phenobarbital has been researched along with Ataxia in 32 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aromatic and heterocyclic esters of 1-methyl-4-piperidinol and 1,4-dimethyl-4-piperidinol and aromatic esters of (dialkylamino)alkanols were prepared and evaluated for antiepileptic activity by the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for minimal central neurotoxicity by the rotorod ataxia test." | 3.67 | Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. ( Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA, 1986) |
| "Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy." | 3.65 | Choreo-athetosis and encephalopathy induced by phenytoin. ( McLellan, DL; Swash, M, 1974) |
| "The aim of this study was to compare ataxia levels in dogs with IE treated chronically with phenobarbitone or imepitoin, the two currently available first-line AED treatments." | 1.43 | Comparing the effects of first-line antiepileptic drugs on the gait of dogs with idiopathic epilepsy. ( Packer, RM; Suiter, EJ; Volk, HA, 2016) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| " Five groups received the prototype mixed-function oxidase (MFO) enzyme inducer phenobarbital (PB) at a dosage of 50 mg/kg body weight for 3 consecutive days by intraperitoneal (i." | 1.27 | The effect of hepatic mixed-function oxidase enzyme inducers on the development of tri-o-tolyl phosphate-induced delayed neurotoxicity. ( Bursian, SJ; Calabrese, LF, 1984) |
| "Muscimol was a more potent stimulator of 36Cl- flux in the DS compared to the DR mice, although no difference between the lines was found in muscimol-stimulation of [3H]flunitrazepam binding." | 1.27 | Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex. ( Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA, 1988) |
| "Baclofen was largely ineffective in reducing withdrawal-induced tremors, although it was capable of producing sedation of a different type than that produced by phenobarbitol and ethanol." | 1.26 | The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey. ( Tarika, JS; Winger, G, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (84.38) | 18.7374 |
| 1990's | 1 (3.13) | 18.2507 |
| 2000's | 2 (6.25) | 29.6817 |
| 2010's | 2 (6.25) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waters, JA | 1 |
| Hollingsworth, EB | 1 |
| Daly, JW | 1 |
| Lewandowski, G | 1 |
| Creveling, CR | 1 |
| Burns, JM | 1 |
| Marino, A | 1 |
| Manno, M | 1 |
| Rhyee, S | 1 |
| Boyer, EW | 1 |
| Suiter, EJ | 1 |
| Packer, RM | 1 |
| Volk, HA | 1 |
| DAVIS, MA | 1 |
| WINTHROP, SO | 1 |
| THOMAS, RA | 1 |
| HERR, F | 1 |
| CHAREST, MP | 1 |
| GAUDRY, R | 1 |
| KUTT, H | 3 |
| WINTERS, W | 1 |
| SCHERMAN, R | 1 |
| MCDOWELL, F | 2 |
| KOKENGE, R | 1 |
| Manna, S | 1 |
| Bhattacharyya, D | 1 |
| Mandal, TK | 1 |
| Dey, S | 1 |
| Calabrese, LF | 1 |
| Bursian, SJ | 1 |
| Tarika, JS | 1 |
| Winger, G | 1 |
| Löscher, W | 2 |
| Fiedler, M | 1 |
| Edwards, PM | 1 |
| Boldyrev, AI | 1 |
| Fleĭs, EP | 1 |
| Vaĭntrub, MIa | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Freund, G | 2 |
| Livingston, S | 1 |
| Berman, W | 1 |
| Pauli, LL | 1 |
| Haidvogl, M | 1 |
| Rosegger, H | 1 |
| Hönack, D | 1 |
| Allan, AM | 1 |
| Gallaher, EJ | 1 |
| Gionet, SE | 1 |
| Harris, RA | 1 |
| Vessell, ES | 1 |
| Passananti, GT | 1 |
| McLellan, DL | 1 |
| Swash, M | 1 |
| Critchley, EM | 1 |
| Clark, DB | 1 |
| Wikler, A | 1 |
| Franko, BV | 1 |
| Ward, JW | 1 |
| Gilbert, DL | 1 |
| Woodard, G | 1 |
| Brenton, DP | 1 |
| Cusworth, DC | 1 |
| Hartley, S | 1 |
| Lumley, S | 1 |
| Kuzemko, JA | 1 |
| Gallagher, BB | 1 |
| Baumel, IP | 1 |
| Mattson, RH | 1 |
| Woodbury, SG | 1 |
| Marcus, RJ | 1 |
| Winters, WD | 1 |
| Roberts, E | 1 |
| Simonsen, DG | 1 |
| Faero, O | 1 |
| Kastrup, KW | 1 |
| Melchior, JC | 1 |
| Thorm, J | 1 |
| Viukari, NM | 1 |
| Kretzschmar, R | 1 |
| Meyer, HJ | 1 |
| Teschendorf, HJ | 1 |
| Zöllner, B | 1 |
| Garrettson, LK | 1 |
| Perel, JM | 1 |
| Dayton, PG | 1 |
| Stark, P | 1 |
| Henderson, JK | 1 |
2 reviews available for phenobarbital and Ataxia
| Article | Year |
|---|---|
Biochemical and genetic factors regulating dilantin metabolism in man.
Topics: Aminosalicylic Acids; Animals; Ataxia; Cats; Chlordan; Cycloserine; DDT; Dicumarol; Disulfiram; Enzy | 1971 |
Utility of clinical chemical determinations of drug concentrations in biological fluids.
Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin | 1971 |
30 other studies available for phenobarbital and Ataxia
| Article | Year |
|---|---|
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compoun | 1986 |
Status epilepticus in a child secondary to ingestion of skin-lightening cream.
Topics: Anticonvulsants; Ataxia; Eating; Emergencies; Humans; Hydroquinones; Infant; Intubation, Intratrache | 2013 |
Comparing the effects of first-line antiepileptic drugs on the gait of dogs with idiopathic epilepsy.
Topics: Animals; Anticonvulsants; Ataxia; Case-Control Studies; Dog Diseases; Dogs; Epilepsy; Gait; Imidazol | 2016 |
ANTICONVULSANTS. I. DIBENZO(A,D)CYCLOHEPTADIENE-5-CARBOXAMIDE AND RELATED COMPOUNDS.
Topics: Amides; Anticonvulsants; Ataxia; Chemistry, Pharmaceutical; Mice; Pentylenetetrazole; Pharmacology; | 1964 |
DIPHENYLHYDANTOIN AND PHENOBARBITAL TOXICITY. THE ROLE OF LIVER DISEASE.
Topics: Ataxia; Barbiturates; Blood Chemical Analysis; Chromatography; Drug Tolerance; Hepatitis; Hepatitis | 1964 |
NEUROLOGICAL SEQUELAE FOLLOWING DILANTIN OVERDOSE IN A PATIENT AND IN EXPERIMENTAL ANIMALS.
Topics: Adolescent; Ataxia; Biomedical Research; Cats; Chlordiazepoxide; Drug Therapy; Epilepsy; Humans; Neu | 1965 |
Neuropharmacological effects of deltamethrin in rats.
Topics: Animals; Ataxia; Brain; Female; gamma-Aminobutyric Acid; Insecticides; Male; Molecular Structure; Ni | 2006 |
The effect of hepatic mixed-function oxidase enzyme inducers on the development of tri-o-tolyl phosphate-induced delayed neurotoxicity.
Topics: Animals; Ataxia; Benzoflavones; beta-Naphthoflavone; Biotransformation; Carboxylic Ester Hydrolases; | 1984 |
The effects of ethanol, phenobarbital, and baclofen on ethanol withdrawal in the rhesus monkey.
Topics: Alcoholism; Animals; Ataxia; Baclofen; Behavior, Animal; Drug Interactions; Ethanol; Humans; Macaca | 1980 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.
Topics: Acrylamides; Animals; Ataxia; Brachial Plexus; Chickens; DDT; Female; Goldfish; Male; Nerve Degenera | 1975 |
[Neurologic complications following medical treatment of epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Benzodiazepines; Consciousness Disorders; Dysarthria; Ey | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
Prevention of ethanol withdrawal seizures in mice by local anesthetics and dextro-propranolol.
Topics: Anesthetics, Local; Animals; Ataxia; Behavior, Animal; Ethanol; Female; Humans; Mice; Mice, Inbred C | 1977 |
Anticonvulsant drug blood levels.
Topics: Anticonvulsants; Ataxia; Diplopia; Drug Therapy, Combination; Epilepsy; Humans; Nystagmus, Pathologi | 1975 |
[Cyclizine-intoxication in six children (author's transl)].
Topics: Adrenal Cortex Hormones; Age Factors; Ataxia; Chemical Phenomena; Chemistry; Child, Preschool; Cycli | 1975 |
The effect of interstimulation interval on the assessment of anticonvulsant drug potency in fully kindled rats.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Kindling, Neurologic; Male; Phenobarbital; Rats; Ra | 1990 |
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscim | 1988 |
Choreo-athetosis and encephalopathy induced by phenytoin.
Topics: Adolescent; Adult; Ataxia; Athetosis; Carbamazepine; Chorea; Diplopia; Electroencephalography; Epile | 1974 |
An adult form of acanthocytosis.
Topics: Abetalipoproteinemia; Adult; Ataxia; Diazepam; Female; Haloperidol; Humans; Huntington Disease; Hydr | 1967 |
Toxicologic studies of glycopyrrolate in combination with other drugs.
Topics: Animals; Ataxia; Body Weight; Carbamates; Catechols; Dogs; Feeding Behavior; Female; Glycopyrrolate; | 1971 |
Argininosuccinicaciduria: clinical, metabolic and dietary study.
Topics: Affective Symptoms; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginase; Arginine; Ataxia; Child | 1974 |
Normal shuttle box avoidance learning after chronic phenobarbital intoxication in mice.
Topics: Animals; Ataxia; Avoidance Learning; Behavior, Animal; Body Weight; Depression, Chemical; Dose-Respo | 1974 |
Primidone, diphenylhydantoin and phenobarbital. Aspects of acute and chronic toxicity.
Topics: Ataxia; Chromatography, Gas; Drug Tolerance; Epilepsy; Humans; Nystagmus, Pathologic; Phenobarbital; | 1973 |
Neuropharmacological studies of imidazole-4-acetic acid actions in the mouse and rat.
Topics: Acetates; Animals; Ataxia; Behavior; Caffeine; Catalepsy; Central Nervous System; Drug Interactions; | 1971 |
Phenobarbital as prophylaxis for febrile convulsions. A preliminary report.
Topics: Age Factors; Ataxia; Child, Preschool; Dermatitis, Contact; Female; Fever; Humans; Infant; Male; Phe | 1971 |
Intolerance to diphenylhydantoin in five cases of Vogt-Spielmeyer disease.
Topics: Ataxia; Brain; Humans; L-Lactate Dehydrogenase; Lipidoses; Phenobarbital; Phenytoin; Primidone; Seiz | 1969 |
[Antagonistic action of natural 5,6-hydrogenated Kava pyrones against strychnine poisoning and experimental local tetanus].
Topics: Anesthetics; Animals; Antidotes; Ataxia; Electromyography; Isonicotinic Acids; Male; Mephenesin; Mic | 1969 |
Methylphenidate interaction with both anticonvulsants and ethyl biscoumacetate.
Topics: Adult; Anticonvulsants; Ataxia; Brain Diseases; Child, Preschool; Depression, Chemical; Ethyl Biscou | 1969 |
Differentiation of classes of neurosedatives using rats with septal lesions.
Topics: Amobarbital; Animals; Ataxia; Behavior, Animal; Cerebral Ventricles; Chlordiazepoxide; Chlorpromazin | 1966 |