phenobarbital has been researched along with Benign Essential Tremor in 3 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kunisawa, N | 1 |
| Shimizu, S | 1 |
| Kato, M | 1 |
| Iha, HA | 1 |
| Iwai, C | 1 |
| Hashimura, M | 1 |
| Ogawa, M | 1 |
| Kawaji, S | 1 |
| Kawakita, K | 1 |
| Abe, K | 1 |
| Ohno, Y | 1 |
| Sampaio, C | 1 |
| Ferreira, J | 1 |
| Melmed, C | 1 |
| Moros, D | 1 |
| Rutman, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Efficacy and Safety of Taro Pharmaceuticals' Pro-Drug T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric Acid) in Patients With Essential Tremor: An Open-Label Dose Continuation Study[NCT00655278] | Phase 2 | 5 participants (Actual) | Interventional | 2007-08-31 | Terminated | ||
| Phase II Efficacy and Safety of Taro Pharmaceuticals' Pro-Drug T2000 (1,3-Dimethoxymethyl-5,5-Diphenyl-Barbituric Acid) In Patients With Myoclonus Dystonia: An Open Label Sequential Dose Escalation Study[NCT00506012] | Phase 2 | 5 participants (Anticipated) | Interventional | 2007-08-31 | Terminated (stopped due to Slow Recruitment of eligible patients) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for phenobarbital and Benign Essential Tremor
| Article | Year |
|---|---|
Essential tremor.
Topics: Botulinum Toxins, Type A; Essential Tremor; Humans; Phenobarbital; Propranolol; Randomized Controlle | 2002 |
1 trial available for phenobarbital and Benign Essential Tremor
| Article | Year |
|---|---|
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
Treatment of essential tremor with the barbiturate T2000 (1,3-dimethoxymethyl-5,5-diphenyl-barbituric acid).
Topics: Adult; Barbiturates; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche | 2007 |
1 other study available for phenobarbital and Benign Essential Tremor
| Article | Year |
|---|---|
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |