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phenobarbital and Biliary Atresia

phenobarbital has been researched along with Biliary Atresia in 8 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Biliary Atresia: Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to re-evaluate the accuracy of phenobarbital-enhanced hepatobiliary scintigraphy in differentiating biliary atresia from other causes of neonatal cholestasis."7.79Phenobarbital-enhanced hepatobiliary scintigraphy in the diagnosis of biliary atresia: two decades of experience at a tertiary center. ( Ghelani, S; Kwatra, N; Majd, M; Mohan, P; Narayanan, S; Shalaby-Rana, E, 2013)
" Group 1 (n = 48), group 2 (n = 29), and group 3 (n = 18) received phenobarbital at the dosage of 5 mg/kg/day for at least 5 days, less than 5 mg/kg/day or less than 5 days, and no premedication, respectively."5.32The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. ( Charearnrad, P; Chongsrisawat, V; Poovorawan, Y; Tepmongkol, S, 2003)
"The purpose of this study was to re-evaluate the accuracy of phenobarbital-enhanced hepatobiliary scintigraphy in differentiating biliary atresia from other causes of neonatal cholestasis."3.79Phenobarbital-enhanced hepatobiliary scintigraphy in the diagnosis of biliary atresia: two decades of experience at a tertiary center. ( Ghelani, S; Kwatra, N; Majd, M; Mohan, P; Narayanan, S; Shalaby-Rana, E, 2013)
"Phenobarbital is a long-acting barbiturate metabolized in the liver by the cytochrome p450 3a4 system."1.33Treatment of acute tacrolimus whole-blood elevation with phenobarbital in the pediatric liver transplant recipient. ( Bristow, LJ; Chang, IF; Goss, JA; Karpen, SJ; Quirós-Tejeira, RE, 2005)
" Group 1 (n = 48), group 2 (n = 29), and group 3 (n = 18) received phenobarbital at the dosage of 5 mg/kg/day for at least 5 days, less than 5 mg/kg/day or less than 5 days, and no premedication, respectively."1.32The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome. ( Charearnrad, P; Chongsrisawat, V; Poovorawan, Y; Tepmongkol, S, 2003)
"Phenobarbital was administered to 22 patients before imaging."1.29Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice. ( Ben-Haim, S; Brown, BP; Johnson, J; Kao, SC; Seabold, JE; Tran, D, 1995)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19901 (12.50)18.7374
1990's3 (37.50)18.2507
2000's3 (37.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kwatra, N1
Shalaby-Rana, E1
Narayanan, S1
Mohan, P1
Ghelani, S1
Majd, M1
Charearnrad, P1
Chongsrisawat, V1
Tepmongkol, S1
Poovorawan, Y1
Quirós-Tejeira, RE1
Chang, IF1
Bristow, LJ1
Karpen, SJ1
Goss, JA1
Sevilla, A1
Howman-Giles, R1
Saleh, H1
Trpezanovski, J1
Concannon, R1
Williams, K1
Chung, D1
Uren, R1
Ben-Haim, S1
Seabold, JE1
Kao, SC1
Johnson, J1
Tran, D1
Brown, BP1
Lin, WY1
Lin, CC1
Changlai, SP1
Shen, YY1
Wang, SJ1
Golladay, ES1
Slezak, JW1
Seibert, JJ1
Rivera-Echegoyen, M1
Ramírez-Mayans, JA1
Casaubón-Garcín, P1
Núñez-Malaver, CE1
Avila-Ramírez, E1
Sosa-Martínez, C1

Other Studies

8 other studies available for phenobarbital and Biliary Atresia

ArticleYear
Phenobarbital-enhanced hepatobiliary scintigraphy in the diagnosis of biliary atresia: two decades of experience at a tertiary center.
    Pediatric radiology, 2013, Volume: 43, Issue:10

    Topics: Biliary Atresia; Causality; Cholestasis; District of Columbia; Female; Humans; Image Enhancement; In

2013
The effect of phenobarbital on the accuracy of technetium-99m diisopropyl iminodiacetic acid hepatobiliary scintigraphy in differentiating biliary atresia from neonatal hepatitis syndrome.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2003, Volume: 86 Suppl 2

    Topics: Biliary Atresia; Excitatory Amino Acid Antagonists; Female; Hepatitis; Humans; Infant; Infant, Newbo

2003
Treatment of acute tacrolimus whole-blood elevation with phenobarbital in the pediatric liver transplant recipient.
    Pediatric transplantation, 2005, Volume: 9, Issue:6

    Topics: Biliary Atresia; Half-Life; Humans; Immunosuppressive Agents; Infant; Liver Transplantation; Male; P

2005
Hepatobiliary scintigraphy with SPECT in infancy.
    Clinical nuclear medicine, 2007, Volume: 32, Issue:1

    Topics: Biliary Atresia; Female; Humans; Infant; Infant, Newborn; Liver Diseases; Male; Phenobarbital; Retro

2007
Utility of Tc-99m mebrofenin scintigraphy in the assessment of infantile jaundice.
    Clinical nuclear medicine, 1995, Volume: 20, Issue:2

    Topics: Aniline Compounds; Biliary Atresia; Cholestasis, Intrahepatic; Female; Glycine; Hepatitis; Humans; I

1995
Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice.
    Pediatric surgery international, 1997, Volume: 12, Issue:1

    Topics: Biliary Atresia; Cholestyramine Resin; Diagnosis, Differential; Female; Humans; Imino Acids; Infant;

1997
Intractable cholangitis due to conduit obstruction.
    The Journal of the Arkansas Medical Society, 1990, Volume: 87, Issue:3

    Topics: Anti-Bacterial Agents; Biliary Atresia; Child; Cholangitis; Clinical Protocols; Humans; Methylpredni

1990
[Neonatal cholestatic syndrome: use of phenobarbital in the gammagram of the bile ducts].
    Boletin medico del Hospital Infantil de Mexico, 1988, Volume: 45, Issue:10

    Topics: Bile Ducts; Biliary Atresia; Bilirubin; Diagnosis, Differential; Female; Humans; Imino Acids; Infant

1988