phenobarbital has been researched along with Benign Familial Infantile Convulsions in 12 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause." | 9.34 | Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. ( Arnell, K; Battin, MR; Bridge, R; Davis, SL; Ernstrom, K; Gold, JJ; Haas, RH; Harbert, MJ; Honold, J; Joe, P; Kim, J; Knodel, E; Kuperman, R; Lane, B; Le, NM; Lee, L; Michelson, D; Mower, A; Nespeca, M; Raman, R; Rasmussen, M; Reiner, GE; Rismanchi, N; Sharpe, C; Wang, S, 2020) |
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 9.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment for neonatal seizures of any cause." | 5.34 | Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial. ( Arnell, K; Battin, MR; Bridge, R; Davis, SL; Ernstrom, K; Gold, JJ; Haas, RH; Harbert, MJ; Honold, J; Joe, P; Kim, J; Knodel, E; Kuperman, R; Lane, B; Le, NM; Lee, L; Michelson, D; Mower, A; Nespeca, M; Raman, R; Rasmussen, M; Reiner, GE; Rismanchi, N; Sharpe, C; Wang, S, 2020) |
| "This study investigated treatment patterns at discharge in infants with neonatal seizures and evaluated the impact of outpatient phenobarbital prophylaxis on the frequency of seizure recurrence and the long-term neurodevelopmental outcome at 1 to 11 years." | 5.12 | Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis. ( Guillet, R; Kwon, J, 2007) |
| "This baby developed persistent electroencephalographic seizures due to massive doses of phenobarbital and midazolam." | 3.80 | Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam. ( Hirose, S; Ihara, Y; Ishii, A; Izumi, T; Maeda, T; Sekiguchi, K; Shimizu, M, 2014) |
| "Phenobarbital failed to abolish or depress recurrent seizures in 70% of hippocampi." | 3.74 | Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. ( Brumback, AC; Dzhala, VI; Staley, KJ, 2008) |
| "Benign familial neonatal convulsions are a rare, autosomal-dominant form of neonatal epileptic syndrome." | 1.35 | Benign familial neonatal convulsions: novel mutation in a newborn. ( Chen, JY; Chen, YJ; Lee, IC; Su, PH; Yu, JS, 2009) |
| "Demographic and clinical pharmacokinetic data collected from term and preterm neonates who were treated with intravenous phenobarbital have been analysed to evaluate the role of patient characteristics in pharmacokinetic parameters." | 1.31 | Clinical pharmacokinetics of phenobarbital in neonates. ( Cranendonk, A; Graafland, O; Touw, DJ; van Weissenbruch, MM; Vermeulen, RJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Falsaperla, R | 1 |
| Criscione, R | 1 |
| Cimino, C | 1 |
| Pisani, F | 1 |
| Ruggieri, M | 1 |
| Sharpe, C | 1 |
| Reiner, GE | 1 |
| Davis, SL | 1 |
| Nespeca, M | 1 |
| Gold, JJ | 1 |
| Rasmussen, M | 1 |
| Kuperman, R | 1 |
| Harbert, MJ | 1 |
| Michelson, D | 1 |
| Joe, P | 1 |
| Wang, S | 1 |
| Rismanchi, N | 1 |
| Le, NM | 1 |
| Mower, A | 1 |
| Kim, J | 1 |
| Battin, MR | 1 |
| Lane, B | 1 |
| Honold, J | 1 |
| Knodel, E | 1 |
| Arnell, K | 1 |
| Bridge, R | 1 |
| Lee, L | 1 |
| Ernstrom, K | 1 |
| Raman, R | 1 |
| Haas, RH | 1 |
| Maeda, T | 1 |
| Shimizu, M | 1 |
| Sekiguchi, K | 1 |
| Ishii, A | 1 |
| Ihara, Y | 1 |
| Hirose, S | 1 |
| Izumi, T | 1 |
| Jain, P | 1 |
| Sankhyan, N | 1 |
| Wasim, S | 1 |
| Upadhyay, A | 1 |
| Roy, M | 1 |
| Saxena, P | 1 |
| Chillar, N | 1 |
| Mathieson, SR | 1 |
| Livingstone, V | 1 |
| Low, E | 1 |
| Pressler, R | 1 |
| Rennie, JM | 1 |
| Boylan, GB | 1 |
| Lee, IC | 1 |
| Chen, JY | 1 |
| Chen, YJ | 1 |
| Yu, JS | 1 |
| Su, PH | 1 |
| Yamagata, T | 1 |
| Castro Conde, JR | 1 |
| Hernández Borges, AA | 1 |
| Doménech Martínez, E | 1 |
| González Campo, C | 1 |
| Perera Soler, R | 1 |
| Guillet, R | 1 |
| Kwon, J | 1 |
| Dzhala, VI | 1 |
| Brumback, AC | 1 |
| Staley, KJ | 1 |
| Touw, DJ | 1 |
| Graafland, O | 1 |
| Cranendonk, A | 1 |
| Vermeulen, RJ | 1 |
| van Weissenbruch, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children[NCT04926844] | Phase 2 | 144 participants (Actual) | Interventional | 2021-06-20 | Completed | ||
| Pilot Study of Bumetanide for Newborn Seizures: A Phase I Study of Pharmacokinetics and Safety of Bumetanide for Neonatal Seizures[NCT00830531] | Phase 1 | 43 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for phenobarbital and Benign Familial Infantile Convulsions
| Article | Year |
|---|---|
KCNQ2-Related Epilepsy: Genotype-Phenotype Relationship with Tailored Antiseizure Medication (ASM)-A Systematic Review.
Topics: Child; Epilepsy, Benign Neonatal; Genotype; Humans; Infant, Newborn; KCNQ2 Potassium Channel; Mutati | 2023 |
[Benign familial neonatal convulsion].
Topics: Diagnosis, Differential; Epilepsy, Benign Neonatal; Humans; Infant, Newborn; KCNQ2 Potassium Channel | 2002 |
4 trials available for phenobarbital and Benign Familial Infantile Convulsions
| Article | Year |
|---|---|
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy, Benign Neonatal; F | 2020 |
Phenobarbital reduces EEG amplitude and propagation of neonatal seizures but does not alter performance of automated seizure detection.
Topics: Anticonvulsants; Electroencephalography; Epilepsy, Benign Neonatal; Humans; Infant, Newborn; Phenoba | 2016 |
Midazolam in neonatal seizures with no response to phenobarbital.
Topics: Age Factors; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Drug Resistance; Electroencep | 2005 |
Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis.
Topics: Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Epilepsy, Benign Neonatal; Fem | 2007 |
6 other studies available for phenobarbital and Benign Familial Infantile Convulsions
| Article | Year |
|---|---|
Exacerbation of benign familial neonatal epilepsy induced by massive doses of phenobarbital and midazolam.
Topics: Electroencephalography; Epilepsy, Benign Neonatal; Female; GABA Modulators; Humans; Midazolam; Pheno | 2014 |
Phenobarbital for Neonatal Seizures: A Time for Perusal.
Topics: Anticonvulsants; Epilepsy, Benign Neonatal; Humans; Infant, Newborn; Phenobarbital; Prospective Stud | 2016 |
Serum Phenobarbitone Levels in Term and Near Term Neonates with Seizures.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy, Benign Neonatal; Humans; Infant, Newborn; Infant, Premat | 2016 |
Benign familial neonatal convulsions: novel mutation in a newborn.
Topics: Amino Acid Sequence; Anticonvulsants; Brain; Diagnosis, Differential; DNA Mutational Analysis; Echoc | 2009 |
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.
Topics: Animals; Anticonvulsants; Bumetanide; Chloride Channels; Chlorides; Drug Synergism; Drug Therapy, Co | 2008 |
Clinical pharmacokinetics of phenobarbital in neonates.
Topics: Anticonvulsants; Body Constitution; Epilepsy, Benign Neonatal; Female; Humans; Infant, Newborn; Infa | 2000 |