phenobarbital has been researched along with Bile Duct Obstruction, Extrahepatic in 6 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 7.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "Depending on the underlying disease state resulting in cholestasis, phenobarbital, ursodiol, bile sequestering agents, and opioid antagonists appear to be most effective for treating pruritus related to intrahepatic cholestasis." | 4.84 | Treatment of cholestatic pruritus in children. ( Cies, JJ; Giamalis, JN, 2007) |
| "This investigation was designed to determine if liver diseases can modify the pharmacodynamics of the central nervous system depressants phenobarbital and ethanol." | 3.67 | Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats. ( Danhof, M; Hisaoka, M; Levy, G, 1985) |
| "The dogs suffered from extrahepatic cholestasis which lasted for 28 days and was surgically induced." | 1.26 | Determination of the activity of nonspecific monophosphoesterases and nonspecific esterase in the liver of dogs in extrahepatic cholestasis treated surgically and with phenobarbital. ( Dadan, H; Danieluk-Gil, I; Rejniak, L; Zalewski, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cies, JJ | 1 |
| Giamalis, JN | 1 |
| Kurasz, S | 1 |
| Dadan, H | 2 |
| Andrzejewska, A | 1 |
| Richter, E | 1 |
| Breimer, DD | 1 |
| Zilly, W | 1 |
| Gupta, DK | 1 |
| Charles, AR | 1 |
| Srinivas, M | 1 |
| Dave, S | 1 |
| Bal, CS | 1 |
| Rejniak, L | 1 |
| Danieluk-Gil, I | 1 |
| Zalewski, J | 1 |
| Danhof, M | 1 |
| Hisaoka, M | 1 |
| Levy, G | 1 |
1 review available for phenobarbital and Bile Duct Obstruction, Extrahepatic
| Article | Year |
|---|---|
Treatment of cholestatic pruritus in children.
Topics: Antipruritics; Child; Cholagogues and Choleretics; Cholestasis, Extrahepatic; Cholestasis, Intrahepa | 2007 |
5 other studies available for phenobarbital and Bile Duct Obstruction, Extrahepatic
| Article | Year |
|---|---|
[Effect of phenobarbital on the liver ultrastructure in dogs under conditions of long-term extrahepatic cholestasis].
Topics: Animals; Cholestasis, Extrahepatic; Chronic Disease; Common Bile Duct Diseases; Dogs; Female; Liver; | 1980 |
Disposition of hexobarbital in intra- and extrahepatic cholestasis in man and the influence of drug metabolism-inducing agents.
Topics: Adult; Aged; Cholestasis, Extrahepatic; Cholestasis, Intrahepatic; Enzyme Induction; Female; Hexobar | 1980 |
Betamethasone in plus phenobarbitone prior to hepatobiliary scintigraphy increases diagnostic accuracy in infants with jaundice.
Topics: Betamethasone; Cholestasis, Extrahepatic; Diagnosis, Differential; Female; Humans; Infant; Infant, N | 2001 |
Determination of the activity of nonspecific monophosphoesterases and nonspecific esterase in the liver of dogs in extrahepatic cholestasis treated surgically and with phenobarbital.
Topics: Animals; Cholestasis, Extrahepatic; Dogs; Esterases; Histocytochemistry; Liver; Phenobarbital; Phosp | 1979 |
Kinetics of drug action in disease states XII: Effect of experimental liver diseases on the pharmacodynamics of phenobarbital and ethanol in rats.
Topics: Animals; Blood Proteins; Brain; Carbon Tetrachloride Poisoning; Cholestasis, Extrahepatic; Ethanol; | 1985 |