Compounds > phenobarbital
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phenobarbital and Arrhythmia

phenobarbital has been researched along with Arrhythmia in 32 studies

Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.

Research Excerpts

ExcerptRelevanceReference
"Phenobarbital treatment decreased blood levels only prior to reaching equilibrium and did not alter the response to epinephrine-induced cardiac arrhythmias."5.26Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits. ( Carlson, GP, 1981)
"Enuresis is a common problem often treated effectively with imipramine hydrochloride."3.66Treatment of imipramine overdose in children. ( Cromie, WJ; Greene, AS, 1981)
"Rabbits treated with benzo(a)pyrene developed cardiac arrhythmias when exposed by inhalation to 8100 ppm trichloroethylene or 15000 ppm halothane to a greater extent and at lower doses of epinephrine challenge than did controls."3.66Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit. ( Carlson, GP; White, JF, 1983)
" Phenobarbital treatment slightly decreased blood levels of methylchloroform and the incidence of cardiac arrhythmias."3.66Effect of alterations in drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform. ( Carlson, GP, 1981)
"Phenobarbital was observed to produce cardiovascular malformations in embryonic chicks."1.27The teratogenic effect of phenobarbital on the embryonic chick heart. ( Bruyere, HJ; Gilbert, EF; Matsuoka, R; Nishikawa, T; Takagi, Y, 1986)
"Phenobarbital pretreatment depressed heart rate, blood pressure and postganglionic cardiac sympathetic neural discharge."1.27Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat. ( Carnel, SB; Lathers, CM; Schraeder, PL, 1985)
"Phenobarbital treatment decreased blood levels only prior to reaching equilibrium and did not alter the response to epinephrine-induced cardiac arrhythmias."1.26Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits. ( Carlson, GP, 1981)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-199031 (96.88)18.7374
1990's1 (3.13)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
MARTELLI, A1
MICHEL, D1
BOCK, K1
HARTLEB, O1
HERBST, M1
SCHMIDT-VOIGT, J1
KIMURA, E1
LEVIN, J1
BULL, AB1
SEKIYA, A1
VAUGHANWILLIAMS, EM1
HARRIS, AS1
KOKERNOT, RH1
FROMMEL, E1
BECK, IT1
Greene, AS1
Cromie, WJ1
Carlson, GP5
White, JF2
Lathers, CM2
Schraeder, PL2
Carnel, SB2
DeSilva, RA1
Graboys, TB1
Podrid, PJ1
Lown, B1
Azarbayjani, F1
Danielsson, BR1
Baudouy, P1
Andreassian, B1
Attuel, P1
Greze, M1
Soulie, J1
Fruchaud, J1
Eastwood, I1
Forshaw, PJ1
Jeyeratnam, J1
Magos, L1
Zamotaev, IP1
Lozinskiĭ, LG1
Sandomirskiĭ, BL1
Data, JL1
Wilkinson, GR1
Nies, AS1
Nishikawa, T1
Bruyere, HJ1
Takagi, Y1
Gilbert, EF1
Matsuoka, R1
Tsueda, K1
Jean-Francois, J1
Richter, RW1
Kaiser, H1
Eisel, K1
Herzfeld, R1
Bigger, JT1
Strauss, HC1
Gassel, WD1
Schneider, D1
Siletchnik, LM1
Kosh, JW1
Appelt, GD1
Chiche, P1
Laruelle, P1
Borgard, JP1
Chassang, MF1
Denizeau, JP1
Emig, W1

Reviews

2 reviews available for phenobarbital and Arrhythmia

ArticleYear
Cardioversion and defibrillation.
    American heart journal, 1980, Volume: 100, Issue:6 Pt 1

    Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Catheterization; Diazepa

1980
Digitalis toxicity: drug interactions promoting toxicity and the management of toxicity.
    Seminars in drug treatment, 1972,Autumn, Volume: 2, Issue:2

    Topics: Adrenergic beta-Antagonists; Anesthetics; Anticholesteremic Agents; Arrhythmias, Cardiac; Cathartics

1972

Other Studies

30 other studies available for phenobarbital and Arrhythmia

ArticleYear
[Sparteine methiodide associated with phenylethylbarbituric acid in therapy of myocardial hyperexcitability; pharmacological study on the effect of sparteine methiodide].
    Gazzetta medica italiana, 1953, Volume: 112, Issue:1

    Topics: Arrhythmias, Cardiac; Barbiturates; Humans; Myocardium; Phenobarbital; Sparteine

1953
[Control of rhythmic disorders in cardiac catheterization by causat].
    Therapie der Gegenwart, 1957, Volume: 96, Issue:6

    Topics: Arrhythmias, Cardiac; Atropine; Cardiac Catheterization; Catheterization; Heart Diseases; Niacin; Ni

1957
[Extrasystolic heart rhythm disorders; practical viewpoints on diagnosis and therapy].
    Medizinische Klinik, 1958, Aug-01, Volume: 53, Issue:31

    Topics: Arrhythmias, Cardiac; Humans; Phenobarbital; Plant Extracts; Procainamide; Quinidine; Vestibule, Lab

1958
[ARRHYTHMIA].
    Naika. Internal medicine, 1963, Volume: 12

    Topics: Adrenal Cortex Hormones; Arrhythmias, Cardiac; Atropine; Diagnosis, Differential; Ephedrine; Epineph

1963
TWO CASES OF BILATERAL PHAEOCHROMOCYTOMA WITH A DISCUSSION ON ANAESTHETIC MANAGEMENT OF CHROMATIN TUMOURS.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1964, Aug-01, Volume: 38

    Topics: Adrenalectomy; Anesthesia; Anesthetics; Arrhythmias, Cardiac; Blood Pressure; Catecholamines; Child;

1964
CENTRAL AND PERIPHRAL ACTIONS OF PRONETHALOL.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Arrhythmias, Cardiac; Blood Pressure; Chloroform; Electrocardiography; Epinephrine; Ethanolamines; E

1965
Effects of diphenylhydantoin sodium (dilantin sodium) and phenobarbital sodium upon ectopic ventricular tachycardia in acute myocardial infarction.
    The American journal of physiology, 1950, Volume: 163, Issue:3

    Topics: Arrhythmias, Cardiac; Barbital; Heart; Hydantoins; Myocardial Infarction; Phenobarbital; Phenytoin;

1950
[The combination of phenobarbital and quinidine in the treatment of cardiovascular, autonomic cardiac neuroses extrasystoles, paroxysmal tachycardia].
    Praxis, 1948, Nov-18, Volume: 37, Issue:46

    Topics: Arrhythmias, Cardiac; Autonomic Nervous System; Barbiturates; Cardiac Complexes, Premature; Cardiova

1948
Treatment of imipramine overdose in children.
    Urology, 1981, Volume: 18, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Bicarbonates; Child; Child, Preschool; Coma; Diazepam; Drug Administrat

1981
Cardiac arrhythmogenic action of benzo(a)pyrene in the rabbit.
    Toxicology letters, 1983, Volume: 15, Issue:1

    Topics: Animals; Arrhythmias, Cardiac; Benzo(a)pyrene; Benzopyrenes; Epinephrine; Ethylene Chlorohydrin; Hal

1983
Intracranial haemorrhage.
    European journal of obstetrics, gynecology, and reproductive biology, 1983, Volume: 15, Issue:4-6

    Topics: Arrhythmias, Cardiac; Cerebral Hemorrhage; Cerebral Ventricles; Cerebrospinal Fluid Shunts; Humans;

1983
Neural mechanisms in cardiac arrhythmias associated with epileptogenic activity: the effect of phenobarbital in the cat.
    Life sciences, 1984, May-14, Volume: 34, Issue:20

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Cats; Disease Models, Anima

1984
Effects of alterations in drug metabolism on chloroform-induced cardiac arrhythmias in rabbits.
    Research communications in chemical pathology and pharmacology, 1981, Volume: 33, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Biphenyl Compounds; Chloroform; Cytochrome P-450 Enzyme System; Dieth

1981
Effect of alterations in drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform.
    Toxicology letters, 1981, Volume: 9, Issue:4

    Topics: Animals; Antimetabolites; Arrhythmias, Cardiac; Biphenyl Compounds; Cytochrome P-450 Enzyme System;

1981
Pharmacologically induced embryonic dysrhythmia and episodes of hypoxia followed by reoxygenation: a common teratogenic mechanism for antiepileptic drugs?
    Teratology, 1998, Volume: 57, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Arrhythmias, Cardiac;

1998
[Romano-Ward syndrome and left stellectomy. General review apropos of a recent case].
    Archives des maladies du coeur et des vaisseaux, 1977, Volume: 70, Issue:6

    Topics: Adult; Arrhythmias, Cardiac; Deafness; Diagnosis, Differential; Drug Therapy, Combination; Electroca

1977
Influence of alterations in drug metabolism on spontaneous and epinephrine-induced cardiac arrhythmias in animals exposed to trichloroethylene.
    Toxicology and applied pharmacology, 1979, Mar-15, Volume: 47, Issue:3

    Topics: Animals; Aroclors; Arrhythmias, Cardiac; Biphenyl Compounds; Diethylamines; Drug Interactions; Elect

1979
Cardiac sensitization induced by phenobarbitone and prolonged by CS2.
    Archives of toxicology, 1977, Jul-19, Volume: 37, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Carbon Disulfide; Drug Synergism; Male; Norepinephrine; Phenobarbital

1977
[Treatment of cardiac rhythm disorders with pulsnorm].
    Klinicheskaia meditsina, 1975, Volume: 53, Issue:7

    Topics: Adolescent; Adult; Aged; Ajmaline; Antazoline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Co

1975
Interaction of quinidine with anticonvulsant drugs.
    The New England journal of medicine, 1976, Mar-25, Volume: 294, Issue:13

    Topics: Adult; Arrhythmias, Cardiac; Depression, Chemical; Drug Interactions; Enzyme Induction; Epilepsy; Fe

1976
The teratogenic effect of phenobarbital on the embryonic chick heart.
    Journal of applied toxicology : JAT, 1986, Volume: 6, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Arrhythmias, Cardiac; Chick Embryo; Dose-Response Relationship

1986
Effect of phenobarbital pretreatment on cardiac neural discharge and pentylenetetrazol-induced epileptogenic activity in the cat.
    Pharmacology, 1985, Volume: 30, Issue:4

    Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electrocardio

1985
Cardiac standstill in tetanus: review of seven consecutive cases.
    International surgery, 1973, Volume: 58, Issue:9

    Topics: Adult; Arrhythmias, Cardiac; Electrocardiography; Female; Heart Arrest; Heroin Dependence; Humans; H

1973
[Oral treatment of heart rhythm disorders with active substance combination, Pulsnorma].
    Medizinische Klinik, 1967, Dec-29, Volume: 62, Issue:52

    Topics: Adolescent; Adult; Aged; Arrhythmia, Sinus; Arrhythmias, Cardiac; Electrocardiography; Female; Hista

1967
[Treatment of heart rhythm disorders in general practice].
    Hippokrates, 1969, Feb-28, Volume: 40, Issue:4

    Topics: Adult; Aged; Arrhythmias, Cardiac; Drug Synergism; Electrocardiography; Histamine H1 Antagonists; Hu

1969
[Acute drug allergic thrombocytopenia caused by antazoline].
    Blut, 1974, Volume: 29, Issue:3

    Topics: Aged; Ajmaline; Aniline Compounds; Arrhythmias, Cardiac; Benzyl Compounds; Bone Marrow Examination;

1974
Cardiac sensitizing effects of 1,1-dichloroethylene: enhancement by phenobarbital pretreatment.
    Archives internationales de pharmacodynamie et de therapie, 1974, Volume: 210, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Drug Synergism; Electrocardiography; Epinephrine; Ethylenes; Heart; H

1974
Selected pharmacological studies of succinic semialdehyde.
    Journal of pharmaceutical sciences, 1972, Volume: 61, Issue:12

    Topics: Aldehydes; Animals; Arrhythmias, Cardiac; Blood Pressure; Central Nervous System; Chromatography, Ga

1972
[Diphenylhydantoin: study of plasmatic concentrations obtained by oral administration and of their antiarrhythmic effects].
    Coeur et medecine interne, 1973, Volume: 12, Issue:4

    Topics: Administration, Oral; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Drug Synergism; Humans

1973
[On the drug therapy of arrhytmias].
    Die Medizinische Welt, 1966, Nov-19, Volume: 47

    Topics: Arrhythmias, Cardiac; Humans; Meprobamate; Phenobarbital; Phytotherapy; Plants, Medicinal; Procainam

1966