phenobarbital has been researched along with Ascorbic Acid Deficiency in 12 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies were carried out to characterize the response of hepatic mixed function oxidase (MFO) activity to chronic ascorbic acid deficiency and excessive ascorbic acid intake in the guinea pig." | 3.66 | Dietary ascorbic acid and hepatic mixed function oxidase activity in the guinea pig. ( Duquette, PH; Holloway, DE; Peterson, FJ; Rivers, JM, 1983) |
| " The influence of inhibitors and activators in vitro, the effect of enzyme preparation technic, aging, starvation, pretreatment with somatotropic hormone, phenobarbital or 3-methylcholanthrene, and the effect of a tumor were studied." | 3.66 | The effect of chemical and physiological factors on the kinetics for product formation as it relates to enzyme activity and concentration, reaction time and to substrate adsorption and affinity. ( Chrastil, J; Wilson, JT, 1982) |
| "The effects of riboflavin deficiency on electron transport components and drug metabolism activities have been noted only in adult animals after prolonged periods of deficiency." | 1.26 | The effect of certain vitamin deficiencies on hepatic drug metabolism. ( Sato, PH; Zannoni, VG, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (91.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peterson, FJ | 1 |
| Holloway, DE | 1 |
| Duquette, PH | 1 |
| Rivers, JM | 1 |
| Chrastil, J | 1 |
| Wilson, JT | 1 |
| Kuenzig, W | 1 |
| Tkaczevski, V | 1 |
| Kamm, JJ | 1 |
| Conney, AH | 1 |
| Burns, JJ | 1 |
| Klein, GL | 1 |
| Florey, JB | 1 |
| Goller, VL | 1 |
| Larese, RJ | 1 |
| Van Meter, QL | 1 |
| Zannoni, VG | 2 |
| Sato, PH | 1 |
| Degkwitz, E | 3 |
| Walsch, S | 2 |
| Dubberstein, M | 2 |
| Winter, J | 2 |
| Nurmagambetov, TZh | 1 |
| Amirov, BB | 1 |
| Kuanysheva, TK | 1 |
| Sharmanov, TSh | 1 |
| Campbell, TC | 1 |
| Hayes, JR | 1 |
| Flynn, EJ | 1 |
| Lynch, M | 1 |
| Wade, AE | 1 |
| Wu, B | 1 |
| Smith, PB | 1 |
1 review available for phenobarbital and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
Role of nutrition in the drug-metabolizing enzyme system.
Topics: Ascorbic Acid Deficiency; Calcium; Carbohydrates; Carcinogens; Catalysis; Chemical and Drug Induced | 1974 |
11 other studies available for phenobarbital and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
Dietary ascorbic acid and hepatic mixed function oxidase activity in the guinea pig.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Benzphetamine; Cytochrome P-450 Enzyme System; Die | 1983 |
The effect of chemical and physiological factors on the kinetics for product formation as it relates to enzyme activity and concentration, reaction time and to substrate adsorption and affinity.
Topics: Adenocarcinoma; Animals; Ascorbic Acid Deficiency; Enzyme Activation; Enzyme Inhibitors; Enzymes; Fe | 1982 |
The effect of ascorbic acid deficiency on extrahepatic microsomal metabolism of drugs and carcinogens in the guinea pig.
Topics: Animals; Ascorbic Acid Deficiency; Carcinogens; Coumarins; Enzyme Induction; Guinea Pigs; In Vitro T | 1977 |
Multiple vitamin deficiencies in association with chronic anticonvulsant therapy.
Topics: Anticonvulsants; Ascorbic Acid Deficiency; Avitaminosis; Beriberi; Child, Preschool; Female; Heart D | 1977 |
The effect of certain vitamin deficiencies on hepatic drug metabolism.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Avitaminosis; Cytochrome P-450 Enzyme System; Cyto | 1976 |
Ascorbic acid and cytochromes.
Topics: Adrenal Glands; Aminolevulinic Acid; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Collagen; Cyc | 1975 |
[Proceedings: Vitamin C and cytochrome].
Topics: Aminolevulinic Acid; Animals; Ascorbic Acid Deficiency; Cytochrome P-450 Enzyme System; Cytochromes; | 1975 |
[The induction of the monooxygenase system and the incorporation of the radioactive label from 2-14C-lysine into the liver microsome fraction of rats exposed to phenobarbital against a background of deficiencies in lysine, methionine, threonine and vitami
Topics: Amino Acids; Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid Deficiency; Avitamin | 1991 |
Ascorbic acid and drug metabolism.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochro | 1972 |
Influence of L-ascorbate on the contents of cytochromes P-450 and b5 in several organs of guinea pigs.
Topics: Adrenal Glands; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cytochrome P-450 Enzyme System; Cy | 1973 |
Effects of ascorbic acid deficiency on kinetics of drug hydroxylation in male guinea pigs.
Topics: Aniline Compounds; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cytochromes; Guine | 1972 |