phenobarbital has been researched along with Apoplexy in 9 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 7.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 7.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 7.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| " In this study, we evaluated the effects of phenobarbital and levetiracetam on PR-QTc intervals in patients with post-stroke seizures." | 3.80 | Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure. ( Albertini, G; De Sarro, G; Gallelli, L; Gratteri, S; Iemolo, F; Manes, MT; Mercuri, NB; Quirino, G; Sanzaro, E; Scaglione, F; Siniscalchi, A, 2014) |
| "Neonatal stroke presents with seizures that are usually treated with phenobarbital." | 3.77 | Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice. ( Comi, AM; Johnston, MV; Kadam, SD; Markowitz, GJ; Smith, DR, 2011) |
| " This is the first report of successful utilization of the prepuce as a skin graft to reconstruct a full thickness skin necrosis due to a phenobarbital extravasation to the forefoot of a newborn." | 3.73 | The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn. ( Donatucci, CF; Erdmann, D; Kukies, S; Levin, LS; Schäfer, T; Stokes, TH, 2005) |
| "Total seizure burden varied widely, with much higher seizure burden in treatment versus control groups (median = 3." | 3.01 | A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. ( Bergin, AM; Dong, M; Fortuno, CR; Hayes, B; Jensen, FE; Krishnamoorthy, K; O'Reilly, D; Rofeberg, V; Singh, A; Soul, JS; Staley, KJ; Stopp, C; Vinks, AA; Wypij, D, 2021) |
| "Neonatal stroke is the second cause of acute symptomatic neonatal seizures after hypoxic-ischemic encephalopathy." | 2.82 | Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review. ( Criscione, R; Falsaperla, R; Marino, S; Pisani, F; Praticò, A; Ruggieri, M; Sortino, V, 2022) |
| "Perinatal arterial stroke is the most frequent form of cerebral infarction in children." | 1.46 | Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model. ( Auvin, S; Baud, O; Bonnin, P; Charriaut-Marlangue, C; Dupuis, N; Enderlin, J; Leger, PL; Morin, L; Perrotte, G, 2017) |
| "Stroke is the major cause of acquired epilepsy in the adult population." | 1.37 | An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. ( Delorenzo, RJ; Deshpande, LS; Ziobro, JM, 2011) |
| "Stroke is the major cause of acquired epilepsy." | 1.31 | Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy". ( DeLorenzo, RJ; Sombati, S; Sun, DA, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sortino, V | 1 |
| Praticò, A | 1 |
| Marino, S | 1 |
| Criscione, R | 1 |
| Ruggieri, M | 1 |
| Pisani, F | 1 |
| Falsaperla, R | 1 |
| Barsch Bergqvist, A | 1 |
| Simatou, E | 1 |
| Skiöld, B | 1 |
| Mitha, A | 1 |
| Bolk, J | 1 |
| Soul, JS | 1 |
| Bergin, AM | 1 |
| Stopp, C | 1 |
| Hayes, B | 1 |
| Singh, A | 1 |
| Fortuno, CR | 1 |
| O'Reilly, D | 1 |
| Krishnamoorthy, K | 1 |
| Jensen, FE | 1 |
| Rofeberg, V | 1 |
| Dong, M | 1 |
| Vinks, AA | 1 |
| Wypij, D | 1 |
| Staley, KJ | 1 |
| Siniscalchi, A | 1 |
| Scaglione, F | 1 |
| Sanzaro, E | 1 |
| Iemolo, F | 1 |
| Albertini, G | 1 |
| Quirino, G | 1 |
| Manes, MT | 1 |
| Gratteri, S | 1 |
| Mercuri, NB | 1 |
| De Sarro, G | 1 |
| Gallelli, L | 1 |
| Morin, L | 1 |
| Enderlin, J | 1 |
| Leger, PL | 1 |
| Perrotte, G | 1 |
| Bonnin, P | 1 |
| Dupuis, N | 1 |
| Baud, O | 1 |
| Charriaut-Marlangue, C | 1 |
| Auvin, S | 1 |
| Ziobro, JM | 1 |
| Deshpande, LS | 1 |
| Delorenzo, RJ | 2 |
| Markowitz, GJ | 1 |
| Kadam, SD | 1 |
| Smith, DR | 1 |
| Johnston, MV | 1 |
| Comi, AM | 1 |
| Schäfer, T | 1 |
| Kukies, S | 1 |
| Stokes, TH | 1 |
| Levin, LS | 1 |
| Donatucci, CF | 1 |
| Erdmann, D | 1 |
| Sun, DA | 1 |
| Sombati, S | 1 |
1 review available for phenobarbital and Apoplexy
| Article | Year |
|---|---|
Efficacy of the anti-seizure medications in acute symptomatic neonatal seizures caused by stroke. A systematic review.
Topics: Anticonvulsants; Bumetanide; Epilepsy; Humans; Infant, Newborn; Infant, Newborn, Diseases; Levetirac | 2022 |
1 trial available for phenobarbital and Apoplexy
| Article | Year |
|---|---|
A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures.
Topics: Anticonvulsants; Bumetanide; Double-Blind Method; Drug Therapy, Combination; Electroencephalography; | 2021 |
7 other studies available for phenobarbital and Apoplexy
| Article | Year |
|---|---|
Term-born infants with a perinatal stroke frequently had seizures and were prescribed anti-seizure medication at discharge.
Topics: Anticonvulsants; Cross-Sectional Studies; Humans; Infant, Newborn; Patient Discharge; Phenobarbital; | 2023 |
Effects of phenobarbital and levetiracetam on PR and QTc intervals in patients with post-stroke seizure.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Levetiracetam; Long QT Syndrome; Male; Mid | 2014 |
Different response to antiepileptic drugs according to the type of epileptic events in a neonatal ischemia-reperfusion model.
Topics: Animals; Animals, Newborn; Anticonvulsants; Brain; Brain Ischemia; Disease Models, Animal; Epilepsy; | 2017 |
An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Survival; Epilepsy; Ethosuximide; Glutamic Acid; H | 2011 |
Different effects of high- and low-dose phenobarbital on post-stroke seizure suppression and recovery in immature CD1 mice.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Atrophy; Body Weight; Cognition Disorders; | 2011 |
The prepuce as a donor site for reconstruction of an extravasation injury to the foot in a newborn.
Topics: Anticonvulsants; Circumcision, Male; Foot Injuries; Humans; Infant, Newborn; Infusions, Intravenous; | 2005 |
Glutamate injury-induced epileptogenesis in hippocampal neurons: an in vitro model of stroke-induced "epilepsy".
Topics: Action Potentials; Animals; Anticonvulsants; Cell Size; Cell Survival; Cells, Cultured; Dose-Respons | 2001 |