat liver.
Topics: Animals; Bile Acids and Salts; Bile Ducts; Bilirubin; Blood Pressure; Body Weight; Bosentan; Carbon | 1998 |
Phenobarbital treatment in primary biliary cirrhosis. Differences in bile acid composition between responders and nonresponders.
Topics: Bile Acids and Salts; Cholic Acids; Deoxycholic Acid; Gas Chromatography-Mass Spectrometry; Humans; | 1979 |
Serum squalene levels in hepatobiliary diseases.
Topics: Acute Disease; Adult; Azathioprine; Biliary Tract Diseases; Cholestasis; Cholesterol; Cholestyramine | 1978 |
[Treatment of various forms of icterus or cholestasis with phenobarbital (author's transl)].
Topics: Adult; Anemia, Hemolytic; Cholangitis; Cholestasis; Crigler-Najjar Syndrome; Gilbert Disease; Humans | 1977 |
[Therapy of the chronic destructive, non-purulent cholangitis (primary biliary cirrhosis)].
Topics: Azathioprine; Calcium; Cholangitis; Cholestyramine Resin; Clofibrate; Humans; Hypercholesterolemia; | 1976 |
Phenobarbital effects in cholestatic liver diseases.
Topics: Adult; Bile Ducts, Intrahepatic; Bilirubin; Chenodeoxycholic Acid; Child; Child, Preschool; Cholangi | 1975 |
[Are there new aspects in the therapy of primary biliary cirrhosis?].
Topics: Azathioprine; Bile Acids and Salts; Bilirubin; Cyclosporins; Humans; Liver Cirrhosis, Biliary; Liver | 1986 |
Effect of microsomal enzyme inducers on the liver changes produced by common bile-duct ligature.
Topics: Animals; Bilirubin; Common Bile Duct; Cytochrome P-450 Enzyme System; Endoplasmic Reticulum; Enzyme | 1974 |
Primary biliary cirrhosis and scleroderma.
Topics: Cholestyramine Resin; Female; Humans; Liver Cirrhosis, Biliary; Middle Aged; Phenobarbital; Sclerode | 1974 |